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Gene Review

CLDN7  -  claudin 7

Homo sapiens

Synonyms: CEPTRL2, CLDN-7, CPETRL2, Claudin-7, Hs.84359, ...
 
 
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Disease relevance of CLDN7

 

High impact information on CLDN7

 

Biological context of CLDN7

 

Anatomical context of CLDN7

 

Associations of CLDN7 with chemical compounds

  • Formalin-fixed paraffin-embedded sections from 141 PACs were immunostained by manual and automated methods on the Xmatrx (BioGenex, San Ramon, CA) using antihuman claudin-1, -3, -4, -5, and -7 antibodies (Zymed, San Francisco, CA) [13].
  • We also found that the expression of CLDN-7 is responsive to androgen stimulation in the LNCaP cell line, suggesting that this protein is involved in the regulatory mechanism of androgen [10].
  • The distinct permeability properties observed in different epithelia and endothelia seemingly result from the restricted tissue expression, variability of the homopolymer and heteropolymer assembly, regulated transcription and translation, and the subcellular localization of claudin family proteins [14].
  • In utero exposure to tributyltin alters the expression of e-cadherin and localization of claudin-1 in intercellular junctions of the rat ventral prostate [15].
 

Other interactions of CLDN7

  • In en face sections, claudin-1 and ZO-1 antibodies showed as bands that corresponded to the junctional complex [12].
  • Occludin staining was seen at the junctional complex, where it was not continuous, but dotted along the cell junctions.The transcripts for claudin-1 and several other claudin isotypes, such as -2, -3, -4, -7, -9 and -14 were identified [12].
  • We now show that treatment of primary human astrocytes with the cytokine interleukin-1beta (IL-1beta) causes rapid induction of claudin-1, with an expression pattern reciprocal to loss of Cx43 [9].
  • Immunohistochemical (IHC) analysis of ductal carcinoma in situ (DCIS) and IDC showed that the loss of CLDN-7 expression correlated with histological grade in both DCIS (P<0.001, n=38) and IDC (P=0.014, n=31), occurring predominantly in high-grade (Nuclear and Elston grade 3) lesions [4].
  • On the basis of our findings, it seems that CLDN 1, CLDN 4, and CLDN 7 may rather have an important role in tumorigenesis or in cell-to-cell adhesion [16].
 

