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Gene Review

Sstr1  -  somatostatin receptor 1

Mus musculus

Synonyms: SRIF-2, SS-1-R, SS1-R, SS1R, Smstr-1, ...
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Disease relevance of Sstr1


High impact information on Sstr1


Chemical compound and disease context of Sstr1


Biological context of Sstr1


Anatomical context of Sstr1

  • Among them, the sst1 receptor has been localised to SRIF-containing amacrine cells in the rat and rabbit retina [16].
  • [125I]-Tyr0-DTrp8-SRIF14 binding was not significantly modified in sst1 KO mouse brain with the noticeable exception of the substantia nigra and only moderately decreased in pituitary [17].
  • Radioligand binding studies were performed in CCL39 cells expressing the five human recombinant receptors and compared to binding in membranes of rat cerebral cortex with [125I]Tyr11-SRIF14 which in the presence of 120 mM labels primarily sst1 receptor as suggested by the better correlation hsst1 and similar rank order of potency [18].
  • In the whole hippocampus of sst1 KO mice, sst2 mRNA, protein and binding are higher than in WT and reverse transcription-polymerase chain reaction of the CA3 subarea confirms an increase of the sst2 messenger [19].
  • Activation in vitro of somatostatin receptor subtypes 2, 3, or 4 stimulates protein tyrosine phosphatase activity in membranes from transfected Ras-transformed NIH 3T3 cells: coexpression with catalytically inactive SHP-2 blocks responsiveness [20].

