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Chemical Compound Review

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Disease relevance of Trilinolein


High impact information on Trilinolein

  • A mixture of CLA-triester/trilinolein (1:9), trilinolein or CLA-triester was separately subjected to pancreatic lipase hydrolysis in vitro to determine whether the lymphatic recovery of CLA was correlated with the initial step of digestion [6].
  • Male broiler chickens were fed 8 g/100 g fat diets differing only in the fat source: palm oil (tripalmitin-rich), olive oil (triolein-rich), safflower oil (trilinolein-rich) and linseed oil (trilinolenin-rich) [7].
  • All three acyl moieties of trilinolein are efficiently oxygenated by recombinant His-tagged lipid body lipoxygenase in vitro [8].
  • Moreover, trilinolein oxygenation by soybean lipoxygenase-1 leads mainly to monohydroperoxy derivatives, whereas oxygenation by lipid body LOX leads to a trihydroperoxy derivative [8].
  • The results suggest that dietary trilinolein inhibits the characteristic increase in liver G6PD, ME and total lipids upon starvation-refeeding [9].

Chemical compound and disease context of Trilinolein


Biological context of Trilinolein


Anatomical context of Trilinolein

  • Adipose tissue G6PD and ME activities decreased slightly with increasing trilinolein in starved-refed rats, but did not decrease in ad libitum fed rats [9].
  • This study confirmed the effect of CPB on erythrocyte deformability and showed that this damage could be significantly improved by mixing blood with trilinolein [17].
  • In the cultured rat brain astrocytes (RBA), the activity of SOD (both Cu,Zn-SOD and Mn-SOD subtypes) was markedly increased by incubation with trilinolein at low concentration (0.1 microM) for 2 days [12].
  • The inhibitory effect of trilinolein on neutrophil adhesion may play a role in its myocardial protective activity [18].
  • Furthermore, the effect of trilinolein on infarct size was evaluated by occluding the coronary artery for 4 h before the infarct zone was stained and weighed [2].

