Gene Review:
FOLR1 - folate receptor 1 (adult)
Homo sapiens
Synonyms:
Adult folate-binding protein, FBP, FOLR, FR-alpha, Folate receptor 1, ...
- mRNA instability in the nucleus due to a novel open reading frame element is a major determinant of the narrow tissue specificity of folate receptor alpha. Zheng, X., Kelley, K., Elnakat, H., Yan, W., Dorn, T., Ratnam, M. Mol. Cell. Biol. (2003)
- Molecular genetic analysis of human folate receptors in neural tube defects. Heil, S.G., van der Put, N.M., Trijbels, F.J., Gabreëls, F.J., Blom, H.J. Eur. J. Hum. Genet. (1999)
- Selective expression of the high-affinity isoform of the folate receptor (FR-alpha) in the human placental syncytiotrophoblast and choriocarcinoma cells. Prasad, P.D., Ramamoorthy, S., Moe, A.J., Smith, C.H., Leibach, F.H., Ganapathy, V. Biochim. Biophys. Acta (1994)
- Loss of heterozygosity and amplification on chromosome 11q in human ovarian cancer. Foulkes, W.D., Campbell, I.G., Stamp, G.W., Trowsdale, J. Br. J. Cancer (1993)
- Structure of Haemophilus influenzae Fe(+3)-binding protein reveals convergent evolution within a superfamily. Bruns, C.M., Nowalk, A.J., Arvai, A.S., McTigue, M.A., Vaughan, K.G., Mietzner, T.A., McRee, D.E. Nat. Struct. Biol. (1997)
- The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate. Yang, R., Kolb, E.A., Qin, J., Chou, A., Sowers, R., Hoang, B., Healey, J.H., Huvos, A.G., Meyers, P.A., Gorlick, R. Clin. Cancer Res. (2007)
- Quantitative topographical EEG compared to FDG PET for classification of vascular and degenerative dementia. Szelies, B., Mielke, R., Herholz, K., Heiss, W.D. Electroencephalography and clinical neurophysiology. (1994)
- Folate receptor-alpha is a cofactor for cellular entry by Marburg and Ebola viruses. Chan, S.Y., Empig, C.J., Welte, F.J., Speck, R.F., Schmaljohn, A., Kreisberg, J.F., Goldsmith, M.A. Cell (2001)
- Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development. Piedrahita, J.A., Oetama, B., Bennett, G.D., van Waes, J., Kamen, B.A., Richardson, J., Lacey, S.W., Anderson, R.G., Finnell, R.H. Nat. Genet. (1999)
- GPI-anchored proteins are organized in submicron domains at the cell surface. Varma, R., Mayor, S. Nature (1998)
- Similarity of folate receptor expression in UMSCC 38 cells to squamous cell carcinoma differentiation markers. Orr, R.B., Kreisler, A.R., Kamen, B.A. J. Natl. Cancer Inst. (1995)
- Modulation of the folate receptor type beta gene by coordinate actions of retinoic acid receptors at activator Sp1/ets and repressor AP-1 sites. Hao, H., Qi, H., Ratnam, M. Blood (2003)
- Differentiation-independent retinoid induction of folate receptor type beta, a potential tumor target in myeloid leukemia. Wang, H., Zheng, X., Behm, F.G., Ratnam, M. Blood (2000)
- Gene transfection and expression of the ovarian carcinoma marker folate binding protein on NIH/3T3 cells increases cell growth in vitro and in vivo. Bottero, F., Tomassetti, A., Canevari, S., Miotti, S., Ménard, S., Colnaghi, M.I. Cancer Res. (1993)
- Growth of ovarian-carcinoma cell lines at physiological folate concentration: effect on folate-binding protein expression in vitro and in vivo. Miotti, S., Facheris, P., Tomassetti, A., Bottero, F., Bottini, C., Ottone, F., Colnaghi, M.I., Bunni, M.A., Priest, D.G., Canevari, S. Int. J. Cancer (1995)
- Role of membrane folate-binding protein in the cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cell lines in vitro. Sen, S., Erba, E., D'Incalci, M., Bottero, F., Canevari, S., Tomassetti, A. Br. J. Cancer (1996)
- Recent insights into the molecular genetics of the homocysteine metabolism. Födinger, M., Wagner, O.F., Hörl, W.H., Sunder-Plassmann, G. Kidney Int. Suppl. (2001)
- Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene. Page, S.T., Owen, W.C., Price, K., Elwood, P.C. J. Mol. Biol. (1993)
- Purified membrane and soluble folate binding proteins from cultured KB cells have similar amino acid compositions and molecular weights but differ in fatty acid acylation. Luhrs, C.A., Pitiranggon, P., da Costa, M., Rothenberg, S.P., Slomiany, B.L., Brink, L., Tous, G.I., Stein, S. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Novel mutations in the 5'-UTR of the FOLR1 gene. Börjel, A.K., Yngve, A., Sjöström, M., Nilsson, T.K. Clin. Chem. Lab. Med. (2006)
