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Gene Review

Hif1a  -  hypoxia-inducible factor 1, alpha subunit...

Rattus norvegicus

Synonyms: HIF-1-alpha, HIF1-alpha, Hypoxia-inducible factor 1-alpha
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Disease relevance of Hif1a


Psychiatry related information on Hif1a

  • RESULTS: When the period of alcohol consumption increased, the positive rate of expression of hypoxia-inducible factor-1 alpha (HIF-1alpha) mRNA was more significantly elevated in the liver of the alcohol group than in the control group (P</=0.05) [4].

High impact information on Hif1a


Chemical compound and disease context of Hif1a


Biological context of Hif1a


Anatomical context of Hif1a


Associations of Hif1a with chemical compounds

  • Angiotensin II induces hypoxia-inducible factor-1 alpha in PC 12 cells through a posttranscriptional mechanism: role of AT2 receptors [18].
  • Preliminary evidence suggests that this effect of vitamin A involves increased mRNA levels of hypoxia-inducible factor 1 alpha (HIF-1 alpha) [19].
  • Cardiac expressions of HIF-1 alpha and HLF/EPAS, two basic loop helix/PAS domain transcription factors involved in adaptative responses to hypoxic stresses [10].
  • The increase in HIF-1alpha in diabetic nerves coincided with a similarly transient increase in the expression of several HIF-1alpha target genes including vascular endothelial growth factor, lactate dehydrogenase and erythropoietin, which subsided 8-10 weeks after induction of diabetes [17].
  • This result suggested that glucose induces HIF-1alpha degradation via a proteasomal pathway [11].

Regulatory relationships of Hif1a


Other interactions of Hif1a

  • To date, virtually nothing is known about the signaling pathways that lead to either EPAS1 or HIF1-alpha activation [20].
  • Linear correlation analysis showed that HIF-1alpha mRNA, HO-1 protein and mPAP were associated with pulmonary remodeling [1].
  • A reduction in SM-20/PHD3 mRNA expression paralleled the increase in HIF-1 alpha [18].
  • Linear correlation analysis showed that iNOS protein was associated with both mean pulmonary arterial pressure (r = 0.74, P < 0.01) and hypoxic pulmonary vascular remodeling (r = 0.78, P < 0.01), whereas the inverse was associated with HIF-1alpha protein (r = -0.52, P < 0.01) [21].
  • HIF-1alpha protein was detected by immunoblot analysis of nuclear protein extracts from normoxic testes [2].

