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Gene Review

FBXO8  -  F-box protein 8

Homo sapiens

Synonyms: DC10, F-box only protein 8, F-box/SEC7 protein FBS, FBS, FBX8, ...
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Disease relevance of FBXO8

  • 2. In this study, cultured human neuroblastoma cells (SHSY-5Y) were incubated in experimental media (media without FBS, the main cholesterol source) in the presence or absence of Abeta (1 microM) for 24 h [1].
  • An amniocentesis and puncture of the ascites were performed, but FBS was not successful [2].
  • Finally, the mAb XIV DC10 which recognized a highly conserved epitope could be useful for an assay to detect HIV-1 and HIV-2 simultaneously [3].
  • MATERIALS AND METHODS: BSA- and DCC-FBS-supplemented medium were used to examine the influence of serum proteins on the antiproliferative effects of (-)-gossypol in DU-145 cells, a human prostate cancer cell line [4].
  • Many defenders of FHR monitoring feel that its use without the availability of FBS is responsible for the overdiagnosis of fetal distress and the subsequent increase in cesarean section rates [5].

Psychiatry related information on FBXO8

  • The fiery crash of a DC-10 at Sioux City, Iowa, on July 19, 1989, caused a crisis of major proportions, with attendant mental health needs [6].
  • The following cut-offs were most effective for identifying spurious PTSD: F greater than 62, F-K = greater than -4, Es = greater than 30, FBS = greater than 24 (men), FBS = greater than 26 (women), total obvious minus subtle = greater than 90, DIS = greater than 60, and DEB = greater than 60 [7].

High impact information on FBXO8

  • Addition of purified human placental beta-hexosaminidase and partially purified bovine liver beta-glucuronidase resulted in the doubling of cell count after 4 d of incubation in medium M199 with 0.4% FBS [8].
  • At low density, cells survive in culture without FBS when the media are conditioned by chondrocytes grown at high density [9].
  • In this paper, we examine the mitochondrial transport of alpha, omega-dicarboxylates ranging from oxalate (DC2) to sebacate (DC10) [10].
  • At 37 degrees C and pH 7.0, DC10 is transported very rapidly at 3 micromol/, and respiring mitochondria swell in the K+ salts of these acids [10].
  • We also demonstrate that DC5-DC10 can also be transported by an electroneutral mechanism mediated by tributyltin, a potent inhibitor of IMAC [10].

Biological context of FBXO8

  • Addition of FBS to the culture media leads to profound changes in the phenotype of chondrocytes seeded at low density [9].
  • Simvastatin (0.1-1.0 muM) significantly inhibited cell proliferation and DNA synthesis induced by FBS in a concentration-dependent manner [11].
  • When stored at room temperature in DMEM containing 10% FBS, fibroblast cultured on the microbeads retained highest viabilities for at least 3 weeks, up to 82% of originals [12].
  • On the contrary, guanidinylation of the parent dendrimer resulted to significant enhancement of its transfection efficiency, this enhancement being dependent on the number of guanidinium groups per dendrimer, the cell line used and the presence or absence of FBS [13].
  • RESULTS: Fas-induced apoptosis in the neutrophils of these surgically treated patients was found to be slightly accelerated at 1 day postoperatively in the presence of FBS, compared with 2 days preoperatively and 5 days postoperatively [14].

Anatomical context of FBXO8

  • Cells maintained in 0.3% FBS were doubly stained with monospecific anti-fibronectin IgG and antibodies against a basement membrane proteoglycan purified from the EHS (Engelbreth-Holm-Swarm) tumor [15].
  • However, 3T6 fibroblasts did not produce leukotriene B(4) (LTB(4)), and lipoxygenase inhibitors and LT antagonists failed to inhibit 3T6 fibroblast growth induced by FBS [16].
  • METHODS: Rabbit and human corneal epithelial cells were cultured in DMEM/F12 medium containing 10% FBS and 5 mug/mL insulin at 37 degrees C in 5% CO(2) [17].
  • Melanocytes were later subcultured in the presence of 1% FBS [18].
  • Cumulus oocyte complexes were in vitro matured in TCM199 supplemented with FSH (10 microg/ml), LH (10 microg/ml), and 10% (v/v) FBS [19].

