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Gene Review

BRS3  -  bombesin-like receptor 3

Homo sapiens

Synonyms: BB3, BRS-3, Bombesin receptor subtype-3
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Disease relevance of BRS3


High impact information on BRS3


Biological context of BRS3


Anatomical context of BRS3

  • Immunoreactive GRP-R and BRS-3 receptors were in many cases predominantly confined to the plasma membrane and uniformly present on nearly all tumor cells [1].
  • (177)Lu-AMBA also identified all NMB-expressing tumours, but did not detect BRS-3-expressing tumours or BRS-3-expressing pancreatic islets [11].
  • In contrast, BRS-3 mRNA is widely expressed in a panel of human cell lines from all histological types of lung carcinoma [7].
  • The adhesion of the cells to laminin induced by BRS-3 activation was accompanied by an increase in vinculin-like immunoreactivity and diminished in the presence of an anti-beta(1) integrin antibody, suggesting that the receptor activation stimulates focal adhesion formation [4].
  • GRP-R mRNA predominated in the pregnant endometrium, whereas BRS-3 mRNA predominated in the membranes and placenta [12].

Associations of BRS3 with chemical compounds

  • In the present study, we have attempted to develop a more selective hBRS-3 ligand by using two strategies: substitutions on phenyl ring of Apa11 and the substitution of other conformationally restricted amino acids into position 11 of [D-Tyr6,beta-Ala11,Phe13,Nle14]Bn(6-14) [2].
  • 4. Endogenous hBRS-3 in NCI-N417 activated by VV-H-7 couples to phospholipase C resulting in changes of intracellular calcium, which is initially released from an inositol trisphosphate (IP(3))-sensitive store followed by a capacitive calcium entry from extracellular space [10].
  • 1. The human orphan G-protein coupled receptor bombesin receptor subtype 3 (hBRS-3) was screened for peptide ligands by a Ca(2+)mobilization assay resulting in the purification and identification of two specific ligands, the naturally occurring VV-hemorphin-7 (VV-H-7) and LVV-hemorphin-7 (LVV-H-7), from human placental tissue [10].
  • Eleven of 20 SCLC expressed NMB receptors, and 5/20 expressed BRS-3, compared with 4/13 and 1/13, respectively, in NSCLC cell lines [13].

Other interactions of BRS3

  • Immunohistochemical detection of bombesin receptor subtypes GRP-R and BRS-3 in human tumors using novel antipeptide antibodies [1].
  • An amplified fragment was detected for GRPR in seven of nine cases, for NMBR in six of 10 cases, and the BRS-3 in three of nine cases [14].
  • In this study, we have isolated and characterized human genomic and complementary DNA (cDNA) clones encoding a new BN-like peptide receptor subtype, BN receptor subtype 3 (BRS-3) [7].
  • A bombesin receptor subtype-3 peptide increases nuclear oncogene expression in a MEK-1 dependent manner in human lung cancer cells [15].
  • The study demostrated that activation of BRS-3 may play an important role in wound repair of AHR [16].

Analytical, diagnostic and therapeutic context of BRS3

  • In contrast, we could not detect BRS-3 mRNA in most tissue samples by rt-PCR [17].
  • In these tissues, PCR for BRS-3 mRNA gave rise to an additional product (approximately 50 bp larger) [12].
  • The results showed that: (1) There was few expression of BRS-3 mRNA in the control group [16].
  • Amplification of mRNA from a human antral cell culture preparation demonstrated the presence of two receptors of the bombesin and gastrin-releasing peptide family, GRPR-1 and BRS-3 [18].


