Gene Review:
NCR3 - natural cytotoxicity triggering receptor 3
Homo sapiens
Synonyms:
1C7, Activating natural killer receptor p30, CD337, LY117, MALS, ...
Al Jijakli,
Cantoni,
Tsang,
Nguyen,
Bottino,
Vitale,
Freeman,
Bettadapura,
Elke Pogge von Strandmann,
Venkateswara Rao Simhadri,
Bastian von Tresckow,
Stephanie Sasse,
Katrin S. Reiners,
Hinrich P. Hansen,
Achim Rothe,
Boris Böll,
Vijaya Lakshmi Simhadri,
Peter Borchmann,
Peter J. McKinnon,
Michael Hallek,
Andreas Engert,
Melioli,
Biassoni,
Langhans,
Jones,
Muller,
Moretta,
Münz,
Rouas-Freiss,
Sauerbruch,
Dhedin,
Nattermann,
Moretta,
Thomas,
Ahlenstiel,
Morandi,
Moretta,
Kuentz,
Ferlazzo,
Moretta,
Steinman,
Ferlazzo,
Boudifa,
Goodman,
Debré,
Lin,
Münz,
Mingari,
Vernant,
Warren,
Feldmann,
Parish,
Pende,
Spengler,
Vieillard,
Carosella,
- LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection. Mulcahy, H., O'Rourke, K.P., Adams, C., Molloy, M.G., O'Gara, F. Immunogenetics (2006)
- Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C. Nattermann, J., Feldmann, G., Ahlenstiel, G., Langhans, B., Sauerbruch, T., Spengler, U. Gut (2006)
- Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction. Castriconi, R., Dondero, A., Corrias, M.V., Lanino, E., Pende, D., Moretta, L., Bottino, C., Moretta, A. Cancer Res. (2004)
- Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan. Warren, H.S., Jones, A.L., Freeman, C., Bettadapura, J., Parish, C.R. J. Immunol. (2005)
- Recognition of vaccinia virus-infected cells by human natural killer cells depends on natural cytotoxicity receptors. Chisholm, S.E., Reyburn, H.T. J. Virol. (2006)
- Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Moretta, A., Bottino, C., Vitale, M., Pende, D., Cantoni, C., Mingari, M.C., Biassoni, R., Moretta, L. Annu. Rev. Immunol. (2001)
- Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus. Arnon, T.I., Achdout, H., Levi, O., Markel, G., Saleh, N., Katz, G., Gazit, R., Gonen-Gross, T., Hanna, J., Nahari, E., Porgador, A., Honigman, A., Plachter, B., Mevorach, D., Wolf, D.G., Mandelboim, O. Nat. Immunol. (2005)
- Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. Ferlazzo, G., Tsang, M.L., Moretta, L., Melioli, G., Steinman, R.M., Münz, C. J. Exp. Med. (2002)
- Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells. Castriconi, R., Cantoni, C., Della Chiesa, M., Vitale, M., Marcenaro, E., Conte, R., Biassoni, R., Bottino, C., Moretta, L., Moretta, A. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Anti-growth factor activities of benzothiophenes in human breast cancer cells. Freiss, G., Galtier, F., Puech, C., Aknin, C., Maudelonde, T., Chalbos, D., Vignon, F. J. Steroid Biochem. Mol. Biol. (2005)
- NKp30 (NCR3) is a pseudogene in 12 inbred and wild mouse strains, but an expressed gene in Mus caroli. Hollyoake, M., Campbell, R.D., Aguado, B. Mol. Biol. Evol. (2005)
- NKp30-dependent cytolysis of filovirus-infected human dendritic cells. Fuller, C.L., Ruthel, G., Warfield, K.L., Swenson, D.L., Bosio, C.M., Aman, M.J., Bavari, S. Cell. Microbiol. (2007)
- Deficient expression of NCR in NK cells from acute myeloid leukemia: evolution during leukemia treatment and impact of leukemia cells in NCRdull phenotype induction. Fauriat, C., Just-Landi, S., Mallet, F., Arnoulet, C., Sainty, D., Olive, D., Costello, R.T. Blood (2007)
- Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. Pende, D., Parolini, S., Pessino, A., Sivori, S., Augugliaro, R., Morelli, L., Marcenaro, E., Accame, L., Malaspina, A., Biassoni, R., Bottino, C., Moretta, L., Moretta, A. J. Exp. Med. (1999)
- A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. Neville, M.J., Campbell, R.D. J. Immunol. (1999)
