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Disease relevance of Pneumonectomy


High impact information on Pneumonectomy

  • Left pneumonectomy in the mature rat led to an increase of [3Ha1 thymidine incorporation into DNA of the remaining lung in the first 3 postoperative days, and resulted in a subsequent 38% increase of lung weight and 41% increase of lung tissue volume measured 1 wk after surgery [6].
  • Functional consequences of lung volume reduction surgery for COPD [7].
  • Lung volume reduction surgery. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, May 1996 [8].
  • In this study, we examined the expression of HIMF in mouse lung after pneumonectomy to test the hypothesis that HIMF expression is upregulated during compensatory lung growth [9].
  • RESULTS: Initial CT scans were obtained 34 months +/- 67 (standard deviation) after pneumonectomy; multiple CT scans were obtained in 58 patients during follow-up of 25.1 months +/- 24 [10].

Chemical compound and disease context of Pneumonectomy


Biological context of Pneumonectomy

  • 52 eligible, consenting, chemotherapy-naïve patients with NSCLC, median age of 60 years, stage IIIA N2 disease and the ability to tolerate a pneumonectomy received paclitaxel 200 mg/m2 as a 3-h infusion followed by carboplatin at an area under the concentration curve (AUC) of 6 every 3 weeks for three courses [16].
  • In our opinion a higher pulmonary drug concentration of amiodarone could exist from a change in pharmacokinetics because of a low fat storage in a thin patient and compensatory growth of the remaining lung which occurs after pneumonectomy [17].
  • OBJECTIVES: A report from the National Emphysema Treatment Trial indicated that lung volume reduction candidates with a forced expiratory volume in 1 second and a diffusing capacity of carbon monoxide of 20% or less of predicted value were at high risk for mortality and were unlikely to benefit from surgical intervention [18].
  • Cardiac output and O2 delivery were reduced at a given O2 consumption after pneumonectomy [19].
  • CONCLUSIONS: Lung volume reduction surgery in select, ventilator-dependent COPD patients can result in improved gas exchange and respiratory mechanics that enable successful weaning and overall improved functional status [20].

Anatomical context of Pneumonectomy

  • Elevation of serum human hepatocyte growth factor (HGF) level in patients with pneumonectomy during a perioperative period [21].
  • METHODS: Between 1/87 and 10/97, 129 patients (90 male, 39 female, mean age 57.8 years, range: 15-78 years) underwent pneumonectomy by one surgeon (W.K.). In 14 patients, additional resection procedures were performed (aorta n = 6, vena cava n = 5, thoracic wall n = 3) [22].
  • Resection extended to the lung (10 wedge resections, 2 lobectomies and 1 pneumonectomy) in 13 patients, diaphragm in 3, abdominal wall in 2, brachiocephalic and subclavian vessels in 5, superior vena cava in 1 and upper limb in 1 [23].
  • Our study suggests that the mediastinum should be stabilized in the midline after repair of a diaphragmatic hernia or after a pneumonectomy in an infant or small child [24].
  • This was due to anatomical changes after the pneumonectomy that resulted in direct blood flow from the inferior vena cava through a previously unrecognised atrial septal defect into the left atrium [25].

Associations of Pneumonectomy with chemical compounds

  • PATIENTS AND METHODS: Forty-seven chemotherapy-naive patients with NSCLC, median age of 58 years, stage IIIA N2 disease, World Health Organization performance status of 0 or 1, and the ability to tolerate a pneumonectomy received gemcitabine 1,000 mg/m(2) on days 1, 8, and 15 and cisplatin 100 mg/m(2) on day 2, every 4 weeks [26].
  • Dynamic pulmonary xenon-133 single-photon emission tomography (SPET) with three-dimensional (3D) displays was preliminarily applied to select resection targets for thoracoscopic lung volume reduction surgery (LVRS) and to assess regional ventilatory changes following surgery [27].
  • For a study of penetration of enoxacin into lung, patients undergoing pneumonectomy were given 400 mg by mouth the night before and again approx 2 h before operation [28].
  • Estimation of diffusion limitation after pneumonectomy from carbon monoxide diffusing capacity [29].
  • After pneumonectomy, the animals reached O2 consumptions close to the maximum expected for normal dogs [19].

Gene context of Pneumonectomy

  • We examined the mRNA abundance of IGF-I, IGF-II, and IGF binding proteins (IGFBPs) in lungs of rats on postoperative days 1, 2, 3, 5, and 7 following left pneumonectomy (PNX) or shamoperation (SC) and in normal animals (CON) [30].
  • We conclude that the changes observed in lung IGF and IGFBP expression following pneumonectomy do not represent major [30].
  • Transcripts for IGFBP-2, -3, -4, -5, and -6 were decreased in both the SC and PNX groups compared to CON animals on the day following pneumonectomy, then rose back to baseline by postoperative day 2-3 [30].
  • Pneumonectomy results in rapid compensatory growth of the remaining lung and also leads to increased flow and shear stress, which are known to stimulate endothelial nitric oxide synthase (eNOS) [31].
  • Changes in atrial natriuretic peptide concentration and expression of its receptors after pneumonectomy in the rat [32].

