Gene Review:
AGXT - alanine-glyoxylate aminotransferase
Homo sapiens
Synonyms:
AGT, AGT1, AGXT1, Alanine--glyoxylate aminotransferase, PH1, ...
- Primary hyperoxaluria type 1 in the Canary Islands: a conformational disease due to I244T mutation in the P11L-containing alanine:glyoxylate aminotransferase. Santana, A., Salido, E., Torres, A., Shapiro, L.J. Proc. Natl. Acad. Sci. U.S.A. (2003)
- The molecular basis of kidney stones. Langman, C.B. Curr. Opin. Pediatr. (2004)
- Novel mutations of the AGXT gene causing primary hyperoxaluria type 1. Yuen, Y.P., Lai, C.K., Tong, G.M., Wong, P.N., Wong, F.K., Mak, S.K., Lo, K.Y., Wong, A.K., Tong, S.F., Chan, Y.W., Lam, C.W. J. Nephrol. (2004)
- Alanine-glyoxylate aminotransferase-deficient mice, a model for primary hyperoxaluria that responds to adenoviral gene transfer. Salido, E.C., Li, X.M., Lu, Y., Wang, X., Santana, A., Roy-Chowdhury, N., Torres, A., Shapiro, L.J., Roy-Chowdhury, J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Overexpression of human alanine:glyoxylate aminotransferase in Escherichia coli: renaturation from guanidine-HCl and affinity for pyridoxal phosphate co-factor. Coulter-Mackie, M.B., Lian, Q., Wong, S.G. Protein Expr. Purif. (2005)
- The relationship of alcohol consumption to total immunoglobulin E and the development of immunoglobulin E sensitization: the Copenhagen Allergy Study. Linneberg, A., Petersen, J., Nielsen, N.H., Madsen, F., Frølund, L., Dirksen, A., Jørgensen, T. Clin. Exp. Allergy (2003)
- Evolution of alanine:glyoxylate aminotransferase 1 peroxisomal and mitochondrial targeting. A survey of its subcellular distribution in the livers of various representatives of the classes Mammalia, Aves and Amphibia. Danpure, C.J., Fryer, P., Jennings, P.R., Allsop, J., Griffiths, S., Cunningham, A. Eur. J. Cell Biol. (1994)
- A memory assessment technique for use in geriatric psychopharmacology: drug efficacy trial with naftidrofuryl. Branconnier, R.J., Cole, J.O. Journal of the American Geriatrics Society. (1977)
- Enactment enhances integration between verb and noun, but not relational processing, in episodic memory. von Essen, J.D. Scandinavian journal of psychology. (2005)
- Geographic variation of p53 mutational profile in nonmalignant human liver. Aguilar, F., Harris, C.C., Sun, T., Hollstein, M., Cerutti, P. Science (1994)
- In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning. Zielske, S.P., Reese, J.S., Lingas, K.T., Donze, J.R., Gerson, S.L. J. Clin. Invest. (2003)
- The serum angiotensinogen concentration and variants of the angiotensinogen gene in white and black children. Bloem, L.J., Manatunga, A.K., Tewksbury, D.A., Pratt, J.H. J. Clin. Invest. (1995)
- Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease. Tada, M., Ohashi, M., Shiratori, Y., Okudaira, T., Komatsu, Y., Kawabe, T., Yoshida, H., Machinami, R., Kishi, K., Omata, M. Gastroenterology (1996)
- Point mutation of K-ras gene codon 12 in biliary tract tumors. Watanabe, M., Asaka, M., Tanaka, J., Kurosawa, M., Kasai, M., Miyazaki, T. Gastroenterology (1994)
- AGXT gene mutations and their influence on clinical heterogeneity of type 1 primary hyperoxaluria. Amoroso, A., Pirulli, D., Florian, F., Puzzer, D., Boniotto, M., Crovella, S., Zezlina, S., Spanò, A., Mazzola, G., Savoldi, S., Ferrettini, C., Berutti, S., Petrarulo, M., Marangella, M. J. Am. Soc. Nephrol. (2001)
- Detection of AGXT bgene mutations by denaturing high-performance liquid chromatography for diagnosis of hyperoxaluria type 1. Pirulli, D., Giordano, M., Lessi, M., Spanò, A., Puzzer, D., Zezlina, S., Boniotto, M., Crovella, S., Florian, F., Marangella, M., Momigliano-Richiardi, P., Savoldi, S., Amoroso, A. Clin. Exp. Med. (2001)
- Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1. Purdue, P.E., Takada, Y., Danpure, C.J. J. Cell Biol. (1990)
- Functional synergism between the most common polymorphism in human alanine:glyoxylate aminotransferase and four of the most common disease-causing mutations. Lumb, M.J., Danpure, C.J. J. Biol. Chem. (2000)
- ATP-dependent degradation of a mutant serine: pyruvate/alanine:glyoxylate aminotransferase in a primary hyperoxaluria type 1 case. Nishiyama, K., Funai, T., Yokota, S., Ichiyama, A. J. Cell Biol. (1993)
