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Chemical Compound Review

Aspegic     2-acetyloxybenzoate; (5-amino-5-carboxy...

Synonyms: Aspisol, Aspegic (TN), AG-G-32203, SureCN1649510, AC1L2BDL, ...
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Disease relevance of Lysine acetylsalicylate


High impact information on Lysine acetylsalicylate

  • Intravenous injection of aspirin DL-lysine (18 mg/kg) 30 minutes later markedly suppressed prostaglandin E2 and renin levels at all sites and clearly lowered arterial blood pressure (mean: from 120 +/- 6 to 110 +/- 5 mm Hg, p less than 0.01) [6].
  • In 7 additional patients with IDDM and in 4 normal subjects, the effect of lysine acetylsalicylate (LAS; 450 mg, iv) on GFR and RPF was studied [7].
  • LAS did not alter GFR and CH2O in normal subjects; however, it reduced CH2O in all the 12 patients (from 5.1 +/- 0.4 to 0.6 +/- 0.3) and the GFR in only 6 of these patients [8].
  • Changes in granulocyte fibrinolytic activity (FA) induced by in vivo treatment with lysine acetylsalicylate (LAS) [9].
  • With an intravenous infusion of 100 mg of lysine acetylsalicylate (Aspisol, Bayer Leverkusen, Germany), HITS decreased by 16 to 41% [10].

Chemical compound and disease context of Lysine acetylsalicylate

  • 3. At the same time, as a prostacyclin synthesis activator, paraquat participates in the efforts of the organism to eliminate the toxic material, but it later weakens the defence mechanisms by enhancing thromboxane A2 synthesis, and it initiates pulmonary fibrosis, which cannot then be averted with Aspisol [11].
  • We investigated the comparative antithrombotic properties of LW 10082, acetylasalicylic acid (Aspisol), low molecular weight heparin (LMWH, CY 216) and sodium heparin using laser-induced thrombosis model [12].
  • In search of possible endogenous factors which impair insulin release, we have investigated the effect of lysine acetylsalicylate (LAS), an inhibitor of endogenous prostaglandin (PGs) synthesis, upon insulin responses to glucose and arginine in subjects with type II (adult-on-set) diabetes mellitus [13].

Biological context of Lysine acetylsalicylate


Anatomical context of Lysine acetylsalicylate


Associations of Lysine acetylsalicylate with other chemical compounds


Gene context of Lysine acetylsalicylate


Analytical, diagnostic and therapeutic context of Lysine acetylsalicylate

  • In the present study lysine-acetylsalicylate (LASA), an injectable form of the prototypical NSAID aspirin, was microinjected into the PAG (100 microg/0.5 microl) in freely moving rats to induce inhibition of tail flick and hot plate responses [26].
  • Aspirin DL-lysine (900 mg) was administered intravenously to 9 of the 18 patients (aspirin group); the other 9 were not given aspirin during the first 24 hours of hospitalization (non-aspirin group) [4].
  • Bleeding due to needle biopsy: effect of venopirin in an animal model and implications for humans [27].
  • The same experiments were done again after treatment with a cyclooxygenase inhibitor, aspirin DL-lysine (54 mg/kg) [28].
  • Ferubinac ethyl and aspirin DL-lysine showed a spike and wave complex in EEG without showing remarkable behavioral changes when they were injected intraventricularly, although a relatively high dose was needed [29].


