Chemical Compound Review:
Glyzac 2-(pentylamino)ethanamide
Synonyms:
Glyzan, Milacemida, Milacemide, Milacemidum, CHEMBL75838, ...
- The novel neuropsychotropic agent milacemide is a specific enzyme-activated inhibitor of brain monoamine oxidase B. Janssens de Varebeke, P., Pauwels, G., Buyse, C., David-Remacle, M., De Mey, J., Roba, J., Youdim, M.B. J. Neurochem. (1989)
- A therapeutic trial of milacemide in myoclonus and the stiff-person syndrome. Brown, P., Thompson, P.D., Rothwell, J.C., Day, B.L., Marsden, C.D. Mov. Disord. (1991)
- Therapeutic trial of milacemide in patients with myoclonus and other intractable movement disorders. Gordon, M.F., Diaz-Olivo, R., Hunt, A.L., Fahn, S. Mov. Disord. (1993)
- Milacemide stimulates deficient glial Na+, K(+)-ATPase in freezing-induced epileptogenic cortex of cats. Laschet, J., Guillaume, D., Vergniolle-Burette, M., Grisar, T. Brain Res. (1990)
- Observation of hepatotoxic effects of 2-n-pentylaminoacetamide (Milacemide) in rat liver by a combined in vivo/in vitro approach. Rogiers, V., Vandenberghe, Y., Vanhaecke, T., Geerts, A., Callaerts, A., Carleer, J., Roba, J., Vercruysse, A. Arch. Toxicol. (1997)
- Cognitive effects of milacemide and methylphenidate in healthy young adults. Camp-Bruno, J.A., Herting, R.L. Psychopharmacology (Berl.) (1994)
- Milacemide: a placebo-controlled study in senile dementia of the Alzheimer type. Dysken, M.W., Mendels, J., LeWitt, P., Reisberg, B., Pomara, N., Wood, J., Skare, S., Fakouhi, J.D., Herting, R.L. Journal of the American Geriatrics Society. (1992)
- Milacemide enhances memory storage and alleviates spontaneous forgetting in mice. Quartermain, D., Nuygen, T., Sheu, J., Herting, R.L. Pharmacol. Biochem. Behav. (1991)
- Acute and subacute CNS effects of milacemide in elderly people: double-blind, placebo-controlled quantitative EEG and psychometric investigations. Saletu, B., Grünberger, J., Linzmayer, L. Archives of gerontology and geriatrics. (1986)
- Milacemide, a glycine pro-drug, inhibits strychnine-allodynia without affecting normal nociception in the rat. Khandwala, H., Loomis, C.W. Pain (1998)
- Inactivation of monoamine oxidase B by analogues of the anticonvulsant agent milacemide (2-(n-pentylamino)acetamide). Nishimura, K., Lu, X., Silverman, R.B. J. Med. Chem. (1993)
- Formation of the neurotransmitter glycine from the anticonvulsant milacemide is mediated by brain monoamine oxidase B. Janssens de Varebeke, P., Cavalier, R., David-Remacle, M., Youdim, M.B. J. Neurochem. (1988)
- Antiepileptic drug pharmacokinetics and neuropharmacokinetics in individual rats by repetitive withdrawal of blood and cerebrospinal fluid: milacemide. Semba, J., Curzon, G., Patsalos, P.N. Br. J. Pharmacol. (1993)
- An NMDA intervention strategy in schizophrenia with "low-dose" milacemide. Rosse, R.B., Schwartz, B.L., Davis, R.E., Deutsch, S.I. Clinical neuropharmacology. (1991)
- Milacemide treatment in mice enhances acquisition of a Morris-type water maze task. Finkelstein, J.E., Hengemihle, J.M., Ingram, D.K., Petri, H.L. Pharmacol. Biochem. Behav. (1994)
- Anticonvulsant activity of milacemide. van Dorsser, W., Barris, D., Cordi, A., Roba, J. Archives internationales de pharmacodynamie et de thérapie. (1983)
- Effects of the glycine prodrug milacemide (2-N-pentylaminoacetamide) on catecholamine secretion from isolated adrenal medulla chromaffin cells. Yadid, G., Zinder, O., Youdim, M.B. Br. J. Pharmacol. (1991)
- Effect of milacemide, a glycinamide derivative, on the rat brain gamma-aminobutyric acid system. de Varebeke, P.J., Niebes, P., Pauwels, G., Roba, J., Korf, J. Biochem. Pharmacol. (1983)
- Microionophoretic study with milacemide, a glycine precursor, on mammalian central nervous system cells. Godfraind, J.M. Br. J. Pharmacol. (1990)
- A microdialysis study of glycinamide, glycine and other amino acid neurotransmitters in rat frontal cortex and hippocampus after the administration of milacemide, a glycine pro-drug. Doheny, M.H., Nagaki, S., Patsalos, P.N. Naunyn Schmiedebergs Arch. Pharmacol. (1996)
- Species differences in the interactions of the anticonvulsant milacemide and some analogues with monoamine oxidase-B. O'Brien, E.M., Dostert, P., Tipton, K.F. Biochem. Pharmacol. (1995)
- A discontinuous luminometric assay for monoamine oxidase. O'Brien, E.M., Kiely, K.A., Tipton, K.F. Biochem. Pharmacol. (1993)
- Simple and rapid micro-analytical procedures for the estimation of milacemide and its metabolite glycinamide in rat plasma and cerebrospinal fluid by high-performance liquid chromatography. Semba, J., Ratnaraj, N., Patsalos, P.N. J. Chromatogr. (1991)
- Milacemide effects on the temporal inter-relationship of amino acids and monoamine metabolites in rat cerebrospinal fluid. Semba, J., Patsalos, P.N. Eur. J. Pharmacol. (1993)
- Effect of milacemide on extracellular and tissue concentrations of dopamine and 5-hydroxytryptamine in rat frontal cortex. Semba, J., Doheny, M., Patsalos, P.N., Sarna, G., Curzon, G. Br. J. Pharmacol. (1992)
- Double-blind study of milacemide in hospitalized therapy-resistant patients with epilepsy. Houtkooper, M.A., van Oorschot, C.A., Rentmeester, T.W., Höppener, P.J., Onkelinx, C. Epilepsia (1986)
- Milacemide and other drugs active at glutamate NMDA receptors as potential treatment for dementia. Herting, R.L. Ann. N. Y. Acad. Sci. (1991)