Associations of Sstr1 with chemical compounds


Physical interactions of Sstr1


Regulatory relationships of Sstr1


Other interactions of Sstr1


Analytical, diagnostic and therapeutic context of Sstr1


  1. Receptor-mediated internalization is critical for the inhibition of the expression of growth hormone by somatostatin in the pituitary cell line AtT-20. Sarret, P., Nouel, D., Dal Farra, C., Vincent, J.P., Beaudet, A., Mazella, J. J. Biol. Chem. (1999) [Pubmed]
  2. T lymphocytes isolated from the hepatic granulomas of schistosome-infected mice express somatostatin receptor subtype II (SSTR2) messenger RNA. Elliott, D.E., Metwali, A., Blum, A.M., Sandor, M., Lynch, R., Weinstock, J.V. J. Immunol. (1994) [Pubmed]
  3. Human ovarian cancers express somatostatin receptors. Halmos, G., Sun, B., Schally, A.V., Hebert, F., Nagy, A. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  4. Antitumor effect of in vivo somatostatin receptor subtype 2 gene transfer in primary and metastatic pancreatic cancer models. Vernejoul, F., Faure, P., Benali, N., Calise, D., Tiraby, G., Pradayrol, L., Susini, C., Buscail, L. Cancer Res. (2002) [Pubmed]
  5. Hormone inhibition of adenylyl cyclase. Differences in the mechanisms for inhibition by hormones and G protein beta gamma. Hildebrandt, J.D., Kohnken, R.E. J. Biol. Chem. (1990) [Pubmed]
  6. High basal gastric acid secretion in somatostatin receptor subtype 2 knockout mice. Martinez, V., Curi, A.P., Torkian, B., Schaeffer, J.M., Wilkinson, H.A., Walsh, J.H., Taché, Y. Gastroenterology (1998) [Pubmed]
  7. Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Yasuda, K., Raynor, K., Kong, H., Breder, C.D., Takeda, J., Reisine, T., Bell, G.I. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  8. Molecular cloning and functional expression of a brain-specific somatostatin receptor. Bruno, J.F., Xu, Y., Song, J., Berelowitz, M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  9. Somatostatin receptor type 5 modulates somatostatin receptor type 2 regulation of adrenocorticotropin secretion. Ben-Shlomo, A., Wawrowsky, K.A., Proekt, I., Wolkenfeld, N.M., Ren, S.G., Taylor, J., Culler, M.D., Melmed, S. J. Biol. Chem. (2005) [Pubmed]
  10. Somatostatin receptor subtypes sst1 and sst2 elicit opposite effects on the response to glutamate of mouse hypothalamic neurones: an electrophysiological and single cell RT-PCR study. Lanneau, C., Viollet, C., Faivre-Bauman, A., Loudes, C., Kordon, C., Epelbaum, J., Gardette, R. Eur. J. Neurosci. (1998) [Pubmed]
  11. Somatostatin coupling to adenylyl cyclase activity in the mouse retina. Pavan, B., Fiorini, S., Dal Monte, M., Lunghi, L., Biondi, C., Bagnoli, P., Cervia, D. Naunyn Schmiedebergs Arch. Pharmacol. (2004) [Pubmed]
  12. Somatostatin activates two types of inwardly rectifying K+ channels in MIN-6 cells. Smith, P.A., Sellers, L.A., Humphrey, P.P. J. Physiol. (Lond.) (2001) [Pubmed]
  13. Localization of somatostatin receptor genes on mouse chromosomes 2, 11, 12, 15, and 17: correlation with growth QTLs. Brinkmeier, M.L., Camper, S.A. Genomics (1997) [Pubmed]
  14. MicroPET imaging of gene transfer with a somatostatin receptor-based reporter gene and (94m)Tc-Demotate 1. Rogers, B.E., Parry, J.J., Andrews, R., Cordopatis, P., Nock, B.A., Maina, T. J. Nucl. Med. (2005) [Pubmed]
  15. The effect of thyroid hormone and a long-acting somatostatin analogue on TtT-97 murine thyrotropic tumors. Woodmansee, W.W., Gordon, D.F., Dowding, J.M., Stolz, B., Lloyd, R.V., James, R.A., Wood, W.M., Ridgway, E.C. Thyroid (2000) [Pubmed]
  16. Genetic deletion of somatostatin receptor 1 alters somatostatinergic transmission in the mouse retina. Dal Monte, M., Petrucci, C., Vasilaki, A., Cervia, D., Grouselle, D., Epelbaum, J., Kreienkamp, H.J., Richter, D., Hoyer, D., Bagnoli, P. Neuropharmacology (2003) [Pubmed]
  17. Characterisation of [125I]-Tyr0DTrp8-somatostatin binding in sst1- to sst4- and SRIF-gene-invalidated mouse brain. Videau, C., Hochgeschwender, U., Kreienkamp, H.J., Brennan, M.B., Viollet, C., Richter, D., Epelbaum, J. Naunyn Schmiedebergs Arch. Pharmacol. (2003) [Pubmed]
  18. Distribution and characterisation of somatostatin receptor mRNA and binding sites in the brain and periphery. Fehlmann, D., Langenegger, D., Schuepbach, E., Siehler, S., Feuerbach, D., Hoyer, D. J. Physiol. Paris (2000) [Pubmed]
  19. Somatostatin receptors differentially affect spontaneous epileptiform activity in mouse hippocampal slices. Cammalleri, M., Cervia, D., Langenegger, D., Liu, Y., Dal Monte, M., Hoyer, D., Bagnoli, P. Eur. J. Neurosci. (2004) [Pubmed]
  20. Activation in vitro of somatostatin receptor subtypes 2, 3, or 4 stimulates protein tyrosine phosphatase activity in membranes from transfected Ras-transformed NIH 3T3 cells: coexpression with catalytically inactive SHP-2 blocks responsiveness. Reardon, D.B., Dent, P., Wood, S.L., Kong, T., Sturgill, T.W. Mol. Endocrinol. (1997) [Pubmed]
  21. Mutation of an aspartate at residue 89 in somatostatin receptor subtype 2 prevents Na+ regulation of agonist binding but does not alter receptor-G protein association. Kong, H., Raynor, K., Yasuda, K., Bell, G.I., Reisine, T. Mol. Pharmacol. (1993) [Pubmed]
  22. Analgesic effects of the somatostatin sst4 receptor selective agonist J-2156 in acute and chronic pain models. Sándor, K., Elekes, K., Szabó, A., Pintér, E., Engström, M., Wurster, S., Szolcsányi, J., Helyes, Z. Eur. J. Pharmacol. (2006) [Pubmed]
  23. Preclinical comparison in AR4-2J tumor-bearing mice of four radiolabeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-somatostatin analogs for tumor diagnosis and internal radiotherapy. Froidevaux, S., Heppeler, A., Eberle, A.N., Meier, A.M., Häusler, M., Beglinger, C., Béhé, M., Powell, P., Mäcke, H.R. Endocrinology (2000) [Pubmed]
  24. Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis. Strowski, M.Z., Kohler, M., Chen, H.Y., Trumbauer, M.E., Li, Z., Szalkowski, D., Gopal-Truter, S., Fisher, J.K., Schaeffer, J.M., Blake, A.D., Zhang, B.B., Wilkinson, H.A. Mol. Endocrinol. (2003) [Pubmed]
  25. Cortistatin radioligand binding in wild-type and somatostatin receptor-deficient mouse brain. Spier, A.D., Fabre, V., de Lecea, L. Regul. Pept. (2005) [Pubmed]
  26. A tyrosine phosphatase is associated with the somatostatin receptor. Delesque, N., Buscail, L., Estève, J.P., Rauly, I., Zeggari, M., Saint-Laurent, N., Bell, G.I., Schally, A.V., Vaysse, N., Susini, C. Ciba Found. Symp. (1995) [Pubmed]
  27. Role of amphiphysin II in somatostatin receptor trafficking in neuroendocrine cells. Sarret, P., Esdaile, M.J., McPherson, P.S., Schonbrunn, A., Kreienkamp, H.J., Beaudet, A. J. Biol. Chem. (2004) [Pubmed]
  28. Gi alpha 3 and G(o) alpha selectively associate with the cloned somatostatin receptor subtype SSTR2. Law, S.F., Yasuda, K., Bell, G.I., Reisine, T. J. Biol. Chem. (1993) [Pubmed]
  29. SSTR2A is the dominant somatostatin receptor subtype expressed by inflammatory cells, is widely expressed and directly regulates T cell IFN-gamma release. Elliott, D.E., Li, J., Blum, A.M., Metwali, A., Patel, Y.C., Weinstock, J.V. Eur. J. Immunol. (1999) [Pubmed]
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