Gene Review:
IL5RA - interleukin 5 receptor, alpha
Homo sapiens
Synonyms:
CD125, CDw125, HSIL5R3, IL-5 receptor subunit alpha, IL-5R subunit alpha, ...
- Allergen-induced increases in IL-5 receptor alpha-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects. A novel marker of progenitor cell commitment towards eosinophilic differentiation. Sehmi, R., Wood, L.J., Watson, R., Foley, R., Hamid, Q., O'Byrne, P.M., Denburg, J.A. J. Clin. Invest. (1997)
- Characterization of a receptor for interleukin-5 on human eosinophils and the myeloid leukemia line HL-60. Ingley, E., Young, I.G. Blood (1991)
- Human B cells express IL-5 receptor messenger ribonucleic acid and respond to IL-5 with enhanced IgM production after mitogenic stimulation with Moraxella catarrhalis. Huston, M.M., Moore, J.P., Mettes, H.J., Tavana, G., Huston, D.P. J. Immunol. (1996)
- Interleukin-5 receptor alpha chain mRNA is down-regulated by transforming growth factor beta 1. Zanders, E.D. Eur. Cytokine Netw. (1994)
- Coiled coil miniprotein randomization on phage leads to charge pattern mimicry of the receptor recognition determinant of interleukin 5. Li, C., Plugariu, C.G., Bajgier, J., White, J.R., Liefer, K.M., Wu, S.J., Chaiken, I. J. Mol. Recognit. (2002)
- A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. Tavernier, J., Devos, R., Cornelis, S., Tuypens, T., Van der Heyden, J., Fiers, W., Plaetinck, G. Cell (1991)
- Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding. Gajiwala, K.S., Chen, H., Cornille, F., Roques, B.P., Reith, W., Mach, B., Burley, S.K. Nature (2000)
- Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival. Pazdrak, K., Adachi, T., Alam, R. J. Exp. Med. (1997)
- IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases. Sato, S., Katagiri, T., Takaki, S., Kikuchi, Y., Hitoshi, Y., Yonehara, S., Tsukada, S., Kitamura, D., Watanabe, T., Witte, O., Takatsu, K. J. Exp. Med. (1994)
- Dinucleotide repeat polymorphism in the IL2 and IL5RA genes. Epplen, C., Frank, G., Gomolka, M., Nagy, M., Nürnberg, P., Epplen, J.T. Hum. Mol. Genet. (1994)
- Localization of the gene encoding the alpha subunit of human interleukin-5 receptor (IL5RA) to chromosome region 3p24-3p26. Isobe, M., Kumura, Y., Murata, Y., Takaki, S., Tominaga, A., Takatsu, K., Ogita, Z. Genomics (1992)
- Association analysis of interleukin 5 receptor alpha subunit (IL5RA) polymorphisms and asthma. Cheong, H.S., Kim, L.H., Park, B.L., Choi, Y.H., Park, H.S., Hong, S.J., Choi, B.W., Park, C.S., Shin, H.D. J. Hum. Genet. (2005)
- Identification and characterization of a functional promoter region in the human eosinophil IL-5 receptor alpha subunit gene. Sun, Z., Yergeau, D.A., Tuypens, T., Tavernier, J., Paul, C.C., Baumann, M.A., Tenen, D.G., Ackerman, S.J. J. Biol. Chem. (1995)
- Detailed analysis of the IL-5-IL-5R alpha interaction: characterization of crucial residues on the ligand and the receptor. Cornelis, S., Plaetinck, G., Devos, R., Van der Heyden, J., Tavernier, J., Sanderson, C.J., Guisez, Y., Fiers, W. EMBO J. (1995)
- Activation of the STAT3/acute phase response factor transcription factor by interleukin-5. Caldenhoven, E., van Dijk, T., Raaijmakers, J.A., Lammers, J.W., Koenderman, L., De Groot, R.P. J. Biol. Chem. (1995)
- Retinoic acid modulates IL-5 receptor expression and selectively inhibits eosinophil-basophil differentiation of hemopoietic progenitor cells. Upham, J.W., Sehmi, R., Hayes, L.M., Howie, K., Lundahl, J., Denburg, J.A. J. Allergy Clin. Immunol. (2002)
