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Chemical Compound Review

CCRIS 5814     disodium dioxido-dioxo-tungsten

Synonyms: CHEBI:63940, HSDB 5057, LS-7747, CHEBI:235858, AC1N3GPG, ...
 
 
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Disease relevance of disodium dioxido-dioxo-tungsten

  • Sodium tungstate has been found to correct hyperglycemia in insulin- and noninsulin-dependent models of diabetes when administered in drinking fluid with a low degree of toxicity; thus, it provides a potential treatment for diabetes [1].
  • Although sodium tungstate (Na2WO4) was less acutely toxic than lead nitrate (Pb(NO3)2) in 14-d spiked field soil acute toxicity assays (lethal concentrations for 50% of organisms: W, 6,250 mg/kg; Pb, 2,490 mg/kg), tungstate completely inhibited reproduction in 28- and 56-d assays at all tested tungsten concentrations (> or = 704 mg/kg) [2].
  • The effect of sodium tungstate in the culture media of three different species of Azotobacter, isolated from Allahabad soil, was studied [3].
  • Growth of five strains of sulfur-oxidizing bacteria Acidithiobacillus thiooxidans, including strain NB1-3, was inhibited completely by 50 microM of sodium tungstate (Na(2)WO(4)) [4].
 

High impact information on disodium dioxido-dioxo-tungsten

 

Biological context of disodium dioxido-dioxo-tungsten

  • Pharmacokinetics of sodium tungstate in rat and dog: a population approach [1].
  • Sodium tungstate followed first order kinetics, and plasma concentration-versus-time data were adequately described by a two-compartment model [1].
  • After oral administration, F (0.61+/-0.086 vs. 0.48+/-0.093), and normalized (to a 7-mg/kg dose of sodium tungstate) AUC (54+/-8.4 vs. 41.2+/-8.5 mg/l x h), C(max) (10.6+/-0.49 vs. 8.5+/-0.57 microg/ml) and C(min) (3.04+/-0.23 vs. 2.04+/-0.22 microg/ml), were higher in male than in female dogs [10].
  • Radioprotective effects of sodium tungstate (ST) on 60Co gamma-ray induced decrease in hematocrit value and in survival rate in Wistar strain male rats were examined [11].
  • Systemic injections of sodium tungstate, a protein-tyrosine phosphatase (PTPase) inhibitor, to pupae immediately after pupation have been shown to efficiently produce characteristic color-pattern modifications on the wings of many species of butterflies [12].
 

Anatomical context of disodium dioxido-dioxo-tungsten

 

Associations of disodium dioxido-dioxo-tungsten with other chemical compounds

 

Gene context of disodium dioxido-dioxo-tungsten

  • Effects of sodium tungstate on insulin and glucagon secretion in the perfused rat pancreas [17].
  • Protein FA addition, however, cannot bring about the activation if 10 mM sodium tungstate is included in the culture medium for the chlB strain [21].
  • The PO-TMB reaction product was stabilized effectively by the addition of sodium tungstate to the reaction mixture, thus making the PO-TMB reaction now generally applicable to in situ hybridization (ISH) [22].
  • Alcoholic PTA and sodium tungstate yielded a selective positive contrast of the two fibrillar components whereas EDTA and RNase-gold reacted with the peripheral granular material [14].
  • We have previously shown that the systemic injection of sodium tungstate, a general protein-tyrosine phosphatase (PTPase) inhibitor, efficiently produces characteristic color-pattern modifications on the wings of the Painted Lady butterfly, Vanessa cardui [23].
 

Analytical, diagnostic and therapeutic context of disodium dioxido-dioxo-tungsten

  • AIMS/HYPOTHESIS: Recent studies have shown the anti diabetic effects of oral sodium tungstate treatment in several animal models of diabetes based on short-term experiments [24].
  • In an investigation of the skin of 853 individuals who are still working or had previously worker in hard metal manufacture, sodium tungstate was included in a patch test with a panel of substances from the environment of the employees [25].
  • Water-soluble proteins were precipitated by adding sodium tungstate and sulfuric acid and removed by centrifugation [26].
  • This paper presents a HPLC and a CZE method for the analysis of sodium tungstate, its equilibrium products and isopolyanions [27].