- Primary hyperoxaluria type 1: a cluster of new mutations in exon 7 of the AGXT gene. von Schnakenburg, C., Rumsby, G. J. Med. Genet. (1997)
- Molecular analysis of hyperoxaluria type 1 in Italian patients reveals eight new mutations in the alanine: glyoxylate aminotransferase gene. Pirulli, D., Puzzer, D., Ferri, L., Crovella, S., Amoroso, A., Ferrettini, C., Marangella, M., Mazzola, G., Florian, F. Hum. Genet. (1999)
- The mouse alanine:glyoxylate aminotransferase gene (Agxt1): cloning, expression, and mapping to chromosome 1. Li, X.M., Salido, E.C., Shapiro, L.J. Somat. Cell Mol. Genet. (1999)
- Enzymological and mutational analysis of a complex primary hyperoxaluria type 1 phenotype involving alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting and intraperoxisomal aggregation. Danpure, C.J., Purdue, P.E., Fryer, P., Griffiths, S., Allsop, J., Lumb, M.J., Guttridge, K.M., Jennings, P.R., Scheinman, J.I., Mauer, S.M. Am. J. Hum. Genet. (1993)
- The peroxisomal targeting sequence type 1 receptor, Pex5p, and the peroxisomal import efficiency of alanine:glyoxylate aminotransferase. Knott, T.G., Birdsey, G.M., Sinclair, K.E., Gallagher, I.M., Purdue, P.E., Danpure, C.J. Biochem. J. (2000)
- Characterization and chromosomal mapping of a genomic clone encoding human alanine:glyoxylate aminotransferase. Purdue, P.E., Lumb, M.J., Fox, M., Griffo, G., Hamon-Benais, C., Povey, S., Danpure, C.J. Genomics (1991)
- Primary hyperoxaluria type 1 and peroxisome-to-mitochondrion mistargeting of alanine:glyoxylate aminotransferase. Danpure, C.J. Biochimie (1993)
- Biochemical and genetic diagnosis of the primary hyperoxalurias: a review. Rumsby, G. Molecular urology. (2000)
- Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1. Zhang, X., Roe, S.M., Hou, Y., Bartlam, M., Rao, Z., Pearl, L.H., Danpure, C.J. J. Mol. Biol. (2003)
- Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide. Kanzawa, T., Germano, I.M., Kondo, Y., Ito, H., Kyo, S., Kondo, S. Br. J. Cancer (2003)
- A glycine-to-glutamate substitution abolishes alanine:glyoxylate aminotransferase catalytic activity in a subset of patients with primary hyperoxaluria type 1. Purdue, P.E., Lumb, M.J., Allsop, J., Minatogawa, Y., Danpure, C.J. Genomics (1992)
- Peroxisomal import of human alanine:glyoxylate aminotransferase requires ancillary targeting information remote from its C terminus. Huber, P.A., Birdsey, G.M., Lumb, M.J., Prowse, D.T., Perkins, T.J., Knight, D.R., Danpure, C.J. J. Biol. Chem. (2005)
- Evaluation of mutation screening as a first line test for the diagnosis of the primary hyperoxalurias. Rumsby, G., Williams, E., Coulter-Mackie, M. Kidney Int. (2004)
- Identification of a novel splice site mutation of CLCN5 gene and characterization of a new alternative 5' UTR end of ClC-5 mRNA in human renal tissue and leukocytes. Forino, M., Graziotto, R., Tosetto, E., Gambaro, G., D'Angelo, A., Anglani, F. J. Hum. Genet. (2004)
- Site-specific oxidation of angiotensin I by copper(II) and L-ascorbate: conversion of histidine residues to 2-imidazolones. Uchida, K., Kawakishi, S. Arch. Biochem. Biophys. (1990)
- Rates of evolution of pyridoxal-5'-phosphate-dependent enzymes. Salzmann, D., Christen, P., Mehta, P.K., Sandmeier, E. Biochem. Biophys. Res. Commun. (2000)
- Presentation and role of transplantation in adult patients with type 1 primary hyperoxaluria and the I244T AGXT mutation: Single-center experience. Lorenzo, V., Alvarez, A., Torres, A., Torregrosa, V., Hernández, D., Salido, E. Kidney Int. (2006)
- Polymorphisms in the alanine:glyoxylate aminotransferase gene and their application to the prenatal diagnosis of primary hyperoxaluria type 1. Rumsby, G., Mandel, H., Avey, C., Geraerts, A. Nephrol. Dial. Transplant. (1995)
- Molecular analysis of the AGXT gene in Italian patients with primary hyperoxaluria type 1 (PH1). Ferrettini, C., Pirulli, D., Cosseddu, D., Marangella, M., Petrarulo, M., Mazzola, G., Vatta, S., Amoroso, A. J. Nephrol. (1998)
- Enzymological diagnosis of primary hyperoxaluria type 1 by measurement of hepatic alanine: glyoxylate aminotransferase activity. Danpure, C.J., Jennings, P.R., Watts, R.W. Lancet (1987)