Associations of FBXO8 with chemical compounds

  • In contrast, we observed that CYP450 inhibitors such as SKF-525A, 17-octadecynoic acid, 1-aminobenzotriazole, and 6-(2-propargyloxyphenyl)hexanoic acid reduced 12(S)-HETE levels, 3T6 fibroblast growth, and DNA synthesis induced by FBS [16].
  • Calcein encapsulation experiments revealed that the liposomes, prepared from the boron cluster lipid 4b, DMPC, PEG-DSPE, and cholesterol, are stable at 37 degrees C in FBS solution for 24 h [20].
  • Two sets each were frozen in a 1:1 mixture of 15% DMSO in Mixed Medium (MM) and 20% FBS in MM using a commonly employed styrofoam freezer insert method for liquid nitrogen refrigerators and a programmed freezer (temperature falls at an optimal rate), respectively [21].
  • Patients with CLD were divided into two groups, one with normal fasting plasma glucose (FBS less than 100 mg/dl (Group I) and the other with higher FBS (Group II) [22].
  • The culture medium consisted of 10% FBS and 90% DMEM, the cells were dosed with various concentrations of fatty acid in ethanol as carrier 24 hours post-trypsinisation, and the viability determined using Trypan Blue exclusion after a further 48 hours [23].

Other interactions of FBXO8

  • Specifically, FBS and FBWD4 proteins contain Sec7 and WD40-repeat domains, respectively [24].

