The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

FEZF2  -  FEZ family zinc finger 2

Homo sapiens

Synonyms: FEZ, FEZL, FKSG36, FLJ10142, Fez family zinc finger protein 2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of FEZF2

  • Sixty-six invasive ovarian carcinomas and nine borderline tumors of the ovary were analyzed by gas chromatography/time-of-flight mass spectrometry (GC-TOF MS) using a novel contamination-free injector system [1].
  • OBJECTIVES: This study was designed to identify echocardiographic predictors of aortopulmonary collaterals (APCs) in infants with tetralogy of Fallot and pulmonary atresia (TOF/PA) and to prospectively validate these predictors [2].
  • DESIGN: To compare profiles of secreted M/M phi proteins from individuals with HAD, HIV-1 infection or controls using surface-enhanced laser desorption/ionization (SELDI)-time of flight (TOF) ProteinChip technology [3].
  • Two complications occurred in the TOF group, with pulmonary emboli despite prophylaxis and an unrecognized cerebrovascular accident in one patient each [4].
  • LC-MALDI-TOF/TOF MS analysis of tryptic peptides from the SCX fractions of an E. coli lysate revealed improved peptide scores, a doubling of the total number of peptides, and a 30% increase in the number of proteins identified, as a result of labeling [5].

Psychiatry related information on FEZF2

  • The T1 and T4 response-time profiles for the three drugs were analysed with respect to amplitude depression and the TOF ratio (T4/T1) during the development of and recovery from neuromuscular blockade [6].
  • 8. Bias in the M/T group decreased significantly to -8.1 when TOF ratio increased to 0.70, resulting in limits of agreement of 12.1 to -28 [7].
  • In addition, a combination of these techniques with MALDI-TOF/TOF and ESI-Q-TOF mass spectrometry analysis is discussed in relation to possible novel signaling pathways relevant to anxiety disorders, and to the development of biomarkers for the evaluation of these conditions [8].

High impact information on FEZF2

  • By generating Fez;Fezl-deficient mice we found that a redundant function of Fez and Fezl is required for the formation of diencephalon subdivisions [9].
  • Fez and Fez-like (Fezl) are zinc-finger genes that encode transcriptional repressors expressed in overlapping domains of the forebrain [9].
  • They are efficient catalysts for the asymmetric hydroamination/cyclization of aminoalkenes, giving TOF of up to 840 h(-1) at 25 degrees C for 2,2-diphenyl-pent-4-enylamine (5c) using (R)-2-Y [10].
  • At 100 degrees C, the effect of variable H(2) and CO pressure on n:i, % ee, and TOF of hydroformylation of styrene was investigated [11].
  • BACKGROUND: In patients with TOF/PA, routine preoperative diagnostic cardiac catheterization is usually performed to determine the presence and distribution of APCs and the anatomy of the branch pulmonary arteries [2].

Chemical compound and disease context of FEZF2

  • CONCLUSIONS: Early reversal after neostigmine is prompt; however, recovery to a TOF ratio of 0.9 is slow in overweight and obese patients when vecuronium is dosed on the basis of the patient's RBW [12].
  • Neuromuscular block was induced with vecuronium 0.1 mg kg(-1) on the basis of the patient's real body weight (RBW) and was monitored using acceleromyographic train-of-four (TOF) of the adductor pollicis [12].
  • The purpose of this study was to examine differences in train-of-four (TOF) ratios between paretic and healthy extremities after pancuronium and neostigmine administration in 31 patients with hemiparesis [13].
  • 9. We compared the adductor pollicis muscle (AP) visually evaluated response to ulnar nerve 100-Hz, 5-s tetanus (RF100 Hz) with the measured AP TOF ratio in 30 ASA physical status I or II adult anesthetized (propofol, sufentanil, N2O/O2) patients [14].
  • A previously healthy 25-year-old man with metastatic testicular teratocarcinoma became resistant to atracurium-induced neuromuscular blockade as evidenced by train-of-four (TOF) monitoring combined with clinical assessment [15].

Biological context of FEZF2

  • We isolated a novel zinc-finger gene fez-like (fezl) from zebrafish, which displays sequence similarities to Xenopus Fez [16].
  • The principles of parallel separation-vacuum deposition should be generally applicable to MALDI/TOF MS analysis for proteomics and other areas where separation and high throughput are required [17].
  • The mass-to-charge ratios and the amino acid sequences of the recovered tryptic peptides were determined by MALDI-TOF/TOF mass spectrometry and the proteins were identified using Mascot software [18].
  • MALDI-TOF/TOF de novo sequence analysis of 2-D PAGE-separated proteins from Halorhodospira halophila, a bacterium with unsequenced genome [19].
  • Because correct identification is essential to environmental monitoring of antimicrobial pharmaceuticals, accurate mass analyses (TOF and Q-TOF-MS/MS) were compared to nominal mass measurement (quadrupole ion trap) [20].

