Disease relevance of Abnormalities, Multiple

• Otx1 null mice exhibit spontaneous epileptic seizures and multiple abnormalities affecting primarily the dorsal telencephalic cortex and components of the acoustic and visual sense organs [1].
• The importance of ACE in these cell types was revealed by generating Ace -/- mice, which exhibit multiple abnormalities including renal structural defects and functions, hypotension, and male sterility [2].
• The hematopoietic cells from patients with Bcr-Abl-positive chronic myelogenous leukemia exhibit multiple abnormalities of cytoskeletal function [3].
• Polycystic ovarian syndrome (PCOS) is a complex disorder with multiple abnormalities, including hyperandrogenism, ovulatory dysfunction, and altered gonadotropin secretion [4].
• The pattern of multiple abnormalities in blood coagulation suggested carbohydrate-deficient glycoprotein syndrome type 1a [5].

High impact information on Abnormalities, Multiple

• Insulin receptor complementary DNA has been cloned from an insulin-resistant patient with leprechaunism whose receptors exhibited multiple abnormalities in insulin binding [6].
• In rats, a single injection of clomiphene citrate (Clomid) during pregnancy causes multiple abnormalities of the reproductive tract in the offspring and mothers [7].
• BCR/ABL induces multiple abnormalities of cytoskeletal function [8].
• These data indicate that patients with factor V Quebec have an inherited bleeding disorder distinct from other platelet disorders and associated with multiple abnormalities, including multimerin deficiency, abnormal platelet factor V, thrombospondin, von Willebrand factor, and fibrinogen, and an epinephrine aggregation defect [9].
• Platelets from patients with this autosomal recessive bleeding disorder have multiple abnormalities, including a markedly reduced von Willebrand factor-dependent adhesiveness due to a deficiency of the platelet membrane glycoprotein (GP) Ib/IX complex [10].

Chemical compound and disease context of Abnormalities, Multiple

• A single injection of either Clomid or Nafoxidine in neonatal rats causes multiple abnormalities of the reproductive tract of the adult female animal [11].
• Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants [12].
• Nondiabetic subjects with microalbuminuria had multiple abnormalities in cardiovascular risk factors including elevated BP, high triglyceride concentration, high insulin concentration, and a low high-density lipoprotein cholesterol concentration, a cluster of risk factors typical for prediabetic individuals [13].
• Multiple abnormalities in insulin responses to nonglucose nutrients in neonatally streptozotocin diabetic rats [14].
• Impaired glucose tolerance is characterized by multiple abnormalities in the regulation of intermediary metabolism [15].

Biological context of Abnormalities, Multiple

• Female phenotype and multiple abnormalities in sibs with a Y chromosome and partial X chromosome duplication: H--Y antigen and Xg blood group findings [16].
• Using this approach, we have identified multiple abnormalities in the regulation of carbohydrate and lipid metabolism in subjects with a diverse array of insulin-resistant states characterized by variable degrees of glucose intolerance [17].
• At the restrictive temperature, top2 strains show multiple abnormalities, including an inability to complete mitotic and meiotic division owing to a defect in chromosome segregation, and hyper-recombination within the repetitive rDNA gene cluster [18].
• Trisomy 16 in a mid-trimester IVF foetus with multiple abnormalities [19].

Anatomical context of Abnormalities, Multiple

• Alx-4 is expressed in several populations of mesenchymal cells, including mesenchymal cells in the anterior limb bud, and mice homozygous for targeted disruption of the Alx-4 gene have multiple abnormalities, including preaxial polydactyly [20].
• Both groups of GBS patients have multiple abnormalities in the lipid composition and physical chemistry of their gallbladder bile-associated with, and possibly due to, an increased proportion of deoxycholic acid (DCA) (percentage of total bile acids) [21].
• The study of DC highlights the importance of telomerase in humans and how its deficiency results in multiple abnormalities, including premature aging, bone marrow failure, and cancer [22].
• This work indicates that MDS patients belonging to the more advanced FAB categories frequently show multiple abnormalities in the expression of neutrophil complement receptors, and granular components (> 3), as well as in cell functions, suggesting the possibility of using these phenotypic abnormalities in the monitoring of disease progression [23].
• Vascular smooth muscle cells isolated from ERbeta-deficient mice show multiple abnormalities of ion channel function [24].

Gene context of Abnormalities, Multiple

• Multiple abnormalities were demonstrated in the CD4 and CD8 populations, both under non-stimulated and superantigen-stimulated conditions [25].
• RESULTS: Majority of c-Myc/E2F1 HCCs exhibited multiple abnormalities in the Wnt pathway regardless of the presence of beta-catenin mutations [26].
• SP-D deficiency results in multiple abnormalities in surfactant forms and metabolism that cannot be attributed to a single mechanism [27].
• A normal titer of Hageman factor (factor XII) argued against participation of contact-activated mechanisms in the induction of the multiple abnormalities observed [28].
• These results compare with 80% retention of CD44 intron 9 in colonic carcinoma tissue mRNA and confirm that multiple abnormalities of CD44 mRNA processing occur in tumor cells [29].

Analytical, diagnostic and therapeutic context of Abnormalities, Multiple

• Technetium-99m MDP bone scintigraphy shows multiple abnormalities in sickle cell disease [30].
• He however remained total parenteral nutrition dependent due to his multiple abnormalities [31].

References