The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

HDAC5  -  histone deacetylase 5

Homo sapiens

Synonyms: Antigen NY-CO-9, FLJ90614, HD5, Histone deacetylase 5, KIAA0600, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of HDAC5


High impact information on HDAC5

  • Here we show that HDAC5 shuttles from the nucleus to the cytoplasm when myoblasts are triggered to differentiate [5].
  • Ca2+-calmodulin-dependent protein kinase II (CaMKII) activation and its ability to regulate histone deacetylase 5 (HDAC5) nuclear shuttling represent a critical Ca2+-dependent signaling circuit for controlling cardiac hypertrophy and heart failure, yet the mechanism of activation by Ca2+ is not known [6].
  • Our results reveal a remarkable variety of signaling pathways that converge on the signal-responsive phosphorylation sites in HDAC5, thereby enabling HDAC5 to connect extracellular signals to the genome [7].
  • The transfection of COS cells with cDNA expression libraries results in activation of luciferase expression by cDNAs encoding HDAC5 kinases or modulators of such kinases that enable phosphorylated GAL4-HDAC5 to recruit 14-3-3-VP16 with consequent reconstitution of a functional transcriptional complex [7].
  • We also show that both HDAC 5 and HDAC 6 are ubiquitinated in vitro and in vivo [8].

Biological context of HDAC5


Anatomical context of HDAC5


Associations of HDAC5 with chemical compounds


Physical interactions of HDAC5

  • Six p53 binding consensus sites were identified in the promoter of HDAC5. p53 binds to one of the sites weakly [2].

Enzymatic interactions of HDAC5

  • These findings support a role for PKD1 in the control of pathological remodeling of the heart via its ability to phosphorylate and neutralize HDAC5 [18].

