Gene Review:
Mertk - c-mer proto-oncogene tyrosine kinase
Mus musculus
Synonyms:
Eyk, Mer, Nyk, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, ...
- A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation. Sather, S., Kenyon, K.D., Lefkowitz, J.B., Liang, X., Varnum, B.C., Henson, P.M., Graham, D.K. Blood (2007)
- A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock. Camenisch, T.D., Koller, B.H., Earp, H.S., Matsushima, G.K. J. Immunol. (1999)
- An RCS-like retinal dystrophy phenotype in mer knockout mice. Duncan, J.L., LaVail, M.M., Yasumura, D., Matthes, M.T., Yang, H., Trautmann, N., Chappelow, A.V., Feng, W., Earp, H.S., Matsushima, G.K., Vollrath, D. Invest. Ophthalmol. Vis. Sci. (2003)
- Lymphoblastic leukemia/lymphoma in mice overexpressing the Mer (MerTK) receptor tyrosine kinase. Keating, A.K., Salzberg, D.B., Sather, S., Liang, X., Nickoloff, S., Anwar, A., Deryckere, D., Hill, K., Joung, D., Sawczyn, K.K., Park, J., Curran-Everett, D., McGavran, L., Meltesen, L., Gore, L., Johnson, G.L., Graham, D.K. Oncogene (2006)
- Phagocytosis and clearance of apoptotic cells is mediated by MER. Scott, R.S., McMahon, E.J., Pop, S.M., Reap, E.A., Caricchio, R., Cohen, P.L., Earp, H.S., Matsushima, G.K. Nature (2001)
- Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Lu, Q., Gore, M., Zhang, Q., Camenisch, T., Boast, S., Casagranda, F., Lai, C., Skinner, M.K., Klein, R., Matsushima, G.K., Earp, H.S., Goff, S.P., Lemke, G. Nature (1999)
- Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin. Nandrot, E.F., Kim, Y., Brodie, S.E., Huang, X., Sheppard, D., Finnemann, S.C. J. Exp. Med. (2004)
- The proximal cis-acting elements Sp1, Sp3 and E2F regulate mouse mer gene transcription in Sertoli cells. Wong, C.C., Lee, W.M. Eur. J. Biochem. (2002)
- Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases. Hafizi, S., Dahlbäck, B. Cytokine Growth Factor Rev. (2006)
- Mer receptor tyrosine kinase signaling: prevention of apoptosis and alteration of cytoskeletal architecture without stimulation or proliferation. Guttridge, K.L., Luft, J.C., Dawson, T.L., Kozlowska, E., Mahajan, N.P., Varnum, B., Earp, H.S. J. Biol. Chem. (2002)
- A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells. Wu, Y., Singh, S., Georgescu, M.M., Birge, R.B. J. Cell. Sci. (2005)
- AAV-Mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa. Smith, A.J., Schlichtenbrede, F.C., Tschernutter, M., Bainbridge, J.W., Thrasher, A.J., Ali, R.R. Mol. Ther. (2003)
- Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases. Caraux, A., Lu, Q., Fernandez, N., Riou, S., Di Santo, J.P., Raulet, D.H., Lemke, G., Roth, C. Nat. Immunol. (2006)
- Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum. Budagian, V., Bulanova, E., Orinska, Z., Duitman, E., Brandt, K., Ludwig, A., Hartmann, D., Lemke, G., Saftig, P., Bulfone-Paus, S. Mol. Cell. Biol. (2005)
- An SH2 domain-dependent, phosphotyrosine-independent interaction between Vav1 and the Mer receptor tyrosine kinase: a mechanism for localizing guanine nucleotide-exchange factor action. Mahajan, N.P., Earp, H.S. J. Biol. Chem. (2003)
- A tamoxifen-inducible chimeric Cre recombinase specifically effective in the fetal and adult mouse liver. Tannour-Louet, M., Porteu, A., Vaulont, S., Kahn, A., Vasseur-Cognet, M. Hepatology (2002)
- Tamoxifen-regulated adenoviral E1A chimeras for the control of tumor selective oncolytic adenovirus replication in vitro and in vivo. Sipo, I., Wang, X., Hurtado Picó, A., Suckau, L., Weger, S., Poller, W., Fechner, H. Gene Ther. (2006)
- The receptor tyrosine kinase MerTK activates phospholipase C gamma2 during recognition of apoptotic thymocytes by murine macrophages. Todt, J.C., Hu, B., Curtis, J.L. J. Leukoc. Biol. (2004)
- The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a phosphatidylinositol 3-kinase-dependent pathway. Shankar, S.L., O'Guin, K., Cammer, M., McMorris, F.A., Stitt, T.N., Basch, R.S., Varnum, B., Shafit-Zagardo, B. J. Neurosci. (2003)