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Chemical Compound Review

Loceryl     (2S,6R)-2,6-dimethyl-4-[2- methyl-3-[4-(2...

Synonyms: amorolfin, Amorolfina, Amorolfine, Amorolfinum, Loceryl (TN), ...
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Disease relevance of Amorolfine


High impact information on Amorolfine


Chemical compound and disease context of Amorolfine


Biological context of Amorolfine

  • Present data suggest that mean percutaneous absorption of amorolfine following topical application of the 0.25% cream formulation should not exceed 8-10% of the dose applied [15].
  • At 0.2, 2 and 5 micrograms/ml amorolfine did not have any significant inhibitory or enhancing effect on phagocytosis whether following simultaneous addition of blastospores and drug to the neutrophils, prior treatment of neutrophils for 2 h before addition of blastospores or prior treatment of blastospores for 2 h [16].
  • Kinetics of amorolfine in human nails [17].

Anatomical context of Amorolfine

  • OBJECTIVE: This open randomized study examined the efficacy of a combination of oral terbinafine and topical amorolfine in the treatment of severe dermatophyte toenail onychomycosis with matrix area involvement [18].
  • Cytoplasmic membranes and other membranous structures of organelles such as nuclei and mitochondria were disrupted or fused, thereby losing their essential physiological activity in hyphal cells pretreated with 80 ng/ml of amorolfine [19].
  • TEM revealed thickening of the cell walls and the accumulation of electron-dense granular structures in both the wall and cytoplasm in thin-sectioned cells pretreated with 8 ng/ml or more of amorolfine, although the nuclear and mitochondrial architecture was not noticeably influenced [19].

