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Chemical Compound Review

AC1MIWWM     disodium; molybdenum; oxygen(-2) anion

Synonyms: CCRIS 3927, 12680-49-8, 7631-95-0 (Parent), Molybdenum sodium oxide, disodium; molybdenum; oxygen(2-)
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Disease relevance of CCRIS 3927


High impact information on CCRIS 3927


Chemical compound and disease context of CCRIS 3927


Biological context of CCRIS 3927


Anatomical context of CCRIS 3927


Associations of CCRIS 3927 with other chemical compounds


Gene context of CCRIS 3927

  • With a modified assay (the presence of sodium molybdate and a reduction in the amount of charcoal used to adsorb "excess" ligand) we found that cytosol from LS180 cells contains a high concentration of AhR (400-500 fmol/mg cytosolic protein) when detected by [3H]TCDD or [3H]MC [28].
  • Routine addition of sodium molybdate to samples analyzed for PR by centrifugation overnight can be expected to yield an increased percent of receptor-positive patients with higher average concentration of receptor, compared with results of previous methodology [29].
  • The hormone-dependent interaction of vaults with estrogen receptor was reproducible in vitro and was prevented by sodium molybdate [30].
  • Expression of the human cDNA in a rabbit reticulocyte lysate system allowed functional analysis of ligand binding, agonist-induced and Ah receptor nuclear translocator-dependent DNA binding, and receptor stabilization by sodium molybdate [31].
  • After the inclusion of sodium molybdate in the reconstitution mixture, active sulfite oxidase was obtained, revealing that in vitro MPT synthase and aposulfite oxidase are sufficient for the insertion of MPT into sulfite oxidase and the conversion of MPT into Moco in the presence of high concentrations of molybdate [26].

