Gene Review:
IGHM - immunoglobulin heavy constant mu
Homo sapiens
Synonyms:
AGM1, Ig mu chain C region, MU, VH
- Clinical and molecular analysis of patients with defects in micro heavy chain gene. Lopez Granados, E., Porpiglia, A.S., Hogan, M.B., Matamoros, N., Krasovec, S., Pignata, C., Smith, C.I., Hammarstrom, L., Bjorkander, J., Belohradsky, B.H., Casariego, G.F., Garcia Rodriguez, M.C., Conley, M.E. J. Clin. Invest. (2002)
- Distinct gene expression patterns in chronic lymphocytic leukemia defined by usage of specific VH genes. Kienle, D., Benner, A., Kröber, A., Winkler, D., Mertens, D., Bühler, A., Seiler, T., Jäger, U., Lichter, P., Döhner, H., Stilgenbauer, S. Blood (2006)
- Crystals of the human heavy chain disease protein Riv and human Fc fragment are isomorphous: further evidence for conformational flexibility in the hinge region of immunoglobulins. Mariuzza, R.A., Poljak, R.J., Mihaesco, C., Mihaesco, E. J. Mol. Biol. (1983)
- The mechanism of chromosome 14 inversion in a human T cell lymphoma. Baer, R., Forster, A., Rabbitts, T.H. Cell (1987)
- Hodgkin's disease with monoclonal and polyclonal populations of Reed-Sternberg cells. Hummel, M., Ziemann, K., Lammert, H., Pileri, S., Sabattini, E., Stein, H. N. Engl. J. Med. (1995)
- Idiotype-antiidiotype regulation. IV. Expression of common regulatory idiotopes on fructosan-binding and non-fructosan-binding monoclonal immunoglobulin. Goldberg, B., Paul, W.E., Bona, C.A. J. Exp. Med. (1983)
- Contributions of a highly conserved VH/VL hydrogen bonding interaction to scFv folding stability and refolding efficiency. Tan, P.H., Sandmaier, B.M., Stayton, P.S. Biophys. J. (1998)
- Mechanisms that generate human immunoglobulin diversity operate from the 8th week of gestation in fetal liver. Cuisinier, A.M., Gauthier, L., Boubli, L., Fougereau, M., Tonnelle, C. Eur. J. Immunol. (1993)
- Perspectives in narcolepsy research and therapy. Mignot, E. Current opinion in pulmonary medicine. (1996)
- VH and VL gene usage by anti-beta-amyloid autoantibodies in Alzheimer's disease: detection of highly mutated V regions in both heavy and light chains. Fang, Q., Kannapell, C.C., Fu, S.M., Xu, S., Gaskin, F. Clin. Immunol. Immunopathol. (1995)
- Avian B-cell development: generation of an immunoglobulin repertoire by gene conversion. McCormack, W.T., Tjoelker, L.W., Thompson, C.B. Annu. Rev. Immunol. (1991)
- The biological origin of antibody diversity. Williamson, A.R. Annu. Rev. Biochem. (1976)
- Restricted immunoglobulin VH usage and VDJ combinations in the human response to Haemophilus influenzae type b capsular polysaccharide. Nucleotide sequences of monospecific anti-Haemophilus antibodies and polyspecific antibodies cross-reacting with self antigens. Adderson, E.E., Shackelford, P.G., Quinn, A., Wilson, P.M., Cunningham, M.W., Insel, R.A., Carroll, W.L. J. Clin. Invest. (1993)
- Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120. Huang, C.C., Venturi, M., Majeed, S., Moore, M.J., Phogat, S., Zhang, M.Y., Dimitrov, D.S., Hendrickson, W.A., Robinson, J., Sodroski, J., Wyatt, R., Choe, H., Farzan, M., Kwong, P.D. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Amino acid sequence of the Fv region of a human monoclonal IgM (protein WEA) with antibody activity against 3,4-pyruvylated galactose in Klebsiella polysaccharides K30 and K33. Goñi, F., Frangione, B. Proc. Natl. Acad. Sci. U.S.A. (1983)
- CD5 and immunoglobulin VH gene expression in B-cell lines from patients with autoimmune diseases. Paavonen, T., Nuutinen, M., Kontiainen, S., Miettinen, A., Müller, K., Andersson, L.C. Immunol. Lett. (1992)
- Antibody VH domains as small recognition units. Davies, J., Riechmann, L. Biotechnology (N.Y.) (1995)
- The complete map of the Ig heavy chain constant gene region reveals evidence for seven IgG isotypes and for IgD in the horse. Wagner, B., Miller, D.C., Lear, T.L., Antczak, D.F. J. Immunol. (2004)
- The AKT1 proto-oncogene maps to human chromosome 14, band q32. Staal, S.P., Huebner, K., Croce, C.M., Parsa, N.Z., Testa, J.R. Genomics (1988)
- mRNA transcripts initiating within the human immunoglobulin mu heavy chain enhancer region contain a non-translatable exon and are extremely heterogeneous at the 5' end. Neale, G.A., Kitchingman, G.R. Nucleic Acids Res. (1991)
