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Chemical Compound Review

Clinium     2-[4-[4,4-bis(4- fluorophenyl)butyl]piperaz...

Synonyms: Klinium, Corflazine, Lidoflazin, Angex, LIDOFLAZINE, ...
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Disease relevance of Ordiflazine


High impact information on Ordiflazine


Chemical compound and disease context of Ordiflazine


Biological context of Ordiflazine


Anatomical context of Ordiflazine


Associations of Ordiflazine with other chemical compounds


Gene context of Ordiflazine

  • Lidoflazine inhibited potently HERG current (I(HERG)) recorded from HEK 293 cells stably expressing wild-type HERG (IC(50) of approximately 16 nM) [23].

Analytical, diagnostic and therapeutic context of Ordiflazine


  1. Lidoflazine in the treatment of comatose survivors of cardiac arrest. Engler, R.L. N. Engl. J. Med. (1991) [Pubmed]
  2. The pathophysiology of angina pectoris and the effect of lidoflazine. Gobel, F.L., Nordstrom, L.A., Nelson, R.R., Wang, Y. Circulation (1982) [Pubmed]
  3. Cardioprotective effects of lidoflazine during 1-hour normothermic global ischemia. Flameng, W., Daenen, W., Borgers, M., Thone, F., Xhonneux, R., van de Water, A., van Belle, H. Circulation (1981) [Pubmed]
  4. Studies on the possible mechanisms of lidoflazine arrhythmogenicity. Keren, G., Tepper, D., Butler, B., Maguire, W., Willens, H., Miura, D., Somberg, J.C. J. Am. Coll. Cardiol. (1984) [Pubmed]
  5. The effects of lidoflazine on exercise performance and thallium stress scintigraphy in patients with stable angina pectoris. Shapiro, W., Narahara, K.A., Park, J. Circulation (1982) [Pubmed]
  6. Cerebral ischemia and reperfusion: prevention of brain mitochondrial injury by lidoflazine. Rosenthal, R.E., Hamud, F., Fiskum, G., Varghese, P.J., Sharpe, S. J. Cereb. Blood Flow Metab. (1987) [Pubmed]
  7. The effect of intravenous lidoflazine on serotonin-induced cerebral vascular contraction--an in vivo study. Rosenwasser, R.H., Tuma, R.F., Buchheit, W.A. Stroke (1986) [Pubmed]
  8. Ventricular arrhythmias associated with lidoflazine: side-effects observed in a randomized trial. Hanley, S.P., Hampton, J.R. Eur. Heart J. (1983) [Pubmed]
  9. Inhibitory effect of lidoflazine on contractions of isolated canine coronary arteries caused by norepinephrine, 5-hydroxytryptamine, high potassium, anoxia and ergonovine maleate. Van Neuten, J.M., Van Beek, J., Vanhoutte, P.M. J. Pharmacol. Exp. Ther. (1980) [Pubmed]
  10. The cardioprotective effects of R 75231 and lidoflazine are not caused by adenosine A1 receptor activation. Grover, G.J., Sleph, P.G. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  11. The effects of lidoflazine and flunarizine on cerebral reactive hyperemia. Phillis, J.W., DeLong, R.E., Towner, J.K. Eur. J. Pharmacol. (1985) [Pubmed]
  12. An analysis of the rate-dependent action of lidoflazine in mammalian sino-atrial node and Purkinje fibres. Hart, G., Dukes, I.D. J. Mol. Cell. Cardiol. (1984) [Pubmed]
  13. Lidoflazine in the early stages of acute myocardial ischaemia. Coker, S.J., Fagbemi, O., Parratt, J.R. Br. J. Pharmacol. (1982) [Pubmed]
  14. In vitro modulation of human neutrophil superoxide anion generation by various calcium channel antagonists used in ischemia-reperfusion resuscitation. Zimmerman, J.J., Zuk, S.M., Millard, J.R. Biochem. Pharmacol. (1989) [Pubmed]
  15. Cell proliferation in developing coronary collaterals and the influence of lidoflazine on this process. Verheyen, A., Xhonneux, R., Borgers, M., Reneman, R.S. J. Mol. Cell. Cardiol. (1976) [Pubmed]
  16. Nucleoside influx and efflux in guinea-pig ventricular myocytes. Inhibition by analogues of lidoflazine. Conant, A.R., Jarvis, S.M. Biochem. Pharmacol. (1994) [Pubmed]
  17. Comparison of negative inotropic potency, reversibility, and effects on calcium influx of six calcium channel antagonists in cultured myocardial cells. Barry, W.H., Horowitz, J.D., Smith, T.W. Br. J. Pharmacol. (1985) [Pubmed]
  18. Inhibition of nucleoside uptake in human erythrocytes by a new series of compounds related to lidoflazine and mioflazine. Pirovano, I.M., Van Belle, H., Ijzerman, A.P. Eur. J. Pharmacol. (1990) [Pubmed]
  19. Randomized, placebo-controlled evaluation of lidoflazine in patients receiving beta-blocker therapy with propranolol: improvement in anginal symptoms and exercise tolerance with combined drug therapy. Strauss, W.E., Parisi, A.F. Am. J. Cardiol. (1984) [Pubmed]
  20. Calcium-channel blockade as an adjunct to heterogeneous delivery of cardioplegia. Guyton, R.A., Dorsey, L.M., Colgan, T.K., Hatcher, C.R. Ann. Thorac. Surg. (1983) [Pubmed]
  21. Nucleoside transport inhibition mediates lidoflazine-induced cardioprotection during intermittent aortic crossclamping. Chang-Chun, C., Masuda, M., Szabò, Z., Szerafin, T., Szècsi, J., Van Belle, H., Flameng, W. J. Thorac. Cardiovasc. Surg. (1992) [Pubmed]
  22. The differential effect of calcium antagonists on the positive inotropic effects induced by calcium and monensin in cardiac preparations of rats and guinea-pigs. Hugtenburg, J.G., Mathy, M.J., Beckeringh, J.J., van Zwieten, P.A. Naunyn Schmiedebergs Arch. Pharmacol. (1989) [Pubmed]
  23. Lidoflazine is a high affinity blocker of the HERG K(+)channel. Ridley, J.M., Dooley, P.C., Milnes, J.T., Witchel, H.J., Hancox, J.C. J. Mol. Cell. Cardiol. (2004) [Pubmed]
  24. Lidoflazine does not improve neurologic outcome when administered after complete cerebral ischemia in primates. Fleischer, J.E., Lanier, W.L., Milde, J.H., Michenfelder, J.D. J. Cereb. Blood Flow Metab. (1987) [Pubmed]
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