Analytical, diagnostic and therapeutic context of FBXO8


  1. Feedback regulation of SREBP and aromatase in A beta(25-35)-supplemented human neuroblastoma cells. Kelicen, P., Nordberg, A. Cell. Mol. Neurobiol. (2006) [Pubmed]
  2. Perinatal case report of unexpected thalassemia Hb Bart. Hofstaetter, C., Gonser, M., Goelz, R. Fetal. Diagn. Ther. (1993) [Pubmed]
  3. Generation, characterization and cross-reactivities of monoclonal antibodies against the p24 core protein and the gp130 envelope glycoprotein of HIV-2ben. Faisst, A.C., Otteken, A., Nick, S., Hunsmann, G. Med. Microbiol. Immunol. (Berl.) (1993) [Pubmed]
  4. Effects of serum on (-)-gossypol-suppressed growth in human prostate cancer cells. Huang, Y.W., Wang, L.S., Chang, H.L., Ye, W., Sugimoto, Y., Dowd, M.K., Wan, P.J., Lin, Y.C. Anticancer Res. (2006) [Pubmed]
  5. The current role of intrapartum fetal blood sampling. Parer, J.T. Clinical obstetrics and gynecology. (1980) [Pubmed]
  6. Lessons from the aftermath of Flight 232. Practical considerations for the mental health profession's response to air disasters. Jacobs, G.A., Quevillon, R.P., Stricherz, M. The American psychologist. (1990) [Pubmed]
  7. Efficacy of MMPI-2 validity scales and MCMI-II modifier scales for detecting spurious PTSD claims: F, F-K, Fake Bad Scale, ego strength, subtle-obvious subscales, DIS, and DEB. Lees-Haley, P.R. Journal of clinical psychology. (1992) [Pubmed]
  8. Mitogenic effect of lysosomal hydrolases on bovine tracheal myocytes in culture. Lew, D.B., Rattazzi, M.C. J. Clin. Invest. (1991) [Pubmed]
  9. Induction and prevention of chondrocyte hypertrophy in culture. Bruckner, P., Hörler, I., Mendler, M., Houze, Y., Winterhalter, K.H., Eich-Bender, S.G., Spycher, M.A. J. Cell Biol. (1989) [Pubmed]
  10. Mechanisms for the transport of alpha,omega-dicarboxylates through the mitochondrial inner membrane. Liu, G., Hinch, B., Beavis, A.D. J. Biol. Chem. (1996) [Pubmed]
  11. Role of RhoA Inactivation in Reduced Cell Proliferation of Human Airway Smooth Muscle by Simvastatin. Takeda, N., Kondo, M., Ito, S., Ito, Y., Shimokata, K., Kume, H. Am. J. Respir. Cell Mol. Biol. (2006) [Pubmed]
  12. High yields of autologous living dermal equivalents using porcine gelatin microbeads as microcarriers for autologous fibroblasts. Liu, J.Y., Hafner, J., Dragieva, G., Burg, G. Cell transplantation. (2006) [Pubmed]
  13. Synthesis and characterization of guanidinylated poly(propylene imine) dendrimers as gene transfection agents. Tziveleka, L.A., Psarra, A.M., Tsiourvas, D., Paleos, C.M. Journal of controlled release : official journal of the Controlled Release Society (2007) [Pubmed]
  14. Regulation of Fas-mediated apoptosis in neutrophils after surgery-induced acute inflammation. Iwase, M., Kondo, G., Watanabe, H., Takaoka, S., Uchida, M., Ohashi, M., Nagumo, M. J. Surg. Res. (2006) [Pubmed]
  15. Extracellular matrix fibers containing fibronectin and basement membrane heparan sulfate proteoglycan coalign with focal contacts and microfilament bundles in stationary fibroblasts. Singer, I.I., Scott, S., Kawka, D.W., Hassell, J.R. Exp. Cell Res. (1987) [Pubmed]
  16. Hydroxyeicosatetraenoic acids released through the cytochrome P-450 pathway regulate 3T6 fibroblast growth. Nieves, D., Moreno, J.J. J. Lipid Res. (2006) [Pubmed]
  17. Pathway-Specific Effect of Caffeine on Protection against UV Irradiation-Induced Apoptosis in Corneal Epithelial Cells. Wang, L., Lu, L. Invest. Ophthalmol. Vis. Sci. (2007) [Pubmed]
  18. Growth characteristics of human epidermal melanocytes in pure culture with special reference to genetic differences. Hirobe, T., Flynn, E., Szabo, G., Vrabel, M., Garcia, R.I. J. Cell. Physiol. (1988) [Pubmed]
  19. Influence of in vitro oxygen concentrations on preimplantation embryo development, gene expression and production of hanwoo calves following embryo transfer. Rho, G.J., S, B., Kim, D.S., Son, W.J., Cho, S.R., Kim, J.G., B, M.K., Choe, S.Y. Mol. Reprod. Dev. (2007) [Pubmed]
  20. Synthesis of Boron Cluster Lipids: closo-Dodecaborate as an Alternative Hydrophilic Function of Boronated Liposomes for Neutron Capture Therapy. Lee, J.D., Ueno, M., Miyajima, Y., Nakamura, H. Org. Lett. (2007) [Pubmed]
  21. Non-random cell killing in cryopreservation: implications for performance of the battery of leukocyte tests (BLT), I. Toxic and immunotoxic effects. Strauss, G.H. Mutat. Res. (1991) [Pubmed]
  22. Glucose, insulin and C-peptide kinetics during intravenous glucose tolerance test in chronic liver disease. Lee, K.U., Rhee, B.D., Lee, H.K., Kim, C.Y., Koh, C.S., Min, H.K. Diabetes Res. Clin. Pract. (1987) [Pubmed]
  23. The influence of C18 fatty acids on the growth of fibroblasts of different degrees of transformation in culture. Davidson, B.C., Giangregorio, A., Girao, L.A. Anticancer Res. (1993) [Pubmed]
  24. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. Ilyin, G.P., Rialland, M., Pigeon, C., Guguen-Guillouzo, C. Genomics (2000) [Pubmed]
  25. Plasma resistin, insulin concentration in non-diabetic and diabetic, overweight/obese thai. Chanchay, S., Tungtrongchitr, R., Harnroongroj, T., Phonrat, B., Rungseesakorn, O., Paksanont, S., Pooudong, S., Saowakontha, S., Varongchayakul, C. International journal for vitamin and nutrition research. Internationale Zeitschrift f??r Vitamin- und Ern??hrungsforschung. Journal international de vitaminologie et de nutrition. (2006) [Pubmed]
  26. The management of feto-maternal alloimmune thrombocytopenia: Report of three cases. Paternoster, D.M., Cester, M., Memmo, A., Scandellari, R., Fabris, F., Girolami, A. J. Matern. Fetal. Neonatal. Med. (2006) [Pubmed]
  27. Diabetes mellitus related treatment goals: awareness and attainment in the Ife-Ijesa zone of south-western Nigeria. Kolawole, B.A., Adegbenro, C., Ayoola, Z.O., Opebiyi, B. African journal of medicine and medical sciences. (2005) [Pubmed]
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