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Gene Review

Fth1  -  ferritin heavy chain 1

Mus musculus

Synonyms: AL022624, AL033366, FHC, Ferritin H subunit, Ferritin heavy chain, ...
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Disease relevance of Fth1


High impact information on Fth1


Biological context of Fth1

  • Multiple ferritin H subunit sequences are present in the genome of higher vertebrates, but it is not yet known with certainty if more than one is expressed [7].
  • Analysis of the genomic structure of FHC suggested the presence of pseudogenes [8].
  • Pacsins are cytoplasmic adapter proteins with an N-terminal FHC, a central coiled coil, and a C-terminal SH3 domain and several potential phosphorylation sites [9].
  • Localization of a new ferritin heavy chain sequence present in human brain mRNA to chromosome 11 [10].
  • Two cell lines (Nara-H and Nara-F) with different phenotypes were established from a myxoid MFH of the uterus [11].

Anatomical context of Fth1


Associations of Fth1 with chemical compounds

  • The plasma glucose concentration and amount of urinary excreted glucose were lower from the HES and MFH diets than from the BAS and WFH diets [17].
  • Each test diet contained 4.0% of the hot-water extract (HES) from defatted sesame (Sesamum indicum L.) seed, 1.4% of the water eluent fraction (WFH) of HES or 0.7% of the methanol eluent fraction (MFH) of HES from a glass column packed with HP-20 resin [17].
  • In situ hybridization was performed with sections obtained from mammary gland at 10 days of lactation and at 1 and 3 days of involution using either digoxigenin-labeled antisense or sense RNA probe in order to localize expression of WDNM1 and ferritin heavy chain mRNA [18].

Other interactions of Fth1


Analytical, diagnostic and therapeutic context of Fth1

  • The molecular cloning and characterization of murine ferritin heavy chain, a tumor necrosis factor-inducible gene [12].
  • This cDNA was used to establish the genomic location of mouse ferritin H subunit genes by chromosomal in situ hybridization [21].
  • Cloned FHC cells were demonstrated to have the ability to maintain hemopoietic progenitors in fetal liver and adult bone marrow in the coculture, and among them, FHC-4D2 clone displayed the greatest activity [15].
  • Nevertheless, divergent differentiations exhibiting unusual double or triple patterns could be documented ultrastructurally in 12/30 xenografts with juxtaposed myomatous as well as nerve sheath-like cells and, in addition, histiocytoid (MFH-like) elements in 3 of the xenografts [22].