  1. Efficacy and tolerability of nimesulide and lysine-acetylsalicylate in the treatment of paediatric acute upper respiratory tract inflammation. Cappella, L., Guerra, A., Laudizi, L., Cavazzuti, G.B. Drugs (1993) [Pubmed]
  2. Beneficial effects of lysine acetylsalicylate, a soluble salt of aspirin, on motor performance in a transgenic model of amyotrophic lateral sclerosis. Barnéoud, P., Curet, O. Exp. Neurol. (1999) [Pubmed]
  3. Aspirin test for differentiation of unilateral renovascular hypertension from hyperreninemic essential hypertension. Imanishi, M., Ohta, M., Kawamura, M., Akabane, S., Matsushima, Y., Kuramochi, M., Kojima, S., Kimura, K., Takamiya, M., Ito, K. Am. J. Hypertens. (1991) [Pubmed]
  4. Effects of aspirin DL-lysine on thrombin generation in unstable angina pectoris. Yasu, T., Oshima, S., Imanishi, M., Nonogi, H., Haze, K., Kuramochi, M., Omae, T., Hayashi, Y., Yamamoto, S. Am. J. Cardiol. (1993) [Pubmed]
  5. The action of arachidonic acid on experimental hypertension in the rat. Laborit, H., Valette, N. Chem. Biol. Interact. (1975) [Pubmed]
  6. Aspirin lowers blood pressure in patients with renovascular hypertension. Imanishi, M., Kawamura, M., Akabane, S., Matsushima, Y., Kuramochi, M., Ito, K., Ohta, M., Kimura, K., Takamiya, M., Omae, T. Hypertension (1989) [Pubmed]
  7. Renal hemodynamic abnormalities in patients with short term insulin-dependent diabetes mellitus: role of renal prostaglandins. Esmatjes, E., Fernandez, M.R., Halperin, I., Camps, J., Gaya, J., Arroyo, V., Rivera, F., Figuerola, D. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
  8. Evidence that renal prostaglandins are involved in renal water metabolism in cirrhosis. Pérez-Ayuso, R.M., Arroyo, V., Camps, J., Rimola, A., Gaya, J., Costa, J., Rivera, F., Rodés, J. Kidney Int. (1984) [Pubmed]
  9. Changes in granulocyte fibrinolytic activity (FA) induced by in vivo treatment with lysine acetylsalicylate (LAS). Ghezzo, F., Trinchero, P., Pegoraro, L. Thromb. Haemost. (1981) [Pubmed]
  10. Impact of high intensity transient signals on the choice of mechanical aortic valve substitutes. Laas, J., Kseibi, S., Perthel, M., Klingbeil, A., El-Ayoubi, L., Alken, A. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (2003) [Pubmed]
  11. Effects of Gramoxone-induced reactive oxygen radicals on eicosanoid synthesis of mouse lung. Matkovics, B., Barabás, K., Mézes, M. Acta. Biol. Hung. (1988) [Pubmed]
  12. Interaction between the sulfated lactobionic acid (LW 10082) and other antithrombotic agents in animal thrombosis model. Giedrojć, J., Krupiński, K., Breddin, H.K., Bielawiec, M. Polish journal of pharmacology. (1996) [Pubmed]
  13. Impaired insulin secretion in human diabetes mellitus. II. A possible role for prostaglandins. Giugliano, D., Sgamboto, S., Coppola, L., Misso, L., Torella, R. Prostaglandins and medicine. (1981) [Pubmed]
  14. Role of nitric oxide in desmopressin-induced vasodilation of microperfused rabbit afferent arterioles. Kiyomoto, K., Tamaki, T., Tomohiro, A., Nishiyama, A., Aki, Y., Kimura, S., Abe, Y. Hypertens. Res. (1997) [Pubmed]
  15. Effects of angiotensin II on isolated rabbit afferent arterioles. Yoshida, H., Tamaki, T., Aki, Y., Kimura, S., Takenaka, I., Abe, Y. Jpn. J. Pharmacol. (1994) [Pubmed]
  16. Comparative pharmacokinetics of Aspegic 1000 mg i.v. versus 1000 mg i.m. thrice daily. Nia, B., Vergnaud, J.M. European journal of drug metabolism and pharmacokinetics. (1996) [Pubmed]
  17. Influence of systemic cyclooxygenase inhibition with single-dose aspisol on kinetics of arachidonic acid metabolites in the venous effluate of transplanted kidney grafts in humans. Storck, M., Schilling, M., Mickley, V., Techt, B., Abendroth, D. Transplant. Proc. (1996) [Pubmed]
  18. Monitoring of microhemodynamic changes during ex vivo xenogeneic liver perfusion using intravital microscopy. Linke, R., Diefenbeck, M., Friedrich, R., Seehofer, D., Hammer, C. Transpl. Int. (1998) [Pubmed]
  19. Low dose of acetylsalicylic acid prolongs refractory periods in normal cat myocardium. Kwiatkowska-Patzer, B., Herbaczyńska-Cedro, K. Arzneimittel-Forschung. (1981) [Pubmed]
  20. Aspirin injection test to predict angioplasty outcome in unilateral renovascular hypertension: preliminary report. Imanishi, M., Ohta, M., Akabane, S., Kawamura, M., Matsushima, Y., Kojima, S., Kuramochi, M., Kimura, K., Takamiya, M., Ito, K. Clinical and investigative medicine. Médecine clinique et experimentale. (1991) [Pubmed]
  21. Effect of lysine-acetylsalicylate and phenylbutazone premedication on the protein content of secondary aqueous humour in the dog. Regnier, A., Bonnefoi, M., Lescure, F. Res. Vet. Sci. (1984) [Pubmed]
  22. The effects of drugs on the arachidonate cascade in experimentally burned rabbits. Ono, I., Ohura, T., Azami, K., Ogino, H., Sasaki, S., Murazumi, M. The Journal of burn care & rehabilitation. (1989) [Pubmed]
  23. Gastro-intestinal motor disturbances induced by lysine-acetylsalicylate treatment in sheep. Honde, C., Buéno, L. J. Vet. Pharmacol. Ther. (1984) [Pubmed]
  24. Effect of lysine-acetylsalicylate on serum gastrin levels. Estler, C.J., Mitznegg, P., Domschke, W., Demling, L. Acta hepato-gastroenterologica. (1977) [Pubmed]
  25. Failure of lysine-acetylsalicylate and phenylbutazone to affect gastrin secretion in healthy adults. Caldara, R., Cutarelli, G., Ferrari, C., Romussi, M. Acta hepato-gastroenterologica. (1978) [Pubmed]
  26. Induction of opioid tolerance by lysine-acetylsalicylate in rats. Pernia-Andrade, A.J., Tortorici, V., Vanegas, H. Pain (2004) [Pubmed]
  27. Bleeding due to needle biopsy: effect of venopirin in an animal model and implications for humans. Gazelle, G.S., Haaga, J.R., Rowland, D.Y. Journal of vascular and interventional radiology : JVIR. (1993) [Pubmed]
  28. Critical degree of renal arterial stenosis that causes hypertension in dogs. Imanishi, M., Akabane, S., Takamiya, M., Kawamura, M., Matsushima, Y., Kuramochi, M., Omae, T. Angiology. (1992) [Pubmed]
  29. Epileptogenic activity induced by combined treatment with antiinflammatory drugs and enoxacin and its inhibition by a calcium antagonist, nicardipine. Kamei, C., Sugimoto, Y., Ohishi, H., Okumura, Y., Kitazumi, K. Methods and findings in experimental and clinical pharmacology. (1996) [Pubmed]
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