- Covalent modification of the interleukin-5 receptor by isothiazolones leads to inhibition of the binding of interleukin-5. Devos, R., Guisez, Y., Plaetinck, G., Cornelis, S., Tavernier, J., van der Heyden, J., Foley, L.H., Scheffler, J.E. Eur. J. Biochem. (1994)
- Cyclic peptide interleukin 5 antagonists mimic CD turn recognition epitope for receptor alpha. Ruchala, P., Varadi, G., Ishino, T., Scibek, J., Bhattacharya, M., Urbina, C., Ryk, D.V., Uings, I., Chaiken, I. Biopolymers (2004)
- Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins. Johanson, K., Appelbaum, E., Doyle, M., Hensley, P., Zhao, B., Abdel-Meguid, S.S., Young, P., Cook, R., Carr, S., Matico, R. J. Biol. Chem. (1995)
- Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common beta-chain bound to an antagonist. Rossjohn, J., McKinstry, W.J., Woodcock, J.M., McClure, B.J., Hercus, T.R., Parker, M.W., Lopez, A.F., Bagley, C.J. Blood (2000)
- Differential regulation of interleukin 5-stimulated signaling pathways by dynamin. Gorska, M.M., Cen, O., Liang, Q., Stafford, S.J., Alam, R. J. Biol. Chem. (2006)
- Selective inhibition of IL-5 receptor alpha-chain gene transcription by IL-5, IL-3, and granulocyte-macrophage colony-stimulating factor in human blood eosinophils. Wang, P., Wu, P., Cheewatrakoolpong, B., Myers, J.G., Egan, R.W., Billah, M.M. J. Immunol. (1998)
- Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils. Gounni, A.S., Gregory, B., Nutku, E., Aris, F., Latifa, K., Minshall, E., North, J., Tavernier, J., Levit, R., Nicolaides, N., Robinson, D., Hamid, Q. Blood (2000)
- Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains. Iwama, A., Pan, J., Zhang, P., Reith, W., Mach, B., Tenen, D.G., Sun, Z. Mol. Cell. Biol. (1999)
- JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization. Martinez-Moczygemba, M., Huston, D.P., Lei, J.T. J. Leukoc. Biol. (2007)
- Expression of interleukin-5 receptors on acute myeloid leukaemia cells: association with immunophenotype and karyotype. Nishii, K., Kita, K., Nadim, M., Miwa, H., Ohoishi, K., Yamaguchi, M., Shirakawa, S. Br. J. Haematol. (1995)
- The activation of the JAK2/STAT5 pathway is commonly involved in signaling through the human IL-5 receptor. Ogata, N., Kikuchi, Y., Kouro, T., Tomonaga, M., Takatsu, K. Int. Arch. Allergy Immunol. (1997)
- Characterization of critical residues in the cytoplasmic domain of the human interleukin-5 receptor alpha chain required for growth signal transduction. Cornelis, S., Fache, I., Van der Heyden, J., Guisez, Y., Tavernier, J., Devos, R., Fiers, W., Plaetinck, G. Eur. J. Immunol. (1995)
- The IL-5 receptor on human bronchus selectively primes for hyperresponsiveness. Rizzo, C.A., Yang, R., Greenfeder, S., Egan, R.W., Pauwels, R.A., Hey, J.A. J. Allergy Clin. Immunol. (2002)
- Interleukin-5 receptors on human lung eosinophils after segmental allergen challenge. Julius, P., Hochheim, D., Böser, K., Schmidt, S., Myrtek, D., Bachert, C., Luttmann, W., Virchow, J.C. Clin. Exp. Allergy (2004)
- Molecular cloning of the guinea-pig IL-5 receptor alpha and beta subunits and reconstitution of a high affinity receptor. Scott, C.W., Logsdon, N.J., Wilkins, D.E., Norris, T.E., Sobotka-Briner, C., Hubbs, S., Graham, A. Cytokine (2000)
- Monomeric isomers of human interleukin 5 show that 1:1 receptor recruitment is sufficient for function. Li, J., Cook, R., Doyle, M.L., Hensley, P., McNulty, D.E., Chaiken, I. Proc. Natl. Acad. Sci. U.S.A. (1997)