References

  1. Pharmacokinetics of sodium tungstate in rat and dog: a population approach. Le Lamer, S., Poucheret, P., Cros, G., de Richter, R.K., Bonnet, P.A., Bressolle, F. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  2. Tungsten effects on survival, growth, and reproduction in the earthworm, Eisenia fetida. Inouye, L.S., Jones, R.P., Bednar, A.J. Environ. Toxicol. Chem. (2006) [Pubmed]
  3. Microbial fixation of nitrogen in presence of sodium tungstate. Bahadur, K., Jyotishmati, U. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Zweite naturwissenschaftliche Abteilung: Mikrobiologie der Landwirtschaft der Technologie und des Umweltschutzes. (1978) [Pubmed]
  4. Growth inhibition by tungsten in the sulfur-oxidizing bacterium Acidithiobacillus thiooxidans. Negishi, A., Muraoka, T., Maeda, T., Takeuchi, F., Kanao, T., Kamimura, K., Sugio, T. Biosci. Biotechnol. Biochem. (2005) [Pubmed]
  5. Epoxide reductase activity of mammalian liver cytosols and aldehyde oxidase. Hirao, Y., Kitamura, S., Tatsumi, K. Carcinogenesis (1994) [Pubmed]
  6. Structure of the mouse glucocorticoid receptor: rapid analysis by size-exclusion high-performance liquid chromatography. LaPointe, M.C., Chang, C.H., Vedeckis, W.V. Biochemistry (1986) [Pubmed]
  7. Interaction of rat liver glucocorticoid receptor with sodium tungstate. Murakami, N., Healy, S.P., Moudgil, V.K. Biochem. J. (1982) [Pubmed]
  8. Sodium tungstate decreases the phosphorylation of tau through GSK3 inactivation. Gómez-Ramos, A., Domínguez, J., Zafra, D., Corominola, H., Gomis, R., Guinovart, J.J., Avila, J. J. Neurosci. Res. (2006) [Pubmed]
  9. Ferrous iron-dependent volatilization of mercury by the plasma membrane of Thiobacillus ferrooxidans. Iwahori, K., Takeuchi, F., Kamimura, K., Sugio, T. Appl. Environ. Microbiol. (2000) [Pubmed]
  10. Estimation of pharmacokinetic parameters of sodium tungstate after multiple-dose during preclinical studies in beagle dogs. Le Lamer, S., Cros, G., Serrano, J.J., Piñol, C., Fernändez-Alvarez, J., Bressolle, F. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2001) [Pubmed]
  11. Radioprotective effects of sodium tungstate on hematopoietic injury by exposure to 60Co gamma-rays in Wistar rats. Sato, K., Ichimasa, M., Miyahara, K., Shiomi, M., Nishimura, Y., Ichimasa, Y. J. Radiat. Res. (1999) [Pubmed]
  12. Tungstate-induced color-pattern modifications of butterfly wings are independent of stress response and ecdysteroid effect. Otaki, J.M., Ogasawara, T., Yamamoto, H. Zool. Sci. (2005) [Pubmed]
  13. Tungstate stimulates insulin release and inhibits somatostatin output in the perfused rat pancreas. Silvestre, R.A., Egido, E.M., Hernández, R., Marco, J. Eur. J. Pharmacol. (2005) [Pubmed]
  14. Cytochemical variations in the nucleolus during spermiogenesis in man and monkey. Dadoune, J.P., Alfonsi, M.F., Fain-Maurel, M.A. Cell Tissue Res. (1991) [Pubmed]
  15. Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats. Miyazono, Y., Gao, F., Horie, T. Scand. J. Gastroenterol. (2004) [Pubmed]
  16. Interaction of chick oviduct progesterone receptor with sodium tungstate: inhibition of activation and DNA binding. Murakami, N., Szocik, J.F., Danloff, T.A., Moudgil, V.K. J. Steroid Biochem. (1982) [Pubmed]
  17. Effects of sodium tungstate on insulin and glucagon secretion in the perfused rat pancreas. Rodríguez-Gallardo, J., Silvestre, R.A., Egido, E.M., Marco, J. Eur. J. Pharmacol. (2000) [Pubmed]
  18. Electron microscopical demonstration of horseradish peroxidase by use of tetramethylbenzidine as chromogen and sodium tungstate as stabilizer (TMB-ST method): a tracing method with high sensitivity and well preserved ultrastructural tissue. Gu, Y., Chen, Y., Ye, L. J. Neurosci. Methods (1992) [Pubmed]
  19. Oral administration of sodium tungstate improves cardiac performance in streptozotocin-induced diabetic rats. Nagareddy, P.R., Vasudevan, H., McNeill, J.H. Can. J. Physiol. Pharmacol. (2005) [Pubmed]
  20. Role of oxyradicals in cold water immersion restraint-induced gastric mucosal injury in the rat. Tarnasky, P.R., Livingston, E.H., Jacobs, K.M., Zimmerman, B.J., Guth, P.H., Garrick, T.R. Dig. Dis. Sci. (1990) [Pubmed]
  21. Activation in vitro of respiratory nitrate reductase of Escherichia coli K12 grown in the presence of tungstate. Involvement of molybdenum cofactor. Saracino, L., Violet, M., Boxer, D.H., Giordano, G. Eur. J. Biochem. (1986) [Pubmed]
  22. A novel triple-color detection procedure for brightfield microscopy, combining in situ hybridization with immunocytochemistry. Speel, E.J., Jansen, M.P., Ramaekers, F.C., Hopman, A.H. J. Histochem. Cytochem. (1994) [Pubmed]
  23. Species-specific color-pattern modifications of butterfly wings. Otaki, J.M., Yamamoto, H. Dev. Growth Differ. (2004) [Pubmed]
  24. Tungstate is an effective antidiabetic agent in streptozotocin-induced diabetic rats: a long-term study. Barberà, A., Gomis, R.R., Prats, N., Rodríguez-Gil, J.E., Domingo, M., Gomis, R., Guinovart, J.J. Diabetologia (2001) [Pubmed]
  25. Patch testing with sodium tungstate. Rystedt, I., Fischer, T., Lagerholm, B. Contact Derm. (1983) [Pubmed]
  26. Determination of lincomycin residue in salmon tissues by ion-pair reversed-phase liquid chromatography with electrochemical detection. Luo, W., Hansen, E.B., Ang, C.Y., Thompson, H.C. Journal of AOAC International. (1996) [Pubmed]
  27. Application of HPLC and CZE to the analysis of polyoxometalates. Hettiarachchi, K., Ha, Y., Tran, T., Cheung, A.P. Journal of pharmaceutical and biomedical analysis. (1995) [Pubmed]
 
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