  1. Heavy chain ferritin acts as an antiapoptotic gene that protects livers from ischemia reperfusion injury. Berberat, P.O., Katori, M., Kaczmarek, E., Anselmo, D., Lassman, C., Ke, B., Shen, X., Busuttil, R.W., Yamashita, K., Csizmadia, E., Tyagi, S., Otterbein, L.E., Brouard, S., Tobiasch, E., Bach, F.H., Kupiec-Weglinski, J.W., Soares, M.P. FASEB J. (2003) [Pubmed]
  2. Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species. Pham, C.G., Bubici, C., Zazzeroni, F., Papa, S., Jones, J., Alvarez, K., Jayawardena, S., De Smaele, E., Cong, R., Beaumont, C., Torti, F.M., Torti, S.V., Franzoso, G. Cell (2004) [Pubmed]
  3. Reduced expression of AP27 protein, the product of a growth factor-repressible gene, is associated with diminished adipocyte differentiation. Wenz, H.M., Hinck, L., Cannon, P., Navre, M., Ringold, G.M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  4. H ferritin knockout mice: a model of hyperferritinemia in the absence of iron overload. Ferreira, C., Santambrogio, P., Martin, M.E., Andrieu, V., Feldmann, G., Hénin, D., Beaumont, C. Blood (2001) [Pubmed]
  5. Overexpression of the ferritin H subunit in cultured erythroid cells changes the intracellular iron distribution. Picard, V., Renaudie, F., Porcher, C., Hentze, M.W., Grandchamp, B., Beaumont, C. Blood (1996) [Pubmed]
  6. Early embryonic lethality of H ferritin gene deletion in mice. Ferreira, C., Bucchini, D., Martin, M.E., Levi, S., Arosio, P., Grandchamp, B., Beaumont, C. J. Biol. Chem. (2000) [Pubmed]
  7. Mouse ferritin H multigene family is polymorphic and contains a single multiallelic functional gene located on chromosome 19. Yachou, A.K., Renaudie, F., Guenet, J.L., Simon-Chazottes, D., Jones, R., Grandchamp, B., Beaumont, C. Genomics (1991) [Pubmed]
  8. Murine ferritin heavy chain: isolation and characterization of a functional gene. Kwak, E.L., Torti, S.V., Torti, F.M. Gene (1990) [Pubmed]
  9. PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family. Sumoy, L., Pluvinet, R., Andreu, N., Estivill, X., Escarceller, M. Gene (2001) [Pubmed]
  10. Localization of a new ferritin heavy chain sequence present in human brain mRNA to chromosome 11. Percy, M.E., Bauer, S.J., Rainey, S., McLachlan, D.R., Dhar, M.S., Joshi, J.G. Genome (1995) [Pubmed]
  11. Novel cell lines established from a human myxoid malignant fibrous histiocytoma arising in the uterus. Kiyozuka, Y., Nakagawa, H., Uemura, Y., Senzaki, H., Yamamoto, A., Noguchi, T., Mizuta, H., Nakanishi, K., Nakano, S., Tsubura, A. Cancer Genet. Cytogenet. (2001) [Pubmed]
  12. The molecular cloning and characterization of murine ferritin heavy chain, a tumor necrosis factor-inducible gene. Torti, S.V., Kwak, E.L., Miller, S.C., Miller, L.L., Ringold, G.M., Myambo, K.B., Young, A.P., Torti, F.M. J. Biol. Chem. (1988) [Pubmed]
  13. Role for NF-kappa B in the regulation of ferritin H by tumor necrosis factor-alpha. Kwak, E.L., Larochelle, D.A., Beaumont, C., Torti, S.V., Torti, F.M. J. Biol. Chem. (1995) [Pubmed]
  14. Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13. Weiss, G., Bogdan, C., Hentze, M.W. J. Immunol. (1997) [Pubmed]
  15. Establishment of a hepatocytic epithelial cell line from the murine fetal liver capable of promoting hemopoietic cell proliferation. Hata, M., Nanno, M., Doi, H., Satomi, S., Sakata, T., Suzuki, R., Itoh, T. J. Cell. Physiol. (1993) [Pubmed]
  16. Effects of Anaplasma phagocytophilum on host cell ferritin mRNA and protein levels. Carlyon, J.A., Ryan, D., Archer, K., Fikrig, E. Infect. Immun. (2005) [Pubmed]
  17. Hypoglycemic effect of a hot-water extract from defatted sesame (Sesamum indicum L.) seed on the blood glucose level in genetically diabetic KK-Ay mice. Takeuchi, H., Mooi, L.Y., Inagaki, Y., He, P. Biosci. Biotechnol. Biochem. (2001) [Pubmed]
  18. In situ localization of WDNM1 and ferritin heavy chain gene expression in mammary gland. Baik, M., Hennighausen, L., Choi, Y. Mol. Cells (1997) [Pubmed]
  19. Mouse ferritin H subunit gene. Functional analysis of the promoter and identification of an upstream regulatory element active in erythroid cells. Beaumont, C., Seyhan, A., Yachou, A.K., Grandchamp, B., Jones, R. J. Biol. Chem. (1994) [Pubmed]
  20. Differential gene expression in wild-type and X-ray-sensitive mutants of Chinese hamster ovary cell lines. Zhu, W., Keng, P.C., Chou, W.G. Mutat. Res. (1992) [Pubmed]
  21. Mouse ferritin H sequences map to chromosomes 3, 6, and 19. Yachou, A., Mattei, M.G., Roeckel, N., Grandchamp, B., Beaumont, C. Genomics (1991) [Pubmed]
  22. Ultrastructural evidence for divergent and alternating differentiations in spindle cell sarcoma xenografts. Schmidt, U., Stüben, G., Stuschke, M., Donhuijsen, K. J. Submicrosc. Cytol. Pathol. (1997) [Pubmed]
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