Gene Review:
MNX1 - motor neuron and pancreas homeobox 1
Homo sapiens
Synonyms:
HB9, HLXB9, HOXHB9, Homeobox protein HB9, Motor neuron and pancreas homeobox protein 1, ...
Horn,
Tönnies,
Neitzel,
Wahl,
Hinkel,
von Moers,
Bartsch,
Tosi,
Hughes,
Scherer,
Nakabayashi,
Harbott,
Haas,
Cazzaniga,
Biondi,
Kempski,
Kearney,
Jozefowicz-Simbeni,
Israel,
Braciszewski,
Hobden,
von Bergh,
van Drunen,
van Wering,
van Zutven,
Hainmann,
Lönnerholm,
Meijerink,
Pieters,
Beverloo,
Noack,
Sayk,
Gembruch,
Le Caignec,
Winer,
Boceno,
Delnatte,
Podevin,
Liet,
Quere,
Joubert,
Rival,
Keppler-Noreuil,
Beverloo,
Panagopoulos,
Isaksson,
van Wering,
van Drunen,
de Klein,
Johansson,
Slater,
Nowaczyk,
Huggins,
Tomkins,
Rossi,
Ramsay,
Woulfe,
Scherer,
Belloni,
- Fusion of the homeobox gene HLXB9 and the ETV6 gene in infant acute myeloid leukemias with the t(7;12)(q36;p13). Beverloo, H.B., Panagopoulos, I., Isaksson, M., van Wering, E., van Drunen, E., de Klein, A., Johansson, B., Slater, R. Cancer Res. (2001)
- Holoprosencephaly, sacral anomalies, and situs ambiguus in an infant with partial monosomy 7q/trisomy 2p and SHH and HLXB9 haploinsufficiency.. Nowaczyk, M.J., Huggins, M.J., Tomkins, D.J., Rossi, E., Ramsay, J.A., Woulfe, J., Scherer, S.W., Belloni, E. Clin. Genet. (2000)
- Prenatal diagnosis of sacrococcygeal teratoma with constitutional partial monosomy 7q/trisomy 2p. Le Caignec, C., Winer, N., Boceno, M., Delnatte, C., Podevin, G., Liet, J.M., Quere, M.P., Joubert, M., Rival, J.M. Prenat. Diagn. (2003)
- Caudal dysgenesis in Islet-1 transgenic mice. Muller, Y.L., Yueh, Y.G., Yaworsky, P.J., Salbaum, J.M., Kappen, C. FASEB J. (2003)
- Currarino syndrome shown by prenatal onset ventriculomegaly and spinal dysraphism. Crétolle, C., Sarnacki, S., Amiel, J., Geneviève, D., Encha-Razavi, F., Zrelli, S., Zérah, M., Nihoul Fékété, C., Lyonnet, S. Am. J. Med. Genet. A (2007)
- Mutation analysis and embryonic expression of the HLXB9 Currarino syndrome gene. Hagan, D.M., Ross, A.J., Strachan, T., Lynch, S.A., Ruiz-Perez, V., Wang, Y.M., Scambler, P., Custard, E., Reardon, W., Hassan, S., Nixon, P., Papapetrou, C., Winter, R.M., Edwards, Y., Morrison, K., Barrow, M., Cordier-Alex, M.P., Correia, P., Galvin-Parton, P.A., Gaskill, S., Gaskin, K.J., Garcia-Minaur, S., Gereige, R., Hayward, R., Homfray, T. Am. J. Hum. Genet. (2000)
- A homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis. Ross, A.J., Ruiz-Perez, V., Wang, Y., Hagan, D.M., Scherer, S., Lynch, S.A., Lindsay, S., Custard, E., Belloni, E., Wilson, D.I., Wadey, R., Goodman, F., Orstavik, K.H., Monclair, T., Robson, S., Reardon, W., Burn, J., Scambler, P., Strachan, T. Nat. Genet. (1998)
- Specification of motoneurons from human embryonic stem cells. Li, X.J., Du, Z.W., Zarnowska, E.D., Pankratz, M., Hansen, L.O., Pearce, R.A., Zhang, S.C. Nat. Biotechnol. (2005)
- Involvement of the HLXB9 homeobox gene in Currarino syndrome. Belloni, E., Martucciello, G., Verderio, D., Ponti, E., Seri, M., Jasonni, V., Torre, M., Ferrari, M., Tsui, L.C., Scherer, S.W. Am. J. Hum. Genet. (2000)
- HLXB9 activates IL6 in Hodgkin lymphoma cell lines and is regulated by PI3K signalling involving E2F3. Nagel, S., Scherr, M., Quentmeier, H., Kaufmann, M., Zaborski, M., Drexler, H.G., MacLeod, R.A. Leukemia (2005)
