The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CRISP3  -  cysteine-rich secretory protein 3

Homo sapiens

Synonyms: Aeg2, CRISP-3, CRS3, Cysteine-rich secretory protein 3, SGP28, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CRISP3


High impact information on CRISP3

  • In addition to previously described genes such as hepsin, overexpression of several genes was found that has not drawn attention before, such as the genes encoding the specific granule protein (SGP28), alpha-methyl-acyl-CoA racemase, low density lipoprotein (LDL)-phospholipase A2, and the anti-apoptotic gene PYCR1 [5].
  • In an attempt to interpret the expression of CRISP-3, normal peripheral blood lymphocytes (PBLs) were activated in vitro at different time points and assayed for CRISP-3 expression [3].
  • Finally, B cells were transfected with the coding region of CRISP-3 and monitored for the up-regulation of different B cell activation markers [3].
  • In addition, CRISP-3 was detected by RT-PCR between 30 minutes and 6 hours in phorbol myristate acetate-activated normal PBLs, while staurosporine inhibited this expression [3].
  • The function of MSP is not known, but a recent study has shown MSP to bind CRISP-3, a protein present in neutrophilic granulocytes [6].

Chemical compound and disease context of CRISP3


Biological context of CRISP3


Anatomical context of CRISP3


Associations of CRISP3 with chemical compounds

  • In the context of the CRISP promoters a 2-fold induction by R1881 was measured for the CRISP-3 upstream region whereas only limited effects were noted for the CRISP-1 upstream region [12].
  • It displays all 16 conserved cysteine residues and shows 82% homology to human and 78% to guinea pig CRISP-2 (AA1, TPX 1) and 77% to human CRISP-3 [13].

Other interactions of CRISP3

  • The A1BG-CRISP-3 complex is noncovalent with a 1:1 stoichiometry and is held together by strong electrostatic forces [8].
  • Rodents express only 2 CRISPs (CRISP-1 and CRISP-2) in their male reproductive system, whereas humans and horses express an additional third member named CRISP-3 [9].
  • On the basis of the relatively high content of CRISP-3 in human plasma and the small size of the protein (28 kDa), we hypothesized that CRISP-3 in plasma was bound to another component [8].
  • An ELISA for SGP28/CRISP-3, a cysteine-rich secretory protein in human neutrophils, plasma, and exocrine secretions [10].
  • Due to far higher abundance of MSP in prostatic fluid, it manifests large overcapacity for CRISP-3 binding [14].

Analytical, diagnostic and therapeutic context of CRISP3


  1. Cysteine-rich secretory protein-3: a potential biomarker for prostate cancer. Kosari, F., Asmann, Y.W., Cheville, J.C., Vasmatzis, G. Cancer Epidemiol. Biomarkers Prev. (2002) [Pubmed]
  2. Preferential expression of cystein-rich secretory protein-3 (CRISP-3) in chronic pancreatitis. Liao, Q., Kleeff, J., Xiao, Y., Guweidhi, A., Schambony, A., Töpfer-Petersen, E., Zimmermann, A., Büchler, M.W., Friess, H. Histol. Histopathol. (2003) [Pubmed]
  3. Characterization of the cysteine-rich secretory protein 3 gene as an early-transcribed gene with a putative role in the pathophysiology of Sjögren's syndrome. Tapinos, N.I., Polihronis, M., Thyphronitis, G., Moutsopoulos, H.M. Arthritis Rheum. (2002) [Pubmed]
  4. Association of cysteine-rich secretory protein 3 and beta-microseminoprotein with outcome after radical prostatectomy. Bjartell, A.S., Al-Ahmadie, H., Serio, A.M., Eastham, J.A., Eggener, S.E., Fine, S.W., Udby, L., Gerald, W.L., Vickers, A.J., Lilja, H., Reuter, V.E., Scardino, P.T. Clin. Cancer Res. (2007) [Pubmed]
  5. Decrease and gain of gene expression are equally discriminatory markers for prostate carcinoma: a gene expression analysis on total and microdissected prostate tissue. Ernst, T., Hergenhahn, M., Kenzelmann, M., Cohen, C.D., Bonrouhi, M., Weninger, A., Klären, R., Gröne, E.F., Wiesel, M., Güdemann, C., Küster, J., Schott, W., Staehler, G., Kretzler, M., Hollstein, M., Gröne, H.J. Am. J. Pathol. (2002) [Pubmed]
  6. Solution Structures of Human and Porcine beta-Microseminoprotein. Ghasriani, H., Teilum, K., Johnsson, Y., Fernlund, P., Drakenberg, T. J. Mol. Biol. (2006) [Pubmed]
  7. Macrophages overloaded with tissue debris in Wegener's granulomatosis. Mackiewicz, Z., Rimkevicius, A., Petersen, J., Andersen, C.B., Dudek, E., Vytrasova, M., Konttinen, Y.T. Ann. Rheum. Dis. (2005) [Pubmed]
  8. Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma. Udby, L., Sørensen, O.E., Pass, J., Johnsen, A.H., Behrendt, N., Borregaard, N., Kjeldsen, L. Biochemistry (2004) [Pubmed]
  9. Characterization and localization of cysteine-rich secretory protein 3 (CRISP-3) in the human male reproductive tract. Udby, L., Bjartell, A., Malm, J., Egesten, A., Lundwall, A., Cowland, J.B., Borregaard, N., Kjeldsen, L. J. Androl. (2005) [Pubmed]
  10. An ELISA for SGP28/CRISP-3, a cysteine-rich secretory protein in human neutrophils, plasma, and exocrine secretions. Udby, L., Cowland, J.B., Johnsen, A.H., Sørensen, O.E., Borregaard, N., Kjeldsen, L. J. Immunol. Methods (2002) [Pubmed]
  11. Identification of human cysteine-rich secretory protein 3 (CRISP-3) as a matrix protein in a subset of peroxidase-negative granules of neutrophils and in the granules of eosinophils. Udby, L., Calafat, J., Sørensen, O.E., Borregaard, N., Kjeldsen, L. J. Leukoc. Biol. (2002) [Pubmed]
  12. Androgen receptor signalling: comparative analysis of androgen response elements and implication of heat-shock protein 90 and 14-3-3eta. Haendler, B., Schüttke, I., Schleuning, W.D. Mol. Cell. Endocrinol. (2001) [Pubmed]
  13. Equine CRISP-3: primary structure and expression in the male genital tract. Schambony, A., Gentzel, M., Wolfes, H., Raida, M., Neumann, U., Töpfer-Petersen, E. Biochim. Biophys. Acta (1998) [Pubmed]
  14. beta-Microseminoprotein binds CRISP-3 in human seminal plasma. Udby, L., Lundwall, A., Johnsen, A.H., Fernlund, P., Valtonen-André, C., Blom, A.M., Lilja, H., Borregaard, N., Kjeldsen, L., Bjartell, A. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
WikiGenes - Universities