- The role of folate receptor alpha in cancer development, progression and treatment: cause, consequence or innocent bystander? Kelemen, L.E. Int. J. Cancer (2006)
- Expression and functional characterization of the beta-isoform of the folate receptor on CD34(+) cells. Reddy, J.A., Haneline, L.S., Srour, E.F., Antony, A.C., Clapp, D.W., Low, P.S. Blood (1999)
- Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis. Nakashima-Matsushita, N., Homma, T., Yu, S., Matsuda, T., Sunahara, N., Nakamura, T., Tsukano, M., Ratnam, M., Matsuyama, T. Arthritis Rheum. (1999)
- Transcellular transfer of folate across the retinal pigment epithelium. Bridges, C.C., El-Sherbeny, A., Ola, M.S., Ganapathy, V., Smith, S.B. Curr. Eye Res. (2002)
- Interaction of folate receptor with signaling molecules lyn and G(alpha)(i-3) in detergent-resistant complexes from the ovary carcinoma cell line IGROV1. Miotti, S., Bagnoli, M., Tomassetti, A., Colnaghi, M.I., Canevari, S. J. Cell. Sci. (2000)
- Clustering of GPI-anchored folate receptor independent of both cross-linking and association with caveolin. Wu, M., Fan, J., Gunning, W., Ratnam, M. J. Membr. Biol. (1997)
- Loss of heterozygosity at the 5,10-methylenetetrahydrofolate reductase locus in human ovarian carcinomas. Viel, A., Dall'Agnese, L., Simone, F., Canzonieri, V., Capozzi, E., Visentin, M.C., Valle, R., Boiocchi, M. Br. J. Cancer (1997)
- Modulation of the folate receptor alpha gene by the estrogen receptor: mechanism and implications in tumor targeting. Kelley, K.M., Rowan, B.G., Ratnam, M. Cancer Res. (2003)
- Novel patterns of gene expression in pituitary adenomas identified by complementary deoxyribonucleic acid microarrays and quantitative reverse transcription-polymerase chain reaction. Evans, C.O., Young, A.N., Brown, M.R., Brat, D.J., Parks, J.S., Neish, A.S., Oyesiku, N.M. J. Clin. Endocrinol. Metab. (2001)
- Membrane vesicles shed into the extracellular medium by human breast carcinoma cells carry tumor-associated surface antigens. Dolo, V., Adobati, E., Canevari, S., Picone, M.A., Vittorelli, M.L. Clin. Exp. Metastasis (1995)
- Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis. Paulos, C.M., Turk, M.J., Breur, G.J., Low, P.S. Adv. Drug Deliv. Rev. (2004)
- Selective delivery of CB300638, a cyclopenta[g]quinazoline-based thymidylate synthase inhibitor into human tumor cell lines overexpressing the alpha-isoform of the folate receptor. Theti, D.S., Bavetsias, V., Skelton, L.A., Titley, J., Gibbs, D., Jansen, G., Jackman, A.L. Cancer Res. (2003)
- Synergistic induction of folate receptor beta by all-trans retinoic acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: mechanism and utility in enhancing selective growth inhibition by antifolates. Qi, H., Ratnam, M. Cancer Res. (2006)
- Membrane receptors for endocytosis in the renal proximal tubule. Christensen, E.I., Birn, H., Verroust, P., Moestrup, S.K. Int. Rev. Cytol. (1998)
- Tissue-specific promoters of the alpha human folate receptor gene yield transcripts with divergent 5' leader sequences and different translational efficiencies. Roberts, S.J., Chung, K.N., Nachmanoff, K., Elwood, P.C. Biochem. J. (1997)
- Characterization of the formae speciales of Fusarium oxysporum causing wilts of cucurbits by DNA fingerprinting with nuclear repetitive DNA sequences. Namiki, F., Shiomi, T., Kayamura, T., Tsuge, T. Appl. Environ. Microbiol. (1994)
- Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein. Coney, L.R., Tomassetti, A., Carayannopoulos, L., Frasca, V., Kamen, B.A., Colnaghi, M.I., Zurawski, V.R. Cancer Res. (1991)
- The conversion of the human membrane-associated folate binding protein (folate receptor) to the soluble folate binding protein by a membrane-associated metalloprotease. Elwood, P.C., Deutsch, J.C., Kolhouse, J.F. J. Biol. Chem. (1991)