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Gene Review

Cp  -  ceruloplasmin

Mus musculus

Synonyms: Ceruloplasmin, D3Ertd555e, Ferroxidase
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Disease relevance of Cp


Psychiatry related information on Cp


High impact information on Cp


Chemical compound and disease context of Cp


Biological context of Cp

  • We recently mapped the major gene, El-1, to chromosome 9 near the predicted location for the ceruloplasmin (Cp) gene [10].
  • The significant increase in silver grain count over chromosome 15 in rats after hybridization with both the Cp and Tf probes suggests the presence of a related pseudogene cluster on this particular chromosome and thus favours its partial homeology to chromosome 7 [11].
  • Use of the rat Cp DNA probe does not indicate synteny of the Cp and Tf genes in man and suggests the existence of a related DNA sequence in 15q11-13 [11].
  • The copper requirement of the multicopper ferroxidases hephaestin and ceruloplasmin likely explains this link between copper and iron homeostasis in mammals [12].
  • Cp(-/-) mice have below normal hematocrit, red cell hemoglobin and volume, and serum iron [3].

Anatomical context of Cp


Associations of Cp with chemical compounds


Regulatory relationships of Cp

  • Using differential display reverse transcription-polymerase chain reaction (DDRT-PCR), seven upregulated genes including S100 calcium binding protein A9 (S100A9) mRNA and antigenic determinant for rec-A protein mRNA and five downregulated genes including caseinolytic protease X (ClpX) mRNA and ceruloplasmin (CP) mRNA by cisplatin were identified [21].

Other interactions of Cp

  • Ceruloplasmin gene defect associated with epilepsy in EL mice [10].
  • Antioxidant and antibacterial genes are upregulated in early involution of the mouse mammary gland: sharp increase of ceruloplasmin and lactoferrin in accumulating breast milk [14].
  • Both Cp and Tf genes were found to be syntenic in rodents, occupying with high probability the regions 9D and 9F1-3 in mice and 7q11-13 and 7q31-34 in rats respectively [11].
  • Cp mRNA was detected in the developing mouse brain, where its expression domain was closely adjacent to that of Shh [22].
  • Subsequently, mutations in the ceruloplasmin gene have been determined to result in the excessive iron accumulation seen in the pancreas, retina, and brain [23].

