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Gene Review

Lrp1  -  low density lipoprotein receptor-related...

Mus musculus

Synonyms: A2MR, A2mr, AI316852, Alpha-2-macroglobulin receptor, CD91, ...
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Disease relevance of Lrp1


Psychiatry related information on Lrp1


High impact information on Lrp1


Biological context of Lrp1


Anatomical context of Lrp1


Associations of Lrp1 with chemical compounds


Physical interactions of Lrp1


Regulatory relationships of Lrp1


Other interactions of Lrp1


Analytical, diagnostic and therapeutic context of Lrp1


  1. Low-density lipoprotein receptor-related protein contributes to the antiangiogenic activity of thrombospondin-2 in a murine glioma model. Fears, C.Y., Grammer, J.R., Stewart, J.E., Annis, D.S., Mosher, D.F., Bornstein, P., Gladson, C.L. Cancer Res. (2005) [Pubmed]
  2. Genetic deficiency in low density lipoprotein receptor-related protein confers cellular resistance to Pseudomonas exotoxin A. Evidence that this protein is required for uptake and degradation of multiple ligands. Willnow, T.E., Herz, J. J. Cell. Sci. (1994) [Pubmed]
  3. Two receptor systems are involved in the plasma clearance of tissue factor pathway inhibitor in vivo. Narita, M., Bu, G., Olins, G.M., Higuchi, D.A., Herz, J., Broze, G.J., Schwartz, A.L. J. Biol. Chem. (1995) [Pubmed]
  4. Activation of dendritic antigen-presenting cells expressing common heat shock protein receptor CD91 during induction of psoriasis. Boyman, O., Conrad, C., Dudli, C., Kielhorn, E., Nickoloff, B.J., Nestle, F.O. Br. J. Dermatol. (2005) [Pubmed]
  5. Low-density lipoprotein receptor-related protein polymorphisms in patients with elevated factor VIII coagulant activity and venous thrombosis. Cunningham, N., Laffan, M.A., Manning, R.A., O'Donnell, J.S. Blood Coagul. Fibrinolysis (2005) [Pubmed]
  6. The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing. Pietrzik, C.U., Busse, T., Merriam, D.E., Weggen, S., Koo, E.H. EMBO J. (2002) [Pubmed]
  7. Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. Zerbinatti, C.V., Wozniak, D.F., Cirrito, J., Cam, J.A., Osaka, H., Bales, K.R., Zhuo, M., Paul, S.M., Holtzman, D.M., Bu, G. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  8. LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation. Herz, J., Clouthier, D.E., Hammer, R.E. Cell (1992) [Pubmed]
  9. Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Wang, X., Lee, S.R., Arai, K., Lee, S.R., Tsuji, K., Rebeck, G.W., Lo, E.H. Nat. Med. (2003) [Pubmed]
  10. Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist. Willnow, T.E., Sheng, Z., Ishibashi, S., Herz, J. Science (1994) [Pubmed]
  11. CD91: a receptor for heat shock protein gp96. Binder, R.J., Han, D.K., Srivastava, P.K. Nat. Immunol. (2000) [Pubmed]
  12. Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development. Roebroek, A.J., Reekmans, S., Lauwers, A., Feyaerts, N., Smeijers, L., Hartmann, D. Mol. Cell. Biol. (2006) [Pubmed]
  13. Functional expression of murine LRP1 requires correction of Lrp1 cDNA sequences. Smeijers, L., Willems, S., Lauwers, A., Thiry, E., van Leuven, F., Roebroek, A.J. Biochim. Biophys. Acta (2002) [Pubmed]
  14. Regulation of Rac1 activation by the low density lipoprotein receptor-related protein. Ma, Z., Thomas, K.S., Webb, D.J., Moravec, R., Salicioni, A.M., Mars, W.M., Gonias, S.L. J. Cell Biol. (2002) [Pubmed]
  15. The low density lipoprotein receptor-related protein modulates protease activity in the brain by mediating the cellular internalization of both neuroserpin and neuroserpin-tissue-type plasminogen activator complexes. Makarova, A., Mikhailenko, I., Bugge, T.H., List, K., Lawrence, D.A., Strickland, D.K. J. Biol. Chem. (2003) [Pubmed]
  16. Low-density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor on murine peritoneal macrophages mediates the binding and catabolism of low-density lipoprotein. Wu, S.M., Pizzo, S.V. Arch. Biochem. Biophys. (1996) [Pubmed]
  17. Low density lipoprotein receptor-related protein mediates apolipoprotein E inhibition of smooth muscle cell migration. Swertfeger, D.K., Bu, G., Hui, D.Y. J. Biol. Chem. (2002) [Pubmed]
  18. Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development. Petersen, H.H., Hilpert, J., Jacobsen, C., Lauwers, A., Roebroek, A.J., Willnow, T.E. FEBS Lett. (2004) [Pubmed]
  19. The low-density lipoprotein receptor-related protein is a pro-survival receptor in schwann cells: possible implications in peripheral nerve injury. Campana, W.M., Li, X., Dragojlovic, N., Janes, J., Gaultier, A., Gonias, S.L. J. Neurosci. (2006) [Pubmed]
