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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Acute Disease

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Disease relevance of Acute Disease


High impact information on Acute Disease

  • Effect of acute disease and ACTH on serum zinc proteins [6].
  • In the absence of IL-2, the acute disease is mild because of reduced T cell effector function, but a chronic and progressive disease develops late and is associated with a failure to generate FoxP3(+) regulatory T (T reg) cells in the periphery [7].
  • Furthermore, induction of tolerance to intact PLP (which inhibits responses to both the initiating PLP139-151 epitope and to the PLP178-191 epitope) after the acute disease episode is sufficient to prevent relapsing disease [8].
  • These experiments demonstrate that IL-10 is produced during infection with a protozoan parasite and suggest a regulatory role for this cytokine in the mediation of susceptibility to acute disease [9].
  • In all individuals tested, IL-10 mRNA production was increased in lymph nodes taken during acute disease over that observed in postacute samples [10].

Chemical compound and disease context of Acute Disease

  • More importantly, induction of myelin-specific tolerance to relapse-associated epitopes, by i.v. injection of ethylene carbodiimide-fixed peptide-pulsed APCs, either before disease initiation or during remission from acute disease effectively blocks the expression of the initial disease relapse [11].
  • Bactericidal faecal concentrations were present in all patients with acute disease receiving oral or intravenous metronidazole, and all responded to therapy [12].
  • In contrast to findings in acute diseases associated with muscle wasting, we found increased muscle glutamine (GLN) levels in our patient group (mean +/- SEM = 10,782 +/- 770 versus 7,844 +/- 293 micromol/kg wet weight, p < 0. 01) [13].
  • A virus with a threonine-to-valine substitution (T81V) did not cause any changes in the pattern or extent of disease seen in mice, whereas a virus with a tryptophan substitution at this position (T81W) produced a similar acute disease but was attenuated for the development of the chronic disease [14].
  • Furthermore, malaria recrudesced in Nu/Nu mice after the termination of acute disease by treatment with clindamycin [15].

Biological context of Acute Disease


Anatomical context of Acute Disease


Gene context of Acute Disease

  • To address whether additional oncogenic events are required for progression to acute disease, we crossed hMRP8p210BCR/ABL mice to apoptosis-resistant hMRP8BCL-2 mice [25].
  • In contrast, uPAR-/- mice had a delayed, less acute disease reflected in delayed infiltration of inflammatory cells [26].
  • In contrast, a substantial level of monocyte chemotactic protein (MCP)-1 expression was not observed until late in acute disease and continued to be evident in the relapsing phase of the disease [27].
  • The best correlation with acute disease activity was given by TNF-alpha, IL-6, IL-8, and LTB4 [28].
  • In a study designed to evaluate the concept of inherited susceptibility to sarcoid arthritis (SA), 42 patients with histologically proved acute disease underwent typing of HLA-A, -B, -C and -DR antigens [29].

