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Gene Review

SHROOM2P1  -  shroom family member 2 pseudogene 1

Homo sapiens

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Disease relevance of APXLP


High impact information on APXLP

  • PTEN-Mediated Apical Segregation of Phosphoinositides Controls Epithelial Morphogenesis through Cdc42 [5].
  • ARNO through Its Coiled-coil Domain Regulates Endocytosis at the Apical Surface of Polarized Epithelial Cells [6].
  • It was designated hAIT for human Apical Iodide Transporter [7].
  • Net taurine transport can also be altered by relatively large, 55 mM, changes in [Na+]o. Apical ouabain, 10(-4) M, inhibited active taurine, rubidium, and potassium transport; in the case of taurine, this inhibition is most likely due to a decrease in the sodium electrochemical gradient [8].
  • RESULTS: Apical adrenergic agonists, isoproterenol and epinephrine (10(-8) M), depolarized the basolateral membrane, decreased total tissue resistance (R:(t)) and increased the ratio of apical-to-basolateral membrane resistance (R:(A)/R:(B)) [9].

Biological context of APXLP


Anatomical context of APXLP


Associations of APXLP with chemical compounds

  • RESULTS: Apical addition of 0.5 mM HgCl2 elicited an 11-fold increase in paracellular conductance and inhibited Jdw by 36%, suggesting that Jdw was predominantly transcellular and that there was a negligible contribution of the paracellular pathway [18].
  • 2. Apical addition of procainamide (10 mM) caused a significant alkalinisation of intracellular pH [19].
  • 3. Apical UTP (30 microm) induced a sustained period of elevated [Ca(2+)](i) between 300 and 600 s following agonist stimulation that extracellular Ca(2+) free studies indicated was dominated by Ca(2+) influx [20].
  • INTERVENTION: Apical, bronchoscopic, segmental airway placement of one-way valves (silicone-based Nitinol bronchial stent; Emphasys Medical; Redwood City, CA) under general anesthesia [21].
  • In the vertebrate limb, the Progress Zone is specified by the Apical Ectodermal Ridge [22].

Other interactions of APXLP

  • 3 Apical membrane permeabilisation to allow recording of basolateral membrane conductance in the presence of a K+ gradient suggested that CBIQ activated the intermediate-conductance calcium-sensitive K(+)-channel (KCNN4) [23].
  • RESULTS: Apical lordosis was present in 97% of patient with AIS and a normal MRI but was absent in 75% of patients with syringomyelia-associated scoliosis (P < 0.0001) [24].

Analytical, diagnostic and therapeutic context of APXLP

  • METHODS: Apical membrane vesicles were purified from mucosal scrapings of colons from organ donors, and 45Ca uptake was measured using a rapid filtration technique [25].
  • CONCLUSIONS: Apical cancer in a radical prostatectomy specimen is simply a sign of a larger volume cancer and is not independently associated with an increased risk of clinical or prostate specific antigen progression [26].
  • RESULTS: Apical nodular subepithelial corneal scars developed within the first month of hyperopic PRK retreatment and progressed until the third month in 12 eyes of 6 patients [27].
  • BACKGROUND: Apical thinning and other image changes at the apex have been described after attenuation correction of myocardial perfusion single photon emission computed tomography (SPECT) studies, but their clinical significance is unknown [28].
  • The teeth were divided into four test groups according to the size of their Master Apical File (#20, #25, #30, #35), and two control groups [29].


