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Gene Review

Lipc  -  lipase, hepatic

Rattus norvegicus

Synonyms: HL, Hepatic lipase, Hepatic triacylglycerol lipase, Lipase member C
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Disease relevance of Lipc


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Chemical compound and disease context of Lipc


Biological context of Lipc


Anatomical context of Lipc


Associations of Lipc with chemical compounds


Physical interactions of Lipc


Enzymatic interactions of Lipc


Regulatory relationships of Lipc


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Analytical, diagnostic and therapeutic context of Lipc


  1. Abnormalities in hepatic lipase in chronic renal failure: role of excess parathyroid hormone. Klin, M., Smogorzewski, M., Ni, Z., Zhang, G., Massry, S.G. J. Clin. Invest. (1996) [Pubmed]
  2. Accelerated lipoprotein uptake by transplantable hepatomas that express hepatic lipase. Donner, C., Choi, S., Komaromy, M., Cooper, A.D. J. Lipid Res. (1998) [Pubmed]
  3. Metabolic consequences of hypoxia from birth and dexamethasone treatment in the neonatal rat: comprehensive hepatic lipid and fatty acid profiling. Bruder, E.D., Lee, P.C., Raff, H. Endocrinology (2004) [Pubmed]
  4. Role of secondary hyperparathyroidism in the genesis of hypertriglyceridemia and VLDL receptor deficiency in chronic renal failure. Liang, K., Oveisi, F., Vaziri, N.D. Kidney Int. (1998) [Pubmed]
  5. Down-regulation of hepatic lipase expression in experimental nephrotic syndrome. Liang, K., Vaziri, N.D. Kidney Int. (1997) [Pubmed]
  6. Catabolism of very low density lipoproteins in experimental nephrosis. Garber, D.W., Gottlieb, B.A., Marsh, J.B., Sparks, C.E. J. Clin. Invest. (1984) [Pubmed]
  7. Effects of heparin and low molecular weight heparin on lipid transport during parenteral feeding in the rat. Roth, B., Ekelund, M., Fan, B.G., Ekstrom, U., Nilsson-Ehle, P. Acta anaesthesiologica Scandinavica. (1996) [Pubmed]
  8. Growth hormone normalizes hepatic lipase in hypothyroid rat liver. Hoogerbrugge, N., Jansen, H., Staels, B., Seip, M.J., Birkenhäger, J.C. Metab. Clin. Exp. (1993) [Pubmed]
  9. Heparin decreases the degradation rate of hepatic lipase in Fu5AH rat hepatoma cells. A model for hepatic lipase efflux from hepatocytes. Cisar, L.A., Melford, K.H., Sensel, M., Bensadoun, A. Biochim. Biophys. Acta (1989) [Pubmed]
  10. Interactions of ethanol with cyclic AMP. Volicer, L., Gold, B.I. Adv. Exp. Med. Biol. (1975) [Pubmed]
  11. Cloning of rat hepatic lipase cDNA: evidence for a lipase gene family. Komaromy, M.C., Schotz, M.C. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  12. Isolation and characterization of clones for the rat hepatic lipase gene upstream regulatory region. Sensel, M.G., Legrand-Lorans, A., Wang, M.E., Bensadoun, A. Biochim. Biophys. Acta (1990) [Pubmed]
  13. Plasma 1-palmitoyl-2-linoleoyl phosphatidylcholine. Evidence for extensive phospholipase A1 hydrolysis and hepatic metabolism of the products. Scagnelli, G.P., Cooper, P.S., VandenBroek, J.M., Berman, W.F., Schwartz, C.C. J. Biol. Chem. (1991) [Pubmed]
  14. Hepatic lipase: site-directed mutagenesis of a serine residue important for catalytic activity. Davis, R.C., Stahnke, G., Wong, H., Doolittle, M.H., Ameis, D., Will, H., Schotz, M.C. J. Biol. Chem. (1990) [Pubmed]
  15. Association of hepatic lipase with proteoglycans stimulates the production of proteoglycans in vivo and in vitro. Lee, S.J., Kadambi, S., David, C., Cooper, A.D., Choi, S.Y. J. Lipid Res. (2004) [Pubmed]
