Chemical Compound Review:
Clinium 2-[4-[4,4-bis(4- fluorophenyl)butyl]piperaz...
Synonyms:
Klinium, Corflazine, Lidoflazin, Angex, LIDOFLAZINE, ...
- Lidoflazine in the treatment of comatose survivors of cardiac arrest. Engler, R.L. N. Engl. J. Med. (1991)
- The pathophysiology of angina pectoris and the effect of lidoflazine. Gobel, F.L., Nordstrom, L.A., Nelson, R.R., Wang, Y. Circulation (1982)
- Cardioprotective effects of lidoflazine during 1-hour normothermic global ischemia. Flameng, W., Daenen, W., Borgers, M., Thone, F., Xhonneux, R., van de Water, A., van Belle, H. Circulation (1981)
- Studies on the possible mechanisms of lidoflazine arrhythmogenicity. Keren, G., Tepper, D., Butler, B., Maguire, W., Willens, H., Miura, D., Somberg, J.C. J. Am. Coll. Cardiol. (1984)
- The effects of lidoflazine on exercise performance and thallium stress scintigraphy in patients with stable angina pectoris. Shapiro, W., Narahara, K.A., Park, J. Circulation (1982)
- Cerebral ischemia and reperfusion: prevention of brain mitochondrial injury by lidoflazine. Rosenthal, R.E., Hamud, F., Fiskum, G., Varghese, P.J., Sharpe, S. J. Cereb. Blood Flow Metab. (1987)
- The effect of intravenous lidoflazine on serotonin-induced cerebral vascular contraction--an in vivo study. Rosenwasser, R.H., Tuma, R.F., Buchheit, W.A. Stroke (1986)
- Ventricular arrhythmias associated with lidoflazine: side-effects observed in a randomized trial. Hanley, S.P., Hampton, J.R. Eur. Heart J. (1983)
- Inhibitory effect of lidoflazine on contractions of isolated canine coronary arteries caused by norepinephrine, 5-hydroxytryptamine, high potassium, anoxia and ergonovine maleate. Van Neuten, J.M., Van Beek, J., Vanhoutte, P.M. J. Pharmacol. Exp. Ther. (1980)
- The cardioprotective effects of R 75231 and lidoflazine are not caused by adenosine A1 receptor activation. Grover, G.J., Sleph, P.G. J. Pharmacol. Exp. Ther. (1994)
- The effects of lidoflazine and flunarizine on cerebral reactive hyperemia. Phillis, J.W., DeLong, R.E., Towner, J.K. Eur. J. Pharmacol. (1985)
- An analysis of the rate-dependent action of lidoflazine in mammalian sino-atrial node and Purkinje fibres. Hart, G., Dukes, I.D. J. Mol. Cell. Cardiol. (1984)
- Lidoflazine in the early stages of acute myocardial ischaemia. Coker, S.J., Fagbemi, O., Parratt, J.R. Br. J. Pharmacol. (1982)
- In vitro modulation of human neutrophil superoxide anion generation by various calcium channel antagonists used in ischemia-reperfusion resuscitation. Zimmerman, J.J., Zuk, S.M., Millard, J.R. Biochem. Pharmacol. (1989)
- Cell proliferation in developing coronary collaterals and the influence of lidoflazine on this process. Verheyen, A., Xhonneux, R., Borgers, M., Reneman, R.S. J. Mol. Cell. Cardiol. (1976)
- Nucleoside influx and efflux in guinea-pig ventricular myocytes. Inhibition by analogues of lidoflazine. Conant, A.R., Jarvis, S.M. Biochem. Pharmacol. (1994)
- Comparison of negative inotropic potency, reversibility, and effects on calcium influx of six calcium channel antagonists in cultured myocardial cells. Barry, W.H., Horowitz, J.D., Smith, T.W. Br. J. Pharmacol. (1985)
- Inhibition of nucleoside uptake in human erythrocytes by a new series of compounds related to lidoflazine and mioflazine. Pirovano, I.M., Van Belle, H., Ijzerman, A.P. Eur. J. Pharmacol. (1990)
- Randomized, placebo-controlled evaluation of lidoflazine in patients receiving beta-blocker therapy with propranolol: improvement in anginal symptoms and exercise tolerance with combined drug therapy. Strauss, W.E., Parisi, A.F. Am. J. Cardiol. (1984)
- Calcium-channel blockade as an adjunct to heterogeneous delivery of cardioplegia. Guyton, R.A., Dorsey, L.M., Colgan, T.K., Hatcher, C.R. Ann. Thorac. Surg. (1983)
- Nucleoside transport inhibition mediates lidoflazine-induced cardioprotection during intermittent aortic crossclamping. Chang-Chun, C., Masuda, M., Szabò, Z., Szerafin, T., Szècsi, J., Van Belle, H., Flameng, W. J. Thorac. Cardiovasc. Surg. (1992)
- The differential effect of calcium antagonists on the positive inotropic effects induced by calcium and monensin in cardiac preparations of rats and guinea-pigs. Hugtenburg, J.G., Mathy, M.J., Beckeringh, J.J., van Zwieten, P.A. Naunyn Schmiedebergs Arch. Pharmacol. (1989)
- Lidoflazine is a high affinity blocker of the HERG K(+)channel. Ridley, J.M., Dooley, P.C., Milnes, J.T., Witchel, H.J., Hancox, J.C. J. Mol. Cell. Cardiol. (2004)
- Lidoflazine does not improve neurologic outcome when administered after complete cerebral ischemia in primates. Fleischer, J.E., Lanier, W.L., Milde, J.H., Michenfelder, J.D. J. Cereb. Blood Flow Metab. (1987)