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Gene Review

CORO1A  -  coronin, actin binding protein, 1A

Homo sapiens

Synonyms: CLABP, CLIPINA, CORO1, Clipin-A, Coronin-1A, ...
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Disease relevance of CORO1A


High impact information on CORO1A

  • This is coupled to decreased expression of the CDK inhibitor p57, and increased levels of BrdU incorporation in HIF-1alpha null growth plates, indicating defects in HIF-1alpha-regulated growth arrest occurs in these animals [6].
  • By biochemical fractionation, we identify Aip1 and coronin as two proteins present in thymus extract that facilitate the cofilin-mediated disassembly of Listeria comet tails [3].
  • Our results show that Coronin 1B is a ubiquitously expressed member of the mammalian Coronin gene family that co-localizes with the Arp2/3 complex at the leading edge of fibroblasts, and co-immunoprecipitates with this complex [7].
  • GenBankTM searches revealed a 45% homology with the Dictyostelium actin-binding protein, coronin, and approximately 67% homology with the previously cloned human and bovine coronin-like homologue, p57. pp66 appears to be most highly expressed in the gastrointestinal mucosa and in kidney and lung [8].
  • Coronin-null Dictyostelium cells show defects in cytokinesis, cell motility and phagocytosis [9].

Chemical compound and disease context of CORO1A


Biological context of CORO1A


Anatomical context of CORO1A

  • A 57 kDa protein (p57) was obtained during the study on phosphatidylinositol-specific phospholipase C. Its cDNA was isolated from calf spleen and human leukemia cell line HL60 libraries and cloned [14].
  • Keeping this in view, the present study explored whether the molecules that have the ability to downregulate TACO gene transcription could also restrict entry/survival of mycobacteria within human macrophages [1].
  • In vivo, a truncated form consisting of the C-terminal coiled-coil domain co-precipitated with full-length p57/coronin-1 when both were co-expressed in COS-1 cells [13].
  • The cooperative activities of cofilin, coronin, and Aip1 should provide a biochemical basis for understanding how actin filaments can grow in some places in the cell while shrinking in others [3].
  • Cytosolic phox proteins interact with and regulate the assembly of coronin in neutrophils [15].

Associations of CORO1A with chemical compounds

  • The study revealed that chenodeoxycholic acid (CDCA), either alone or in combination with retinoic acid (RA), had the inherent capacity to downregulate TACO gene transcription in a dose-dependent fashion [1].
  • When two leucine residues out of the four that constitute the leucine zipper structure in p57LZ or full-length p57 were replaced with alanine residues, the mutants failed to form homodimers [13].
  • Recombinant p57/coronin-1 protein in solution formed a homodimer, as analysed by Superose 12 column chromatography and by sucrose density gradient centrifugation [13].
  • Together, these data indicate that a Src-type tyrosine kinase is necessary for the initiation of Ca(2+) release from the egg ER at fertilization and identify a Src-type p57 protein as a candidate in the signaling pathway leading to this Ca(2+) release [16].
  • Two membrane proteins with apparent molecular masses of 54-61 kDa (p57) and 86-107 kDa (p97) could be covalently modified with 125I-C3a, and this cross-linking was inhibited with an excess of unlabeled C3a [17].