  1. Immunohistochemical detection of bombesin receptor subtypes GRP-R and BRS-3 in human tumors using novel antipeptide antibodies. Schulz, S., Röcken, C., Schulz, S. Virchows Arch. (2006) [Pubmed]
  2. Development of bombesin analogs with conformationally restricted amino acid substitutions with enhanced selectivity for the orphan receptor human bombesin receptor subtype 3. Mantey, S.A., Coy, D.H., Entsuah, L.K., Jensen, R.T. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  3. Presence of receptors for bombesin/gastrin-releasing peptide and mRNA for three receptor subtypes in human prostate cancers. Sun, B., Halmos, G., Schally, A.V., Wang, X., Martinez, M. Prostate (2000) [Pubmed]
  4. Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells. Hou, X., Wei, L., Harada, A., Tatamoto, K. Lung Cancer (2006) [Pubmed]
  5. Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3. Ryan, R.R., Weber, H.C., Hou, W., Sainz, E., Mantey, S.A., Battey, J.F., Coy, D.H., Jensen, R.T. J. Biol. Chem. (1998) [Pubmed]
  6. Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors. Mantey, S.A., Weber, H.C., Sainz, E., Akeson, M., Ryan, R.R., Pradhan, T.K., Searles, R.P., Spindel, E.R., Battey, J.F., Coy, D.H., Jensen, R.T. J. Biol. Chem. (1997) [Pubmed]
  7. BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. Fathi, Z., Corjay, M.H., Shapira, H., Wada, E., Benya, R., Jensen, R., Viallet, J., Sausville, E.A., Battey, J.F. J. Biol. Chem. (1993) [Pubmed]
  8. Systematic optimization of a lead-structure identities for a selective short peptide agonist for the human orphan receptor BRS-3. Weber, D., Berger, C., Heinrich, T., Eickelmann, P., Antel, J., Kessler, H. J. Pept. Sci. (2002) [Pubmed]
  9. The distribution of the orphan bombesin receptor subtype-3 in the rat CNS. Jennings, C.A., Harrison, D.C., Maycox, P.R., Crook, B., Smart, D., Hervieu, G.J. Neuroscience (2003) [Pubmed]
  10. Identification and functional characterization of hemorphins VV-H-7 and LVV-H-7 as low-affinity agonists for the orphan bombesin receptor subtype 3. Lammerich, H.P., Busmann, A., Kutzleb, C., Wendland, M., Seiler, P., Berger, C., Eickelmann, P., Meyer, M., Forssmann, W.G., Maronde, E. Br. J. Pharmacol. (2003) [Pubmed]
  11. Selective in vitro targeting of GRP and NMB receptors in human tumours with the new bombesin tracer (177)Lu-AMBA. Waser, B., Eltschinger, V., Linder, K., Nunn, A., Reubi, J.C. Eur. J. Nucl. Med. Mol. Imaging (2007) [Pubmed]
  12. Expression of gastrin-releasing peptide (GRP) and GRP receptors in the pregnant human uterus at term. Whitley, J.C., Giraud, A.S., Shulkes, A. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  13. Clinical correlates of bombesin-like peptide receptor subtype expression in human lung cancer cells. Toi-Scott, M., Jones, C.L., Kane, M.A. Lung Cancer (1996) [Pubmed]
  14. Expression of mRNA for three bombesin receptor subtypes in human bronchial epithelial cells. DeMichele, M.A., Davis, A.L., Hunt, J.D., Landreneau, R.J., Siegfried, J.M. Am. J. Respir. Cell Mol. Biol. (1994) [Pubmed]
  15. A bombesin receptor subtype-3 peptide increases nuclear oncogene expression in a MEK-1 dependent manner in human lung cancer cells. Weber, H.C., Walters, J., Leyton, J., Casibang, M., Purdom, S., Jensen, R.T., Coy, D.H., Ellis, C., Clark, G., Moody, T.W. Eur. J. Pharmacol. (2001) [Pubmed]
  16. Wound repair and proliferation of bronchial epithelial cells enhanced by bombesin receptor subtype 3 activation. Tan, Y.R., Qi, M.M., Qin, X.Q., Xiang, Y., Li, X., Wang, Y., Qu, F., Liu, H.J., Zhang, J.S. Peptides (2006) [Pubmed]
  17. In situ hybridization for gastrin-releasing peptide receptor (GRP receptor) expression in prostatic carcinoma. Bartholdi, M.F., Wu, J.M., Pu, H., Troncoso, P., Eden, P.A., Feldman, R.I. Int. J. Cancer (1998) [Pubmed]
  18. Bombesin-evoked gastrin release and calcium signaling in human antral G cells in culture. Squires, P.E., Meloche, R.M., Buchan, A.M. Am. J. Physiol. (1999) [Pubmed]
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