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Gene Review

PLAC8  -  placenta-specific 8

Homo sapiens

Synonyms: BM-004, C15, DGIC, Placenta-specific gene 8 protein, Protein C15, ...
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Disease relevance of PLAC8

  • (ii) Transcription is tightly regulated and restricted in the C15 tumour with many latent genes, notably EBNAs 2-6, being 'switched off.' (iii) A family of cytoplasmic RNAs are transcribed in an antisense direction to a number of existing open reading frames in the EBV genome [1].
  • No gross alterations exist in viral DNA from C15 relative to other human isolates and the large deletion present in the B95-8 'prototype' viral strain established in marmoset cells is not found; C15 contains no linear virion DNA [1].
  • Furthermore, the combined treatment in nude mice led to a complete tumor remission without increasing toxicity in two human EBV-related cancer xenografts (Raji and C15) [2].
  • Acholeplasma laidlawii B cells, highly enriched in saturated C14 and C15 fatty acids, have been grown at several temperatures [3].
  • Branched chain fatty acids are substrates for cytochrome P450(BM3) (CYP102) from Bacillus megaterium; oxidation of C15 and C17 iso and anteiso fatty acids by P450(BM3) leads to the formation of hydroxylated products that possess high levels of regiochemical and stereochemical purity [4].

High impact information on PLAC8


Chemical compound and disease context of PLAC8

  • C15 surfactin monomethyl ester also inactivated SFV which was resistant to the mixture of surfactin isoforms as produced by Bacillus subtilis [6].
  • For the purpose of understanding better the mode of action of alkanes on insects, the relationship between mortality, weight loss in oxygen enriched atmospheres and dietary antioxidants was examined using an alkane, C15 Ampol CPD and a spray oil, C23 DC-Tron NR, on lightbrown apple moth, Epiphyas postvittana Walker, (LBAM) [7].

Biological context of PLAC8

  • Genomic sequence comparisons reveal that in addition to an apparent pseudogene on chromosome 1, Plac8 is expressed at mouse cytoband 5e3 [8].
  • 3. Putative promoter regions up to 10 kb 5' of the transcription units for Plac1, Plac8, and Plac9 contain sites for widely-expressed transcription factors which, by analogy to other instances, may be sufficient to explain placental enrichment [8].
  • The structural features that govern the ability of particular proteins to serve as substrates for isoprenylation by C15 or C20 groups are not completely defined, but studies of the p21ras modification using purified farnesyl:protein transferase suggest that the sequence of the carboxyl-terminal tetrapeptide is important [9].
  • The observation that homoallylic (or latent homoallylic) C-O bonds are present at C5, C9, C15, C19, and C23 led to the strategic decision to rely heavily on the asymmetric glycolate alkylation to construct both the C1-C14 fragment 3 and the C15-C27 subunit 4 [10].
  • These investigations led to a number of important structure-activity relationships, including the conclusion that neither the epoxide nor the stereochemistry at C12 are essential, while the stereochemistry at both C13 and C15 are crucial for biological activity [11].

Anatomical context of PLAC8

  • This increased expression is transcriptionally regulated during butyrate induction of an eosinophilic subline (C15) of the promyelocytic leukemia cell line HL-60, as shown by nuclear run-on assays [12].
  • We have conducted a search for additional onzin-interacting proteins and identified phospholipid scramblase 1 (PLSCR1), an endofacial membrane protein, which is proposed to mediate the bidirectional movement of plasma membrane phospholipids during proliferation and apoptosis [5].
  • Onzin, the product of a negatively c-Myc-regulated target gene, is highly expressed in myeloid cells [5].
  • In this study, using the carcinoembryonic antigen (CEA)-expressing C15 murine colon carcinoma system in syngeneic C57BL/6 mice, we have evaluated the efficacy of bone marrow-derived dendritic cells (DCs) pulsed with the murine anti-idiotype antibody 3H1 as a tumor vaccine [13].
  • The influence of chemical modifications in the C15 side chain and in C12 on binding affinity and microtubule elongation was characterized [14].

