The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Versene     calcium 2-[2-(carboxylatomethyl...

Synonyms: Antallin, Chelaton, Edetamin, Sormetal, Tetazine, ...
This record was replaced with 6049.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Edathamil


High impact information on Edathamil

  • The effects of calcium, EDTA, and temperature on the binding of lipoproteins to the hepatic membranes were also evaluated [6].
  • Versene dissociation of the 13762 solid tumor produced better growth rates than did pronase-DNase, but the former decreased cell viability and yields [7].
  • The effect of iron status on calcium disodium edetate (CaNa2EDTA)-induced lead diuresis was examined in 112 children with moderate lead intoxication [8].
  • In parallel experiments, we compared neuronal cell death in TUNEL-stained brain sections in traumatized rats with and without calcium EDTA treatment [5].
  • The membrane penetrating chelator diethyldithiocarbamate (DEDTC) was found to block the AMG staining whereas calcium-EDTA, known not to pass through cell membranes, did not influence the staining, proving that the detected zinc ions are intracellularly located [9].

Chemical compound and disease context of Edathamil


Biological context of Edathamil


Anatomical context of Edathamil

  • Calcium-EDTA therapy had no influence on erythrocyte, serum, or urine chromium level [18].
  • After sufficient outgrowth, cultures were dispersed with trypsin/versene and maintained as independent cell lines [19].
  • These findings and the fact that calcium EDTA acid blocks the plasma and surface staining, but not the acrosomal and mitochondrial staining, suggest that chelatable zinc ions exist in two separate pools in human semen [20].
  • Based on the experiments performed, chorionic villus cells are more sensitive to pronase, trypsin, and versene during subculture and have a higher DNA content per single cell and release more [125I]-Beta-human chorionic gonadotropin into culture medium than those found in amniotic fluid cells [21].
  • When endothelial cells were induced to retract from their substrate by exposure to cold or versene and then incubated with PRP, platelets were observed adhering to endothelial cell processes and to an extracellular microfilamentous network, located beneath the cell [22].

