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Gene Review

Mpg  -  N-methylpurine-DNA glycosylase

Mus musculus

Synonyms: 3-alkyladenine DNA glycosylase, 3-methyladenine DNA glycosidase, 3-methyladenine DNA glycosylase, 9830006D05, ADPG, ...
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Disease relevance of Mpg


High impact information on Mpg


Chemical compound and disease context of Mpg


Biological context of Mpg


Anatomical context of Mpg


Associations of Mpg with chemical compounds


Other interactions of Mpg


Analytical, diagnostic and therapeutic context of Mpg


  1. Role of nucleotide- and base-excision repair in genotoxin-induced neuronal cell death. Kisby, G.E., Lesselroth, H., Olivas, A., Samson, L., Gold, B., Tanaka, K., Turker, M.S. DNA Repair (Amst.) (2004) [Pubmed]
  2. Increased susceptibility to streptozotocin-induced beta-cell apoptosis and delayed autoimmune diabetes in alkylpurine-DNA-N-glycosylase-deficient mice. Cardinal, J.W., Margison, G.P., Mynett, K.J., Yates, A.P., Cameron, D.P., Elder, R.H. Mol. Cell. Biol. (2001) [Pubmed]
  3. The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death. Trivedi, R.N., Almeida, K.H., Fornsaglio, J.L., Schamus, S., Sobol, R.W. Cancer Res. (2005) [Pubmed]
  4. Increased formation and persistence of 1,N(6)-ethenoadenine in DNA is not associated with higher susceptibility to carcinogenesis in alkylpurine-DNA-N-glycosylase knockout mice treated with vinyl carbamate. Barbin, A., Wang, R., O'Connor, P.J., Elder, R.H. Cancer Res. (2003) [Pubmed]
  5. Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing. Engelward, B.P., Dreslin, A., Christensen, J., Huszar, D., Kurahara, C., Samson, L. EMBO J. (1996) [Pubmed]
  6. Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase. Engelward, B.P., Weeda, G., Wyatt, M.D., Broekhof, J.L., de Wit, J., Donker, I., Allan, J.M., Gold, B., Hoeijmakers, J.H., Samson, L.D. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  7. Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine. Hang, B., Singer, B., Margison, G.P., Elder, R.H. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  8. Repair of 8-hydroxyguanine in DNA by mammalian N-methylpurine-DNA glycosylase. Bessho, T., Roy, R., Yamamoto, K., Kasai, H., Nishimura, S., Tano, K., Mitra, S. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  9. Activity of fotemustine in medulloblastoma and malignant glioma xenografts in relation to O6-alkylguanine-DNA alkyltransferase and alkylpurine-DNA N-glycosylase activity. Vassal, G., Boland, I., Terrier-Lacombe, M.J., Watson, A.J., Margison, G.P., Vénuat, A.M., Morizet, J., Parker, F., Lacroix, C., Lellouch-Tubiana, A., Pierre-Kahn, A., Poullain, M.G., Gouyette, A. Clin. Cancer Res. (1998) [Pubmed]
  10. Structure of the mouse 3-methyladenine DNA glycosylase gene and exact localization upstream of the alpha-globin gene cluster on chromosome 11. Kielman, M.F., Smits, R., Bernini, L.F. Mamm. Genome (1995) [Pubmed]
  11. Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate. Elder, R.H., Jansen, J.G., Weeks, R.J., Willington, M.A., Deans, B., Watson, A.J., Mynett, K.J., Bailey, J.A., Cooper, D.P., Rafferty, J.A., Heeran, M.C., Wijnhoven, S.W., van Zeeland, A.A., Margison, G.P. Mol. Cell. Biol. (1998) [Pubmed]
  12. The effect of dietary folic acid deficiency on the cytotoxic and mutagenic responses to methyl methanesulfonate in wild-type and in 3-methyladenine DNA glycosylase-deficient Aag null mice. Branda, R.F., O'Neill, J.P., Brooks, E.M., Powden, C., Naud, S.J., Nicklas, J.A. Mutat. Res. (2007) [Pubmed]
  13. Free radical scavengers can differentially modulate the genotoxicity of amsacrine in normal and cancer cells. Blasiak, J., Gloc, E., Drzewoski, J., Wozniak, K., Zadrozny, M., Skórski, T., Pertynski, T. Mutat. Res. (2003) [Pubmed]
  14. 3-Methyladenine DNA glycosylase-deficient Aag null mice display unexpected bone marrow alkylation resistance. Roth, R.B., Samson, L.D. Cancer Res. (2002) [Pubmed]
  15. Quantitative reverse transcriptase polymerase chain reaction for measuring the N-methylpurine-DNA glycosylase mRNA level in rodent cells. Roy, G., Roy, R., Mitra, S. Anal. Biochem. (1997) [Pubmed]
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