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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Animals, Newborn

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Disease relevance of Animals, Newborn


High impact information on Animals, Newborn


Chemical compound and disease context of Animals, Newborn


Biological context of Animals, Newborn


Anatomical context of Animals, Newborn

  • Finally, the sensitivity of the arterial baroreceptor reflex was evaluated by comparing the regression of pulse interval (PI) on systolic arterial pressure (SAP) after an intravenous dose of methoxamine in conscious, adult and newborn animals [21].
  • Whereas blood cell counts in adult PLSCR1(-/-) mice were normal, in both fetus and newborn animals neutrophil counts were significantly depressed relative to age-matched wild type (WT) [22].
  • Exposure of mitochondria to [3H]etomoxir (a covalent ligand for CPT I), followed by fluorographic analysis of the membrane proteins, established that while in the adult heart L-CPT I represents a very minor constituent, its contribution is much greater in the newborn animal [23].
  • When cultures were started from 9-day-old postnatal rat brain, fibronectin-positive astrocytes appeared earlier than in those from newborn animals, in all areas studied [24].
  • In the brains of newborn animals, however, additional benzodiazepine receptor subtypes seem to exist in cerebellum as well as in inferior colliculus [25].

Associations of Animals, Newborn with chemical compounds

  • The beta-actin isoform is predominant in fetal and newborn animals, but gradually the alpha-isoform becomes quantitatively the most important, as seen by bidimensional polyacrylamide gels [26].
  • The effects of enteric galactose alimentation on neonatal glucose turnover and hepatic glycogen synthesis were investigated in a newborn animal model of diabetic pregnancy [27].
  • Thymic androgen and estrogen receptors were determined; in the newborn animals up to 2 wk of age, receptor levels were barely detectable [28].
  • Taken together, these results indicate that PGHS-2 is the predominant form of prostaglandin G/H synthase in the newborn brain and cerebral microvasculature and the main contributor to the brain prostaglandin levels in the newborn animal [29].
  • Survival Rate (ratio of number of animals that survived 30 min under 5% O2 to total number of animals exposed) and the time from onset of exposure until the last gasp (Survival Time) were maximum in newborn animals and decreased as a function of age [30].

Gene context of Animals, Newborn

  • Beta-galactosidase activity in Dlx5+/- embryos and newborn animals reproduces the known pattern of expression of the gene [31].
  • BDNF is therefore required for expression of normal respiratory behavior in newborn animals [32].
  • In the lung, Tie1 expression increases markedly immediately prior to birth and rises further in the newborn animal, a pattern not found in other organs [33].
  • PAM expression was markedly higher in newborn animals, which accords well with the more elevated concentrations of ADM measured by RIA in newborn than adult rat thymuses [34].
  • These results thus showed that newborn animals were nonspecifically and tolerant animals specifically deficient in IL-2 production, but that IL-10 in neither case appeared to be responsible for this IL-2 hyporeactivity [35].