Analytical, diagnostic and therapeutic context of CLDN7

References

  1. Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis. Johnson, A.H., Frierson, H.F., Zaika, A., Powell, S.M., Roche, J., Crowe, S., Moskaluk, C.A., El-Rifai, W. Am. J. Pathol. (2005) [Pubmed]
  2. Intercellular junctions in Ewing sarcoma/primitive neuroectodermal tumor: additional evidence of epithelial differentiation. Schuetz, A.N., Rubin, B.P., Goldblum, J.R., Shehata, B., Weiss, S.W., Liu, W., Wick, M.R., Folpe, A.L. Mod. Pathol. (2005) [Pubmed]
  3. Mutations in the Tight-Junction Gene Claudin 19 (CLDN19) Are Associated with Renal Magnesium Wasting, Renal Failure, and Severe Ocular Involvement. Konrad, M., Schaller, A., Seelow, D., Pandey, A.V., Waldegger, S., Lesslauer, A., Vitzthum, H., Suzuki, Y., Luk, J.M., Becker, C., Schlingmann, K.P., Schmid, M., Rodriguez-Soriano, J., Ariceta, G., Cano, F., Enriquez, R., Juppner, H., Bakkaloglu, S.A., Hediger, M.A., Gallati, S., Neuhauss, S.C., Nurnberg, P., Weber, S. Am. J. Hum. Genet. (2006) [Pubmed]
  4. Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. Kominsky, S.L., Argani, P., Korz, D., Evron, E., Raman, V., Garrett, E., Rein, A., Sauter, G., Kallioniemi, O.P., Sukumar, S. Oncogene (2003) [Pubmed]
  5. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.P., Ricciardi-Castagnoli, P. Nat. Immunol. (2001) [Pubmed]
  6. Tight junction protein claudin-1 enhances the invasive activity of oral squamous cell carcinoma cells by promoting cleavage of laminin-5 gamma2 chain via matrix metalloproteinase (MMP)-2 and membrane-type MMP-1. Oku, N., Sasabe, E., Ueta, E., Yamamoto, T., Osaki, T. Cancer Res. (2006) [Pubmed]
  7. Dysregulation of claudin-7 leads to loss of e-cadherin expression and the increased invasion of esophageal squamous cell carcinoma cells. Lioni, M., Brafford, P., Andl, C., Rustgi, A., El-Deiry, W., Herlyn, M., Smalley, K.S. Am. J. Pathol. (2007) [Pubmed]
  8. Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells. Ohta, A., Yang, S.S., Rai, T., Chiga, M., Sasaki, S., Uchida, S. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  9. Reciprocal regulation of the junctional proteins claudin-1 and connexin43 by interleukin-1beta in primary human fetal astrocytes. Duffy, H.S., John, G.R., Lee, S.C., Brosnan, C.F., Spray, D.C. J. Neurosci. (2000) [Pubmed]
  10. Regulation of the expression of the prostate-specific antigen by claudin-7. Zheng, J.Y., Yu, D., Foroohar, M., Ko, E., Chan, J., Kim, N., Chiu, R., Pang, S. J. Membr. Biol. (2003) [Pubmed]
  11. Study of claudin function by RNA interference. Hou, J., Gomes, A.S., Paul, D.L., Goodenough, D.A. J. Biol. Chem. (2006) [Pubmed]
  12. Tight junction-related protein expression and distribution in human corneal epithelium. Ban, Y., Dota, A., Cooper, L.J., Fullwood, N.J., Nakamura, T., Tsuzuki, M., Mochida, C., Kinoshita, S. Exp. Eye Res. (2003) [Pubmed]
  13. Loss of claudins-1 and -7 and expression of claudins-3 and -4 correlate with prognostic variables in prostatic adenocarcinomas. Sheehan, G.M., Kallakury, B.V., Sheehan, C.E., Fisher, H.A., Kaufman, R.P., Ross, J.S. Hum. Pathol. (2007) [Pubmed]
  14. The roles of claudin superfamily proteins in paracellular transport. Heiskala, M., Peterson, P.A., Yang, Y. Traffic (2001) [Pubmed]
  15. In utero exposure to tributyltin alters the expression of e-cadherin and localization of claudin-1 in intercellular junctions of the rat ventral prostate. Barthelemy, J., Adeeko, A., Robaire, B., Cyr, D.G. Mol. Reprod. Dev. (2007) [Pubmed]
  16. The expression of five different claudins in invasive breast carcinomas: comparison of pT1pN1 and pT1pN0 tumors. Tokés, A.M., Kulka, J., Paku, S., Máthé, M., Páska, C., Lódi, C., Kiss, A., Schaff, Z. Pathol. Res. Pract. (2005) [Pubmed]
  17. Annexin A2 heterotetramer: role in tight junction assembly. Lee, D.B., Jamgotchian, N., Allen, S.G., Kan, F.W., Hale, I.L. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  18. Transepithelial Leak in Barrett's Esophagus. Mullin, J.M., Valenzano, M.C., Trembeth, S., Allegretti, P.D., Verrecchio, J.J., Schmidt, J.D., Jain, V., Meddings, J.B., Mercogliano, G., Thornton, J.J. Dig. Dis. Sci. (2006) [Pubmed]
  19. A novel strategy for a drug delivery system using a claudin modulator. Kondoh, M., Takahashi, A., Fujii, M., Yagi, K., Watanabe, Y. Biol. Pharm. Bull. (2006) [Pubmed]
 
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