Gene Review:
HSPB1 - heat shock 27kDa protein 1
Homo sapiens
Synonyms:
28 kDa heat shock protein, CMT2F, Estrogen-regulated 24 kDa protein, HEL-S-102, HMN2B, ...
Cohen,
Baines,
Downey,
Tilly,
Gaestel,
Engel,
Edixhoven,
de Jonge,
Niwa,
Hotta,
Hara,
Hirade,
Ito,
Kato,
Kozawa,
Doak,
Jenkins,
Parry,
Griffiths,
Baxter,
Parry,
Sarto,
Valsecchi,
Magni,
Tremolada,
Arizzi,
Cordani,
Casellato,
Doro,
Favini,
Perego,
Raimondo,
Ferrero,
Mocarelli,
Galli-Kienle,
Evgrafov,
Mersiyanova,
Irobi,
Van Den Bosch,
Dierick,
Leung,
Schagina,
Verpoorten,
Van Impe,
Fedotov,
Dadali,
Auer-Grumbach,
Windpassinger,
Wagner,
Mitrovic,
Hilton-Jones,
Talbot,
Martin,
Vasserman,
Tverskaya,
Polyakov,
Liem,
Gettemans,
Robberecht,
De Jonghe,
Timmerman,
- Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance. Chauhan, D., Li, G., Hideshima, T., Podar, K., Mitsiades, C., Mitsiades, N., Catley, L., Tai, Y.T., Hayashi, T., Shringarpure, R., Burger, R., Munshi, N., Ohtake, Y., Saxena, S., Anderson, K.C. Blood (2003)
- Suppression of thermotolerance in mumps virus-infected cells is caused by lack of HSP27 induction contributed by STAT-1. Yokota, S., Yokosawa, N., Kubota, T., Okabayashi, T., Arata, S., Fujii, N. J. Biol. Chem. (2003)
- Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosis. Rashmi, R., Kumar, S., Karunagaran, D. Carcinogenesis (2004)
- Differential expression of the MAD2, BUB1 and HSP27 genes in Barrett's oesophagus-their association with aneuploidy and neoplastic progression. Doak, S.H., Jenkins, G.J., Parry, E.M., Griffiths, A.P., Baxter, J.N., Parry, J.M. Mutat. Res. (2004)
- Alpha B crystallin and HSP28 are enhanced in the cerebral cortex of patients with Alzheimer's disease. Shinohara, H., Inaguma, Y., Goto, S., Inagaki, T., Kato, K. J. Neurol. Sci. (1993)
- Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy. Irobi, J., Van Impe, K., Seeman, P., Jordanova, A., Dierick, I., Verpoorten, N., Michalik, A., De Vriendt, E., Jacobs, A., Van Gerwen, V., Vennekens, K., Mazanec, R., Tournev, I., Hilton-Jones, D., Talbot, K., Kremensky, I., Van Den Bosch, L., Robberecht, W., Van Vandekerckhove, J., Broeckhoven, C., Gettemans, J., De Jonghe, P., Timmerman, V. Nat. Genet. (2004)
- Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. Evgrafov, O.V., Mersiyanova, I., Irobi, J., Van Den Bosch, L., Dierick, I., Leung, C.L., Schagina, O., Verpoorten, N., Van Impe, K., Fedotov, V., Dadali, E., Auer-Grumbach, M., Windpassinger, C., Wagner, K., Mitrovic, Z., Hilton-Jones, D., Talbot, K., Martin, J.J., Vasserman, N., Tverskaya, S., Polyakov, A., Liem, R.K., Gettemans, J., Robberecht, W., De Jonghe, P., Timmerman, V. Nat. Genet. (2004)
- Heat-shock proteins protect cells from monocyte cytotoxicity: possible mechanism of self-protection. Jäättelä, M., Wissing, D. J. Exp. Med. (1993)
- Modulation of estrogen signaling by the novel interaction of heat shock protein 27, a biomarker for atherosclerosis, and estrogen receptor beta: mechanistic insight into the vascular effects of estrogens. Miller, H., Poon, S., Hibbert, B., Rayner, K., Chen, Y.X., O'Brien, E.R. Arterioscler. Thromb. Vasc. Biol. (2005)
- Expression of heat shock protein 27 in human renal cell carcinoma. Sarto, C., Valsecchi, C., Magni, F., Tremolada, L., Arizzi, C., Cordani, N., Casellato, S., Doro, G., Favini, P., Perego, R.A., Raimondo, F., Ferrero, S., Mocarelli, P., Galli-Kienle, M. Proteomics (2004)
- Increased Hsp27 after androgen ablation facilitates androgen-independent progression in prostate cancer via signal transducers and activators of transcription 3-mediated suppression of apoptosis. Rocchi, P., Beraldi, E., Ettinger, S., Fazli, L., Vessella, R.L., Nelson, C., Gleave, M. Cancer Res. (2005)
- Heat shock proteins hsp27 and hsp70: lack of correlation with response to tamoxifen and clinical course of disease in estrogen receptor-positive metastatic breast cancer (a Southwest Oncology Group Study). Ciocca, D.R., Green, S., Elledge, R.M., Clark, G.M., Pugh, R., Ravdin, P., Lew, D., Martino, S., Osborne, C.K. Clin. Cancer Res. (1998)
- Heat shock proteins and drug resistance. Fuqua, S.A., Oesterreich, S., Hilsenbeck, S.G., Von Hoff, D.D., Eckardt, J., Osborne, C.K. Breast Cancer Res. Treat. (1994)
- A mutation in the small heat-shock protein HSPB1 leading to distal hereditary motor neuronopathy disrupts neurofilament assembly and the axonal transport of specific cellular cargoes. Ackerley, S., James, P.A., Kalli, A., French, S., Davies, K.E., Talbot, K. Hum. Mol. Genet. (2006)