Regulatory relationships of HDAC5


Other interactions of HDAC5


Analytical, diagnostic and therapeutic context of HDAC5


  1. Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5. Vega, R.B., Harrison, B.C., Meadows, E., Roberts, C.R., Papst, P.J., Olson, E.N., McKinsey, T.A. Mol. Cell. Biol. (2004) [Pubmed]
  2. Histone deacetylase 5 is not a p53 target gene, but its overexpression inhibits tumor cell growth and induces apoptosis. Huang, Y., Tan, M., Gosink, M., Wang, K.K., Sun, Y. Cancer Res. (2002) [Pubmed]
  3. Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation. Watamoto, K., Towatari, M., Ozawa, Y., Miyata, Y., Okamoto, M., Abe, A., Naoe, T., Saito, H. Oncogene (2003) [Pubmed]
  4. Innate immunity and colonic inflammation: enhanced expression of epithelial alpha-defensins. Wehkamp, J., Schwind, B., Herrlinger, K.R., Baxmann, S., Schmidt, K., Duchrow, M., Wohlschläger, C., Feller, A.C., Stange, E.F., Fellermann, K. Dig. Dis. Sci. (2002) [Pubmed]
  5. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. McKinsey, T.A., Zhang, C.L., Lu, J., Olson, E.N. Nature (2000) [Pubmed]
  6. Dichotomy of Ca2+ in the heart: contraction versus intracellular signaling. Molkentin, J.D. J. Clin. Invest. (2006) [Pubmed]
  7. An expression screen reveals modulators of class II histone deacetylase phosphorylation. Chang, S., Bezprozvannaya, S., Li, S., Olson, E.N. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  8. Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. Hook, S.S., Orian, A., Cowley, S.M., Eisenman, R.N. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  9. Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein. Hoshino, M., Tagawa, K., Okuda, T., Murata, M., Oyanagi, K., Arai, N., Mizutani, T., Kanazawa, I., Wanker, E.E., Okazawa, H. J. Neurochem. (2003) [Pubmed]
  10. Class II histone deacetylases: structure, function, and regulation. Bertos, N.R., Wang, A.H., Yang, X.J. Biochem. Cell Biol. (2001) [Pubmed]
  11. Screening of histone deacetylases (HDAC) expression in human prostate cancer reveals distinct class I HDAC profiles between epithelial and stromal cells. Waltregny, D., North, B., Van Mellaert, F., de Leval, J., Verdin, E., Castronovo, V. European journal of histochemistry : EJH. (2004) [Pubmed]
  12. Identification of a signal-responsive nuclear export sequence in class II histone deacetylases. McKinsey, T.A., Zhang, C.L., Olson, E.N. Mol. Cell. Biol. (2001) [Pubmed]
  13. Direct interaction of Ca2+/calmodulin inhibits histone deacetylase 5 repressor core binding to myocyte enhancer factor 2. Berger, I., Bieniossek, C., Schaffitzel, C., Hassler, M., Santelli, E., Richmond, T.J. J. Biol. Chem. (2003) [Pubmed]
  14. Altered HDAC5 and CREB mRNA expressions in the peripheral leukocytes of major depression. Iga, J., Ueno, S., Yamauchi, K., Numata, S., Kinouchi, S., Tayoshi-Shibuya, S., Song, H., Ohmori, T. Prog. Neuropsychopharmacol. Biol. Psychiatry (2007) [Pubmed]
  15. Differential expression of human alpha- and beta-defensins mRNA in gastrointestinal epithelia. Frye, M., Bargon, J., Lembcke, B., Wagner, T.O., Gropp, R. Eur. J. Clin. Invest. (2000) [Pubmed]
  16. High level expression of human epithelial beta-defensins (hBD-1, 2 and 3) in papillomavirus induced lesions. Chong, K.T., Xiang, L., Wang, X., Jun, E.L., Xi, L.F., Schweinfurth, J.M. Virol. J. (2006) [Pubmed]
  17. Protein kinase D directly phosphorylates histone deacetylase 5 via a random sequential kinetic mechanism. Huynh, Q.K., McKinsey, T.A. Arch. Biochem. Biophys. (2006) [Pubmed]
  18. Regulation of cardiac stress signaling by protein kinase d1. Harrison, B.C., Kim, M.S., van Rooij, E., Plato, C.F., Papst, P.J., Vega, R.B., McAnally, J.A., Richardson, J.A., Bassel-Duby, R., Olson, E.N., McKinsey, T.A. Mol. Cell. Biol. (2006) [Pubmed]
  19. Myocardin induces cardiomyocyte hypertrophy. Xing, W., Zhang, T.C., Cao, D., Wang, Z., Antos, C.L., Li, S., Wang, Y., Olson, E.N., Wang, D.Z. Circ. Res. (2006) [Pubmed]
  20. Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5. Zhou, X., Richon, V.M., Rifkind, R.A., Marks, P.A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  21. Three proteins define a class of human histone deacetylases related to yeast Hda1p. Grozinger, C.M., Hassig, C.A., Schreiber, S.L. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  22. SMRTE inhibits MEF2C transcriptional activation by targeting HDAC4 and 5 to nuclear domains. Wu, X., Li, H., Park, E.J., Chen, J.D. J. Biol. Chem. (2001) [Pubmed]
  23. Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. Bradbury, C.A., Khanim, F.L., Hayden, R., Bunce, C.M., White, D.A., Drayson, M.T., Craddock, C., Turner, B.M. Leukemia (2005) [Pubmed]
  24. Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition. Castet, A., Boulahtouf, A., Versini, G., Bonnet, S., Augereau, P., Vignon, F., Khochbin, S., Jalaguier, S., Cavaillès, V. Nucleic Acids Res. (2004) [Pubmed]
  25. Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Grozinger, C.M., Schreiber, S.L. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  26. Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5). Mahlknecht, U., Schnittger, S., Ottmann, O.G., Schoch, C., Mosebach, M., Hiddemann, W., Hoelzer, D. Biochim. Biophys. Acta (2000) [Pubmed]
  27. Is the international prognostic score for advanced stage Hodgkin's disease applicable to early stage patients? German Hodgkin Lymphoma Study Group. Franklin, J., Paulus, U., Lieberz, D., Breuer, K., Tesch, H., Diehl, V. Ann. Oncol. (2000) [Pubmed]
WikiGenes - Universities