- The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic. Ferlazzo, G., Thomas, D., Lin, S.L., Goodman, K., Morandi, B., Muller, W.A., Moretta, A., Münz, C. J. Immunol. (2004)
- Identification of novel single nucleotide substitutions in the NKp30 gene expressed in human natural killer cells. Sato, M., Ohashi, J., Tsuchiya, N., Tadokoro, K., Juji, T., Hanaoka, K., Tokunaga, K., Yabe, T. Tissue Antigens (2001)
- Membrane-associated heparan sulfate proteoglycans are involved in the recognition of cellular targets by NKp30 and NKp46. Bloushtain, N., Qimron, U., Bar-Ilan, A., Hershkovitz, O., Gazit, R., Fima, E., Korc, M., Vlodavsky, I., Bovin, N.V., Porgador, A. J. Immunol. (2004)
- The corticosteroid-induced inhibitory effect on NK cell function reflects down-regulation and/or dysfunction of triggering receptors involved in natural cytotoxicity. Vitale, C., Chiossone, L., Cantoni, C., Morreale, G., Cottalasso, F., Moretti, S., Pistorio, A., Haupt, R., Lanino, E., Dini, G., Moretta, L., Mingari, M.C. Eur. J. Immunol. (2004)
- Expression and function of KIR and natural cytotoxicity receptors in NK-type lymphoproliferative diseases of granular lymphocytes. Zambello, R., Falco, M., Della Chiesa, M., Trentin, L., Carollo, D., Castriconi, R., Cannas, G., Carlomagno, S., Cabrelle, A., Lamy, T., Agostini, C., Moretta, A., Semenzato, G., Vitale, M. Blood (2003)
- The maturation potential of NK cell clones toward autologous dendritic cells correlates with HMGB1 secretion. Semino, C., Ceccarelli, J., Lotti, L.V., Torrisi, M.R., Angelini, G., Rubartelli, A. J. Leukoc. Biol. (2007)
- Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells. Pogge von Strandmann, E., Simhadri, V.R., von Tresckow, B., Sasse, S., Reiners, K.S., Hansen, H.P., Rothe, A., Böll, B., Simhadri, V.L., Borchmann, P., McKinnon, P.J., Hallek, M., Engert, A. Immunity (2007)
- Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity. Pende, D., Rivera, P., Marcenaro, S., Chang, C.C., Biassoni, R., Conte, R., Kubin, M., Cosman, D., Ferrone, S., Moretta, L., Moretta, A. Cancer Res. (2002)
- Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation. Spaggiari, G.M., Capobianco, A., Becchetti, S., Mingari, M.C., Moretta, L. Blood (2006)
- Association of HLA-A*3303-B*4403-DRB1*1302 haplotype, but not of TNFA promoter and NKp30 polymorphism, with postherpetic neuralgia (PHN) in the Japanese population. Sato, M., Ohashi, J., Tsuchiya, N., Kashiwase, K., Ishikawa, Y., Arita, H., Hanaoka, K., Tokunaga, K., Yabe, T. Genes Immun. (2002)
- NK-cell reconstitution after haploidentical hematopoietic stem-cell transplantations: immaturity of NK cells and inhibitory effect of NKG2A override GvL effect. Nguyen, S., Dhedin, N., Vernant, J.P., Kuentz, M., Al Jijakli, A., Rouas-Freiss, N., Carosella, E.D., Boudifa, A., Debré, P., Vieillard, V. Blood (2005)
- NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor. Vitale, M., Della Chiesa, M., Carlomagno, S., Pende, D., Aricò, M., Moretta, L., Moretta, A. Blood (2005)
- NK cell-mediated lysis of autologous antigen-presenting cells is triggered by the engagement of the phosphatidylinositol 3-kinase upon ligation of the natural cytotoxicity receptors NKp30 and NKp46. Spaggiari, G.M., Carosio, R., Pende, D., Marcenaro, S., Rivera, P., Zocchi, M.R., Moretta, L., Poggi, A. Eur. J. Immunol. (2001)
- Expression of Natural Cytotoxicity Receptors and a2V-ATPase on Peripheral Blood NK Cell Subsets in Women with Recurrent Spontaneous Abortions and Implantation Failures. Fukui, A., Ntrivalas, E., Gilman-Sachs, A., Kwak-Kim, J., Lee, S.K., Levine, R., Beaman, K. Am. J. Reprod. Immunol. (2006)