Analytical, diagnostic and therapeutic context of Acute Disease


  1. CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB x NZW F1 mice. Foell, J., Strahotin, S., O'Neil, S.P., McCausland, M.M., Suwyn, C., Haber, M., Chander, P.N., Bapat, A.S., Yan, X.J., Chiorazzi, N., Hoffmann, M.K., Mittler, R.S. J. Clin. Invest. (2003) [Pubmed]
  2. Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis. Howard, L.M., Miga, A.J., Vanderlugt, C.L., Dal Canto, M.C., Laman, J.D., Noelle, R.J., Miller, S.D. J. Clin. Invest. (1999) [Pubmed]
  3. Tissue-specific splicing mutation in acute intermittent porphyria. Grandchamp, B., Picat, C., Mignotte, V., Wilson, J.H., Te Velde, K., Sandkuyl, L., Roméo, P.H., Goossens, M., Nordmann, Y. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  4. Reversal of ongoing proteinuria in autoimmune mice by treatment with C-reactive protein. Rodriguez, W., Mold, C., Kataranovski, M., Hutt, J., Marnell, L.L., Du Clos, T.W. Arthritis Rheum. (2005) [Pubmed]
  5. Evolution and emergence of Bordetella in humans. Bjørnstad, O.N., Harvill, E.T. Trends Microbiol. (2005) [Pubmed]
  6. Effect of acute disease and ACTH on serum zinc proteins. Falchuk, K.H. N. Engl. J. Med. (1977) [Pubmed]
  7. Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. Knoechel, B., Lohr, J., Kahn, E., Bluestone, J.A., Abbas, A.K. J. Exp. Med. (2005) [Pubmed]
  8. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis. McRae, B.L., Vanderlugt, C.L., Dal Canto, M.C., Miller, S.D. J. Exp. Med. (1995) [Pubmed]
  9. Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection. Silva, J.S., Morrissey, P.J., Grabstein, K.H., Mohler, K.M., Anderson, D., Reed, S.G. J. Exp. Med. (1992) [Pubmed]
  10. Interleukin 10 production correlates with pathology in human Leishmania donovani infections. Ghalib, H.W., Piuvezam, M.R., Skeiky, Y.A., Siddig, M., Hashim, F.A., el-Hassan, A.M., Russo, D.M., Reed, S.G. J. Clin. Invest. (1993) [Pubmed]
  11. Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis. Vanderlugt, C.L., Neville, K.L., Nikcevich, K.M., Eagar, T.N., Bluestone, J.A., Miller, S.D. J. Immunol. (2000) [Pubmed]
  12. Faecal metronidazole concentrations during oral and intravenous therapy for antibiotic associated colitis due to Clostridium difficile. Bolton, R.P., Culshaw, M.A. Gut (1986) [Pubmed]
  13. Plasma and muscle amino acid levels in relation to resting energy expenditure and inflammation in stable chronic obstructive pulmonary disease. Pouw, E.M., Schols, A.M., Deutz, N.E., Wouters, E.F. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  14. Theiler's viruses with mutations in loop I of VP1 lead to altered tropism and pathogenesis. McCright, I.J., Tsunoda, I., Whitby, F.G., Fujinami, R.S. J. Virol. (1999) [Pubmed]
  15. Prevention of recrudescent malaria in nude mice by thymic grafting or by treatment with hyperimmune serum. Roberts, D.W., Rank, R.G., Weidanz, W.P., Finerty, J.F. Infect. Immun. (1977) [Pubmed]
  16. Myosin autoimmunity is not essential for cardiac inflammation in acute Chagas' disease. Leon, J.S., Wang, K., Engman, D.M. J. Immunol. (2003) [Pubmed]
  17. In vivo administration of recombinant IFN-gamma induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infections. Reed, S.G. J. Immunol. (1988) [Pubmed]
  18. IDDM in rats induced by thymectomy and irradiation. Stumbles, P.A., Penhale, W.J. Diabetes (1993) [Pubmed]
  19. The role of p53 and Fas in a model of acute murine graft-versus-host disease. Yada, S., Takamura, N., Inagaki-Ohara, K., O'leary, M.K., Wasem, C., Brunner, T., Green, D.R., Lin, T., Pinkoski, M.J. J. Immunol. (2005) [Pubmed]
  20. Native myelin oligodendrocyte glycoprotein promotes severe chronic neurological disease and demyelination in Biozzi ABH mice. Smith, P.A., Heijmans, N., Ouwerling, B., Breij, E.C., Evans, N., van Noort, J.M., Plomp, A.C., Delarasse, C., 't Hart, B., Pham-Dinh, D., Amor, S. Eur. J. Immunol. (2005) [Pubmed]
  21. Immune-mediated mechanisms and immune activation of fibroblasts in the pathogenesis of eosinophilia-myalgia syndrome induced by L-tryptophan. Illa, I., Dinsmore, S., Dalakas, M.C. Hum. Pathol. (1993) [Pubmed]
  22. Selective increases in adrenal steroidogenic capacity during acute respiratory disease in infants. Hanukoglu, A., Fried, D., Nakash, I., Hanukoglu, I. Eur. J. Endocrinol. (1995) [Pubmed]
  23. Cytokines in the conjunctiva of acute and chronic mucous membrane pemphigoid: an immunohistochemical analysis. Bernauer, W., Wright, P., Dart, J.K., Leonard, J.N., Lightman, S. Graefes Arch. Clin. Exp. Ophthalmol. (1993) [Pubmed]
  24. A study of monokine release and natural killer activity in the bronchoalveolar lavage of subjects with farmer's lung. Denis, M., Bedard, M., Laviolette, M., Cormier, Y. Am. Rev. Respir. Dis. (1993) [Pubmed]
  25. Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias. Jaiswal, S., Traver, D., Miyamoto, T., Akashi, K., Lagasse, E., Weissman, I.L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  26. A role for the plasminogen activator system in inflammation and neurodegeneration in the central nervous system during experimental allergic encephalomyelitis. East, E., Baker, D., Pryce, G., Lijnen, H.R., Cuzner, M.L., Gverić, D. Am. J. Pathol. (2005) [Pubmed]
  27. Acute and relapsing experimental autoimmune encephalomyelitis are regulated by differential expression of the CC chemokines macrophage inflammatory protein-1alpha and monocyte chemotactic protein-1. Kennedy, K.J., Strieter, R.M., Kunkel, S.L., Lukacs, N.W., Karpus, W.J. J. Neuroimmunol. (1998) [Pubmed]
  28. Local and systemic inflammatory mediator release in patients with acute and chronic posttraumatic osteomyelitis. Klosterhalfen, B., Peters, K.M., Tons, C., Hauptmann, S., Klein, C.L., Kirkpatrick, C.J. The Journal of trauma. (1996) [Pubmed]
  29. Class II MHC antigen (HLA-DR3) predisposes to sarcoid arthritis. Krause, A., Goebel, K.M. Journal of clinical & laboratory immunology. (1987) [Pubmed]
  30. Enhanced proteolysis of plasma von Willebrand factor in thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome. Mannucci, P.M., Lombardi, R., Lattuada, A., Ruggenenti, P., Viganò, G.L., Barbui, T., Remuzzi, G. Blood (1989) [Pubmed]
  31. Serological response and detection of viraemia in acute hepatitis C virus infection. Dourakis, S., Brown, J., Kumar, U., Karayiannis, P., Kernoff, P., Chiba, J., Ohba, H., Miyamura, T., Saito, I., Monjardino, J. J. Hepatol. (1992) [Pubmed]
  32. Contra-indications to metformin therapy are largely disregarded. Holstein, A., Nahrwold, D., Hinze, S., Egberts, E.H. Diabet. Med. (1999) [Pubmed]
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