Associations of PLAC8 with chemical compounds

  • Analysis of the donor specificity revealed that short chain (C5 and C15) analogues of dolichol phosphate can act as substrates for the trypanosomal dolichol-phosphomannose synthetase, whereas the corresponding mannopyranosides cannot act as donors for the Dol-P-Man:GlcN-PI alpha 1-4-mannosyltransferase [15].
  • Pure isomers of head group 2H-labeled geraniol (C10) and solanesol (C45) gave rise to single splittings while farnesol (C15) gave rise to two sets of splittings due to cis-trans isomerization at the polar terminal double bond [16].
  • The fatty acid- and GTP-dependent accumulation of Ca2+ was highly chain length-specific; pentadecanoate (C15) and palmitate (C16) were equally effective, whereas fatty acids of shorter or longer chain length were either marginally effective or devoid of effect [17].
  • In this paper, a nonrefocused (1)H,(15)N CPMG HSQC of uniformly (13)C,(15)N-labeled 33-mer PEMV-1 RNA has been tailored to reveal a correlation of the 2'-OH hydroxyl proton of C15 to the N1 nitrogen resonance of A27 mediated by a cross hydrogen bond scalar coupling [18].
  • A new approach to the C1-C15 (AB) portion features a vinyllithium addition to an aldehyde followed by a palladium-catalyzed allylic reduction to install the troublesome C13-C15 segment [19].

Other interactions of PLAC8

  • The results revealed that expression levels of Mx protein, beta(2)m, placenta-specific 8 genes, and Cyba were significantly upregulated at 30h after induction with poly I:C, and the CD2BP1 expression was also induced by polyI:C, suggesting that these genes may be involved in an immune response induced by poly I:C in large yellow croaker [20].

Analytical, diagnostic and therapeutic context of PLAC8

  • Sequence analysis of clones that correspond to spliced transcripts in a cDNA library from such a tumor, C15, generates a profile of the main complementary mRNA [21].
  • Intratumoral injection of PMEA (75 microl of 2% solution) in C15 NPC xenografts, which are latently infected with EBV, slowed tumor growth moderately, whereas PMPA (75 microl of 2% solution) slowed tumor growth only marginally [22].
  • In situ hybridization of a 35S-labeled RNA probe homologous to the BamHI-A cDNA to tissue sections revealed that the BamHI-A mRNA is not focally expressed and is transcribed in all cells within the C15 tumor [23].
  • In order to investigate NPC-specific raft partners of LMP1, rafts derived from the C15 NPC xenograft were submitted to preparative immunoprecipitation of LMP1 combined with mass spectrometry analysis of coimmunoprecipitated proteins [24].
  • The effect of hydrostatic pressure on the secondary structure of recombinant human interferon-gamma (rhIFN-gamma) and its biologically inactive truncated form rhIFN-Delta C15 has been studied using Fourier-transform IR (FTIR) spectroscopy [25].


