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Gene Review

FGF2  -  fibroblast growth factor 2 (basic)

Ovis aries

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Disease relevance of FGF-2

  • Elevated FGF-2 signaling by PASMC and PAEC exposed to increased pulmonary blood flow may play a role in the pulmonary vascular remodeling associated with the shunt model of pulmonary hypertension secondary to congenital heart disease [1].
  • We conclude that carotid artery occlusion results in quantifiable white matter lesions that are associated with a loss of MBP from myelin, and that FGF-2, a purported mediator of recovery from brain injury in adult subjects, increases in concentration in proportion to the severity of brain damage in the fetus [2].
  • Compared with untreated sheep with aortic stenosis, in heparin-treated sheep LV FGF-2 protein increased 2-fold, whereas FGF-2 mRNA remained unchanged [3].
  • CONCLUSIONS: Heparin administration during LV hypertension increases heparin-binding angiogenic factors FGF-2 and VEGF in the LV and ameliorates decreases in LV perfusion capacity and capillary density [3].

High impact information on FGF-2

  • Neither growth hormone (GH), fibroblast growth factor-2, nor thyroxine (T(4)) had any effect on IGFBP expression or release [4].
  • We have characterized an intracellular binding protein (FGFBP) for FGF-2 that undergoes a juxtanuclear localization coincident with the nuclear translocation of the growth factor [5].
  • Fibroblast growth factor-2 (FGF-2) is a potent autocrine mitogen for fetal epiphyseal growth plate chondrocytes and exhibits a transient nuclear translocation during G1 of the cell cycle [5].
  • Cells were incubated with protamine sulfate to prevent the binding of endogenous, cell membrane-associated FGF-2 to high affinity FGFRs and their subsequent internalization [5].
  • Ligand blot analysis using 125I-labeled FGF-2 showed that a FGFBP of 46-48 kDa (represented by a double band) was present on the nuclear membrane at mid to late G1, and Western blot showed this to be immunologically related to a part of the extracellular domain of the high affinity FGF receptor 1 (FGFR1) [5].

Biological context of FGF-2


Anatomical context of FGF-2


Associations of FGF-2 with chemical compounds

  • In Experiment 2, heparin-, heat-, or trypsin-treatment and immunoneutralization with FGF-1 or FGF-2 antibodies influenced mitogenic activity of all of the peaks [8].

Other interactions of FGF-2


Analytical, diagnostic and therapeutic context of FGF-2

  • FGFBPs were separated using FGF-2 affinity chromatography [5].
  • Expression of VEGF and FGF-2 was determined by Northern blot analysis [6].
  • FGF-2 concentrations were higher (p < 0.05) in the I/R-72 than the control group and there was a direct correlation between the pathologic scores (PS) and FGF-2 concentrations (FGF-2 = e((1.6 PS-0.90)) + 743, n = 17, r = 0.73, p < 0.001) [2].
  • The five peaks of mitogenic activity were further purified by using chromatography, then were concentrated and subjected to SDS-PAGE and Western analysis for FGF-2 [8].
  • Moreover, FGF-2 was immunolocalized by using a primary antibody and fluorescein isothiocyanate (FITC)-labeled secondary antibody, and immunofluorescence was quantified by using an interactive laser cytometer and image analysis [7].


  1. Fibroblast growth factor-2 expression is altered in lambs with increased pulmonary blood flow and pulmonary hypertension. Wedgwood, S., Devol, J.M., Grobe, A., Benavidez, E., Azakie, A., Fineman, J.R., Black, S.M. Pediatr. Res. (2007) [Pubmed]
  2. White matter injury after cerebral ischemia in ovine fetuses. Petersson, K.H., Pinar, H., Stopa, E.G., Faris, R.A., Sadowska, G.B., Hanumara, R.C., Stonestreet, B.S. Pediatr. Res. (2002) [Pubmed]
  3. Effects of chronic heparin administration on coronary vascular adaptation to hypertension and ventricular hypertrophy in sheep. Flanagan, M.F., Aoyagi, T., Arnold, L.W., Maute, C., Fujii, A.M., Currier, J., Bergau, D., Warren, H.B., Rakusan, K. Circulation (1999) [Pubmed]
  4. Expression and release of insulin-like growth factor binding proteins in isolated epiphyseal growth plate chondrocytes from the ovine fetus. De Los Rios, P., Hill, D.J. J. Cell. Physiol. (2000) [Pubmed]
  5. Perinuclear localization of an intracellular binding protein related to the fibroblast growth factor (FGF) receptor 1 is temporally associated with the nuclear trafficking of FGF-2 in proliferating epiphyseal growth plate chondrocytes. Kilkenny, D.M., Hill, D.J. Endocrinology (1996) [Pubmed]
  6. Cyclic mechanical stretch induces VEGF and FGF-2 expression in pulmonary vascular smooth muscle cells. Quinn, T.P., Schlueter, M., Soifer, S.J., Gutierrez, J.A. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  7. Cellular proliferation and fibroblast growth factors in the corpus luteum during early pregnancy in ewes. Jablonka-Shariff, A., Grazul-Bilska, A.T., Redmer, D.A., Reynolds, L.P. Growth Factors (1997) [Pubmed]
  8. Initial characterization of mitogenic activity of ovine corpora lutea from early pregnancy. Grazul-Bilska, A.T., Redmer, D.A., Zheng, J., Killilea, S.D., Reynolds, L.P. Growth Factors (1995) [Pubmed]
  9. Spatial and temporal localization of transforming growth factor-beta, fibroblast growth factor-2, and osteonectin, and identification of cells expressing alpha-smooth muscle actin in the injured anulus fibrosus: implications for extracellular matrix repair. Melrose, J., Smith, S., Little, C.B., Kitson, J., Hwa, S.Y., Ghosh, P. Spine. (2002) [Pubmed]
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