Analytical, diagnostic and therapeutic context of Hif1a


  1. Hypoxia inducible factor-1 alpha correlates the expression of heme oxygenase 1 gene in pulmonary arteries of rat with hypoxia-induced pulmonary hypertension. Li, Q.F., Dai, A.G. Acta Biochim. Biophys. Sin. (Shanghai) (2004) [Pubmed]
  2. Stimulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) protein in the adult rat testis following ischemic injury occurs without an increase in HIF-1alpha messenger RNA expression. Powell, J.D., Elshtein, R., Forest, D.J., Palladino, M.A. Biol. Reprod. (2002) [Pubmed]
  3. Sex-related dimorphic response of HIF-1 alpha expression in myocardial ischemia. Zampino, M., Yuzhakova, M., Hansen, J., McKinney, R.D., Goldspink, P.H., Geenen, D.L., Buttrick, P.M. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  4. Is the hypoxia-inducible factor-1 alpha mRNA expression activated by ethanol-induced injury, the mechanism underlying alcoholic liver disease? Li, L., Chen, S.H., Zhang, Y., Yu, C.H., Li, S.D., Li, Y.M. HBPD INT (2006) [Pubmed]
  5. Hypoxic stress tolerance of the blind subterranean mole rat: expression of erythropoietin and hypoxia-inducible factor 1 alpha. Shams, I., Avivi, A., Nevo, E. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  6. Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation. Naranjo-Suárez, S., Castellanos, M.C., Alvarez-Tejado, M., Vara, A., Landázuri, M.O., del Peso, L. J. Biol. Chem. (2003) [Pubmed]
  7. Myocardial infarction in diabetic rats: role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1. Marfella, R., D'Amico, M., Di Filippo, C., Piegari, E., Nappo, F., Esposito, K., Berrino, L., Rossi, F., Giugliano, D. Diabetologia (2002) [Pubmed]
  8. Differential profile of Nix upregulation and translocation during hypoxia/ischaemia in vivo versus in vitro. Birse-Archbold, J.L., Kerr, L.E., Jones, P.A., McCulloch, J., Sharkey, J. J. Cereb. Blood Flow Metab. (2005) [Pubmed]
  9. Identification of potential stroke targets by lentiviral vector mediated overexpression of HIF-1 alpha and HIF-2 alpha in a primary neuronal model of hypoxia. Ralph, G.S., Parham, S., Lee, S.R., Beard, G.L., Craigon, M.H., Ward, N., White, J.R., Barber, R.D., Rayner, W., Kingsman, S.M., Mundy, C.R., Mazarakis, N.D., Krige, D. J. Cereb. Blood Flow Metab. (2004) [Pubmed]
  10. Cardiac expressions of HIF-1 alpha and HLF/EPAS, two basic loop helix/PAS domain transcription factors involved in adaptative responses to hypoxic stresses. Ladoux, A., Frelin, C. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  11. Glucose uptake and adenoviral mediated GLUT1 infection decrease hypoxia-induced HIF-1alpha levels in cardiac myocytes. Malhotra, R., Tyson, D.G., Sone, H., Aoki, K., Kumagai, A.K., Brosius, F.C. J. Mol. Cell. Cardiol. (2002) [Pubmed]
  12. Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha. Koukourakis, M.I., Giatromanolaki, A., Chong, W., Simopoulos, C., Polychronidis, A., Sivridis, E., Harris, A.L. Cancer Chemother. Pharmacol. (2004) [Pubmed]
  13. The effects of L-arginine on neurological function, histopathology, and expression of hypoxia-inducible factor-1 alpha following spinal cord ischemia in rats. Tuncer, M.C., Hatipoglu, E.S., Ozturk, H., Kervancioglu, P., Buyukbayram, H. European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes. (2005) [Pubmed]
  14. Regulatory role of vHL/HIF-1alpha in hypoxia-induced VEGF production in hepatic stellate cells. Wang, Y.Q., Luk, J.M., Ikeda, K., Man, K., Chu, A.C., Kaneda, K., Fan, S.T. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  15. Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Cai, Z., Manalo, D.J., Wei, G., Rodriguez, E.R., Fox-Talbot, K., Lu, H., Zweier, J.L., Semenza, G.L. Circulation (2003) [Pubmed]
  16. Recombinant human interleukin (IL)-1 beta-mediated regulation of hypoxia-inducible factor-1 alpha (HIF-1 alpha) stabilization, nuclear translocation and activation requires an antioxidant/reactive oxygen species (ROS)-sensitive mechanism. Haddad, J.J. Eur. Cytokine Netw. (2002) [Pubmed]
  17. Transient expression of hypoxia-inducible factor-1 alpha and target genes in peripheral nerves from diabetic rats. Chavez, J.C., Almhanna, K., Berti-Mattera, L.N. Neurosci. Lett. (2005) [Pubmed]
  18. Angiotensin II induces hypoxia-inducible factor-1 alpha in PC 12 cells through a posttranscriptional mechanism: role of AT2 receptors. Wolf, G., Schroeder, R., Stahl, R.A. American journal of nephrology. (2004) [Pubmed]
  19. Effects of antioxidant vitamins on renal and hepatic erythropoietin production. Jelkmann, W., Pagel, H., Hellwig, T., Fandrey, J. Kidney Int. (1997) [Pubmed]
  20. EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. Conrad, P.W., Freeman, T.L., Beitner-Johnson, D., Millhorn, D.E. J. Biol. Chem. (1999) [Pubmed]
  21. Hypoxia-inducible factor 1 alpha upregulates the expression of inducible nitric oxide synthase gene in pulmonary arteries of hyposic rat. Hu, R., Dai, A., Tan, S. Chin. Med. J. (2002) [Pubmed]
  22. Esophageal ulceration triggers expression of hypoxia-inducible factor-1 alpha and activates vascular endothelial growth factor gene: implications for angiogenesis and ulcer healing. Baatar, D., Jones, M.K., Tsugawa, K., Pai, R., Moon, W.S., Koh, G.Y., Kim, I., Kitano, S., Tarnawski, A.S. Am. J. Pathol. (2002) [Pubmed]
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