Disease relevance of OBP2A

• CONCLUSION: Shoulder dystocia in the setting of vacuum extraction is a prominent risk factor for OBPP in the newborn [1].
• Most studies regarding EPO-induced hypertension have involved evaluation using office/clinic BP (OBP) [2].
• An increasing number of methods are being developed for the physical therapy and the early repair of the nerve lesions in OBPP, including neuroma excision and nerve grafting, neurolysis and neurotization [3].
• BACKGROUND: People with congenital conditions such as obstetric brachial plexus palsy (OBPP), sometimes known as Erb's palsy, may experience adverse effects as a result of compensatory strategies adopted to achieve improved function [4].
• These results suggest that OBP, which is expressed at millimolar levels, might reduce HNE toxicity by removing from the nasal mucus a significant fraction of the aldehyde that is produced as a consequence of direct exposure to the oxygen present in inhaled air [5].

Psychiatry related information on OBP2A

• However, no specific interaction between OBP and olfactory receptors (ORs) has yet been shown and early events in olfaction remain so far poorly understood at a molecular level [6].
• Differences were, however, found in self-esteem for sport/motor activities, with self-esteem being significantly lower in teenagers with the most severe type of OBPP [7].

High impact information on OBP2A

• The -195 to -165 region of the gamma-globin promoter contains binding sites for two proteins: a ubiquitously distributed octamer binding protein, OBP, and the erythroid-specific protein, GF-1 [8].
• In order to decipher the domain swapping determinants we have produced a mutant of OBPb in which a glycine residue was inserted after position 121, and a mutant of OBPp in which glycine 121 was deleted [9].
• OBJECTIVE: The risk of obstetric brachial plexus palsy (OBPP) is increased in infants delivered instrumentally [1].
• The following variables increased significantly the risk of OBPP in the newborn: shoulder dystocia (odds ratio 16.0; 95% confidence interval 8.9-28.7), fetal birth weight of 3,999 g or greater (7.1; 4.8-10.5), and administration of fundal pressure (1.6; 1.1-2.3) [1].
• In children the difference may be even greater due to anatomical differences causing the dramatic increases in the strength of supination after surgery for OBPP [10].

Biological context of OBP2A

• METHODS: Fourteen children, presenting with OBPP to the Clinical Neurophysiology Lab, were analyzed [11].
• BACKGROUND: Obstetrical brachial plexus palsy (OBPP) occurs as sequelae of birth-related trauma, antenatal and parturition related complications [11].
• This study investigated the binding properties and chemical resistance of OBP to the chemically reactive lipid peroxidation end-product 4-hydroxy-2-nonenal (HNE), in an attempt to establish a functional relationship between this protein and the molecular mechanisms combating free radical cellular damage [5].

Anatomical context of OBP2A

• The integrated peak V activity (I-ENGv) showed a linear relationship to OBP (r = 0.944) in the glottis occluded frog, but a curvilinear relationship to peak buccal pressure (peak BP) in the spontaneously breathing frog during inflation period [12].
• Odorant binding proteins (OBP) are soluble lipocalins produced in large amounts in the nasal mucosa of several mammalian species [5].
• Resection of neuroma-in-continuity, conducting or not, offers the best opportunity for maximal functional recovery of the compromised upper limb in OBPP [13].
• Finally, preliminary experiments in a simplified model resembling nasal epithelium showed that extracellular OBP can preserve the viability of an epithelial cell line derived from bovine turbinates exposed to toxic amounts of the aldehyde [5].

Associations of OBP2A with chemical compounds

• These movements were chosen as they primarily assess the C5, C6 and C7 nerve roots, the most frequently involved in OBPP [14].
• 54: PSEF 2006 Scientific Essay Contest Senior Award - Clinical Research, Integra Foundation: Restoration of Shoulder External Rotation in OBPP by Rerouting of Latissimus Dorsi and Teres Major [15].
• Furthermore, OBP functionality, as determined by measuring the binding of the fluorescent ligand 1-aminoanthracene, was partially lost only when incubating HNE levels and exposure time to HNE exceeded physiological values in nasal mucosa [5].

Analytical, diagnostic and therapeutic context of OBP2A

• Cesarean section was associated with a decreased risk of OBPP [16].
• METHODS: The PEDI self-care domain results for 45 children with OBPP (30 without hand impairment, 15 with hand impairment) were reviewed retrospectively [17].
• The first reported case of live-donor nerve transplantation is presented, performed in an 8-month-old infant with global obstetric brachial plexus palsy (OBPP) and four root avulsions who had undergone prior sural nerve autografting at 3 months [18].

References