Disease relevance of Lysine acetylsalicylate

• In a single-blind study that recruited 70 children aged 5 to 12 years with acute upper respiratory tract infection and fever (in- or outpatients), the effectiveness and tolerability of nimesulide 50 mg/dose were compared with those of lysine-acetylsalicylate 720 mg/dose (equivalent to 200mg of salicylate) [1].
• We have studied the effect of lysine acetylsalicylate (LAS; Aspegic), a soluble salt of aspirin, on motor deficits in transgenic mice expressing a human superoxide dismutase SOD1 mutation (Gly-93 --> Ala), an animal model of familial amyotrophic lateral sclerosis (FALS) [2].
• Responses of renin release and blood pressure to aspirin DL-lysine (ASP) were examined to find out if the responses could help in the differentiation between unilateral renovascular hypertension (RVH) and hyperreninemic essential hypertension (EHT) [3].
• Effects of aspirin DL-lysine on thrombin generation in unstable angina pectoris [4].
• The administration of lysine-acetylsalicylate diminished this hypertension [5].

High impact information on Lysine acetylsalicylate

• Intravenous injection of aspirin DL-lysine (18 mg/kg) 30 minutes later markedly suppressed prostaglandin E2 and renin levels at all sites and clearly lowered arterial blood pressure (mean: from 120 +/- 6 to 110 +/- 5 mm Hg, p less than 0.01) [6].
• In 7 additional patients with IDDM and in 4 normal subjects, the effect of lysine acetylsalicylate (LAS; 450 mg, iv) on GFR and RPF was studied [7].
• LAS did not alter GFR and CH2O in normal subjects; however, it reduced CH2O in all the 12 patients (from 5.1 +/- 0.4 to 0.6 +/- 0.3) and the GFR in only 6 of these patients [8].
• Changes in granulocyte fibrinolytic activity (FA) induced by in vivo treatment with lysine acetylsalicylate (LAS) [9].
• With an intravenous infusion of 100 mg of lysine acetylsalicylate (Aspisol, Bayer Leverkusen, Germany), HITS decreased by 16 to 41% [10].

Chemical compound and disease context of Lysine acetylsalicylate

• 3. At the same time, as a prostacyclin synthesis activator, paraquat participates in the efforts of the organism to eliminate the toxic material, but it later weakens the defence mechanisms by enhancing thromboxane A2 synthesis, and it initiates pulmonary fibrosis, which cannot then be averted with Aspisol [11].
• We investigated the comparative antithrombotic properties of LW 10082, acetylasalicylic acid (Aspisol), low molecular weight heparin (LMWH, CY 216) and sodium heparin using laser-induced thrombosis model [12].
• In search of possible endogenous factors which impair insulin release, we have investigated the effect of lysine acetylsalicylate (LAS), an inhibitor of endogenous prostaglandin (PGs) synthesis, upon insulin responses to glucose and arginine in subjects with type II (adult-on-set) diabetes mellitus [13].

Biological context of Lysine acetylsalicylate

• Aspirin-DL-lysine (10(-4)M) did not influence dDAVP-induced afferent arteriolar vasodilation (aspirin + NE, 6.4 +/- 0.8 microns; aspirin + NE + dDAVP, 9.6 +/- 1.3 microns *; *p < 0.05, n = 5) [14].
• After the afferent arterioles were pretreated with aspirin DL-lysine or indomethacin, Ang II (10(-7) M) caused transient vasoconstriction in the afferent arterioles [15].
• Comparative pharmacokinetics of Aspegic 1000 mg i.v. versus 1000 mg i.m. thrice daily [16].
• Among others, it was found that the metabolic effect impaired by paraquat is influenced in a favourable direction by Aspisol treatment, including the % of survival, the lipid peroxidation values and the superoxide dismutase activity in the lung [11].
• Influence of systemic cyclooxygenase inhibition with single-dose aspisol on kinetics of arachidonic acid metabolites in the venous effluate of transplanted kidney grafts in humans [17].

Anatomical context of Lysine acetylsalicylate

• Acetylsalicylate (Aspisol) and the platelet-activating factor antagonist WEB 2170 improved the microcirculation and function of the xenoperfused liver [18].
• The effect of acetylsalicylic acid (ASA, Aspisol) upon diastolic threshold and refractory period in normal myocardium was investigated in the experiments on cats [19].
• We examined the usefulness of aspirin DL-lysine for prediction of the outcome of renal artery angioplasty in renovascular hypertension [20].
• Inhibitory effects of the anti-inflammatory agents lysine-acetylsalicylate (LAS) and phenylbutazone (PBZ) on the breakdown of the blood-aqueous barrier by paracentesis were studied in canine eyes using protein determination of ocular fluid [21].

Associations of Lysine acetylsalicylate with other chemical compounds

• In this article two new drugs, prostaglandin I2 analog OP-41483 (Venopirin) and thromboxane synthetase inhibitor OKY-046 (Cataclot), were tested in addition to aspirin in animal experiments with rabbits [22].
• The effects of intravenous (i.v.), intramuscular (i.m.) and oral administration of lysine-acetylsalicylate (Lys-ASA) on gastro-intestinal motility were investigated in sheep using electromyography [23].

Gene context of Lysine acetylsalicylate

• Effect of lysine-acetylsalicylate on serum gastrin levels [24].
• Failure of lysine-acetylsalicylate and phenylbutazone to affect gastrin secretion in healthy adults [25].

Analytical, diagnostic and therapeutic context of Lysine acetylsalicylate

• In the present study lysine-acetylsalicylate (LASA), an injectable form of the prototypical NSAID aspirin, was microinjected into the PAG (100 microg/0.5 microl) in freely moving rats to induce inhibition of tail flick and hot plate responses [26].
• Aspirin DL-lysine (900 mg) was administered intravenously to 9 of the 18 patients (aspirin group); the other 9 were not given aspirin during the first 24 hours of hospitalization (non-aspirin group) [4].
• Bleeding due to needle biopsy: effect of venopirin in an animal model and implications for humans [27].
• The same experiments were done again after treatment with a cyclooxygenase inhibitor, aspirin DL-lysine (54 mg/kg) [28].
• Ferubinac ethyl and aspirin DL-lysine showed a spike and wave complex in EEG without showing remarkable behavioral changes when they were injected intraventricularly, although a relatively high dose was needed [29].

References