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Gene Review

FTH1  -  ferritin, heavy polypeptide 1

Homo sapiens

Synonyms: Cell proliferation-inducing gene 15 protein, FHC, FTH, FTHL6, Ferritin H subunit, ...
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Disease relevance of FTH1


High impact information on FTH1


Biological context of FTH1

  • Iron regulatory proteins (IRPs) 1 and 2 post-transcriptionally control mammalian iron homeostasis by binding to iron-responsive elements (IREs), conserved RNA stem-loop structures located in the 5'- or 3'-untranslated regions of genes involved in iron metabolism (e.g. FTH1, FTL, and TFRC) [9].
  • We describe here a third ferritin-related subunit cloned from human placenta cDNA library and named PLIF (placental immunomodulatory ferritin) [2].
  • PLIF protein was found to localize in syncytiotrophoblasts of placentas (8 weeks of gestation) at the fetal-maternal interface [2].
  • In contrast to FTH, PLIF mRNA does not include the iron response element in the 5'-untranslated region, suggesting that PLIF synthesis is not regulated by iron [2].
  • This additional sequence shows 94.1%, 62.5%, and 58.9% identity to the 3' flanking sequence of the human liver and mouse and rat FTH genomic clones, respectively [10].

Anatomical context of FTH1

  • Biochemical analyses of these bodies isolated from the striatum and cerebellar cortex revealed that ferritin light polypeptide (FTL) and ferritin heavy polypeptide (FTH1) were the main constituents [11].
  • The functionality of the gene was demonstrated by the fact that both transient transfectants and stable transformants of murine fibroblasts actively transcribe human ferritin heavy-chain mRNA [1].
  • Increased levels of PLIF transcript and protein were also detected in the breast carcinoma cell lines T47D and MCF-7 but not in the benign corresponding cell line HBL-100 [2].
  • METHODS: The in vitro effect of PLIF/C48 was tested in mixed lymphocyte cultures (MLCs) of allogeneic mouse splenocytes [12].
  • The differential PLIF-C48 effects (i.e., myeloid progenitor cell growth and T-cell suppression) are due to their effect on the cytokine-chemokine networks [13].

