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Gene Review

LPHN1  -  latrophilin 1

Homo sapiens

Synonyms: CIRL-1, CIRL1, CL1, Calcium-independent alpha-latrotoxin receptor 1, KIAA0821, ...
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Disease relevance of LPHN1


High impact information on LPHN1

  • In stimulating exocytosis, alpha-latrotoxin binds to two distinct families of neuronal cell-surface receptors, neurexins and CLs (Cirl/latrophilins), which probably have a physiological function in synaptic cell adhesion [6].
  • Consistent with this, CD4 synthesized by the Lec2 mutant, which does not add sialic acid to oligosaccharides, was identical to the glycoprotein produced by wild-type CHO cells [7].
  • RP were then compared at three equivalent CL ranges: CL1, 850-600; CL2 599-460; CL3 459-280 [8].
  • Topotecan efflux was inhibited and accumulation was partially restored in CL1/Tpt and MCF7/TPT cells when cells were incubated simultaneously with gefitinib [3].
  • In contrast, these concentrations of gefitinib caused a dose-dependent reversal of resistance to paclitaxel in CL1/Pac cells, to doxorubicin in MCF7/ADR cells, and to topotecan in CL1/Tpt and MCF7/TPT cells [3].

Chemical compound and disease context of LPHN1


Biological context of LPHN1


Anatomical context of LPHN1

  • In situ hybridization revealed that ProSAP1 and CIRL1 are co-expressed in the cortex, hippocampus, and cerebellum [16].
  • Follicles and CL were divided according to their different developmental stages; follicles: previtellogenic, early-vitellogenic, mid-vitellogenic and fully-grown; CL: CL1 (unshelled eggs in the oviducts), CL2 (shelled eggs in the oviducts), CL3 (eggs laid 6 h previously) and CL4 (eggs laid 48 h previously) [17].
  • The interaction of T. rubrum with chinese hamster ovary epithelial cells and their glycosylation-deficient mutants demonstrated a higher adhesion index in Lec1 and Lec2 mutants, that express mannose and galactose, respectively [18].
  • Examination of thin section by transmission electron microscopy showed that after fungal ingestion by Lec2 cells the fungi are enclosed in a 'loose'-type vacuole while the other cells are found within a 'tight'-type membrane-bound cytoplasmic vacuole [19].
  • In this study we examine the effects of expression of a newly cloned Ca2+-independent receptor for alpha-Ltx (CIRL) on secretion from bovine chromaffin cells [20].

Associations of LPHN1 with chemical compounds

  • Lec8 and Lec2 cells show an overall reduction of galactose and/or sialic acid in their glycoconjugates due to defects in the translocation of UDP-galactose and CMP-sialic acid, respectively [21].
  • PGF2 alpha release was highest in CL4, and PGE2 in CL1 and CL2, corticosterone was highest in CL4 [17].
  • PGF2 alpha increased corticosterone in CL1, CL2 and CL3 [17].
  • SGnRH and SP decreased PGE2 and progesterone and increased PGF2 alpha by CL1 and CL2 [22].
  • Addition of the carbohydrates methyl alpha-D-mannopyranoside and methyl alpha-D-galactopyranoside to the interaction medium, pretreatment of Lec1 and Lec2 cells with lectins Concanavalina A and Arachis hypogaea and pretreatment with sodium periodate decreased the adhesion and the endocytic index [19].