  1. Morphological onset and early diagnosis in apical hypertrophic cardiomyopathy: a long term analysis with nuclear magnetic resonance imaging. Suzuki, J., Shimamoto, R., Nishikawa, J., Yamazaki, T., Tsuji, T., Nakamura, F., Shin, W.S., Nakajima, T., Toyo-Oka, T., Ohotomo, K. J. Am. Coll. Cardiol. (1999) [Pubmed]
  2. Sustained cavity obliteration and apical aneurysm formation in apical hypertrophic cardiomyopathy. Matsubara, K., Nakamura, T., Kuribayashi, T., Azuma, A., Nakagawa, M. J. Am. Coll. Cardiol. (2003) [Pubmed]
  3. Long-term outcome in patients with apical hypertrophic cardiomyopathy. Eriksson, M.J., Sonnenberg, B., Woo, A., Rakowski, P., Parker, T.G., Wigle, E.D., Rakowski, H. J. Am. Coll. Cardiol. (2002) [Pubmed]
  4. Apical ventricular septal defects: follow-up concerning anatomic and surgical considerations. Van Praagh, S., Mayer, J.E., Berman, N.B., Flanagan, M.F., Geva, T., Van Praagh, R. Ann. Thorac. Surg. (2002) [Pubmed]
  5. PTEN-Mediated Apical Segregation of Phosphoinositides Controls Epithelial Morphogenesis through Cdc42. Martin-Belmonte, F., Gassama, A., Datta, A., Yu, W., Rescher, U., Gerke, V., Mostov, K. Cell (2007) [Pubmed]
  6. ARNO through Its Coiled-coil Domain Regulates Endocytosis at the Apical Surface of Polarized Epithelial Cells. Shmuel, M., Santy, L.C., Frank, S., Avrahami, D., Casanova, J.E., Altschuler, Y. J. Biol. Chem. (2006) [Pubmed]
  7. Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes. Rodriguez, A.M., Perron, B., Lacroix, L., Caillou, B., Leblanc, G., Schlumberger, M., Bidart, J.M., Pourcher, T. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  8. Potassium modulation of taurine transport across the frog retinal pigment epithelium. Miller, S.S., Steinberg, R.H. J. Gen. Physiol. (1979) [Pubmed]
  9. Adrenergic receptor activated ion transport in human fetal retinal pigment epithelium. Quinn, R.H., Quong, J.N., Miller, S.S. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  10. Identification, expression, and functional characterization of MAEBL, a sporozoite and asexual blood stage chimeric erythrocyte-binding protein of Plasmodium falciparum. Ghai, M., Dutta, S., Hall, T., Freilich, D., Ockenhouse, C.F. Mol. Biochem. Parasitol. (2002) [Pubmed]
  11. The pivotal role of tumor necrosis factor-alpha in signaling apoptosis in intestinal epithelial cells under shock conditions. Diebel, L.N., Liberati, D.M., Baylor, A.E., Brown, W.J., Diglio, C.A. The Journal of trauma. (2005) [Pubmed]
  12. Acute pulpal-alveolar cellulitis syndrome V. Apical closure of immature teeth by infection control: case report and a possible microbial-immunologic etiology. Part 1. Matusow, R.J. Oral Surg. Oral Med. Oral Pathol. (1991) [Pubmed]
  13. Innate immune responses of human tracheal epithelium to Pseudomonas aeruginosa flagellin, TNF-alpha, and IL-1beta. Tseng, J., Do, J., Widdicombe, J.H., Machen, T.E. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  14. Monocarboxylate Transporter 1 Mediates DL-2-Hydroxy-(4-Methylthio)Butanoic Acid Transport across the Apical Membrane of Caco-2 Cell Monolayers. Mart??n-Venegas, R., Rodr??guez-Lagunas, M.J., Geraert, P.A., Ferrer, R. J. Nutr. (2007) [Pubmed]
  15. Regulation of human placental chloride channel by arachidonic acid and other cis unsaturated fatty acids. Riquelme, G., Parra, M. Am. J. Obstet. Gynecol. (1999) [Pubmed]
  16. Effect of luminal ethanol on epithelial resistances and cell volume in isolated Necturus gastric mucosa. Mustonen, H., Kivilaakso, E. Dig. Dis. Sci. (2003) [Pubmed]
  17. Apical suction leads to severe ischemia of the ventricular apex. Fernández, A.L., García-Bengochea, J.B., Alvarez, J., Pérez, L.F., Suárez, J.M., Forteza, J., Cortés, J., Martínez, A. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (2006) [Pubmed]
  18. Reduction of water permeability by anisotonic solutions in frog corneal epithelium. Candia, O.A., Patarca, R., Alvarez, L.J. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  19. pH-dependent transport of procainamide in cultured renal epithelial monolayers of OK cells: consistent with nonionic diffusion. Dudley, A.J., Brown, C.D. Br. J. Pharmacol. (1995) [Pubmed]
  20. P2Y2-receptor-mediated activation of a contralateral, lanthanide-sensitive calcium entry pathway in the human airway epithelium. Bahra, P., Mesher, J., Li, S., Poll, C.T., Danahay, H. Br. J. Pharmacol. (2004) [Pubmed]
  21. The potential for bronchoscopic lung volume reduction using bronchial prostheses: a pilot study. Snell, G.I., Holsworth, L., Borrill, Z.L., Thomson, K.R., Kalff, V., Smith, J.A., Williams, T.J. Chest (2003) [Pubmed]
  22. The progress zone model for specifying positional information. Wolpert, L. Int. J. Dev. Biol. (2002) [Pubmed]
  23. 4-Chloro-benzo[F]isoquinoline (CBIQ) activates CFTR chloride channels and KCNN4 potassium channels in Calu-3 human airway epithelial cells. Szkotak, A.J., Murthy, M., MacVinish, L.J., Duszyk, M., Cuthbert, A.W. Br. J. Pharmacol. (2004) [Pubmed]
  24. Sagittal plane deformity in the thoracic spine: a clue to the presence of syringomyelia as a cause of scoliosis. Ouellet, J.A., LaPlaza, J., Erickson, M.A., Birch, J.G., Burke, S., Browne, R. Spine. (2003) [Pubmed]
  25. Calcium transport mechanism in human colonic apical membrane vesicles. Elsharydah, A., Syed, R., Tyagi, S., Khudeira, A.K., Harig, J.M., Dudeja, P.K. Gastroenterology (1995) [Pubmed]
  26. Pathological features and prognostic significance of prostate cancer in the apical section determined by whole mount histology. Ohori, M., Abbas, F., Wheeler, T.M., Kattan, M.W., Scardino, P.T., Lerner, S.P. J. Urol. (1999) [Pubmed]
  27. Apical nodular subepithelial corneal scar after retreatment in hyperopic photorefractive keratectomy. Sener, B., Ozdamar, A., Aras, C. Journal of cataract and refractive surgery. (2000) [Pubmed]
  28. Clinical significance of apical thinning after attenuation correction. Links, J.M., Becker, L.C., Anstett, F. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. (2004) [Pubmed]
  29. Determination of the minimum instrumentation size for penetration of irrigants to the apical third of root canal systems. Khademi, A., Yazdizadeh, M., Feizianfard, M. Journal of endodontics. (2006) [Pubmed]
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