Analytical, diagnostic and therapeutic context of CCRIS 3927


  1. The nontransformed progesterone and estrogen receptors in gastric cancer. Wu, C.W., Chang, H.M., Kao, H.L., Lui, W.Y., P'eng, F.K., Chi, C.W. Gastroenterology (1992) [Pubmed]
  2. Molybdate and the measurements of androgen receptors in prostate cancer. Hawkins, E.F., Lieskovsky, G., Markland, F.S. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  3. Studies on the genotoxicity of molybdenum salts in human cells in vitro and in mice in vivo. Titenko-Holland, N., Shao, J., Zhang, L., Xi, L., Ngo, H., Shang, N., Smith, M.T. Environ. Mol. Mutagen. (1998) [Pubmed]
  4. The effect of molybdate on the intracellular distribution of estrogen receptor in mammary tumors. Lazier, C.B., Richman, J., Lonergan, K. Breast Cancer Res. Treat. (1984) [Pubmed]
  5. Effects of molybdenum on fertility of male rats. Pandey, R., Singh, S.P. Biometals (2002) [Pubmed]
  6. A mutation that causes lability of the androgen receptor under conditions that normally promote transformation to the DNA-binding state. Kovacs, W.J., Griffin, J.E., Weaver, D.D., Carlson, B.R., Wilson, J.D. J. Clin. Invest. (1984) [Pubmed]
  7. Resistance to 1,25-dihydroxyvitamin D. Association with heterogeneous defects in cultured skin fibroblasts. Liberman, U.A., Eil, C., Marx, S.J. J. Clin. Invest. (1983) [Pubmed]
  8. Evidence that the modulator of the glucocorticoid-receptor complex is the endogenous molybdate factor. Bodine, P.V., Litwack, G. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  9. Protein kinase activity associated with the purified rat hepatic glucocorticoid receptor. Miller-Diener, A., Schmidt, T.J., Litwack, G. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  10. Protective mechanism of sodium molybdate against the acute toxicity of cadmium in rats. II. Prevention of cytoplasmic acidification. Koizumi, T., Yokota, T., Fukuchi, M., Tatsumoto, H., Yamane, Y. Cell Biol. Toxicol. (1991) [Pubmed]
  11. Protective effect of sodium molybdate on the acute toxicity of mercuric chloride. V. Enhancement of renal regeneration after exposure to HgCl2. Koizumi, T., Yamane, Y. Chem. Biol. Interact. (1988) [Pubmed]
  12. Microbial fixation of nitrogen in presence of lanthanum sulphate with sodium molybdate. Bahadur, K., Prakash, S., Jyotishmati, U. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Zweite naturwissenschaftliche Abteilung: Mikrobiologie der Landwirtschaft der Technologie und des Umweltschutzes. (1978) [Pubmed]
  13. Comparison of sex steroid receptor determinations in human breast cancer by enzyme immunoassay and radioligand binding. Pasic, R., Djulbegovic, B., Wittliff, J.L. J. Clin. Lab. Anal. (1990) [Pubmed]
  14. Ah receptor in human placenta: stabilization by molybdate and characterization of binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 3-methylcholanthrene, and benzo(a)pyrene. Manchester, D.K., Gordon, S.K., Golas, C.L., Roberts, E.A., Okey, A.B. Cancer Res. (1987) [Pubmed]
  15. Effect of 17 beta-estradiol on the growth of estrogen receptor-positive human melanoma in vitro and in athymic mice. Feucht, K.A., Walker, M.J., Das Gupta, T.K., Beattie, C.W. Cancer Res. (1988) [Pubmed]
  16. Sulfate-reducing bacteria in floating macrophyte rhizospheres from an Amazonian floodplain lake in Bolivia and their association with Hg methylation. Achá, D., Iñiguez, V., Roulet, M., Guimarães, J.R., Luna, R., Alanoca, L., Sanchez, S. Appl. Environ. Microbiol. (2005) [Pubmed]
  17. Effect of sodium molybdate on the status of lipids, lipid peroxidation and antioxidant systems in alloxan-induced diabetic rats. Panneerselvam, S.R., Govindasamy, S. Clin. Chim. Acta (2004) [Pubmed]
  18. Estrogen and progesterone receptors in human gallbladder. Singletary, B.K., Van Thiel, D.H., Eagon, P.K. Hepatology (1986) [Pubmed]
  19. Characterization of two 8 S forms of chick oviduct progesterone receptor. Dougherty, J.J., Toft, D.O. J. Biol. Chem. (1982) [Pubmed]
  20. Degradation without apparent change in size of molybdate-stabilized nonactivated glucocorticoid-receptor complexes in rat thymus cytosol. Mendel, D.B., Holbrook, N.J., Bodwell, J.E. J. Biol. Chem. (1985) [Pubmed]
  21. Action of glycerol and sodium molybdate in stabilization of the progesterone receptor from rat trophoblast. Ogle, T.F. J. Biol. Chem. (1983) [Pubmed]
  22. Glucocorticoid binding by human fetal membranes at term. López Bernal, A., Anderson, A.B., Demers, L.M., Turnbull, A.C. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  23. Use of chromatofocusing to distinguish estradiol receptor from ovarian-dependent and -independent rat mammary tumors. Coufalik, A.H., Feldman, M., Platica, M., Toth, L., Dreiling, D., Hollander, V.P. Cancer Res. (1983) [Pubmed]
  24. Analysis of the steroid receptor of Achlya ambisexualis. Riehl, R.M., Toft, D.O. J. Biol. Chem. (1984) [Pubmed]
  25. Inhibition of uterine estrogen receptor transformation by sodium molybdate. Shyamala, G., Leonard, L. J. Biol. Chem. (1980) [Pubmed]
  26. In vitro incorporation of nascent molybdenum cofactor into human sulfite oxidase. Leimkühler, S., Rajagopalan, K.V. J. Biol. Chem. (2001) [Pubmed]
  27. Characterization of the calf uterine progesterone receptor and its stabilization by nucleic acids. Theofan, G., Notides, A.C. Endocrinology (1984) [Pubmed]
  28. Detection and characterization of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the human colon adenocarcinoma cell line LS180. Harper, P.A., Prokipcak, R.D., Bush, L.E., Golas, C.L., Okey, A.B. Arch. Biochem. Biophys. (1991) [Pubmed]
  29. Stabilization of human breast cancer progesterone (5020) receptor by sodium molybdate. Anderson, K.M., Marogil, M., Bonomi, P.D., Hendrickson, C., Economou, S. Clin. Chim. Acta (1980) [Pubmed]
  30. Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell. Abbondanza, C., Rossi, V., Roscigno, A., Gallo, L., Belsito, A., Piluso, G., Medici, N., Nigro, V., Molinari, A.M., Moncharmont, B., Puca, G.A. J. Cell Biol. (1998) [Pubmed]
  31. Cloning and expression of a human Ah receptor cDNA. Dolwick, K.M., Schmidt, J.V., Carver, L.A., Swanson, H.I., Bradfield, C.A. Mol. Pharmacol. (1993) [Pubmed]
  32. Interaction of the Mr = 90,000 heat shock protein with the steroid-binding domain of the glucocorticoid receptor. Denis, M., Gustafsson, J.A., Wikström, A.C. J. Biol. Chem. (1988) [Pubmed]
  33. A new affinity resin for purification of non-transformed avian progesterone receptor. Grandics, P., Puri, R.K., Toft, D.O. Endocrinology (1982) [Pubmed]
  34. High-resolution separation of molybdate-stabilized progestin receptors using high-performance liquid chromatography. van der Walt, L.A., Wittliff, J.L. J. Chromatogr. (1988) [Pubmed]
  35. ATP-dependent activation of glucocorticoid-receptor complexes from the rat's heart. Kôrge, P. J. Steroid Biochem. (1984) [Pubmed]
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