Other interactions of LPHN1


Analytical, diagnostic and therapeutic context of LPHN1


  1. Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer. White, G.R., Varley, J.M., Heighway, J. Oncogene (1998) [Pubmed]
  2. Differential expression of glial fibrillary acidic protein in human glioma cell lines. Nishiyama, A., Onda, K., Washiyama, K., Kumanishi, T., Kuwano, R., Sakimura, K., Takahashi, Y. Acta Neuropathol. (1989) [Pubmed]
  3. Gefitinib reverses chemotherapy resistance in gefitinib-insensitive multidrug resistant cancer cells expressing ATP-binding cassette family protein. Yang, C.H., Huang, C.J., Yang, C.S., Chu, Y.C., Cheng, A.L., Whang-Peng, J., Yang, P.C. Cancer Res. (2005) [Pubmed]
  4. Drug interactions between the proteasome inhibitor bortezomib and cytotoxic chemotherapy, tumor necrosis factor (TNF) alpha, and TNF-related apoptosis-inducing ligand in prostate cancer. An, J., Sun, Y.P., Adams, J., Fisher, M., Belldegrun, A., Rettig, M.B. Clin. Cancer Res. (2003) [Pubmed]
  5. Proteomic analysis of differential protein expression in a human hepatoma revertant cell line by using an improved two-dimensional electrophoresis procedure combined with matrix assisted laser desorption/ionization-time of flight-mass spectrometry. Yuan, Q., An, J., Liu, D.G., Sun, L., Ge, Y.Z., Huang, Y.L., Xu, G.J., Zhao, F.K. Electrophoresis (2004) [Pubmed]
  6. alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins. Südhof, T.C. Annu. Rev. Neurosci. (2001) [Pubmed]
  7. Overexpression and biosynthesis of CD4 in Chinese hamster ovary cells: coamplification using the multiple drug resistance gene. König, R., Ashwell, G., Hanover, J.A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  8. Comparison of cardiac refractory periods in children and adults. DuBrow, W., Fisher, E.A., Amaty-Leon, G., Denes, P., Wu, D., Rosen, K., Hastreiter, A.R. Circulation (1975) [Pubmed]
  9. Multiple forms of cyclohexanone oxygenase from Nocardia globerula CL1. Norris, D.B., Trudgill, P.W. Eur. J. Biochem. (1976) [Pubmed]
  10. Immunodiagnosis of Fasciola hepatica infection (fascioliasis) in a human population in the Bolivian Altiplano using purified cathepsin L cysteine proteinase. O'Neill, S.M., Parkinson, M., Strauss, W., Angles, R., Dalton, J.P. Am. J. Trop. Med. Hyg. (1998) [Pubmed]
  11. High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS production in prostate cancer cell lines. Chowdhury, S.K., Gemin, A., Singh, G. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  12. Sialylated complex-type N-glycans enhance the signaling activity of soluble intercellular adhesion molecule-1 in mouse astrocytes. Otto, V.I., Schürpf, T., Folkers, G., Cummings, R.D. J. Biol. Chem. (2004) [Pubmed]
  13. Functional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha/Podoplanin) molecules expressed in Chinese hamster ovary cells. Kaneko, M., Kato, Y., Kunita, A., Fujita, N., Tsuruo, T., Osawa, M. J. Biol. Chem. (2004) [Pubmed]
  14. Population pharmacodynamics and pharmacokinetics of remifentanil as a supplement to nitrous oxide anesthesia for elective abdominal surgery. Drover, D.R., Lemmens, H.J. Anesthesiology (1998) [Pubmed]
  15. Sequence differences between HLA-B and TNF distinguish different MHC ancestral haplotypes. Abraham, L.J., Leelayuwat, C., Grimsley, G., Degli-Esposti, M.A., Mann, A., Zhang, W.J., Christiansen, F.T., Dawkins, R.L. Tissue Antigens (1992) [Pubmed]
  16. The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. Kreienkamp, H.J., Zitzer, H., Gundelfinger, E.D., Richter, D., Bockers, T.M. J. Biol. Chem. (2000) [Pubmed]
  17. Prostaglandins and corticosterone in the oviparous female lizard, Podarcis sicula sicula, during reproduction. Gobbetti, A., Zerani, M., Bellini-Cardellini, L., Bolelli, G.F. Acta Physiol. Scand. (1995) [Pubmed]
  18. The influence of surface carbohydrates during in vitro infection of mammalian cells by the dermatophyte Trichophyton rubrum. Esquenazi, D., Alviano, C.S., de Souza, W., Rozental, S. Res. Microbiol. (2004) [Pubmed]
  19. The role of surface carbohydrates on the interaction of microconidia of Trichophyton mentagrophytes with epithelial cells. Esquenazi, D., de Souza, W., Alviano, C.S., Rozental, S. FEMS Immunol. Med. Microbiol. (2003) [Pubmed]
  20. A Ca2+-independent receptor for alpha-latrotoxin, CIRL, mediates effects on secretion via multiple mechanisms. Bittner, M.A., Krasnoperov, V.G., Stuenkel, E.L., Petrenko, A.G., Holz, R.W. J. Neurosci. (1998) [Pubmed]
  21. The role of asparagine-linked carbohydrate in natural killer cell-mediated cytolysis. Ahrens, P.B., Ankel, H. J. Biol. Chem. (1987) [Pubmed]
  22. GnRH and substance P regulate prostaglandins and sex steroids from reptilian (Podarcis sicula sicula) ovarian follicles and corpora lutea. Gobbetti, A., Zerani, M., Di Fiore, M.M. Gen. Comp. Endocrinol. (1994) [Pubmed]
  23. Latrophilin, neurexin, and their signaling-deficient mutants facilitate alpha -latrotoxin insertion into membranes but are not involved in pore formation. Volynski, K.E., Meunier, F.A., Lelianova, V.G., Dudina, E.E., Volkova, T.M., Rahman, M.A., Manser, C., Grishin, E.V., Dolly, J.O., Ashley, R.H., Ushkaryov, Y.A. J. Biol. Chem. (2000) [Pubmed]
  24. Mechanisms of alpha-latrotoxin action. Henkel, A.W., Sankaranarayanan, S. Cell Tissue Res. (1999) [Pubmed]
  25. Genomic organization of a polymorphic duplicated region centromeric of HLA-B. Leelayuwat, C., Abraham, L.J., Tabarias, H., Christiansen, F.T., Dawkins, R.L. Immunogenetics (1992) [Pubmed]
  26. Suppression of human prostate tumor growth in mice by a cytolytic D-, L-amino Acid Peptide: membrane lysis, increased necrosis, and inhibition of prostate-specific antigen secretion. Papo, N., Braunstein, A., Eshhar, Z., Shai, Y. Cancer Res. (2004) [Pubmed]
  27. Impact of O-glycosylation on the function of human intestinal lactase-phlorizin hydrolase. Characterization of glycoforms varying in enzyme activity and localization of O-glycoside addition. Naim, H.Y., Lentze, M.J. J. Biol. Chem. (1992) [Pubmed]
  28. Loss of CD10 (neutral endopeptidase) is a frequent and early event in human prostate cancer. Freedland, S.J., Seligson, D.B., Liu, A.Y., Pantuck, A.J., Paik, S.H., Horvath, S., Wieder, J.A., Zisman, A., Nguyen, D., Tso, C.L., Palotie, A.V., Belldegrun, A.S. Prostate (2003) [Pubmed]
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