Analytical, diagnostic and therapeutic context of Cp


  1. Extrahepatic expression of plasma protein genes during inflammation. Kalmovarin, N., Friedrichs, W.E., O'Brien, H.V., Linehan, L.A., Bowman, B.H., Yang, F. Inflammation (1991) [Pubmed]
  2. Quantitative evaluation of expression of iron-metabolism genes in ceruloplasmin-deficient mice. Yamamoto, K., Yoshida, K., Miyagoe, Y., Ishikawa, A., Hanaoka, K., Nomoto, S., Kaneko, K., Ikeda, S., Takeda, S. Biochim. Biophys. Acta (2002) [Pubmed]
  3. Anemia and impaired stress-induced erythropoiesis in aceruloplasminemic mice. Cherukuri, S., Tripoulas, N.A., Nurko, S., Fox, P.L. Blood Cells Mol. Dis. (2004) [Pubmed]
  4. Ceruloplasmin and regulation of transferrin iron during Neisseria meningitidis infection in mice. Letendre, E.D., Holbein, B.E. Infect. Immun. (1984) [Pubmed]
  5. Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury. Patel, B.N., Dunn, R.J., Jeong, S.Y., Zhu, Q., Julien, J.P., David, S. J. Neurosci. (2002) [Pubmed]
  6. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Vulpe, C.D., Kuo, Y.M., Murphy, T.L., Cowley, L., Askwith, C., Libina, N., Gitschier, J., Anderson, G.J. Nat. Genet. (1999) [Pubmed]
  7. Ceruloplasmin gene defect associated with epilepsy in EL mice. Garey, C.E., Schwarzman, A.L., Rise, M.L., Seyfried, T.N. Nat. Genet. (1995) [Pubmed]
  8. Ceruloplasmin gene expression in the murine central nervous system. Klomp, L.W., Farhangrazi, Z.S., Dugan, L.L., Gitlin, J.D. J. Clin. Invest. (1996) [Pubmed]
  9. Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis. Shiva, S., Wang, X., Ringwood, L.A., Xu, X., Yuditskaya, S., Annavajjhala, V., Miyajima, H., Hogg, N., Harris, Z.L., Gladwin, M.T. Nat. Chem. Biol. (2006) [Pubmed]
  10. Ceruloplasmin gene defect associated with epilepsy in EL mice. Garey, C.E., Schwarzman, A.L., Rise, M.L., Seyfried, T.N. Nat. Genet. (1994) [Pubmed]
  11. Chromosomal localization of ceruloplasmin and transferrin genes in laboratory rats, mice and in man by hybridization with specific DNA probes. Baranov, V.S., Schwartzman, A.L., Gorbunova, V.N., Gaitskhoki, V.S., Rubtsov, N.B., Timchenko, N.A., Neifakh, S.A. Chromosoma (1987) [Pubmed]
  12. Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency. Chen, H., Huang, G., Su, T., Gao, H., Attieh, Z.K., McKie, A.T., Anderson, G.J., Vulpe, C.D. J. Nutr. (2006) [Pubmed]
  13. Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system. Jeong, S.Y., David, S. J. Biol. Chem. (2003) [Pubmed]
  14. Antioxidant and antibacterial genes are upregulated in early involution of the mouse mammary gland: sharp increase of ceruloplasmin and lactoferrin in accumulating breast milk. Nakamura, M., Tomita, A., Nakatani, H., Matsuda, T., Nadano, D. DNA Cell Biol. (2006) [Pubmed]
  15. Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency. Chen, H., Su, T., Attieh, Z.K., Fox, T.C., McKie, A.T., Anderson, G.J., Vulpe, C.D. Blood (2003) [Pubmed]
  16. Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice. Chen, H., Attieh, Z.K., Su, T., Syed, B.A., Gao, H., Alaeddine, R.M., Fox, T.C., Usta, J., Naylor, C.E., Evans, R.W., McKie, A.T., Anderson, G.J., Vulpe, C.D. Blood (2004) [Pubmed]
  17. Copper transport and metabolism are normal in aceruloplasminemic mice. Meyer, L.A., Durley, A.P., Prohaska, J.R., Harris, Z.L. J. Biol. Chem. (2001) [Pubmed]
  18. The blue copper ceruloplasmin induces aggregation of newly differentiated neurons: a potential modulator of nervous system organization. Maltais, D., Desroches, D., Aouffen, M., Mateescu, M.A., Wang, R., Paquin, J. Neuroscience (2003) [Pubmed]
  19. A human mitochondrial ferritin encoded by an intronless gene. Levi, S., Corsi, B., Bosisio, M., Invernizzi, R., Volz, A., Sanford, D., Arosio, P., Drysdale, J. J. Biol. Chem. (2001) [Pubmed]
  20. Ferritin stimulation of a monokine inhibitor of lipopolysaccharide-augmented myelopoiesis is ferroxidase dependent. Kreisberg, R., Broxmeyer, H.E., Moore, R.N. Infect. Immun. (1994) [Pubmed]
  21. Abrogation of cisplatin-induced hepatotoxicity in mice by xanthorrhizol is related to its effect on the regulation of gene transcription. Kim, S.H., Hong, K.O., Chung, W.Y., Hwang, J.K., Park, K.K. Toxicol. Appl. Pharmacol. (2004) [Pubmed]
  22. Identification of sonic hedgehog-responsive genes using cDNA microarray. Kato, M., Seki, N., Sugano, S., Hashimoto, K., Masuho, Y., Muramatsu, M., Kaibuchi, K., Nakafuku, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  23. Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis. Xu, X., Pin, S., Gathinji, M., Fuchs, R., Harris, Z.L. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
  24. Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Harris, Z.L., Durley, A.P., Man, T.K., Gitlin, J.D. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  25. Unexpected role of ceruloplasmin in intestinal iron absorption. Cherukuri, S., Potla, R., Sarkar, J., Nurko, S., Harris, Z.L., Fox, P.L. Cell metabolism. (2005) [Pubmed]
  26. Dual role of insulin in transcriptional regulation of the acute phase reactant ceruloplasmin. Seshadri, V., Fox, P.L., Mukhopadhyay, C.K. J. Biol. Chem. (2002) [Pubmed]
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