Gene Review:
DUSP2 - dual specificity phosphatase 2
Homo sapiens
Synonyms:
Dual specificity protein phosphatase 2, Dual specificity protein phosphatase PAC-1, PAC-1, PAC1
- PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Rohan, P.J., Davis, P., Moskaluk, C.A., Kearns, M., Krutzsch, H., Siebenlist, U., Kelly, K. Science (1993)
- Characterization of a variant of PAC-1 in large granular lymphocyte leukemia. Kothapalli, R., Yoder, S.J., Kusmartseva, I., Loughran, T.P. Protein Expr. Purif. (2003)
- Tumor suppression and apoptosis of human prostate carcinoma mediated by a genetic locus within human chromosome 10pter-q11. Sanchez, Y., Lovell, M., Marin, M.C., Wong, P.E., Wolf-Ledbetter, M.E., McDonnell, T.J., Killary, A.M. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Detection of platelets activated during acetylcholine-induced coronary vasospasm. Inoue, T., Fujito, T., Hoshi, K., Sakai, Y., Morooka, S., Sohma, R. Thromb. Haemost. (1998)
- The PAC-1 dual specificity phosphatase predicts poor outcome in serous ovarian carcinoma. Givant-Horwitz, V., Davidson, B., Goderstad, J.M., Nesland, J.M., Tropé, C.G., Reich, R. Gynecol. Oncol. (2004)
- Activated platelets in transient global amnesia and TIA. Hirabayashi, H., Shimizu, M., Kohara, S., Shinohara, Y. Neurology (2004)
- PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression. Yin, Y., Liu, Y.X., Jin, Y.J., Hall, E.J., Barrett, J.C. Nature (2003)
- Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1. Ward, Y., Gupta, S., Jensen, P., Wartmann, M., Davis, R.J., Kelly, K. Nature (1994)
- Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells. Kersting, U., Kersting, D., Spring, K.R. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Platelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a low-molecular-weight heparin and with a direct thrombin inhibitor. Xiao, Z., Théroux, P. Circulation (1998)
- Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies. Ginsberg, M.H., Frelinger, A.L., Lam, S.C., Forsyth, J., McMillan, R., Plow, E.F., Shattil, S.J. Blood (1990)
- The high affinity alphaIIb beta3 integrin is involved in invasion of human melanoma cells. Trikha, M., Timar, J., Lundy, S.K., Szekeres, K., Cai, Y., Porter, A.T., Honn, K.V. Cancer Res. (1997)
- Induction of the fibrinogen receptor on human platelets by intracellular mediators. Shattil, S.J., Brass, L.F. J. Biol. Chem. (1987)
- Genomic organization and chromosomal localization of the DUSP2 gene, encoding a MAP kinase phosphatase, to human 2p11.2-q11. Yi, H., Morton, C.C., Weremowicz, S., McBride, O.W., Kelly, K. Genomics (1995)
- Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosis. Franklin, C.C., Srikanth, S., Kraft, A.S. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1. Jeffrey, K.L., Brummer, T., Rolph, M.S., Liu, S.M., Callejas, N.A., Grumont, R.J., Gillieron, C., Mackay, F., Grey, S., Camps, M., Rommel, C., Gerondakis, S.D., Mackay, C.R. Nat. Immunol. (2006)
- A point mutation in the cysteine-rich domain of glycoprotein (GP) IIIa results in the expression of a GPIIb-IIIa (alphaIIbbeta3) integrin receptor locked in a high-affinity state and a Glanzmann thrombasthenia-like phenotype. Ruiz, C., Liu, C.Y., Sun, Q.H., Sigaud-Fiks, M., Fressinaud, E., Muller, J.Y., Nurden, P., Nurden, A.T., Newman, P.J., Valentin, N. Blood (2001)
- Differential regulation of the dual-specificity protein-tyrosine phosphatases CL100, B23, and PAC1 in mesangial cells. Bokemeyer, D., Sorokin, A., Dunn, M.J. J. Am. Soc. Nephrol. (1997)
- Effect of nitroxyl on human platelets function. Bermejo, E., Sáenz, D.A., Alberto, F., Rosenstein, R.E., Bari, S.E., Lazzari, M.A. Thromb. Haemost. (2005)
- Stimulated Glanzmann's thrombasthenia platelets produced microvesicles. Microvesiculation correlates better to exposure of procoagulant surface than to activation of GPIIb-IIIa. Holme, P.A., Solum, N.O., Brosstad, F., Egberg, N., Lindahl, T.L. Thromb. Haemost. (1995)
- Combined defect in membrane expression and activation of platelet GPIIb--IIIa complex without primary sequence abnormalities in myeloproliferative disease. Kaplan, R., Gabbeta, J., Sun, L., Mao, G.F., Rao, A.K. Br. J. Haematol. (2000)
- Relationship between the expression levels of CD61, CD63, and PAC-1 on platelet surface in peripheral blood and the transplanted kidney function. Zhang, Y., Guan, D.L., Xia, C.Q., Han, Z.Y., Xu, J.J., Gao, J.Z., Wu, K.R., Zhang, Y.G., Guan, D. Transplant. Proc. (2003)
- Platelet GPIIb/IIIa is activated and platelet-leukocyte coaggregates formed in vivo during hemodialysis. Kawabata, K., Nakai, S., Miwa, M., Sugiura, T., Otsuka, Y., Shinzato, T., Hiki, Y., Tomimatsu, I., Ushida, Y., Hosono, F., Maeda, K. Nephron (2002)
- A new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg----214Trp mutation. Lanza, F., Stierlé, A., Fournier, D., Morales, M., André, G., Nurden, A.T., Cazenave, J.P. J. Clin. Invest. (1992)
- Activation of platelets in blood perfusing angioplasty-damaged coronary arteries. Flow cytometric detection. Scharf, R.E., Tomer, A., Marzec, U.M., Teirstein, P.S., Ruggeri, Z.M., Harker, L.A. Arterioscler. Thromb. (1992)
- Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation. Shattil, S.J., Hoxie, J.A., Cunningham, M., Brass, L.F. J. Biol. Chem. (1985)