The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

netilmicin     (2R,3R,4R,5S)-2- [(1S,2S,3R,4S,6R)-4-amino...

Synonyms: Nettacin, Vectacin, Netilyn, SureCN18442, HSDB 3584, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of netilmicin


Psychiatry related information on netilmicin


High impact information on netilmicin


Chemical compound and disease context of netilmicin


Biological context of netilmicin


Anatomical context of netilmicin


Associations of netilmicin with other chemical compounds


Gene context of netilmicin

  • We feel that the aminoglycoside, netilmicin, might provide an alternative agent (to intravenously administered vancomycin) for treating multiply-antimicrobial resistant MRSA [28].
  • The pharmacokinetics of intravenous netilmicin was studied in cystic fibrosis (CF) and non-CF patients who were closely matched according to age [29].
  • In this improved simple method for determination of aminoglycoside antibiotics in dried-blood spots on filter paper, gentamicin or netilmicin is recovered from the blood spot most effectively by incubation for 60 min in an ultrafiltration tube containing 500 microL of 0.5 mol/L Na2HPO4 buffer [30].
  • All of the plasmids encoded intermediate resistance to amikacin and netilmicin and resistance to ethidium bromide; some encoded beta-lactamase production [31].
  • After administration of 150 mg netilmicin samples of CSF and blood were obtained [32].