- Heterogeneity of the 7q36 breakpoints in the t(7;12) involving ETV6 in infant leukemia. Tosi, S., Hughes, J., Scherer, S.W., Nakabayashi, K., Harbott, J., Haas, O.A., Cazzaniga, G., Biondi, A., Kempski, H., Kearney, L. Genes Chromosomes Cancer (2003)
- Activation of HLXB9 by juxtaposition with MYB via formation of t(6;7)(q23;q36) in an AML-M4 cell line (GDM-1). Nagel, S., Kaufmann, M., Scherr, M., Drexler, H.G., MacLeod, R.A. Genes Chromosomes Cancer (2005)
- Population differences in the polyalanine domain and 6 new mutations in HLXB9 in patients with Currarino syndrome. Garcia-Barceló, M., So, M.T., Lau, D.K., Leon, T.Y., Yuan, Z.W., Cai, W.S., Lui, V.C., Fu, M., Herbrick, J.A., Gutter, E., Proud, V., Li, L., Pierre-Louis, J., Aleck, K., van Heurn, E., Belloni, E., Scherer, S.W., Tam, P.K. Clin. Chem. (2006)
- OEIS complex (omphalocele-exstrophy-imperforate anus-spinal defects): a review of 14 cases. Keppler-Noreuil, K.M. Am. J. Med. Genet. (2001)
- Derivation of Motor Neurons from three Clonal Human Embryonic Stem Cell Lines. Lim, U.M., Sidhu, K.S., Tuch, B.E. Current neurovascular research (2006)
- Selective expression of two homeobox genes in CD34-positive cells from human bone marrow. Deguchi, Y., Kehrl, J.H. Blood (1991)
- A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues. Harrison, K.A., Druey, K.M., Deguchi, Y., Tuscano, J.M., Kehrl, J.H. J. Biol. Chem. (1994)
- Monoclonal antibodies VIB-E3, IB5 and HB9 to the leucocyte/epithelial antigen CD24 resemble BA-1 in recognizing sialic acid-dependent epitope(s). Evidence that VIB-E3 recognizes NeuAc alpha 2-6GalNAc and NeuAc alpha 2-6Gal sequences. Larkin, M., Knapp, W., Stoll, M.S., Mehmet, H., Feizi, T. Clin. Exp. Immunol. (1991)
- The "big tent" of community psychology: reactions to Paul Toro's 2004 presidential address. Jozefowicz-Simbeni, D.M., Israel, N., Braciszewski, J., Hobden, K. American journal of community psychology. (2005)
- High incidence of t(7;12)(q36;p13) in infant AML but not in infant ALL, with a dismal outcome and ectopic expression of HLXB9. von Bergh, A.R., van Drunen, E., van Wering, E.R., van Zutven, L.J., Hainmann, I., Lönnerholm, G., Meijerink, J.P., Pieters, R., Beverloo, H.B. Genes Chromosomes Cancer (2006)
- Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro. Moriscot, C., de Fraipont, F., Richard, M.J., Marchand, M., Savatier, P., Bosco, D., Favrot, M., Benhamou, P.Y. Stem Cells (2005)
- Minimal clinical expression of the holoprosencephaly spectrum and of Currarino syndrome due to different cytogenetic rearrangements deleting the Sonic Hedgehog gene and the HLXB9 gene at 7q36.3. Horn, D., Tönnies, H., Neitzel, H., Wahl, D., Hinkel, G.K., von Moers, A., Bartsch, O. Am. J. Med. Genet. A (2004)
- Omphalocoele-exstrophy-imperforate anus-spinal defects complex in dizygotic twins. Noack, F., Sayk, F., Gembruch, U. Fetal. Diagn. Ther. (2005)
- Preimplantation diagnosis for homeobox gene HLXB9 mutation causing Currarino syndrome. Verlinsky, Y., Rechitsky, S., Schoolcraft, W., Kuliev, A. Am. J. Med. Genet. A (2005)
- Expression and localization of homeodomain proteins DLX4, HB9 and HB24 in malignant and benign human colorectal tissues. Hollington, P., Neufing, P., Kalionis, B., Waring, P., Bentel, J., Wattchow, D., Tilley, W.D. Anticancer Res. (2004)