- Structure of the catfish IGH locus: analysis of the region including the single functional IGHM gene. Bengt??n, E., Quiniou, S., Hikima, J., Waldbieser, G., Warr, G.W., Miller, N.W., Wilson, M. Immunogenetics (2006)
- A new case of autosomal recessive agammaglobulinaemia with impaired pre-B cell differentiation due to a large deletion of the IGH locus. Milili, M., Antunes, H., Blanco-Betancourt, C., Nogueiras, A., Santos, E., Vasconcelos, J., Castro e Melo, J., Schiff, C. Eur. J. Pediatr. (2002)
- Early function of Pax5 (BSAP) before the pre-B cell receptor stage of B lymphopoiesis. Thévenin, C., Nutt, S.L., Busslinger, M. J. Exp. Med. (1998)
- Molecular basis of the cell-surface expression of immunoglobulin mu chain without light chain in human B lymphocytes. Pollok, B.A., Anker, R., Eldridge, P., Hendershot, L., Levitt, D. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Enhancer and promoter activity in the JH to IGHM intron of the Pekin duck, Anas platyrhynchos. Lundqvist, M.L., McElveen, B.R., Middleton, D.L., Warr, G.W. Dev. Comp. Immunol. (2007)
- Regulation of endoplasmic reticulum stress proteins in COS cells transfected with immunoglobulin mu heavy chain cDNA. Lenny, N., Green, M. J. Biol. Chem. (1991)
- The Immunoglobulin G Heavy Chain (IGHG) genes of the Atlantic bottlenose dolphin, Tursiops truncatus. Mancia, A., Romano, T.A., Gefroh, H.A., Chapman, R.W., Middleton, D.L., Warr, G.W., Lundqvist, M.L. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2006)
- A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B. Pahl, H.L., Baeuerle, P.A. EMBO J. (1995)
- Chimeric immunoglobulin-T cell receptor proteins form functional receptors: implications for T cell receptor complex formation and activation. Goverman, J., Gomez, S.M., Segesman, K.D., Hunkapiller, T., Laug, W.E., Hood, L. Cell (1990)
- The JAM family of junctional adhesion molecules. Bazzoni, G. Curr. Opin. Cell Biol. (2003)
- The mouse antibody response to infection with Cryptococcus neoformans: VH and VL usage in polysaccharide binding antibodies. Casadevall, A., Scharff, M.D. J. Exp. Med. (1991)
- Transcriptional activation by ETS and leucine zipper-containing basic helix-loop-helix proteins. Tian, G., Erman, B., Ishii, H., Gangopadhyay, S.S., Sen, R. Mol. Cell. Biol. (1999)
- Complex regulation of the immunoglobulin mu heavy-chain gene enhancer: microB, a new determinant of enhancer function. Nelsen, B., Kadesch, T., Sen, R. Mol. Cell. Biol. (1990)
- A DNA insertion/deletion necessitates an aberrant RNA splice accounting for a mu heavy chain disease protein. Bakhshi, A., Guglielmi, P., Siebenlist, U., Ravetch, J.V., Jensen, J.P., Korsmeyer, S.J. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Three-dimensional modeling of a pre-B-cell receptor. Lanig, H., Bradl, H., Jäck, H.M. Mol. Immunol. (2004)
- Fetal versus adult PreB or B cells: the human VH repertoire. Tonnelle, C., Cuisinier, A.M., Gauthier, L., Guelpa-Fonlupt, V., Milili, M., Schiff, C., Fougereau, M. Ann. N. Y. Acad. Sci. (1995)
- Genomic alterations in a case of alpha heavy chain disease leading to the generation of composite exons from the JH region. Bentaboulet, M., Mihaesco, E., Gendron, M.C., Brouet, J.C., Tsapis, A. Eur. J. Immunol. (1989)
- SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression. Dobreva, G., Dambacher, J., Grosschedl, R. Genes Dev. (2003)
- Cloning of the IgM heavy chain of the bottlenose dolphin (Tursiops truncatus), and initial analysis of VH gene usage. Lundqvist, M.L., Kohlberg, K.E., Gefroh, H.A., Arnaud, P., Middleton, D.L., Romano, T.A., Warr, G.W. Dev. Comp. Immunol. (2002)
- The VDJ repertoire expressed in human preB cells reflects the selection of bona fide heavy chains. Milili, M., Schiff, C., Fougereau, M., Tonnelle, C. Eur. J. Immunol. (1996)
- Comparative mapping of IGHG1, IGHM, FES, and FOS in domestic cattle. Tobin-Janzen, T.C., Womack, J.E. Immunogenetics (1992)
- Genetic and structural evidence for antigen selection of anti-DNA antibodies. Radic, M.Z., Weigert, M. Annu. Rev. Immunol. (1994)
- Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobulin heavy chain diversity. Hinds-Frey, K.R., Nishikata, H., Litman, R.T., Litman, G.W. J. Exp. Med. (1993)