Analytical, diagnostic and therapeutic context of netilmicin


  1. Randomised, controlled trial of the comparative efficacy, auditory toxicity, and nephrotoxicity of tobramycin and netilmicin. Lerner, A.M., Reyes, M.P., Cone, L.A., Blair, D.C., Jansen, W., Wright, G.E., Lorber, R.R. Lancet (1983) [Pubmed]
  2. Peritonitis in continuous ambulatory peritoneal dialysis. Laboratory and clinical studies. Gokal, R., Ramos, J.M., Francis, D.M., Ferner, R.E., Goodship, T.H., Proud, G., Bint, A.J., Ward, M.K., Kerr, D.N. Lancet (1982) [Pubmed]
  3. A prospective randomized trial of ceftazidime versus netilmicin plus mezlocillin in the empirical therapy of presumed sepsis in cirrhotic patients. McCormick, P.A., Greenslade, L., Kibbler, C.C., Chin, J.K., Burroughs, A.K., McIntyre, N. Hepatology (1997) [Pubmed]
  4. Clinical evaluation of netilmicin therapy in serious infections. Jahre, J.A., Fu, K.P., Neu, H.C. Am. J. Med. (1979) [Pubmed]
  5. Once-daily dosing regimen for aminoglycoside plus beta-lactam combination therapy of serious bacterial infections: comparative trial with netilmicin plus ceftriaxone. ter Braak, E.W., de Vries, P.J., Bouter, K.P., van der Vegt, S.G., Dorrestein, G.C., Nortier, J.W., van Dijk, A., Verkooyen, R.P., Verbrugh, H.A. Am. J. Med. (1990) [Pubmed]
  6. Relative efficacy and toxicity of netilmicin and tobramycin in oncology patients. Bernstein, J.M., Gorse, G.J., Linzmayer, M.I., Pegram, P.S., Levin, R.D., Brummett, R.E., Markowitz, N., Saravolatz, L.D., Lorber, R.R. Arch. Intern. Med. (1986) [Pubmed]
  7. A review of chemoprophylaxis and therapy of bacterial infections in neutropenic patients. Klastersky, J. Diagn. Microbiol. Infect. Dis. (1989) [Pubmed]
  8. Population pharmacokinetic analysis of netilmicin in neonates and infants with use of a nonparametric method. Tréluyer, J.M., Merlé, Y., Semlali, A., Pons, G. Clin. Pharmacol. Ther. (2000) [Pubmed]
  9. Tolerance of once-daily dosing of netilmicin and teicoplanin, alone or in combination, in healthy volunteers. Pierre, C., Blanchet, F., Seta, N., Chaigne, P., Labarre, C., Sterkers, O., Amiel, C., Carbon, C. Clin. Pharmacol. Ther. (1988) [Pubmed]
  10. Netilmicin and gentamicin multidose kinetics in normal subjects. Laskin, O.L., Longstreth, J.A., Smith, C.R., Lietman, P.S. Clin. Pharmacol. Ther. (1983) [Pubmed]
  11. Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase. Magnet, S., Smith, T.A., Zheng, R., Nordmann, P., Blanchard, J.S. Antimicrob. Agents Chemother. (2003) [Pubmed]
  12. Prospective, randomized trial of netilmicin and amikacin, with emphasis on eighth-nerve toxicity. Barza, M., Lauermann, M.W., Tally, F.P., Gorbach, S.L. Antimicrob. Agents Chemother. (1980) [Pubmed]
  13. Enhanced phagocytosis of encapsulated Escherichia coli strains after exposure to sub-MICs of antibiotics is correlated to changes of the bacterial cell surface. Raponi, G., Keller, N., Overbeek, B.P., Rozenberg-Arska, M., van Kessel, K.P., Verhoef, J. Antimicrob. Agents Chemother. (1990) [Pubmed]
  14. Cefazolin plus netilmicin versus cefazolin plus ceftazidime for treating CAPD peritonitis: effect on residual renal function. Lui, S.L., Cheng, S.W., Ng, F., Ng, S.Y., Wan, K.M., Yip, T., Tse, K.C., Lam, M.F., Lai, K.N., Lo, W.K. Kidney Int. (2005) [Pubmed]
  15. Pharmacokinetics and bacteriological efficacy of moxalactam (LY127935), netilmicin, and ampicillin in experimental gram-negative enteric bacillary meningitis. Schaad, U.B., McCracken, G.H., Loock, C.A., Thomas, M.L. Antimicrob. Agents Chemother. (1980) [Pubmed]
  16. Synergistic activity of ceftriaxone combined with netilmicin administered once daily for treatment of experimental streptococcal endocarditis. Francioli, P.B., Glauser, M.P. Antimicrob. Agents Chemother. (1993) [Pubmed]
  17. Kinetics of netilmicin in man. Pechere, J.C., Dugal, R., Pechere, M.M. Clin. Pharmacol. Ther. (1978) [Pubmed]
  18. Netilmicin in the neonate: population pharmacokinetic analysis and dosing recommendations. Fattinger, K., Vozeh, S., Olafsson, A., Vlcek, J., Wenk, M., Follath, F. Clin. Pharmacol. Ther. (1991) [Pubmed]
  19. Clinical pharmacology of netilmicin. Yap, B.S., Stewart, D., Bodey, G.P. Antimicrob. Agents Chemother. (1977) [Pubmed]
  20. Apoptosis in renal proximal tubules of rats treated with low doses of aminoglycosides. El Mouedden, M., Laurent, G., Mingeot-Leclercq, M.P., Taper, H.S., Cumps, J., Tulkens, P.M. Antimicrob. Agents Chemother. (2000) [Pubmed]
  21. Netilmicin treatment of complicated urinary tract infection in patients with renal function impairment. Frimodt-Möller, N., Maigaard, S., Madsen, P.O. Antimicrob. Agents Chemother. (1979) [Pubmed]
  22. Comparative uptake of gentamicin, netilmicin, and amikacin in the guinea pig cochlea and vestibule. Dulon, D., Aran, J.M., Zajic, G., Schacht, J. Antimicrob. Agents Chemother. (1986) [Pubmed]
  23. Residual bodies in the retinal pigment epithelium induced by intravitreal netilmicin. Tabatabay, C.A., D'Amico, D.J., Hanninen, L.A., Casey, V.N., Kenyon, K.R. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
  24. Once-daily dosing decreases renal accumulation of gentamicin and netilmicin. Verpooten, G.A., Giuliano, R.A., Verbist, L., Eestermans, G., De Broe, M.E. Clin. Pharmacol. Ther. (1989) [Pubmed]
  25. Influence of pH on adaptive resistance of Pseudomonas aeruginosa to aminoglycosides and their postantibiotic effects. Xiong, Y.Q., Caillon, J., Drugeon, H., Potel, G., Baron, D. Antimicrob. Agents Chemother. (1996) [Pubmed]
  26. Effect of concomitant administration of piperacillin on the dispositions of netilmicin and tobramycin in patients with end-stage renal disease. Halstenson, C.E., Hirata, C.A., Heim-Duthoy, K.L., Abraham, P.A., Matzke, G.R. Antimicrob. Agents Chemother. (1990) [Pubmed]
  27. Sisomicin versus netilmicin: in vitro susceptibility testing. Flournoy, D.J. Antimicrob. Agents Chemother. (1976) [Pubmed]
  28. In vitro antimicrobial susceptibilities of 349 methicillin-resistant Staphylococcus aureus isolates from veterans. Flournoy, D.J., Robinson, M.C. Methods and findings in experimental and clinical pharmacology. (1990) [Pubmed]
  29. Pharmacokinetics of netilmicin in children with and without cystic fibrosis. Michalsen, H., Bergan, T. Antimicrob. Agents Chemother. (1981) [Pubmed]
  30. Fluorescence polarization immunoassay of gentamicin or netilmicin in blood spotted on filter paper. Fujimoto, T., Tsuda, Y., Tawa, R., Hirose, S. Clin. Chem. (1989) [Pubmed]
  31. Self-transmissible plasmids in staphylococci that encode resistance to aminoglycosides. Archer, G.L., Johnston, J.L. Antimicrob. Agents Chemother. (1983) [Pubmed]
  32. Netilmicin in human CSF after parenteral administration in patients with slightly and severely impaired blood CSF barrier. Brückner, O., Trautmann, M., Kolodziejczyk, D., Alexander, M., Collmann, H. J. Antimicrob. Chemother. (1983) [Pubmed]
  33. Kinetics of netilmicin and gentamicin. Jahre, J.A., Fu, K.P., Neu, H.C. Clin. Pharmacol. Ther. (1978) [Pubmed]
  34. Homogeneous enzyme immunoassay for netilmicin. Wenk, M., Hemmann, R., Follath, F. Antimicrob. Agents Chemother. (1982) [Pubmed]
  35. 125I radioimmunoassay of netilmicin. Stevens, P., Young, L.S., Hewitt, W.L. Antimicrob. Agents Chemother. (1977) [Pubmed]
  36. Tentative interpretive criteria for the diffusion susceptibility test using 30-microgram netilmicin disks. Jones, R.N., Barry, A.L., Thornsberry, C. Antimicrob. Agents Chemother. (1980) [Pubmed]
WikiGenes - Universities