Associations of Trilinolein with other chemical compounds


Gene context of Trilinolein


Analytical, diagnostic and therapeutic context of Trilinolein


  1. Molecular mechanism of the inhibitory effect of trilinolein on endothelin-1-induced hypertrophy of cultured neonatal rat cardiomyocytes. Chen, S.C., Cheng, J.J., Hsieh, M.H., Chu, Y.L., Kao, P.F., Cheng, T.H., Chan, P. Planta Med. (2005) [Pubmed]
  2. Trilinolein reduces infarct size and suppresses ventricular arrhythmias in rats subjected to coronary ligation. Chan, P., Tsai, S.K., Chiang, B.N., Hong, C.Y. Pharmacology (1995) [Pubmed]
  3. Identification and kinetic study of tyrosinase inhibitors found in sake lees. Jeon, H.J., Noda, M., Maruyama, M., Matoba, Y., Kumagai, T., Sugiyama, M. J. Agric. Food Chem. (2006) [Pubmed]
  4. Trilinolein preserves mitochondria ultrastructure in isolated rat heart subjected to global ischemia through antioxidant activity as measured by chemiluminescence. Chan, P., Niu, C.S., Cheng, J.T., Tsao, C.W., Tsai, S.K., Hong, C.Y. Pharmacology (1996) [Pubmed]
  5. Effect of trilinolein on strophanthidin-induced ventricular tachycardia in guinea pigs. Chen, Y., Chen, S., Tai, C., Chiang, C., Chang, M., Hong, C. Pharmacology (1999) [Pubmed]
  6. Lymphatic delivery and in vitro pancreatic lipase hydrolysis of glycerol esters of conjugated linoleic acids in rats. Martin, J.C., Sébédio, J.L., Caselli, C., Pimont, C., Martine, L., Bernard, A. J. Nutr. (2000) [Pubmed]
  7. Preparation of chylomicrons and VLDL with monoacid-rich triacylglycerol and characterization of kinetic parameters in lipoprotein lipase-mediated hydrolysis in chickens. Sato, K., Takahashi, T., Takahashi, Y., Shiono, H., Katoh, N., Akiba, Y. J. Nutr. (1999) [Pubmed]
  8. All three acyl moieties of trilinolein are efficiently oxygenated by recombinant His-tagged lipid body lipoxygenase in vitro. Feussner, I., Bachmann, A., Höhne, M., Kindl, H. FEBS Lett. (1998) [Pubmed]
  9. Regulation of glucose-6-phosphate dehydrogenase and malic enzyme in liver and adipose tissue: effect of dietary trilinolein level in starved-refed and ad libitum-fed rats. Nace, C.S., Szepesi, B., Michaelis, O.E. J. Nutr. (1979) [Pubmed]
  10. Myocardial protective effect of trilinolein: an antioxidant isolated from the medicinal plant Panax pseudoginseng. Chan, P., Hong, C.Y., Tomlinson, B., Chang, N.C., Chen, J.P., Lee, S.T., Cheng, J.T. Life Sci. (1997) [Pubmed]
  11. Comparison of thermally oxidized lipids and acetaminophen with concurrent consumption of ethanol as inducers of liver cirrhosis. Fouad, F.M., Shahidi, F., Mamer, O.A. Journal of toxicology and environmental health. (1995) [Pubmed]
  12. Effect of trilinolein on the activity and gene expression of superoxide dismutase in cultured rat brain astrocytes. Chiu, W.T., Chan, P., Liao, S.S., Liou, J.R., Cheng, J.T. Neurosci. Lett. (1999) [Pubmed]
  13. Inhibitory effect of trilinolein on endothelin-1-induced c-fos gene expression in cultured neonatal rat cardiomyocytes. Yang, H.Y., Liu, J.C., Chen, Y.L., Chen, C.H., Lin, H., Lin, J.W., Chiu, W.T., Chen, J.J., Cheng, T.H. Naunyn Schmiedebergs Arch. Pharmacol. (2005) [Pubmed]
  14. Inhibitory effect of trilinolein on angiotensin II-induced cardiomyocyte hypertrophy. Liu, J.C., Cheng, T.H., Lee, H.M., Lee, W.S., Shih, N.L., Chen, Y.L., Chen, J.J., Chan, P. Eur. J. Pharmacol. (2004) [Pubmed]
  15. Cucumber cotyledon lipoxygenase oxygenizes trilinolein at the lipid/water interface. Matsui, K., Kajiwara, T. Lipids (1995) [Pubmed]
  16. Degradation of trilinolein by laccase enzymes. Zhang, X., Eigendorf, G., Stebbing, D.W., Mansfield, S.D., Saddler, J.N. Arch. Biochem. Biophys. (2002) [Pubmed]
  17. Trilinolein improves erythrocyte deformability during cardiopulmonary bypass. Tsai, S.K., Chan, P., Lee, T.Y., Yung, J.M., Hong, C.Y. British journal of clinical pharmacology. (1994) [Pubmed]
  18. Trilinolein inhibits the adhesion of neutrophils to endothelial cells. Hong, C.Y., Huang, S.S., Wang, R., Sung, Y.J., Kwok, C.F. Clin. Exp. Pharmacol. Physiol. (1998) [Pubmed]
  19. Substrate specificities of lipases from corn and other seeds. Lin, Y.H., Yu, C., Huang, A.H. Arch. Biochem. Biophys. (1986) [Pubmed]
  20. Lipid synthesis in macrophages derived from the human cell line THP-1: modulation of the effects of native and oxidized chylomicron-remnant-like particles by oestrogen. Napolitano, M., Batt, K.V., Avella, M., Bravo, E., Botham, K.M. Clin. Sci. (2001) [Pubmed]
  21. Antioxidant effects of Chinese traditional medicine: focus on trilinolein isolated from the Chinese herb sanchi (Panax pseudoginseng). Chan, P., Tomlinson, B. Journal of clinical pharmacology. (2000) [Pubmed]
  22. Anti-apolipoprotein A-I autoantibody: characterization of monoclonal autoantibodies from patients with systemic lupus erythematosus. Abe, H., Tsuboi, N., Suzuki, S., Sakuraba, H., Takanashi, H., Tahara, K., Tonozuka, N., Hayashi, T., Umeda, M. J. Rheumatol. (2001) [Pubmed]
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