The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Lipe  -  lipase, hormone sensitive

Rattus norvegicus

Synonyms: HSL, Hormone-sensitive lipase
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Lipe


High impact information on Lipe

  • Hormone-sensitive lipase, a key enzyme in fatty acid mobilization, overall energy homeostasis, and possibly steroidogenesis, is acutely controlled through reversible phosphorylation by catecholamines and insulin [6].
  • The human hormone-sensitive lipase gene mapped to chromosome 19 cent-q13.3 [6].
  • Insulin-mediated glucose and FFA uptake were reduced by 33% and 36%, respectively, whereas the activity of the catabolic enzyme hormone-sensitive lipase increased by 51% [7].
  • Besides the catalytic site motif (Gly-Xaa-Ser-Xaa-Gly) found in most lipases, HSL shows no homology with other known lipases or proteins, except for a recently reported unexpected homology between the region surrounding its catalytic site and that of the lipase 2 of Moraxella TA144, an antarctic psychrotrophic bacterium [3].
  • Mechanism of hormone-stimulated lipolysis in adipocytes: translocation of hormone-sensitive lipase to the lipid storage droplet [8].

Chemical compound and disease context of Lipe


Biological context of Lipe


Anatomical context of Lipe


Associations of Lipe with chemical compounds

  • Through its action, HSL is involved in regulating intracellular cholesterol metabolism and making unesterified cholesterol available for steroid hormone production [15].
  • In the current studies we demonstrate a direct interaction of HSL with StAR using in vitro glutathione S-transferase pull-down experiments [15].
  • These effects were consistent with increased LPL and HSL activities as well as respiration rates, mainly in response to exogenous palmitate [10].
  • At a time when type L HSL activity was increased and TG content decreased, the cyclic AMP concentration of heart remained unchanged, ruling out the possibility that cyclic AMP might be activating any one of the identified cardiac TG lipases [13].
  • Relationship between type L hormone-sensitive lipase activity and endogenous triacylglycerol in the hearts of colchicine-treated rats [13].

