Disease relevance of radium

• A case-control study including 78 patients with malignant melanoma of the skin and 131 controls with the diagnoses of malignant lymphoma, testicular cancer or bone and soft-tissue sarcoma, was performed at the Norwegian Radium Hospital 1974-1975 [1].
• Virus particles with the biochemical properties of C-type retroviruses appeared transiently in bone tissues of (C3H x 101) f1 hybrid mice early after treatment with 224 Radium; such particles were then again detected in the bones of the irradiated animals at the onset of osteosarcoma formation and in the osteosarcomas [2].
• The incidence of a new primary non-germ cell malignancy was determined in 876 patients with testicular cancer treated at the Norwegian Radium Hospital from 1956 to 1977 [3].
• Treatment of Burkitt's/Burkitt-like lymphoma in adolescents and adults: a 20-year experience from the Norwegian Radium Hospital with the use of three successive regimens [4].
• Preoperative radiation therapy in squamous cell carcinoma of the anterior two-thirds of the tongue at the Norwegian Radium Hospital [5].

High impact information on radium

• The American Radium Society. Radiation oncology in the 3rd millennium [6].
• METHODS AND MATERIALS: We analyzed the prostate-specific antigen (PSA) and survival records of 1571 men with clinically localized prostate cancer treated with external beam radiotherapy monotherapy at the former Queensland Radium Institute between 1990 and 1997 [7].
• Treatment and outcome of patients with extragonadal germ cell tumours--the Norwegian Radium Hospital's experience 1979-94 [8].
• Data from the Norwegian Radium Hospital showed that the majority of borderline tumors have DNA diploid tumors and good prognosis, DNA aneuploidy indicates high risk [9].
• Information about occurrence of testicular cancer (TC) in relatives of TC patients has been collected using questionnaires from 797 out of 922 consecutive Norwegian and 178 out of 237 Swedish patients with TC seen at the Norwegian Radium Hospital and the University Hospital Lund in Sweden during 1981-91 [10].

Chemical compound and disease context of radium

• Radon daughter exposures at the Radium Hill uranium mine and lung cancer rates among former workers, 1952-87 [11].
• The prediction of the relative toxicities of radium 224 and of radium 226 in the bones of mice using Monte Carlo techniques [12].

Biological context of radium

• The Public Health Response to Nasopharyngeal Radium Irradiation: a Workshop. Introduction [13].
• Harrison S. Martland, MD. The Radium watch-dial workers and the evolution of industrial medicine [14].
• A total of 1002 patients with cancer of the oesophagus seen at the Finsen Institute, Copenhagen, Radium Centre and/or Department of Surgery, during the 25-year period ending 31.12.1969, were analysed with a view to sex, age, localization of tumour, histology, and survival [15].
• The Norwegian Radium Hospital provides clinical genetics services for families at high risk for hereditary breast and ovarian cancer [16].
• At the Center for Human Radiobiology (Argonne National Laboratory, Massachusetts Institute of Technology, New Jersey Radium Research Project) measurements were made of radium body content in 2259 occupationally or iatrogenically exposed persons [17].

Anatomical context of radium

• In a retrospective analysis of 1,390 consecutive patients with carcinoma of the cervix treated by high dose radiation therapy alone at the Queensland Radium Institute, we report a quantitative relationship between the early and late gastrointestinal complications arising from such treatment [18].
• Symptoms, delay in diagnosis, tumour stage and the clinical value of a follow-up programme were studied in 107 patients admitted to the Norwegian Radium Hospital for anal canal carcinoma [19].
• PURPOSE: A retrospective review of carcinomas of the nasal vestibule seen at the Queensland Radium Institute over a 30-year period was undertaken [20].
• Forty patients, 10 women and 30 men, median age 41.5 years (range 16-61) with PTCL were treated with HDT and autologous stem cell support at The Norwegian Radium Hospital, Oslo, Norway and The University Hospital, Uppsala, Sweden, between February 1990 and September 1999 [21].
• One hundred and seventy-five patients with endometrial cancer, seen in the Norwegian Radium Hospital from 1960 to 1977, had tumor extension outside the uterus but not outside the true pelvis [22].

Associations of radium with other chemical compounds

• A total of 117 patients were admitted to the Norwegian Radium Hospital during the period of 1983-1989, of which 106 received a combination of radiotherapy (50 Gy to the pelvis) and chemotherapy (mitomycin C + 5-fluorouracil) [23].
• Participants were former workers from the Radium Hill uranium mine, which operated in eastern South Australia from 1952 to 1961 [11].
• Experiments are described which investigate the long-term damage to haemopoietic progenitor cells (CFU-S) and their microenvironment in mouse marrow resulting from the administration of leukaemogenic amounts of plutonium-239 and radium-224 [24].
• From 1989 to 1995 the Norwegian Radium Hospital entered 85 patients in an international multicentre trial assessing cisplatin-based neoadjuvant chemotherapy in T2-T4a bladder cancer [25].

Gene context of radium

• STUDY DESIGN: Tumor specimens from 185 patients with stage III ovarian cancer, treated at the Department of Gynecologic Oncology of the Norwegian Radium Hospital, were examined immunohistochemically for overexpression of EGFR [26].
• A revision of bone tumor pathology in patients treated with multiple injections of the short-lived alpha-particle emitter radium-224, predominantly for tuberculosis and ankylosing spondylitis, revealed an unexpectedly high proportion of bone sarcomas of the fibrous connective tissue type [27].
• Stage IB carcinoma of the cervix, the Norwegian Radium Hospital: results and complications. III. Urinary and gastrointestinal complications [28].
• METHODS: In total, 220 patients who underwent radical hysterectomy and bilateral lymphadenectomy at the Norwegian Radium Hospital for stage IB SCC between 1987 and 1993 were studied [29].
• From 1971 to 1985 a total of 122 patients with non-distant metastatic nasopharyngeal carcinoma were treated at the Norwegian Radium Hospital with radiation doses that increased from 50 Gy (at 2 Gy/fractions) to 70 Gy (at 2 Gy/fractions) during the treatment period [30].

Analytical, diagnostic and therapeutic context of radium

• PATIENTS AND METHODS: The 99 women included in the study were treated between 1975 and 1992 at the Norwegian Radium Hospital. All patients received radiotherapy and 67 of the women also received chemotherapy [31].
• PATIENTS AND METHODS: Forty-nine patients aged 15-70 years admitted to the Norwegian Radium Hospital in the period 1982-2001 with a diagnosis of BL/BLL on histological review and who were given chemotherapy with curative intent are included in this analysis [4].
• CONCLUSION: The incidence of side effects after brachytherapy at the Norwegian Radium Hospital seems to have been somewhat higher in the period under investigation than at other institutions [32].
• METHODS AND MATERIALS: This descriptive cross-sectional study comprises 154 patients who had undergone definitive radiotherapy (RAD) and 108 patients with radical prostatectomy (PRECT) at the Norwegian Radium Hospital during 1987-1995 [33].
• PURPOSE: To evaluate the role of semen cryopreservation (SCP) in the fertility saving management of testicular cancer (TC) patients, treated at the Norwegian Radium Hospital between 1983 and 2002 [34].

References