Analytical, diagnostic and therapeutic context of Pneumonectomy


  1. Empyema seven years after pneumonectomy. Detection by Gallium 67 scan. Kutty, C.P., Varkey, B. JAMA (1979) [Pubmed]
  2. Neoadjuvant chemotherapy followed by extrapleural pneumonectomy in malignant pleural mesothelioma. Weder, W., Kestenholz, P., Taverna, C., Bodis, S., Lardinois, D., Jerman, M., Stahel, R.A. J. Clin. Oncol. (2004) [Pubmed]
  3. Use of radionuclide scanning in the preoperative estimation of pulmonary function after pneumonectomy. Corris, P.A., Ellis, D.A., Hawkins, T., Gibson, G.J. Thorax (1987) [Pubmed]
  4. Lung volume reduction surgery: lessons learned. Miller, J.I., Lee, R.B., Mansour, K.A. Ann. Thorac. Surg. (1996) [Pubmed]
  5. Survival related to lymph node involvement in lung cancer after sleeve lobectomy compared with pneumonectomy. Okada, M., Yamagishi, H., Satake, S., Matsuoka, H., Miyamoto, Y., Yoshimura, M., Tsubota, N. J. Thorac. Cardiovasc. Surg. (2000) [Pubmed]
  6. Time course of and stimuli to compensatory growth of the lung after pneumonectomy. Brody, J.S. J. Clin. Invest. (1975) [Pubmed]
  7. Functional consequences of lung volume reduction surgery for COPD. Wagner, P.D. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  8. Lung volume reduction surgery. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, May 1996. Fein, A.M., Branman, S.S., Casaburi, R., Irvin, C.G., Make, B.J., Rodarte, J.R., Solway, J. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  9. Upregulation of hypoxia-induced mitogenic factor in compensatory lung growth after pneumonectomy. Li, D., Fernandez, L.G., Dodd-o, J., Langer, J., Wang, D., Laubach, V.E. Am. J. Respir. Cell Mol. Biol. (2005) [Pubmed]
  10. Postpneumonectomy pulmonary artery stump thrombosis: CT features and imaging follow-up. Kwek, B.H., Wittram, C. Radiology. (2005) [Pubmed]
  11. Extended indications for lung volume reduction surgery in advanced emphysema. Argenziano, M., Moazami, N., Thomashow, B., Jellen, P.A., Gorenstein, L.A., Rose, E.A., Weinberg, A.D., Steinglass, K.M., Ginsburg, M.E. Ann. Thorac. Surg. (1996) [Pubmed]
  12. Cardiopulmonary hypoxic response 5 years postpneumonectomy in beagles. Murray, G.F., Lucas, C.L., Wilcox, B.R., Shallal, J.A. J. Surg. Res. (1986) [Pubmed]
  13. Recall phenomenon or severe skin and muscle necrosis following Adriamycin extravasation in the hand. Mamakos, M.S. International surgery. (1984) [Pubmed]
  14. Endoscopic closure of bronchopleural fistula after pneumonectomy by submucosal injection of polidocanol. Kanno, R., Suzuki, H., Fujiu, K., Ohishi, A., Gotoh, M. The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi. (2002) [Pubmed]
  15. Multidisciplinary treatment by pneumonectomy, PMX and CHDF in a case of pulmonary suppuration complicated with septic shock. Takahashi, N., Ohsawa, H., Mawatari, T., Watanabe, A., Abe, T. Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia. (2003) [Pubmed]
  16. Carboplatin and paclitaxol (Taxol) as an induction regimen for patients with biopsy-proven stage IIIA N2 non-small cell lung cancer. an EORTC phase II study (EORTC 08958). O'Brien, M.E., Splinter, T., Smit, E.F., Biesma, B., Krzakowski, M., Tjan-Heijnen, V.C., Van Bochove, A., Stigt, J., Smid-Geirnaerdt, M.J., Debruyne, C., Legrand, C., Giaccone, G. Eur. J. Cancer (2003) [Pubmed]
  17. Low dose amiodarone pulmonary toxicity in a patient with a history of pneumonectomy. van der Zeyden, H., Zandstra, D., van Hengstum, M. Intensive care medicine. (1992) [Pubmed]
  18. Results of lung volume reduction surgery in patients meeting a national emphysema treatment trial high-risk criterion. Meyers, B.F., Yusen, R.D., Guthrie, T.J., Patterson, G.A., Lefrak, S.S., Davis, G.E., Cooper, J.D. J. Thorac. Cardiovasc. Surg. (2004) [Pubmed]
  19. Gas exchange abnormalities after pneumonectomy in conditioned foxhounds. Hsia, C.C., Carlin, J.I., Wagner, P.D., Cassidy, S.S., Johnson, R.L. J. Appl. Physiol. (1990) [Pubmed]