- PRAK, a novel protein kinase regulated by the p38 MAP kinase. New, L., Jiang, Y., Zhao, M., Liu, K., Zhu, W., Flood, L.J., Kato, Y., Parry, G.C., Han, J. EMBO J. (1998)
- The 29-kDa proteins phosphorylated in thrombin-activated human platelets are forms of the estrogen receptor-related 27-kDa heat shock protein. Mendelsohn, M.E., Zhu, Y., O'Neill, S. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Copurification of small heat shock protein with alpha B crystallin from human skeletal muscle. Kato, K., Shinohara, H., Goto, S., Inaguma, Y., Morishita, R., Asano, T. J. Biol. Chem. (1992)
- Ischemic preconditioning: from adenosine receptor to KATP channel. Cohen, M.V., Baines, C.P., Downey, J.M. Annu. Rev. Physiol. (2000)
- Heat shock protein 27 controls apoptosis by regulating Akt activation. Rane, M.J., Pan, Y., Singh, S., Powell, D.W., Wu, R., Cummins, T., Chen, Q., McLeish, K.R., Klein, J.B. J. Biol. Chem. (2003)
- Arsenite pre-conditioning reduces UVB-induced apoptosis in corneal epithelial cells through the anti-apoptotic activity of 27 kDa heat shock protein (HSP27). Shi, B., Isseroff, R.R. J. Cell. Physiol. (2006)
- Protective role of HSP27 against UVC-induced cell death in human cells. Wano, C., Kita, K., Takahashi, S., Sugaya, S., Hino, M., Hosoya, H., Suzuki, N. Exp. Cell Res. (2004)
- Hypo-osmotic cell swelling activates the p38 MAP kinase signalling cascade. Tilly, B.C., Gaestel, M., Engel, K., Edixhoven, M.J., de Jonge, H.R. FEBS Lett. (1996)
- Overexpression of human 27 kDa heat shock protein in laryngeal cancer cells confers chemoresistance associated with cell growth delay. Lee, J.H., Sun, D., Cho, K.J., Kim, M.S., Hong, M.H., Kim, I.K., Lee, J.S., Lee, J.H. J. Cancer Res. Clin. Oncol. (2007)
- The protein kinase inhibitor SB203580 uncouples PMA-induced differentiation of HL-60 cells from phosphorylation of Hsp27. Schultz, H., Rogalla, T., Engel, K., Lee, J.C., Gaestel, M. Cell Stress Chaperones (1997)
- Suppression of NF-kappaB activation by Entamoeba histolytica in intestinal epithelial cells is mediated by heat shock protein 27. Kammanadiminti, S.J., Chadee, K. J. Biol. Chem. (2006)
- The 28-kDa protein whose phosphorylation is induced by protein kinase C activators in MCF-7 cells belongs to the family of low molecular mass heat shock proteins and is the estrogen-regulated 24-kDa protein. Faucher, C., Capdevielle, J., Canal, I., Ferrara, P., Mazarguil, H., McGuire, W.L., Darbon, J.M. J. Biol. Chem. (1993)
- Hsp27 enhances recovery of splicing as well as rephosphorylation of SRp38 after heat shock. Marin-Vinader, L., Shin, C., Onnekink, C., Manley, J.L., Lubsen, N.H. Mol. Biol. Cell (2006)
- Involvement of c-Jun NH2-terminal kinase-1 in heat-induced apoptotic cell death of human monoblastic leukaemia U937 cells. Enomoto, A., Suzuki, N., Liu, C., Kang, Y., Zhu, J., Serizawa, S., Matsumoto, Y., Morita, A., Ito, M., Hosoi, Y. Int. J. Radiat. Biol. (2001)
- Changes in the phosphorylation status of the 27 kDa heat shock protein (HSP27) associated with the modulation of growth and/or differentiation in MCF-7 cells. Horman, S., Galand, P., Mosselmans, R., Legros, N., Leclercq, G., Mairesse, N. Cell Prolif. (1997)
- Interleukin-1-induced intracellular signaling pathways converge in the activation of mitogen-activated protein kinase and mitogen-activated protein kinase-activated protein kinase 2 and the subsequent phosphorylation of the 27-kilodalton heat shock protein in monocytic cells. Ahlers, A., Belka, C., Gaestel, M., Lamping, N., Sott, C., Herrmann, F., Brach, M.A. Mol. Pharmacol. (1994)
- Activation of MAP kinase-activated protein kinase 2 in human neutrophils after phorbol ester or fMLP peptide stimulation. Zu, Y.L., Ai, Y., Gilchrist, A., Labadia, M.E., Sha'afi, R.I., Huang, C.K. Blood (1996)
- HspB8, a small heat shock protein mutated in human neuromuscular disorders, has in vivo chaperone activity in cultured cells. Carra, S., Sivilotti, M., Chávez Zobel, A.T., Lambert, H., Landry, J. Hum. Mol. Genet. (2005)
- Decreased expression of Hsp27 and Hsp70 in transformed lymphoblastoid cells from patients with spinocerebellar ataxia type 7. Tsai, H.F., Lin, S.J., Li, C., Hsieh, M. Biochem. Biophys. Res. Commun. (2005)
- Small heat shock protein 27 (HSP27) associates with tubulin/microtubules in HeLa cells. Hino, M., Kurogi, K., Okubo, M.A., Murata-Hori, M., Hosoya, H. Biochem. Biophys. Res. Commun. (2000)
- TNF-alpha decreases hsp 27 in human blood mononuclear cells: Involvement of protein kinase c. Niwa, M., Hotta, K., Hara, A., Hirade, K., Ito, H., Kato, K., Kozawa, O. Life Sci. (2006)