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Chemical Compound Review

Performic acid     methaneperoxoic acid

Synonyms: AG-D-22672, HSDB 7861, LS-90051, HC(O)OOH, CTK0I0906, ...
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Disease relevance of peroxyformic acid


High impact information on peroxyformic acid


Chemical compound and disease context of peroxyformic acid

  • Since performic acid is used as a potent disinfectant, chemical sterilant and/or skin antiseptics, information related to its toxicity for living tissues was needed to evaluate the degree of its biotolerance and compare it to that of peracetic acid [4].

Biological context of peroxyformic acid


Anatomical context of peroxyformic acid


Associations of peroxyformic acid with other chemical compounds


Gene context of peroxyformic acid


Analytical, diagnostic and therapeutic context of peroxyformic acid

  • Reverse-phase HPLC elution behavior before and after performic acid oxidation and amino acid composition of the protein products led to their identification as NP-I-(9-93) (the 9-93 sequence) and [des-19,20]NP-I-(9-93) (the 9-93 sequence with the dipeptide 19-20 missing) for the more rapidly and more slowly formed species, respectively [30].
  • Strong bases, boiling 3 N HCl, and performic acid did attack the sheath; in these cases, the array was systematically disassembled in a progressive manner, which was followed by electron microscopy [31].
  • However, no cleavable [14C]phenylalanine could be detected after treatment with performic acid, indicating that the resulting mutant was unable to form thioester with phenylalanine [32].
  • The identity of some of the disulfide-linked peptides was further verified by performic acid oxidation followed by sequence analysis of the resulting peptides [33].
  • The resulting crude peptide mixture was oxidized by performic acid and the insulin A-chain, which contains no cleavage side for trypsin, was quantified by HPLC in the form of a tetrasulfonate derivative to reduce artefacts due to free -SH groups [34].


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