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Chemical Compound Review

Besylic acid     benzenesulfonic acid

Synonyms: CCRIS 4595, AG-C-32364, CHEBI:64455, ANW-43958, HSDB 2642, ...
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Disease relevance of benzenesulfonic acid


High impact information on benzenesulfonic acid


Chemical compound and disease context of benzenesulfonic acid


Biological context of benzenesulfonic acid


Anatomical context of benzenesulfonic acid


Associations of benzenesulfonic acid with other chemical compounds

  • HPLC methods have been developed for the quantitation of the principal degradation products (diphenyl-mercury, benzenesulphonic acid and benzenesulphinic acid) and a mechanism is proposed for their formation [26].
  • GC/FID and HPLC/MS single ion monitoring methods have been evaluated for the determination of trace levels of methyl, ethyl and isopropyl esters of p-toluenesulfonic acid and methyl, ethyl, isopropyl and n-butyl esters of benzenesulfonic acid in drug substances [27].
  • Many of the gene expression changes were found to be induced only by exposure to the allergen, DNBS, and not by exposure to a structurally similar non-allergen, benzenesulfonic acid [28].
  • The kinetics of ultimate biodegradation (mineralization to CO2) of linear alkylbenzene sulfonate (LAS) were studied in sludge-amended agricultural soils for a series of pure chain length LAS homologs containing 10 to 14 carbon atoms in the alkyl chain [29].
  • Biodegradation of five chemicals (aniline, anthracene, chlornitrophen (CNP), fenitrothion (FNT) and linear alkylbenzene sulphonate (LAS)) by aquatic bacteria in three different types of ponds was determined according to the cultivation method developed by this group [30].