  1. EBV gene expression in an NPC-related tumour. Hitt, M.M., Allday, M.J., Hara, T., Karran, L., Jones, M.D., Busson, P., Tursz, T., Ernberg, I., Griffin, B.E. EMBO J. (1989) [Pubmed]
  2. Antiviral agent cidofovir decreases Epstein-Barr virus (EBV) oncoproteins and enhances the radiosensitivity in EBV-related malignancies. Abdulkarim, B., Sabri, S., Zelenika, D., Deutsch, E., Frascogna, V., Klijanienko, J., Vainchenker, W., Joab, I., Bourhis, J. Oncogene (2003) [Pubmed]
  3. Adaptation to altered growth temperatures in Acholeplasma laidlawii B: Fourier transform infrared studies of acyl chain conformational order in live cells. Moore, D.J., Mendelsohn, R. Biochemistry (1994) [Pubmed]
  4. Are branched chain fatty acids the natural substrates for P450(BM3)? Cryle, M.J., Espinoza, R.D., Smith, S.J., Matovic, N.J., De Voss, J.J. Chem. Commun. (Camb.) (2006) [Pubmed]
  5. The negative c-Myc target onzin affects proliferation and apoptosis via its obligate interaction with phospholipid scramblase 1. Li, Y., Rogulski, K., Zhou, Q., Sims, P.J., Prochownik, E.V. Mol. Cell. Biol. (2006) [Pubmed]
  6. Antiviral and hemolytic activities of surfactin isoforms and their methyl ester derivatives. Kracht, M., Rokos, H., Ozel, M., Kowall, M., Pauli, G., Vater, J. J. Antibiot. (1999) [Pubmed]
  7. Evidence for oil-induced oxidative stress to larvae of the lightbrown apple moth, Epiphyas postvittana Walker (Lepidoptera: Tortricidae). Taverner, P.D., Bailey, P.T., Roush, R.T. Pest Manag. Sci. (2002) [Pubmed]
  8. Plac8 and Plac9, novel placental-enriched genes identified through microarray analysis. Galaviz-Hernandez, C., Stagg, C., de Ridder, G., Tanaka, T.S., Ko, M.S., Schlessinger, D., Nagaraja, R. Gene (2003) [Pubmed]
  9. Posttranslational modification of proteins by isoprenoids in mammalian cells. Maltese, W.A. FASEB J. (1990) [Pubmed]
  10. Asymmetric total synthesis of (-)-laulimalide: exploiting the asymmetric glycolate alkylation reaction. Crimmins, M.T., Stanton, M.G., Allwein, S.P. J. Am. Chem. Soc. (2002) [Pubmed]
  11. Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues. Nicolaou, K.C., Namoto, K., Ritzén, A., Ulven, T., Shoji, M., Li, J., D'Amico, G., Liotta, D., French, C.T., Wartmann, M., Altmann, K.H., Giannakakou, P. J. Am. Chem. Soc. (2001) [Pubmed]
  12. Human eosinophil Charcot-Leyden crystal protein: cloning and characterization of a lysophospholipase gene promoter. Gomolin, H.I., Yamaguchi, Y., Paulpillai, A.V., Dvorak, L.A., Ackerman, S.J., Tenen, D.G. Blood (1993) [Pubmed]
  13. Murine dendritic cells pulsed with an anti-idiotype antibody induce antigen-specific protective antitumor immunity. Saha, A., Chatterjee, S.K., Foon, K.A., Primus, F.J., Bhattacharya-Chatterjee, M. Cancer Res. (2003) [Pubmed]
  14. Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity. Buey, R.M., Díaz, J.F., Andreu, J.M., O'Brate, A., Giannakakou, P., Nicolaou, K.C., Sasmal, P.K., Ritzén, A., Namoto, K. Chem. Biol. (2004) [Pubmed]
  15. Substrate specificity of the dolichol phosphate mannose: glucosaminyl phosphatidylinositol alpha1-4-mannosyltransferase of the glycosylphosphatidylinositol biosynthetic pathway of African trypanosomes. Smith, T.K., Cottaz, S., Brimacombe, J.S., Ferguson, M.A. J. Biol. Chem. (1996) [Pubmed]
  16. 2H NMR investigation of the organization and dynamics of polyisoprenols in membranes. de Ropp, J.S., Troy, F.A. J. Biol. Chem. (1985) [Pubmed]
  17. Fatty acid-mediated calcium sequestration within intracellular calcium pools. Rys-Sikora, K.E., Gill, D.L. J. Biol. Chem. (1998) [Pubmed]
  18. Detection of scalar couplings involving 2'-hydroxyl protons across hydrogen bonds in a frameshifting mRNA pseudoknot. Giedroc, D.P., Cornish, P.V., Hennig, M. J. Am. Chem. Soc. (2003) [Pubmed]
  19. A second-generation synthesis of the C1-C28 portion of the altohyrtins (spongistatins). Hubbs, J.L., Heathcock, C.H. J. Am. Chem. Soc. (2003) [Pubmed]
  20. Expression analysis of immune-relevant genes in the spleen of large yellow croaker (Pseudosciaena crocea) stimulated with poly I:C. Zheng, W., Liu, G., Ao, J., Chen, X. Fish Shellfish Immunol. (2006) [Pubmed]
  21. Expression of a family of complementary-strand transcripts in Epstein-Barr virus-infected cells. Karran, L., Gao, Y., Smith, P.R., Griffin, B.E. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  22. Prevention and inhibition of nasopharyngeal carcinoma growth by antiviral phosphonated nucleoside analogs. Murono, S., Raab-Traub, N., Pagano, J.S. Cancer Res. (2001) [Pubmed]
  23. Novel transcription from the Epstein-Barr virus terminal EcoRI fragment, DIJhet, in a nasopharyngeal carcinoma. Gilligan, K., Sato, H., Rajadurai, P., Busson, P., Young, L., Rickinson, A., Tursz, T., Raab-Traub, N. J. Virol. (1990) [Pubmed]
  24. In nasopharyngeal carcinoma cells, Epstein-Barr virus LMP1 interacts with galectin 9 in membrane raft elements resistant to simvastatin. Pioche-Durieu, C., Keryer, C., Souquère, S., Bosq, J., Faigle, W., Loew, D., Hirashima, M., Nishi, N., Middeldorp, J., Busson, P. J. Virol. (2005) [Pubmed]
  25. Pressure- and temperature-induced unfolding and aggregation of recombinant human interferon-gamma: a Fourier transform infrared spectroscopy study. Goossens, K., Haelewyn, J., Meersman, F., De Ley, M., Heremans, K. Biochem. J. (2003) [Pubmed]
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