  16. Hepatic lipase in the rat ovary. Ovaries cannot synthesize hepatic lipase but accumulate it from the circulation. Hixenbaugh, E.A., Sullivan, T.R., Strauss, J.F., Laposata, E.A., Komaromy, M., Paavola, L.G. J. Biol. Chem. (1989) [Pubmed]
  17. Hepatic lipase. Synthesis, processing, and secretion by isolated rat hepatocytes. Laposata, E.A., Laboda, H.M., Glick, J.M., Strauss, J.F. J. Biol. Chem. (1987) [Pubmed]
  18. Dietary grape seed tannins affect lipoproteins, lipoprotein lipases and tissue lipids in rats fed hypercholesterolemic diets. Tebib, K., Besançon, P., Rouanet, J.M. J. Nutr. (1994) [Pubmed]
  19. Inactive hepatic lipase in rat plasma. Galan, X., Peinado-Onsurbe, J., Julve, J., Ricart-Jané, D., Robert, M.Q., Llobera, M., Ramírez, I. J. Lipid Res. (2003) [Pubmed]
  20. Pathogenesis of hepatic steatosis in the parenterally fed rat. Hall, R.I., Grant, J.P., Ross, L.H., Coleman, R.A., Bozovic, M.G., Quarfordt, S.H. J. Clin. Invest. (1984) [Pubmed]
  21. Hepatic lipase hydrolysis of lipid monolayers. Regulation by apolipoproteins. Thuren, T., Wilcox, R.W., Sisson, P., Waite, M. J. Biol. Chem. (1991) [Pubmed]
  22. Intracellular activation of rat hepatic lipase requires transport to the Golgi compartment and is associated with a decrease in sedimentation velocity. Verhoeven, A.J., Neve, B.P., Jansen, H. J. Biol. Chem. (2000) [Pubmed]
  23. Chylomicron remnants: hepatic receptors and metabolism. Havel, R.J. Curr. Opin. Lipidol. (1995) [Pubmed]
  24. Activation of hepatic lipase catalyzed phosphatidylcholine hydrolysis by apolipoprotein E. Thuren, T., Sisson, P., Waite, M. Biochim. Biophys. Acta (1991) [Pubmed]
  25. Secretion of rat hepatic lipase is blocked by inhibition of oligosaccharide processing at the stage of glucosidase I. Verhoeven, A.J., Jansen, H. J. Lipid Res. (1990) [Pubmed]
  26. Rat plasma VLDL composition and concentration and hepatic lipase and lipoprotein lipase activities are impaired during two types of protein malnutrition and unaffected by balanced refeeding. Lamri, M.Y., Meghelli-Bouchenak, M., Boualga, A., Belleville, J., Prost, J. J. Nutr. (1995) [Pubmed]
  27. Stimulatory release of hepatic lipase activity from liver by epidermal growth factor. Morita, T., Mikami, F., Kanagawa, A., Ueki, H. Biol. Pharm. Bull. (1993) [Pubmed]
  28. Enhanced insulin secretion and cholesterol metabolism in congenic strains of the spontaneously diabetic (Type 2) Goto Kakizaki rat are controlled by independent genetic loci in rat chromosome 8. Wallis, R.H., Wallace, K.J., Collins, S.C., McAteer, M., Argoud, K., Bihoreau, M.T., Kaisaki, P.J., Gauguier, D. Diabetologia (2004) [Pubmed]
  29. Differences in the mechanisms of uptake and endocytosis of small and large chylomicron remnants by rat liver. Windler, E., Greeve, J., Robenek, H., Rinninger, F., Greten, H., Jäckle, S. Hepatology (1996) [Pubmed]
  30. Serine phospholipid-specific phospholipase A that is secreted from activated platelets. A new member of the lipase family. Sato, T., Aoki, J., Nagai, Y., Dohmae, N., Takio, K., Doi, T., Arai, H., Inoue, K. J. Biol. Chem. (1997) [Pubmed]
  31. Removal of chylomicron remnants in transgenic mice overexpressing normal and membrane-anchored hepatic lipase. Lee, S.J., Kadambi, S., Yu, K.C., David, C., Azhar, S., Cooper, A.D., Choi, S.Y. J. Lipid Res. (2005) [Pubmed]
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