Analytical, diagnostic and therapeutic context of Animals, Newborn


  1. Sn-protoporphyrin inhibition of fetal and neonatal brain heme oxygenase. Transplacental passage of the metalloporphyrin and prenatal suppression of hyperbilirubinemia in the newborn animal. Drummond, G.S., Kappas, A. J. Clin. Invest. (1986) [Pubmed]
  2. Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage. Mårtensson, J., Steinherz, R., Jain, A., Meister, A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  3. Effect of capsaicin and resiniferatoxin on peptidergic neurons in cultured dorsal root ganglion. Jeftinija, S., Liu, F., Jeftinija, K., Urban, L. Regul. Pept. (1992) [Pubmed]
  4. Changes in the concentration of thyroxine in the plasma of rat fetuses during late gestation: influence of ligation of the maternal uterine vein and artery. Wrutniak, C., Cabello, G. J. Endocrinol. (1983) [Pubmed]
  5. Effect of hypoxia on mitochondrial mass and cytochrome concentrations in rat heart and liver during postnatal development. Kinnula, V.L., Hassinen, I. Acta Physiol. Scand. (1977) [Pubmed]
  6. Carnitine--metabolism and functions. Bremer, J. Physiol. Rev. (1983) [Pubmed]
  7. Human chorionic gonadotropin hormone prevents wasting syndrome and death in HIV-1 transgenic mice. De, S.K., Wohlenberg, C.R., Marinos, N.J., Doodnauth, D., Bryant, J.L., Notkins, A.L. J. Clin. Invest. (1997) [Pubmed]
  8. An experimental model of postnatal jaundice in the suckling rat. Suppression of induced hyperbilirubinemia by Sn-protoporphyrin. Drummond, G.S., Kappas, A. J. Clin. Invest. (1984) [Pubmed]
  9. Effects of melanotropic peptides on fetal adrenal gland. Rudman, D., Hollins, B.M., Lewis, N.C., Chawla, R.K. J. Clin. Invest. (1980) [Pubmed]
  10. Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptors. Nicoletti, F., Iadarola, M.J., Wroblewski, J.T., Costa, E. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  11. Alpha-lipoic acid prevents buthionine sulfoximine-induced cataract formation in newborn rats. Maitra, I., Serbinova, E., Trischler, H., Packer, L. Free Radic. Biol. Med. (1995) [Pubmed]
  12. Effects of graded doses of epinephrine during asphxia-induced bradycardia in newborn lambs. Burchfield, D.J., Preziosi, M.P., Lucas, V.W., Fan, J. Resuscitation. (1993) [Pubmed]
  13. Pretreatment with allopurinol in cardiac hypoxic-ischemic reperfusion injury in newborn lambs exerts its beneficial effect through afterload reduction. Shadid, M., Van Bel, F., Steendijk, P., Dorrepaal, C.A., Moison, R., Van der Velde, E.T., Baan, J. Basic Res. Cardiol. (1999) [Pubmed]
  14. Maturational changes in cerebral lactate and acid clearance following ischemia measured in vivo using magnetic resonance spectroscopy and microdialysis. Corbett, R., Laptook, A., Kim, B., Tollefsbol, G., Silmon, S., Garcia, D. Brain Res. Dev. Brain Res. (1999) [Pubmed]
  15. Adenosine in the immature kidney. Gouyon, J.B., Guignard, J.P. Developmental pharmacology and therapeutics. (1989) [Pubmed]
  16. Prevention of postasphyxia electroretinal dysfunction with a pyridoxal hydrazone. Bhattacharya, M., Ponka, P., Hardy, P., Hanna, N., Varma, D.R., Lachapelle, P., Chemtob, S. Free Radic. Biol. Med. (1997) [Pubmed]
  17. Segmental nephron sodium and potassium reabsorption in newborn and adult dogs during saline expansion. Kleinman, L.I., Banks, R.O. Proc. Soc. Exp. Biol. Med. (1983) [Pubmed]
  18. Up-regulation of brain PGE2 and PGF2 alpha receptors and receptor-coupled second messengers by cyclooxygenase inhibition in newborn pigs. Li, D.Y., Varma, D.R., Chemtob, S. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  19. Failure of the loop diuretic torasemide to improve renal function of hypoxemic vasomotor nephropathy in the newborn rabbit. Dubourg, L., Drukker, A., Guignard, J.P. Pediatr. Res. (2000) [Pubmed]
  20. Arginine vasopressin modulation of arterial baroreflex responses in fetal and newborn sheep. Nuyt, A.M., Segar, J.L., Holley, A.T., O'Mara, M.S., Chapleau, M.W., Robillard, J.E. Am. J. Physiol. (1996) [Pubmed]
  21. Depressed responsiveness to vasoconstrictor and dilator agents and baroreflex sensitivity in conscious, newborn lambs. Manders, W.T., Pagani, M., Vatner, S.F. Circulation (1979) [Pubmed]
  22. Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1. Zhou, Q., Zhao, J., Wiedmer, T., Sims, P.J. Blood (2002) [Pubmed]
  23. Mitochondrial carnitine palmitoyltransferase I isoform switching in the developing rat heart. Brown, N.F., Weis, B.C., Husti, J.E., Foster, D.W., McGarry, J.D. J. Biol. Chem. (1995) [Pubmed]
  24. Fibronectin is expressed by astrocytes cultured from embryonic and early postnatal rat brain. Liesi, P., Kirkwood, T., Vaheri, A. Exp. Cell Res. (1986) [Pubmed]
  25. Comparison of benzodiazepine receptors in cerebellum and inferior colliculus. Sieghart, W. J. Neurochem. (1986) [Pubmed]
  26. Cytoskeletal features of rat aortic cells during development. An electron microscopic, immunohistochemical, and biochemical study. Kocher, O., Skalli, O., Cerutti, D., Gabbiani, F., Gabbiani, G. Circ. Res. (1985) [Pubmed]
  27. Galactose assimilation in pups of diabetic canine mothers. Kliegman, R.M., Morton, S. Diabetes (1987) [Pubmed]
  28. Thymic sensitivity to sex hormones develops post-natally; an in vivo and an in vitro study. Barr, I.G., Pyke, K.W., Pearce, P., Toh, B.H., Funder, J.W. J. Immunol. (1984) [Pubmed]
  29. Prostaglandin G/H synthase-2 is a major contributor of brain prostaglandins in the newborn. Peri, K.G., Hardy, P., Li, D.Y., Varma, D.R., Chemtob, S. J. Biol. Chem. (1995) [Pubmed]
  30. Survival under hypoxia. Age dependence and effect of cholinergic drugs. Scremin, A.M., Scremin, O.U., Brechner, T. Stroke (1980) [Pubmed]
  31. Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5. Acampora, D., Merlo, G.R., Paleari, L., Zerega, B., Postiglione, M.P., Mantero, S., Bober, E., Barbieri, O., Simeone, A., Levi, G. Development (1999) [Pubmed]
  32. Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing. Erickson, J.T., Conover, J.C., Borday, V., Champagnat, J., Barbacid, M., Yancopoulos, G., Katz, D.M. J. Neurosci. (1996) [Pubmed]
  33. A unique pattern of Tie1 expression in the developing murine lung. Taichman, D.B., Schachtner, S.K., Li, Y., Puri, M.C., Bernstein, A., Scott Baldwin, H. Exp. Lung Res. (2003) [Pubmed]
  34. Differential expression of adrenomedullin and its receptors in newborn and adult rat thymus. Carraro, G., Albertin, G., Bova, S., Malendowicz, L.K., Belloni, A.S., Nussdorfer, G.G. Int. J. Mol. Med. (2002) [Pubmed]
  35. On the role of interleukin-10 in the induction and maintenance of specific transplantation tolerance. Holán, V., Kosarová, M., Lipoldová, M. Folia Biol. (Praha) (1994) [Pubmed]
  36. Functional consequences of a neutral pH in neonatal rat stratum corneum. Fluhr, J.W., Mao-Qiang, M., Brown, B.E., Hachem, J.P., Moskowitz, D.G., Demerjian, M., Haftek, M., Serre, G., Crumrine, D., Mauro, T.M., Elias, P.M., Feingold, K.R. J. Invest. Dermatol. (2004) [Pubmed]
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