Associations of FTH1 with chemical compounds


Other interactions of FTH1


Analytical, diagnostic and therapeutic context of FTH1


  1. Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene. Hentze, M.W., Keim, S., Papadopoulos, P., O'Brien, S., Modi, W., Drysdale, J., Leonard, W.J., Harford, J.B., Klausner, R.D. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  2. PLIF, a novel human ferritin subunit from placenta with immunosuppressive activity. Moroz, C., Traub, L., Maymon, R., Zahalka, M.A. J. Biol. Chem. (2002) [Pubmed]
  3. Aedes aegypti ferritin. Geiser, D.L., Chavez, C.A., Flores-Munguia, R., Winzerling, J.J., Pham, D.Q. Eur. J. Biochem. (2003) [Pubmed]
  4. Accumulation and translation of ferritin heavy chain transcripts following anoxia exposure in a marine invertebrate. Larade, K., Storey, K.B. J. Exp. Biol. (2004) [Pubmed]
  5. Cloning and sequencing of an Escherichia coli K12 gene which encodes a polypeptide having similarity to the human ferritin H subunit. Izuhara, M., Takamune, K., Takata, R. Mol. Gen. Genet. (1991) [Pubmed]
  6. T-cell mitogenesis stimulates the synthesis of a mRNA species coding for a 43-kDa peptide reactive with CM-H-9, a monoclonal antibody specific for placental isoferritin. Moroz, C., Shterman, N., Kupfer, B., Ginzburg, I. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  7. Human ferritin genes: chromosomal assignments and polymorphisms. Gatti, R.A., Shaked, R., Mohandas, T.K., Salser, W. Am. J. Hum. Genet. (1987) [Pubmed]
  8. Influence of altered transcription on the translational control of human ferritin expression. Rouault, T.A., Hentze, M.W., Dancis, A., Caughman, W., Harford, J.B., Klausner, R.D. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  9. Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy. Sanchez, M., Galy, B., Dandekar, T., Bengert, P., Vainshtein, Y., Stolte, J., Muckenthaler, M.U., Hentze, M.W. J. Biol. Chem. (2006) [Pubmed]
  10. Differential processing of the ferritin heavy chain mRNA in human liver and adult human brain. Dhar, M.S., Joshi, J.G. J. Neurochem. (1993) [Pubmed]
  11. Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene. Vidal, R., Ghetti, B., Takao, M., Brefel-Courbon, C., Uro-Coste, E., Glazier, B.S., Siani, V., Benson, M.D., Calvas, P., Miravalle, L., Rascol, O., Delisle, M.B. J. Neuropathol. Exp. Neurol. (2004) [Pubmed]
  12. Placental immunomodulator ferritin, a novel immunoregulator, suppresses experimental arthritis. Weinberger, A., Halpern, M., Zahalka, M.A., Quintana, F., Traub, L., Moroz, C. Arthritis Rheum. (2003) [Pubmed]
  13. Treatment of human bone marrow with recombinant placenta immunoregulator ferritin results in myelopoiesis and T-cell suppression through modulation of the cytokine-chemokine networks. Moroz, C., Grunspan, A., Zahalka, M.A., Traub, L., Kodman, Y., Yaniv, I. Exp. Hematol. (2006) [Pubmed]
  14. Tumor necrosis factor-alpha and interleukin 1-alpha regulate transferrin receptor in human diploid fibroblasts. Relationship to the induction of ferritin heavy chain. Tsuji, Y., Miller, L.L., Miller, S.C., Torti, S.V., Torti, F.M. J. Biol. Chem. (1991) [Pubmed]
  15. Chemokine CXCL12 Induces Binding of Ferritin Heavy Chain to the Chemokine Receptor CXCR4, Alters CXCR4 Signaling, and Induces Phosphorylation and Nuclear Translocation of Ferritin Heavy Chain. Li, R., Luo, C., Mines, M., Zhang, J., Fan, G.H. J. Biol. Chem. (2006) [Pubmed]
  16. Ferritin and the response to oxidative stress. Orino, K., Lehman, L., Tsuji, Y., Ayaki, H., Torti, S.V., Torti, F.M. Biochem. J. (2001) [Pubmed]
  17. Kinetics of OH radical reaction with anthracene and anthracene-d10. Ananthula, R., Yamada, T., Taylor, P.H. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2006) [Pubmed]
  18. JunD activates transcription of the human ferritin H gene through an antioxidant response element during oxidative stress. Tsuji, Y. Oncogene (2005) [Pubmed]
  19. Exclusion of ferritins and iron-responsive element (IRE)-binding proteins as candidates for the hemochromatosis gene. Zheng, H., Bhavsar, D., Volz, A., Ziegler, A., Drysdale, J. Hum. Genet. (1994) [Pubmed]
  20. Effects of grazing program and subsequent finishing on gene expression in different adipose tissue depots in beef steers. Ross, J.W., Smith, T.K., Krehbiel, C.R., Malayer, J.R., DeSilva, U., Morgan, J.B., White, F.J., Hersom, M.J., Horn, G.W., Geisert, R.D. J. Anim. Sci. (2005) [Pubmed]
  21. NF-kappaB and JNK: an intricate affair. Bubici, C., Papa, S., Pham, C.G., Zazzeroni, F., Franzoso, G. Cell Cycle (2004) [Pubmed]
  22. Sequence of a cDNA encoding the ferritin H-chain from an 11-week-old human fetal brain. Dhar, M., Chauthaiwale, V., Joshi, J.G. Gene (1993) [Pubmed]
  23. Blocking of the placental immune-modulatory ferritin activates Th1 type cytokines and affects placenta development, fetal growth and the pregnancy outcome. Nahum, R., Brenner, O., Zahalka, M.A., Traub, L., Quintana, F., Moroz, C. Hum. Reprod. (2004) [Pubmed]
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