Associations of Amorolfine with other chemical compounds


Analytical, diagnostic and therapeutic context of Amorolfine


  1. The KEX2 gene of Candida glabrata is required for cell surface integrity. Bader, O., Schaller, M., Klein, S., Kukula, J., Haack, K., Mühlschlegel, F., Korting, H.C., Schäfer, W., Hube, B. Mol. Microbiol. (2001) [Pubmed]
  2. Amorolfine. A review of its pharmacological properties and therapeutic potential in the treatment of onychomycosis and other superficial fungal infections. Haria, M., Bryson, H.M. Drugs (1995) [Pubmed]
  3. Effects of temperature on anti-Candida activities of antifungal antibiotics. Odds, F.C. Antimicrob. Agents Chemother. (1993) [Pubmed]
  4. Allergic contact dermatitis from amorolfine cream. Kaneko, K., Aoki, N., Hata, M., Yajima, J., Kawana, S., Hattori, S. Contact Derm. (1997) [Pubmed]
  5. Reverse transcription - 3' rapid amplification of cDNA ends-nested PCR of ACT1 and SAP2 mRNA as a means of detecting viable Candida albicans in an in vitro cutaneous candidiasis model. Okeke, C.N., Tsuboi, R., Kawai, M., Yamazaki, M., Reangchainam, S., Ogawa, H. J. Invest. Dermatol. (2000) [Pubmed]
  6. Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents. Favre, B., Ryder, N.S. Antimicrob. Agents Chemother. (1996) [Pubmed]
  7. 5-Fluorocytosine antagonizes the action of sterol biosynthesis inhibitors in Candida glabrata. Siau, H., Kerridge, D. J. Antimicrob. Chemother. (1999) [Pubmed]
  8. Amorolfine and itraconazole combination for severe toenail onychomycosis; results of an open randomized trial in Spain. Lecha, M. Br. J. Dermatol. (2001) [Pubmed]
  9. A retrospective cost-effectiveness analysis of the treatment of onychomycosis in general practice. Humphrey, K.M., Cork, M.J., Haycox, A. Br. J. Dermatol. (1998) [Pubmed]
  10. A randomized trial of amorolfine 5% solution nail lacquer in association with itraconazole pulse therapy compared with itraconazole alone in the treatment of Candida fingernail onychomycosis. Rigopoulos, D., Katoulis, A.C., Ioannides, D., Georgala, S., Kalogeromitros, D., Bolbasis, I., Karistinou, A., Christofidou, E., Polydorou, D., Balkou, P., Fragouli, E., Katsambas, A.D. Br. J. Dermatol. (2003) [Pubmed]
  11. The use of topical therapies to treat onychomycosis. Gupta, A.K., Ryder, J.E., Baran, R. Dermatologic clinics. (2003) [Pubmed]
  12. A clinical double-blind trial comparing amorolfine cream 0.5% (RO-14-4767) with bifonazole cream 1% in the treatment of dermatomycoses. del Palacio-Hernanz, A., López-Gómez, S., Moreno-Palancar, P., González-Lastra, F. Clin. Exp. Dermatol. (1989) [Pubmed]
  13. Testing of antifungal combinations against yeasts and dermatophytes. Harman, S., Ashbee, H.R., Evans, E.G. The Journal of dermatological treatment. (2004) [Pubmed]
  14. Candida-related denture stomatitis: a pilot study of the efficacy of an amorolfine antifungal varnish. Milillo, L., Lo Muzio, L., Carlino, P., Serpico, R., Coccia, E., Scully, C. The International journal of prosthodontics. (2005) [Pubmed]
  15. Percutaneous absorption of amorolfine following a single topical application of an amorolfine cream formulation. Roncari, G., Ponelle, C., Zumbrunnen, R., Guenzi, A., Dingemanse, J., Jonkman, J.H. Clin. Exp. Dermatol. (1992) [Pubmed]
  16. Effect of amorolfine (Ro 14-4767/002) on in vitro phagocytosis and intracellular killing of Candida albicans by human neutrophils. Richardson, M.D., Shankland, G.S., Gray, C.A. Mycoses (1989) [Pubmed]
  17. Kinetics of amorolfine in human nails. Polak, A. Mycoses (1993) [Pubmed]
  18. Topical amorolfine for 15 months combined with 12 weeks of oral terbinafine, a cost-effective treatment for onychomycosis. Baran, R. Br. J. Dermatol. (2001) [Pubmed]
  19. Morphological changes associated with growth inhibition of Trichophyton mentagrophytes by amorolfine. Nishiyama, Y., Asagi, Y., Hiratani, T., Yamaguchi, H., Yamada, N., Osumi, M. Clin. Exp. Dermatol. (1992) [Pubmed]
  20. In-vitro permeability of the human nail and of a keratin membrane from bovine hooves: prediction of the penetration rate of antimycotics through the nail plate and their efficacy. Mertin, D., Lippold, B.C. J. Pharm. Pharmacol. (1997) [Pubmed]
  21. A randomized comparison of nail surface remanence of three nail lacquers, containing amorolfine 5%, ciclopirox 8% or tioconazole 28%, in healthy volunteers. Sidou, F., Soto, P. International journal of tissue reactions. (2004) [Pubmed]
  22. Pathogenicity of Sporotrichum pruninosum and Cladosporium oxysporum, isolated from the bronchial secretions of a patient, for laboratory mice. Singh, S.M., Singh, M., Mukherjee, S. Mycopathologia (1992) [Pubmed]
  23. Actin gene-targeted RT-PCR could be a useful method for evaluating in vitro fungicidal activity against dermatophytes. Nimura, K., Niwano, Y., Ishiduka, S., Kato, M. J. Int. Med. Res. (2003) [Pubmed]
  24. Effect of oxiconazole and Ro 14-4767/002 on sterol pattern in Candida albicans. Polak-Wyss, A., Lengsfeld, H., Oesterhelt, G. Sabouraudia. (1985) [Pubmed]
  25. In vitro susceptibility testing of amorolfine in pathogenic fungi isolated from dermatomycosis patients in China. Li, R.Y., Wan, Z., Wang, A.P., Shen, Y.N., Lu, C.M., Li, M., Xi, L.Y., Liu, W.D., Zeng, F.Q. Mycoses (2004) [Pubmed]
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