Regulatory relationships of Lipe


Other interactions of Lipe


Analytical, diagnostic and therapeutic context of Lipe


  1. Chronic effects of dehydroepiandrosterone on rat adipose tissue metabolism. Mauriège, P., Martel, C., Langin, D., Lacaille, M., Després, J.P., Bélanger, A., Labrie, F., Deshaies, Y. Metab. Clin. Exp. (2003) [Pubmed]
  2. Comparison of the changes in lipid metabolism between hepatoma-bearing and lipopolysaccharide-treated rats. Kawasaki, M., Yagasaki, K., Miura, Y., Funabiki, R. Biosci. Biotechnol. Biochem. (2004) [Pubmed]
  3. Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium. Langin, D., Laurell, H., Holst, L.S., Belfrage, P., Holm, C. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  4. Chronic exposure of rat fat cells to insulin enhances lipolysis and activation of partially purified hormone-sensitive lipase. Kang, E.S., Betts, D., Fain, J.N., Bahouth, S.W., Myers, L.K. Diabetes (1993) [Pubmed]
  5. The expression of hormone-sensitive lipase in clonal beta-cells and rat islets is induced by long-term exposure to high glucose. Winzell, M.S., Svensson, H., Arner, P., Ahrén, B., Holm, C. Diabetes (2001) [Pubmed]
  6. Hormone-sensitive lipase: sequence, expression, and chromosomal localization to 19 cent-q13.3. Holm, C., Kirchgessner, T.G., Svenson, K.L., Fredrikson, G., Nilsson, S., Miller, C.G., Shively, J.E., Heinzmann, C., Sparkes, R.S., Mohandas, T. Science (1988) [Pubmed]
  7. Selective parasympathetic innervation of subcutaneous and intra-abdominal fat--functional implications. Kreier, F., Fliers, E., Voshol, P.J., Van Eden, C.G., Havekes, L.M., Kalsbeek, A., Van Heijningen, C.L., Sluiter, A.A., Mettenleiter, T.C., Romijn, J.A., Sauerwein, H.P., Buijs, R.M. J. Clin. Invest. (2002) [Pubmed]
  8. Mechanism of hormone-stimulated lipolysis in adipocytes: translocation of hormone-sensitive lipase to the lipid storage droplet. Egan, J.J., Greenberg, A.S., Chang, M.K., Wek, S.A., Moos, M.C., Londos, C. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  9. Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose. Claus, T.H., Lowe, D.B., Liang, Y., Salhanick, A.I., Lubeski, C.K., Yang, L., Lemoine, L., Zhu, J., Clairmont, K.B. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  10. Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats. Teruel, T., Hernandez, R., Rial, E., Martin-Hidalgo, A., Lorenzo, M. Diabetologia (2005) [Pubmed]
  11. Mutational analysis of the "regulatory module" of hormone-sensitive lipase. Wang, J., Shen, W.J., Patel, S., Harada, K., Kraemer, F.B. Biochemistry (2005) [Pubmed]
  12. Lipoprotein lipase and hormone-sensitive lipase activity and mRNA in rat adipose tissue during pregnancy. Martin-Hidalgo, A., Holm, C., Belfrage, P., Schotz, M.C., Herrera, E. Am. J. Physiol. (1994) [Pubmed]
  13. Relationship between type L hormone-sensitive lipase activity and endogenous triacylglycerol in the hearts of colchicine-treated rats. Miller, W.C., Palmer, W.K., Oscai, L.B. Biochem. J. (1984) [Pubmed]
  14. Type L hormone-sensitive lipase hydrolyzes endogenous triacylglycerols in muscle in exercised rats. Oscai, L.B. Medicine and science in sports and exercise. (1983) [Pubmed]
  15. Interaction of hormone-sensitive lipase with steroidogenic acute regulatory protein: facilitation of cholesterol transfer in adrenal. Shen, W.J., Patel, S., Natu, V., Hong, R., Wang, J., Azhar, S., Kraemer, F.B. J. Biol. Chem. (2003) [Pubmed]
  16. Growth hormone-mediated breakdown of body fat: effects of GH on lipases in adipose tissue and skeletal muscle of old rats fed different diets. Johansen, T., Richelsen, B., Hansen, H.S., Din, N., Malmlöf, K. Horm. Metab. Res. (2003) [Pubmed]
  17. Fatty Acids Inhibit Intramyocellular Triglyceride Synthesis and Turnover Acutely in High Fat-fed Obese Rats. Guo, Z., Zhou, L. Horm. Metab. Res. (2006) [Pubmed]
  18. Chronic ethanol feeding suppresses beta-adrenergic receptor-stimulated lipolysis in adipocytes isolated from epididymal fat. Kang, L., Nagy, L.E. Endocrinology (2006) [Pubmed]
  19. Acute central infusion of leptin modulates fatty acid mobilization by affecting lipolysis and mRNA expression for uncoupling proteins. Tajima, D., Masaki, T., Hidaka, S., Kakuma, T., Sakata, T., Yoshimatsu, H. Exp. Biol. Med. (Maywood) (2005) [Pubmed]
  20. The metabolism of 3-phenoxybenzoic acid-containing xenobiotic triacylglycerols in vitro by pancreatic, hormone-sensitive and lipoprotein lipases. Haselden, J.N., Hutson, D.H., Dodds, P.F. Biochem. Pharmacol. (1998) [Pubmed]
  21. Effects of capsaicin on lipid metabolism in rats fed a high fat diet. Kawada, T., Hagihara, K., Iwai, K. J. Nutr. (1986) [Pubmed]
  22. Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro. Anthonsen, M.W., Rönnstrand, L., Wernstedt, C., Degerman, E., Holm, C. J. Biol. Chem. (1998) [Pubmed]
  23. A novel hormone-sensitive lipase isoform expressed in pancreatic beta-cells. Lindvall, H., Nevsten, P., Ström, K., Wallenberg, R., Sundler, F., Langin, D., Winzell, M.S., Holm, C. J. Biol. Chem. (2004) [Pubmed]
  24. Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase. Holst, L.S., Langin, D., Mulder, H., Laurell, H., Grober, J., Bergh, A., Mohrenweiser, H.W., Edgren, G., Holm, C. Genomics (1996) [Pubmed]
  25. Hormonal regulation of myocardial lipolysis. Palmer, W.K. Medicine and science in sports and exercise. (1983) [Pubmed]
WikiGenes - Universities