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Chemical Compound Review

AC1O3DBE     methyl(1R,2R,6S)-9- (hydroxymethyl)-2-[(2S...

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Disease relevance of Geniposide


Psychiatry related information on Geniposide


High impact information on Geniposide


Chemical compound and disease context of Geniposide


Biological context of Geniposide


Anatomical context of Geniposide


Associations of Geniposide with other chemical compounds


Gene context of Geniposide

  • The results suggest that geniposide induced GST activity and the expression of GST M1 and GST M2 acting through MEK-1 pathway by activating and increasing expression of Ras/Raf/MEK-1 signaling mediators [6].
  • Apoptosis induced by penta-acetyl geniposide in C6 glioma cells is associated with JNK activation and Fas ligand induction [20].
  • Western blotting data demonstrated that geniposide induced increased protein levels of GSTM1 and GSTM2 (approximately 1.7- and 1.8-fold of control, respectively), but did not increase those of GSTA1 [21].
  • Topical application of geniposide inhibited tumor promoter-caused induction of epidermal ODC activity by TPA (5 nmol) [3].
  • Suppressive effect of geniposide on the hepatotoxicity and hepatic DNA binding of aflatoxin B1 in rats [4].

Analytical, diagnostic and therapeutic context of Geniposide


  1. Penta-acetyl geniposide induce apoptosis in C6 glioma cells by modulating the activation of neutral sphingomyelinase-induced p75 nerve growth factor receptor and protein kinase Cdelta pathway. Peng, C.H., Huang, C.N., Hsu, S.P., Wang, C.J. Mol. Pharmacol. (2006) [Pubmed]
  2. Hepatotoxicity of geniposide in rats. Yamano, T., Tsujimoto, Y., Noda, T., Shimizu, M., Ohmori, M., Morita, S., Yamada, A. Food Chem. Toxicol. (1990) [Pubmed]
  3. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in benzo[a]pyrene-initiated CD-1 mouse skin by geniposide. Lee, M.J., Hsu, J.D., Wang, C.J. Anticancer Res. (1995) [Pubmed]
  4. Suppressive effect of geniposide on the hepatotoxicity and hepatic DNA binding of aflatoxin B1 in rats. Wang, C.J., Wang, S.W., Lin, J.K. Cancer Lett. (1991) [Pubmed]
  5. Neurotrophic property of geniposide for inducing the neuronal differentiation of PC12 cells. Liu, J., Zheng, X., Yin, F., Hu, Y., Guo, L., Deng, X., Chen, G., Jiajia, J., Zhang, H. Int. J. Dev. Neurosci. (2006) [Pubmed]
  6. Geniposide activates GSH S-transferase by the induction of GST M1 and GST M2 subunits involving the transcription and phosphorylation of MEK-1 signaling in rat hepatocytes. Kuo, W.H., Chou, F.P., Young, S.C., Chang, Y.C., Wang, C.J. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  7. Modulation of cytochrome P-450-dependent monooxygenases, glutathione and glutathione S-transferase in rat liver by geniposide from Gardenia jasminoides. Kang, J.J., Wang, H.W., Liu, T.Y., Chen, Y.C., Ueng, T.H. Food Chem. Toxicol. (1997) [Pubmed]
  8. Enzymic studies on the animal and intestinal bacterial metabolism of geniposide. Akao, T., Kobashi, K., Aburada, M. Biol. Pharm. Bull. (1994) [Pubmed]
  9. Antithrombotic effect of geniposide and genipin in the mouse thrombosis model. Suzuki, Y., Kondo, K., Ikeda, Y., Umemura, K. Planta Med. (2001) [Pubmed]
  10. Effect of in vitro and in vivo aerosolized treatment with geniposide on tracheal permeability in ovalbumin-induced guinea pigs. Liaw, J., Chao, Y.C. Eur. J. Pharmacol. (2001) [Pubmed]
  11. Identification and determination of geniposide contained in Gardenia jasminoides and in two preparations of mixed traditional Chinese medicines. Tsai, T.R., Tseng, T.Y., Chen, C.F., Tsai, T.H. Journal of chromatography. A. (2002) [Pubmed]
  12. Inhibition of cell cycle progression by penta-acetyl geniposide in rat C6 glioma cells. Chang, Y.C., Chou, F.P., Huang, H.P., Hsu, J.D., Wang, C.J. Toxicol. Appl. Pharmacol. (2004) [Pubmed]
  13. Anti-inflammatory evaluation of gardenia extract, geniposide and genipin. Koo, H.J., Lim, K.H., Jung, H.J., Park, E.H. Journal of ethnopharmacology. (2006) [Pubmed]
  14. Geniposide from Gardenia jasminoides attenuates neuronal cell death in oxygen and glucose deprivation-exposed rat hippocampal slice culture. Lee, P., Lee, J., Choi, S.Y., Lee, S.E., Lee, S., Son, D. Biol. Pharm. Bull. (2006) [Pubmed]
  15. Purification and characterization of a geniposide-hydrolyzing beta-glucosidase from Eubacterium sp. A-44, a strict anaerobe from human feces. Yang, L., Akao, T., Kobashi, K. Biol. Pharm. Bull. (1995) [Pubmed]
  16. Determination of geniposide, gardenoside, geniposidic acid and genipin-1-beta-gentiobioside in Gardenia jasminoides by high-performance liquid chromatography. Oshima, T., Sagara, K., Yoshida, T., Tong, Y.Y., Zhang, G.D., Chen, Y.H. J. Chromatogr. (1988) [Pubmed]
  17. Aqueous two-phase extraction as an effective tool for isolation of geniposide from gardenia fruit. Pan, I.H., Chiu, H.H., Lu, C.H., Lee, L.T., Li, Y.K. Journal of chromatography. A. (2002) [Pubmed]
  18. Iridoid glucosides from the fruit of Genipa americana. Ono, M., Ueno, M., Masuoka, C., Ikeda, T., Nohara, T. Chem. Pharm. Bull. (2005) [Pubmed]
  19. Improvement of leaching process of Geniposide with ultrasound. Ji, J.B., Lu, X.H., Cai, M.Q., Xu, Z.C. Ultrasonics sonochemistry. (2006) [Pubmed]
  20. Apoptosis induced by penta-acetyl geniposide in C6 glioma cells is associated with JNK activation and Fas ligand induction. Peng, C.H., Tseng, T.H., Huang, C.N., Hsu, S.P., Wang, C.J. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  21. Differential induction of the expression of GST subunits by geniposide in rat hepatocytes. Kuo, W.H., Wang, C.J., Young, S.C., Sun, Y.C., Chen, Y.J., Chou, F.P. Pharmacology (2004) [Pubmed]
  22. HPLC method for the determination and pharmacokinetic studies on geniposide in rat serum after oral administration of traditional Chinese medicinal preparation Yin-Zhi-Ku decoction. Ye, G., Zhu, H.Y., Zhao, H.L., Xu, B., Huang, C.G. Biomed. Chromatogr. (2006) [Pubmed]
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