Physical interactions of CORO1A


Analytical, diagnostic and therapeutic context of CORO1A


  1. Downregulation of TACO gene transcription restricts mycobacterial entry/survival within human macrophages. Anand, P.K., Kaul, D. FEMS Microbiol. Lett. (2005) [Pubmed]
  2. Effusion and solid lymphomas have distinctive gene and protein expression profiles in an animal model of primary effusion lymphoma. Yanagisawa, Y., Sato, Y., Asahi-Ozaki, Y., Ito, E., Honma, R., Imai, J., Kanno, T., Kano, M., Akiyama, H., Sata, T., Shinkai-Ouchi, F., Yamakawa, Y., Watanabe, S., Katano, H. J. Pathol. (2006) [Pubmed]
  3. Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1. Brieher, W.M., Kueh, H.Y., Ballif, B.A., Mitchison, T.J. J. Cell Biol. (2006) [Pubmed]
  4. Adrenocortical tumors: recent advances in basic concepts and clinical management. Bornstein, S.R., Stratakis, C.A., Chrousos, G.P. Ann. Intern. Med. (1999) [Pubmed]
  5. Coronin is involved in uptake of Mycobacterium bovis BCG in human macrophages but not in phagosome maintenance. Schüller, S., Neefjes, J., Ottenhoff, T., Thole, J., Young, D. Cell. Microbiol. (2001) [Pubmed]
  6. Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Schipani, E., Ryan, H.E., Didrickson, S., Kobayashi, T., Knight, M., Johnson, R.S. Genes Dev. (2001) [Pubmed]
  7. Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility. Cai, L., Holoweckyj, N., Schaller, M.D., Bear, J.E. J. Biol. Chem. (2005) [Pubmed]
  8. Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway. Parente, J.A., Chen, X., Zhou, C., Petropoulos, A.C., Chew, C.S. J. Biol. Chem. (1999) [Pubmed]
  9. Coronin localizes to leading edges and is involved in cell spreading and lamellipodium extension in vertebrate cells. Mishima, M., Nishida, E. J. Cell. Sci. (1999) [Pubmed]
  10. Green tea polyphenol inhibits Mycobacterium tuberculosis survival within human macrophages. Anand, P.K., Kaul, D., Sharma, M. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
  11. Evidence for a pool of coronin in mammalian cells that is sensitive to PI 3-kinase. Didichenko, S.A., Segal, A.W., Thelen, M. FEBS Lett. (2000) [Pubmed]
  12. Identification of actin-binding proteins from sea urchin eggs by F-actin affinity column chromatography. Terasaki, A.G., Ohnuma, M., Mabuchi, I. J. Biochem. (1997) [Pubmed]
  13. Homotypic dimerization of the actin-binding protein p57/coronin-1 mediated by a leucine zipper motif in the C-terminal region. Oku, T., Itoh, S., Ishii, R., Suzuki, K., Nauseef, W.M., Toyoshima, S., Tsuji, T. Biochem. J. (2005) [Pubmed]
  14. Molecular cloning of a novel actin-binding protein, p57, with a WD repeat and a leucine zipper motif. Suzuki, K., Nishihata, J., Arai, Y., Honma, N., Yamamoto, K., Irimura, T., Toyoshima, S. FEBS Lett. (1995) [Pubmed]
  15. Cytosolic phox proteins interact with and regulate the assembly of coronin in neutrophils. Grogan, A., Reeves, E., Keep, N., Wientjes, F., Totty, N.F., Burlingame, A.L., Hsuan, J.J., Segal, A.W. J. Cell. Sci. (1997) [Pubmed]
  16. Evidence that Src-type tyrosine kinase activity is necessary for initiation of calcium release at fertilization in sea urchin eggs. Abassi, Y.A., Carroll, D.J., Giusti, A.F., Belton, R.J., Foltz, K.R. Dev. Biol. (2000) [Pubmed]
  17. Expression of high- and low-affinity receptors for C3a on the human mast cell line, HMC-1. Legler, D.F., Loetscher, M., Jones, S.A., Dahinden, C.A., Arock, M., Moser, B. Eur. J. Immunol. (1996) [Pubmed]
  18. The influence of clinical intervention on pressure-volume relationships--the conductance (volume) technique. Thormann, J. Eur. Heart J. (1992) [Pubmed]
  19. Recurrent pregnancy loss and autoantibody profile in autoimmune diseases. Mavragani, C.P., Ioannidis, J.P., Tzioufas, A.G., Hantoumi, I.E., Moutsopoulos, H.M. Rheumatology (Oxford, England) (1999) [Pubmed]
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