Gene context of benzenesulfonic acid


Analytical, diagnostic and therapeutic context of benzenesulfonic acid


  1. Solid-phase contact assay that uses a lux-marked Nitrosomonas europaea reporter strain to estimate toxicity of bioavailable linear alkylbenzene sulfonate in soil. Brandt, K.K., Pedersen, A., Sørensen, J. Appl. Environ. Microbiol. (2002) [Pubmed]
  2. Toxic effects of linear alkylbenzene sulfonate on metabolic activity, growth rate, and microcolony formation of Nitrosomonas and Nitrosospira strains. Brandt, K.K., Hesselsøe, M., Roslev, P., Henriksen, K., Sørensen, J. Appl. Environ. Microbiol. (2001) [Pubmed]
  3. Physicochemical determinants of linear alkylbenzene sulfonate (LAS) disposition in skin exposed to aqueous cutting fluid mixtures. Baynes, R.E., Brooks, J.D., Barlow, B.M., Riviere, J.E. Toxicology and industrial health. (2002) [Pubmed]
  4. Structure-activity considerations and in vitro approaches to assess the genotoxicity of 19 methane-, benzene- and toluenesulfonic acid esters. Glowienke, S., Frieauff, W., Allmendinger, T., Martus, H.J., Suter, W., Mueller, L. Mutat. Res. (2005) [Pubmed]
  5. Fourth isoform of preprotachykinin messenger RNA encoding for substance P in the rat intestine. Khan, I., Collins, S.M. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  6. Area and depth of surfactant-induced corneal injury predicts extent of subsequent ocular responses. Jester, J.V., Petroll, W.M., Bean, J., Parker, R.D., Carr, G.J., Cavanagh, H.D., Maurer, J.K. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  7. In vitro and in vivo evidence for the formation of methyl radical from procarbazine: a spin-trapping study. Goria-Gatti, L., Iannone, A., Tomasi, A., Poli, G., Albano, E. Carcinogenesis (1992) [Pubmed]
  8. Biodegradation of organic wastes containing surfactants in a biomass recycle reactor. Konopka, A., Zakharova, T., Oliver, L., Camp, D., Turco, R.F. Appl. Environ. Microbiol. (1996) [Pubmed]
  9. Location of the sulphonylurea receptor at the cytoplasmic face of the beta-cell membrane. Schwanstecher, M., Schwanstecher, C., Dickel, C., Chudziak, F., Moshiri, A., Panten, U. Br. J. Pharmacol. (1994) [Pubmed]
  10. Complete oxidation of linear alkylbenzene sulfonate by bacterial communities selected from coastal seawater. Sigoillot, J.C., Nguyen, M.H. Appl. Environ. Microbiol. (1992) [Pubmed]
  11. Acute toxicity of anionic surfactants sodium dodecyl sulphate (SDS) and linear alkylbenzene sulphonate (LAS) on the fertilizing capability of gilthead (Sparus aurata L.) sperm. Rosety, M., Ordóñez, F.J., Rosety-Rodríguez, M., Rosety, J.M., Rosety, I., Carrasco, C., Ribelles, A. Histol. Histopathol. (2001) [Pubmed]
  12. Applicability of tetrazolium salts for the measurement of respiratory activity and viability of groundwater bacteria. Hatzinger, P.B., Palmer, P., Smith, R.L., Peñarrieta, C.T., Yoshinari, T. J. Microbiol. Methods (2003) [Pubmed]
  13. Germicidal persistence of teat dips by modified excised teat procedure. Schmidt, A.L., Oliver, S.P., Fydenkevez, M.E. J. Dairy Sci. (1985) [Pubmed]
  14. Acute toxicity of LAS homologues in marine microalgae: esterase activity and inhibition growth as endpoints of toxicity. Hampel, M., Moreno-Garrido, I., Sobrino, C., Lubián, L.M., Blasco, J. Ecotoxicol. Environ. Saf. (2001) [Pubmed]
  15. Initial steps in the degradation of benzene sulfonic acid, 4-toluene sulfonic acids, and orthanilic acid in Alcaligenes sp. strain O-1. Thurnheer, T., Zürrer, D., Höglinger, O., Leisinger, T., Cook, A.M. Biodegradation (1990) [Pubmed]
  16. Vitamin K(2) selectively induced apoptosis in ovarian TYK-nu and pancreatic MIA PaCa-2 cells out of eight solid tumor cell lines through a mechanism different from geranylgeraniol. Shibayama-Imazu, T., Sakairi, S., Watanabe, A., Aiuchi, T., Nakajo, S., Nakaya, K. J. Cancer Res. Clin. Oncol. (2003) [Pubmed]
  17. A comparison of river water quality sampling methodologies under highly variable load conditions. Facchi, A., Gandolfi, C., Whelan, M.J. Chemosphere (2007) [Pubmed]
  18. Teratology studies of a mixture of tallow alkyl ethoxylate and linear alkylbenzene sulfonate in rats and rabbits. Nolen, G.A., Klusman, L.W., Patrick, L.F., Geil, R.G. Toxicology (1975) [Pubmed]
  19. Assessment of bioconcentration and secondary poisoning of surfactants. Comber, M.H., de Wolf, W., Cavalli, L., van Egmond, R., Steber, J., Tattersfield, L., Priston, R.A. Chemosphere (2003) [Pubmed]
  20. Toxicology studies of linear alkylbenzene sulphonate (LAS) in rhesus monkeys. I. Simultaneous oral and subcutaneous administration for 28 days. Heywood, R., James, R.W., Sortwell, R.J. Toxicology (1978) [Pubmed]
  21. Transport of benzenesulfonic acid derivatives through the rat erythrocyte membrane. Kitagawa, S., Terada, H., Kametani, F. J. Membr. Biol. (1982) [Pubmed]
  22. Killing of preimplantation mouse embryos by main ingredients of cleansers AS and LAS. Nomura, T., Hata, S., Shibata, K., Kusafuka, T. Mutat. Res. (1987) [Pubmed]
  23. Colorimetric assay using XTT for assessing virulence of avian Pasteurella multocida strains. Choi, K.H., Maheswaran, S.K., Choi, C.S. Vet. Microbiol. (1995) [Pubmed]
  24. Correlation of the photosynthetic reduction of p-(diazonium-) benzenesulfonic acid with the increased binding of the probe to the thylakoid membrane. Lockau, W., Selman, B.R. Z. Naturforsch., C, Biosci. (1976) [Pubmed]
  25. Effect of linear alkylbenzene sulfonate (LAS) on ion transport and intracellular calcium in kidney distal epithelial cells (A6). Bjerregaard, H.F., Staermose, S., Vang, J. Toxicology in vitro : an international journal published in association with BIBRA. (2001) [Pubmed]
  26. High-performance liquid chromatographic investigation of the interaction of phenylmercuric nitrate and sodium metabisulphite in eye drop formulations. Parkin, J.E. J. Chromatogr. (1990) [Pubmed]
  27. Low level determination of p-toluenesulfonate and benzenesulfonate esters in drug substance by high performance liquid chromatography/mass spectrometry. Taylor, G.E., Gosling, M., Pearce, A. Journal of chromatography. A. (2006) [Pubmed]
  28. Gene expression changes in peripheral blood-derived dendritic cells following exposure to a contact allergen. Ryan, C.A., Gildea, L.A., Hulette, B.C., Dearman, R.J., Kimber, I., Gerberick, G.F. Toxicol. Lett. (2004) [Pubmed]
  29. Biodegradation kinetics of linear alkylbenzene sulfonate in sludge-amended agricultural soils. Ward, T.E., Larson, R.J. Ecotoxicol. Environ. Saf. (1989) [Pubmed]
  30. Biodegradation of aniline, anthracene, chlornitrophen, fenitrothion and linear alkylbenzene sulphonate in pond water. Nishihara, T., Hasebe, S., Nishikawa, J., Kondo, M. J. Appl. Microbiol. (1997) [Pubmed]
  31. Raman spectroscopic study of hydrogen bonding in benzenesulfonic acid/acrylonitrile solutions. Alía, J.M., Edwards, H.G., Kiernan, B.M. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. (2005) [Pubmed]
  32. Simple and sensitive method for spectrofluorimetric determination of dodecyl benzene sulfonic acid sodium. Liu, J., Liu, Y., Li, P., Wang, L. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2006) [Pubmed]
  33. Analysis of linear alkylbenzene sulfonate homologues in environmental water samples by mixed admicelle-based extraction and liquid chromatography/mass spectrometry. Lunar, L., Rubio, S., Pérez-Bendito, D. The Analyst. (2006) [Pubmed]
  34. Application of a linear alkylbenzene sulfonate biosensor to river water monitoring. Nomura, Y., Ikebukuro, K., Yokoyama, K., Takeuchi, T., Arikawa, Y., Ohno, S., Karube, I. Biosensors & bioelectronics. (1998) [Pubmed]
  35. Assessment of the teratogenic potential of surfactants. Part III--dermal application of LAS and soap. Palmer, A.K., Readshaw, M.A., Neuff, A.M. Toxicology (1975) [Pubmed]
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