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Gene Review

Gcgr  -  glucagon receptor

Mus musculus

Synonyms: GL-R, GR, Glucagon receptor
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Disease relevance of Gcgr


High impact information on Gcgr


Biological context of Gcgr


Anatomical context of Gcgr


Associations of Gcgr with chemical compounds

  • Furthermore, the acute insulin response (AIR) to intravenous glucose was higher in Gcgr(-/-) mice [9].
  • In contrast, AIR to intravenous administration of other secretagogues was either not affected (carbachol) or significantly reduced (arginine, cholecystokinin octapeptide) in Gcgr(-/-) mice [9].
  • METHODS: Gcgr (-/-) mice were challenged with a high-fat diet (HFD) and with streptozotocin, which induces beta cell damage [2].
  • In addition, a 1000-bp region of the GR promoter has been sequenced which contains consensus sequences for putative DNA-binding proteins involved in tissue specificity (c/EBP; HNFI) or hormonal regulation (steroid receptor) [6].
  • There was no significant effect on fasting plasma cholesterol or triglyceride levels associated with deletion of the glucagon receptor [10].

Other interactions of Gcgr

  • These issues were examined in a line of mice with a global deletion of the GLU receptor (Gcgr-/-), which are characterized by lower blood glucose levels and by alpha- and delta-cell hyperplasia in adults [11].
  • These data suggest multiple modes of action of OXM: 1) it directly elevates murine intrinsic HR through a GLP-1R-independent mechanism, perhaps via the glucagon receptor or an unidentified OXM receptor, and 2) it lowers food intake, activity, and T(b) in a GLP-1R-dependent fashion [12].

Analytical, diagnostic and therapeutic context of Gcgr


  1. Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Gelling, R.W., Du, X.Q., Dichmann, D.S., Romer, J., Huang, H., Cui, L., Obici, S., Tang, B., Holst, J.J., Fledelius, C., Johansen, P.B., Rossetti, L., Jelicks, L.A., Serup, P., Nishimura, E., Charron, M.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia. Conarello, S.L., Jiang, G., Mu, J., Li, Z., Woods, J., Zycband, E., Ronan, J., Liu, F., Roy, R.S., Zhu, L., Charron, M.J., Zhang, B.B. Diabetologia (2007) [Pubmed]
  3. Hypoglycemia leads to age-related loss of vision. Umino, Y., Everhart, D., Solessio, E., Cusato, K., Pan, J.C., Nguyen, T.H., Brown, E.T., Hafler, R., Frio, B.A., Knox, B.E., Engbretson, G.A., Haeri, M., Cui, L., Glenn, A.S., Charron, M.J., Barlow, R.B. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. Hormone receptor modulates the regulatory component of adenylyl cyclase by reducing its requirement for Mg2+ and enhancing its extent of activation by guanine nucleotides. Iyengar, R., Birnbaumer, L. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  5. Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. Campos, R.V., Lee, Y.C., Drucker, D.J. Endocrinology (1994) [Pubmed]
  6. Cloning and sequence analysis of the murine glucagon receptor-encoding gene. Burcelin, R., Li, J., Charron, M.J. Gene (1995) [Pubmed]
  7. Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice. Liang, Y., Osborne, M.C., Monia, B.P., Bhanot, S., Gaarde, W.A., Reed, C., She, P., Jetton, T.L., Demarest, K.T. Diabetes (2004) [Pubmed]
  8. Characterization of an enhancer element in the proximal promoter of the mouse glucagon receptor gene. Geiger, A., Salazar, G., Le Cam, A., Kervran, A. Biochim. Biophys. Acta (2001) [Pubmed]
  9. Glucagon Receptor Knockout Mice Display Increased Insulin Sensitivity and Impaired {beta}-Cell Function. S??rensen, H., Winzell, M.S., Brand, C.L., Fosgerau, K., Gelling, R.W., Nishimura, E., Ahren, B. Diabetes (2006) [Pubmed]
  10. Glycemic control in mice with targeted disruption of the glucagon receptor gene. Parker, J.C., Andrews, K.M., Allen, M.R., Stock, J.L., McNeish, J.D. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  11. Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation. Vuguin, P.M., Kedees, M.H., Cui, L., Guz, Y., Gelling, R.W., Nejathaim, M., Charron, M.J., Teitelman, G. Endocrinology (2006) [Pubmed]
  12. Oxyntomodulin increases intrinsic heart rate in mice independent of the glucagon-like peptide-1 receptor. Sowden, G.L., Drucker, D.J., Weinshenker, D., Swoap, S.J. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2007) [Pubmed]
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