  20. The low density lipoprotein receptor-related protein complexes with cell surface heparan sulfate proteoglycans to regulate proteoglycan-mediated lipoprotein catabolism. Wilsie, L.C., Orlando, R.A. J. Biol. Chem. (2003) [Pubmed]
  21. Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein. Lorent, K., Overbergh, L., Moechars, D., De Strooper, B., Van Leuven, F., Van den Berghe, H. Neuroscience (1995) [Pubmed]
  22. Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). Su, H.P., Nakada-Tsukui, K., Tosello-Trampont, A.C., Li, Y., Bu, G., Henson, P.M., Ravichandran, K.S. J. Biol. Chem. (2002) [Pubmed]
  23. Two receptor systems are involved in the plasma clearance of tissue-type plasminogen activator (t-PA) in vivo. Narita, M., Bu, G., Herz, J., Schwartz, A.L. J. Clin. Invest. (1995) [Pubmed]
  24. Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment. Herz, J., Kowal, R.C., Goldstein, J.L., Brown, M.S. EMBO J. (1990) [Pubmed]
  25. Analysis of the binding of pro-urokinase and urokinase-plasminogen activator inhibitor-1 complex to the low density lipoprotein receptor-related protein using a Fab fragment selected from a phage-displayed Fab library. Horn, I.R., Moestrup, S.K., van den Berg, B.M., Pannekoek, H., Nielsen, M.S., van Zonneveld, A.J. J. Biol. Chem. (1995) [Pubmed]
  26. Adenovirus binding to blood factors results in liver cell infection and hepatotoxicity. Shayakhmetov, D.M., Gaggar, A., Ni, S., Li, Z.Y., Lieber, A. J. Virol. (2005) [Pubmed]
  27. Collagenase-3 binds to a specific receptor and requires the low density lipoprotein receptor-related protein for internalization. Barmina, O.Y., Walling, H.W., Fiacco, G.J., Freije, J.M., López-Otín, C., Jeffrey, J.J., Partridge, N.C. J. Biol. Chem. (1999) [Pubmed]
  28. The alpha -chains of C4b-binding protein mediate complex formation with low density lipoprotein receptor-related protein. Westein, E., Denis, C.V., Bouma, B.N., Lenting, P.J. J. Biol. Chem. (2002) [Pubmed]
  29. Identification of coagulation factor VIII A2 domain residues forming the binding epitope for low-density lipoprotein receptor-related protein. Sarafanov, A.G., Makogonenko, E.M., Pechik, I.V., Radtke, K.P., Khrenov, A.V., Ananyeva, N.M., Strickland, D.K., Saenko, E.L. Biochemistry (2006) [Pubmed]
  30. Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in ApoE/LDLR double knockout mice. Hu, L., Boesten, L.S., May, P., Herz, J., Bovenschen, N., Huisman, M.V., Berb??e, J.F., Havekes, L.M., van Vlijmen, B.J., Tamsma, J.T. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
  31. Apolipoprotein E binding to low density lipoprotein receptor-related protein-1 inhibits cell migration via activation of cAMP-dependent protein kinase A. Zhu, Y., Hui, D.Y. J. Biol. Chem. (2003) [Pubmed]
  32. Low density lipoprotein receptor-related protein-1 promotes beta1 integrin maturation and transport to the cell surface. Salicioni, A.M., Gaultier, A., Brownlee, C., Cheezum, M.K., Gonias, S.L. J. Biol. Chem. (2004) [Pubmed]
  33. IL-1beta down-regulates tissue-type plasminogen activator by up-regulating low-density lipoprotein receptor-related protein in AML 12 cells. Noguchi, T., Noguchi, M., Masubuchi, H., Seki, T., Ariga, T. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  34. LRP2/megalin is required for patterning of the ventral telencephalon. Spoelgen, R., Hammes, A., Anzenberger, U., Zechner, D., Andersen, O.M., Jerchow, B., Willnow, T.E. Development (2005) [Pubmed]
  35. Low density lipoprotein receptor-related protein is necessary for the internalization of both tissue-type plasminogen activator-inhibitor complexes and free tissue-type plasminogen activator. Orth, K., Willnow, T., Herz, J., Gething, M.J., Sambrook, J. J. Biol. Chem. (1994) [Pubmed]
  36. Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol. Espirito Santo, S.M., Pires, N.M., Boesten, L.S., Gerritsen, G., Bovenschen, N., van Dijk, K.W., Jukema, J.W., Princen, H.M., Bensadoun, A., Li, W.P., Herz, J., Havekes, L.M., van Vlijmen, B.J. Blood (2004) [Pubmed]
  37. Heparan sulfate-dependent and low density lipoprotein receptor-related protein-dependent catabolic pathways for lipoprotein lipase in mouse embryonic fibroblasts. Sehayek, E., Wang, X.X., Vlodavsky, I., Avner, R., Levkovitz, H., Olivecrona, T., Olivecrona, G., Willnow, T.E., Herz, J., Eisenberg, S. Isr. J. Med. Sci. (1996) [Pubmed]
  38. Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages. Misra, U.K., Gawdi, G., Pizzo, S.V. Arch. Biochem. Biophys. (1999) [Pubmed]
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