Associations of Edathamil with other chemical compounds


Gene context of Edathamil


Analytical, diagnostic and therapeutic context of Edathamil


  1. Chronic renal failure with gout: a marker of chronic lead poisoning. Craswell, P.W., Price, J., Boyle, P.D., Heazlewood, V.J., Baddeley, H., Lloyd, H.M., Thomas, B.J., Thomas, B.W. Kidney Int. (1984) [Pubmed]
  2. Zinc metabolism in the brain: relevance to human neurodegenerative disorders. Cuajungco, M.P., Lees, G.J. Neurobiol. Dis. (1997) [Pubmed]
  3. Effects of calcium disodium versenate (CaNa2EDTA) chelation in moderate childhood lead poisoning. Markowitz, M.E., Bijur, P.E., Ruff, H., Rosen, J.F. Pediatrics (1993) [Pubmed]
  4. Neurotoxicity of dental amalgam is mediated by zinc. Lobner, D., Asrari, M. J. Dent. Res. (2003) [Pubmed]
  5. Protective effects of zinc chelation in traumatic brain injury correlate with upregulation of neuroprotective genes in rat brain. Hellmich, H.L., Frederickson, C.J., DeWitt, D.S., Saban, R., Parsley, M.O., Stephenson, R., Velasco, M., Uchida, T., Shimamura, M., Prough, D.S. Neurosci. Lett. (2004) [Pubmed]
  6. Characterization of hepatic low density lipoprotein binding and cholesterol metabolism in normal and homozygous familial hypercholesterolemic subjects. Hoeg, J.M., Demosky, S.J., Schaefer, E.J., Starzl, T.E., Brewer, H.B. J. Clin. Invest. (1984) [Pubmed]
  7. Suitability of rat mammary adenocarcinoma 13762 as a model for BCG immunotherapy. Kreider, J.W., Bartlett, G.L., Purnell, D.M. J. Natl. Cancer Inst. (1976) [Pubmed]
  8. Effects of iron deficiency on lead excretion in children with moderate lead intoxication. Markowitz, M.E., Rosen, J.F., Bijur, P.E. J. Pediatr. (1990) [Pubmed]
  9. Autometallographic demonstration of zinc ions in rat sperm cells. Stoltenberg, M., Sørensen, M.B., Danscher, G., Juhl, S., Andreasen, A., Ernst, E. Mol. Hum. Reprod. (1997) [Pubmed]
  10. Lead mobilization test in children with lead poisoning: validation of a 5-hour edetate calcium disodium provocation test. Iniguez, J.L., Leverger, G., Dollfus, C., Gouraud, F., Garnier, R., Beauvais, P. Archives of pediatrics & adolescent medicine. (1995) [Pubmed]
  11. Chelation in metal intoxication XVIII: Combined effects of thiamine and calcium disodium versenate on lead toxicity. Flora, S.J., Singh, S., Tandon, S.K. Life Sci. (1986) [Pubmed]
  12. Experimental lead nephropathy: treatment with calcium disodium ethylenediaminetetraacetate. Sánchez-Fructuoso, A.I., Blanco, J., Cano, M., Ortega, L., Arroyo, M., Fernández, C., Prats, D., Barrientos, A. Am. J. Kidney Dis. (2002) [Pubmed]
  13. Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats. Saxena, G., Flora, S.J. J. Biochem. Mol. Toxicol. (2004) [Pubmed]
  14. Chelatable lead body burden (by calcium-disodium EDTA) and blood lead concentration in man. Hansen, J.P., Døssing, M., Paulev, P.E. Journal of occupational medicine. : official publication of the Industrial Medical Association. (1981) [Pubmed]
  15. The influence of radiographic contrast media on some granulocyte functions. Rasmussen, F. Acta radiologica. Supplementum. (1998) [Pubmed]
  16. Bite the bullet: lead poisoning after ingestion of 206 lead bullets. McNutt, T.K., Chambers-Emerson, J., Dethlefsen, M., Shah, R. Veterinary and human toxicology. (2001) [Pubmed]
  17. The relationship between total and ionized calcium in the blood sheep when calcium levels are altered. Belonje, P.C. Journal of the South African Veterinary Association. (1976) [Pubmed]
  18. Acute potassium dichromate poisoning: a toxicokinetic case study. Kołaciński, Z., Kostrzewski, P., Kruszewska, S., Raźniewska, G., Mielczarska, J. J. Toxicol. Clin. Toxicol. (1999) [Pubmed]
  19. Enhanced in vitro growth suppression of human glioblastoma cultures treated with the combination of recombinant fibroblast and immune interferons. Vita, J.R., Edwalds, G.M., Gorey, T., Housepian, E.M., Fetell, M.R., Guarini, L., Langer, J.A., Fisher, P.B. Anticancer Res. (1988) [Pubmed]
  20. Histochemical demonstration of zinc ions in ejaculated human semen. Stoltenberg, M., Sørensen, M.B., Danscher, G. Int. J. Androl. (1997) [Pubmed]
  21. In vitro characteristics of human fetal cells obtained from chorionic villus sampling and amniocentesis. Chang, H.C., Jones, O.W. Prenat. Diagn. (1988) [Pubmed]
  22. Platelet adherence in endothelial cell cultures. Wechezak, A.R., Holbrook, K.A., Way, S.A., Mansfield, P.B. Blood vessels. (1979) [Pubmed]
  23. Inhibition of human hepatocellular carcinoma and hepatoblastoma cell lines by deferoxamine. Tabor, E., Kim, C.M. J. Med. Virol. (1991) [Pubmed]
  24. Beneficial effects of zinc supplementation during chelation treatment of lead intoxication in rats. Flora, S.J., Tandon, S.K. Toxicology (1990) [Pubmed]
  25. Lead, zinc, and erythrocyte delta-aminolevulinic acid dehydratase: relationships in lead toxicity. Thomasino, J.A., Zuroweste, E., Brooks, S.M., Petering, H.G., Lerner, S.I., Finelli, V.N. Arch. Environ. Health (1977) [Pubmed]
  26. Effect of edetate calcium disodium on yttrium-90 activity in bone of mice. Watanabe, N., Oriuchi, N., Tanada, S., Murata, H., Inoue, T., Kim, E.E., Sasaki, Y., Endo, K. Annals of nuclear medicine. (1999) [Pubmed]
  27. Acute lead arsenate poisoning. Tallis, G.A. Australian and New Zealand journal of medicine. (1989) [Pubmed]
  28. Short-term administration of dimercaptopropanol (BAL) and calcium disodium edetate (EDTA) for diagnostic and therapeutic lead mobilization. Haust, H.L., Ali, H., Haines, D.S., Forret, C.J. Int. J. Biochem. (1980) [Pubmed]
  29. Moderate lead poisoning: trends in blood lead levels in unchelated children. Markowitz, M.E., Bijur, P.E., Ruff, H.A., Balbi, K., Rosen, J.F. Environ. Health Perspect. (1996) [Pubmed]
  30. Chelated lead and bone lead. Tell, I., Somervaille, L.J., Nilsson, U., Bensryd, I., Schütz, A., Chettle, D.R., Scott, M.C., Skerfving, S. Scandinavian journal of work, environment & health. (1992) [Pubmed]
  31. Body burdens of lead in hypertensive nephropathy. Osterloh, J.D., Selby, J.V., Bernard, B.P., Becker, C.E., Menke, D.J., Tepper, E., Ordonez, J.D., Behrens, B. Arch. Environ. Health (1989) [Pubmed]
  32. Injection of sheep with organic compounds of copper. Mahmoud, O.H., Ford, E.J. Vet. Rec. (1981) [Pubmed]
  33. Lead poisoning from Indian herbal medicine (Ayurveda). Dunbabin, D.W., Tallis, G.A., Popplewell, P.Y., Lee, R.A. Med. J. Aust. (1992) [Pubmed]
WikiGenes - Universities