  20. Lung volume reduction surgery in ventilator-dependent COPD patients. Criner, G.J., O'Brien, G., Furukawa, S., Cordova, F., Swartz, M., Fallahnejad, M., D'Alonzo, G. Chest (1996) [Pubmed]
  21. Elevation of serum human hepatocyte growth factor (HGF) level in patients with pneumonectomy during a perioperative period. Sugahara, K., Matsumoto, M., Baba, T., Nakamura, T., Kawamoto, T. Intensive care medicine. (1998) [Pubmed]
  22. Impact of different coverage techniques on incidence of postpneumonectomy stump fistula. Klepetko, W., Taghavi, S., Pereszlenyi, A., Bîrsan, T., Groetzner, J., Kupilik, N., Artemiou, O., Wolner, E. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (1999) [Pubmed]
  23. Chest wall reconstruction following resection of large primary malignant tumors. Chapelier, A., Macchiarini, P., Rietjens, M., Lenot, B., Margulis, A., Petit, J.Y., Dartevelle, P. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (1994) [Pubmed]
  24. The effect of overdistention of the lung on pulmonary function in beagle puppies. Raffensperger, J.G., Luck, S.R., Inwood, R.J., Gora, P., Hunt, C.E. J. Pediatr. Surg. (1979) [Pubmed]
  25. A rare complication of pneumonectomy: diagnosis made by a literature search. Crosbie, P.A., Cooper, A.N., Ray, S., O'Driscoll, R. Respiratory medicine. (2005) [Pubmed]
  26. Gemcitabine and cisplatin as induction regimen for patients with biopsy-proven stage IIIA N2 non-small-cell lung cancer: a phase II study of the European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group (EORTC 08955). Van Zandwijk, N., Smit, E.F., Kramer, G.W., Schramel, F., Gans, S., Festen, J., Termeer, A., Schlosser, N.J., Debruyne, C., Curran, D., Giaccone, G. J. Clin. Oncol. (2000) [Pubmed]
  27. Preliminary application of dynamic pulmonary xenon-133 single-photon emission tomography in the evaluation of patients with pulmonary emphysema for thoracoscopic lung volume reduction surgery. Suga, K., Nishigauchi, K., Matsunaga, N., Matsumoto, T., Kume, N., Sugi, K., Esato, K. European journal of nuclear medicine. (1998) [Pubmed]
  28. Penetration of enoxacin into lung tissue. Newsom, S.W., Eden, C.G., Wells, F.C., Meredith, P. J. Antimicrob. Chemother. (1989) [Pubmed]
  29. Estimation of diffusion limitation after pneumonectomy from carbon monoxide diffusing capacity. Hsia, C.C., Carlin, J.I., Ramanathan, M., Cassidy, S.S., Johnson, R.L. Respiration physiology. (1991) [Pubmed]
  30. Expression of the insulin-like growth factor system in postpneumonectomy lung growth. Price, W.A., Moats-Staats, B.M., Sekhon, H.S., Chrzanowska, B.L., Thurlbeck, W.M., Stiles, A.D. Exp. Lung Res. (1998) [Pubmed]
  31. Inhibition of compensatory lung growth in endothelial nitric oxide synthase-deficient mice. Leuwerke, S.M., Kaza, A.K., Tribble, C.G., Kron, I.L., Laubach, V.E. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  32. Changes in atrial natriuretic peptide concentration and expression of its receptors after pneumonectomy in the rat. Tamura, K., Takamori, S., Mifune, H., Hayashi, A., Shirouzu, K. Clin. Sci. (2000) [Pubmed]
  33. Pulmonary hemodynamics in advanced COPD candidates for lung volume reduction surgery or lung transplantation. Thabut, G., Dauriat, G., Stern, J.B., Logeart, D., Lévy, A., Marrash-Chahla, R., Mal, H. Chest (2005) [Pubmed]
  34. Single lung transplantation with cyclosporin immunosuppression. Evaluation of canine and human recipients. Kamholz, S.L., Veith, F.J., Mollenkopf, F.P., Pinsker, K.L., Kaleya, R.R., Norin, A.J., Gliedman, M.L., Emeson, E.E., Merav, A.D., Brodman, R. J. Thorac. Cardiovasc. Surg. (1983) [Pubmed]
  35. COPD in perspective. Petty, T.L. Chest (2002) [Pubmed]
  36. Operative approaches for left-sided carinoplasty. Maeda, M., Nakamoto, K., Tsubota, N., Okada, T., Katsura, H. Ann. Thorac. Surg. (1993) [Pubmed]
  37. Utility of C-reactive protein measurements for empyema diagnosis after pneumonectomy. Icard, P., Fleury, J.P., Regnard, J.F., Libert, J.M., Magdeleinat, P., Gharbi, N., Brachet, A., Levi, J.F., Levasseur, P. Ann. Thorac. Surg. (1994) [Pubmed]
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