Anatomical context of FEZF2

  • CONCLUSIONS: Three-dimensional TOF MRA is feasible and moderately accurate for evaluation of mild atherosclerotic changes of carotid arteries [21].
  • A proteomic approach, based upon 2-DE coupled to MS (MALDI-TOF/TOF) has been chosen in an attempt to establish a comprehensive reference database of proteins expressed in the mouse hippocampus [22].
  • For CAE-MALDI/TOF MS, the same number of separation capillaries were coupled with an array of eight infusion capillaries using a common liquid junction, containing matrix solution [17].
  • The EMG response of the adductor pollicis was monitored after train-of-four (TOF) stimulation of the ulnar nerve every 20 s [23].
  • BACKGROUND AND PURPOSE: Three-dimensional time-of-flight (3D TOF) magnetic resonance angiography (MRA) is generally considered to overestimate the degree of stenosis in the internal carotid artery (ICA) in comparison with the reference standard intraarterial digital subtraction angiography (DSA) [24].

Associations of FEZF2 with chemical compounds

  • This is based on stereospecific two-step conversion of the mono-thionucleotide into the corresponding deoxyadenosine 5'-O-alpha-[(18)O]thiotriphosphate, followed by the use of terminal deoxyribonucleotidyl transferase and MALDI TOF mass spectrometry of the resulting elongated primer [25].
  • Paralyzed patients received either TOF monitoring with a goal of three twitches or best clinical assessment while receiving atracurium by continuous infusion [4].
  • The high resolving power of the quadrupole TOF instrument enables the selective detection of phosphotyrosine immonium ions without interference from other peptide fragments of the same nominal mass [26].
  • Discrimination of neolacto-series gangliosides with alpha2-3- and alpha2-6-linked N-acetylneuraminic acid by nanoelectrospray ionization low-energy collision-induced dissociation tandem quadrupole TOF MS [27].
  • Enrichment and identification of cysteine-containing peptides from tryptic digests of performic oxidized proteins by strong cation exchange LC and MALDI-TOF/TOF MS [28].

Analytical, diagnostic and therapeutic context of FEZF2

  • Radiation hybrid mapping revealed that the fezl gene is localized to linkage group 11 [16].
  • Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI TOF MS) can detect primer extension products, mass-tagged oligonucleotides, DNA created by restriction endonuclease cleavage, and genomic DNA [29].
  • Time-of-flight secondary ion mass spectrometry (TOF SIMS) has been used in conjunction with a mass spectrometry cleavable linker to determine the percent conversion of reactions that were conducted site-selectively on an addressable microelectrode array [30].
  • METHODS: The clinical and diagnostic imaging data of infants with TOF/PA treated between 1990 and 2000 were reviewed [2].
  • CONCLUSIONS: Echocardiography is a sensitive and specific test for the detection of >or=1 APCs in infants with TOF/PA [2].


  1. Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors. Denkert, C., Budczies, J., Kind, T., Weichert, W., Tablack, P., Sehouli, J., Niesporek, S., K??nsgen, D., Dietel, M., Fiehn, O. Cancer Res. (2006) [Pubmed]
  2. Echocardiographic predictors of aortopulmonary collaterals in infants with tetralogy of fallot and pulmonary atresia. Mackie, A.S., Gauvreau, K., Perry, S.B., del Nido, P.J., Geva, T. J. Am. Coll. Cardiol. (2003) [Pubmed]
  3. Loss of macrophage-secreted lysozyme in HIV-1-associated dementia detected by SELDI-TOF mass spectrometry. Sun, B., Rempel, H.C., Pulliam, L. AIDS (2004) [Pubmed]
  4. Comparison of train-of-four and best clinical assessment during continuous paralysis. Strange, C., Vaughan, L., Franklin, C., Johnson, J. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
  5. Coumarin tags for analysis of peptides by MALDI-TOF MS and MS/MS. 2. Alexa Fluor 350 tag for increased peptide and protein Identification by LC-MALDI-TOF/TOF MS. Pashkova, A., Chen, H.S., Rejtar, T., Zang, X., Giese, R., Andreev, V., Moskovets, E., Karger, B.L. Anal. Chem. (2005) [Pubmed]
  6. Train-of-four fade during neuromuscular blockade induced by tubocurarine, succinylcholine or alpha-bungarotoxin in the rat isolated hemidiaphragm. Cheah, L.S., Gwee, M.C. Clin. Exp. Pharmacol. Physiol. (1988) [Pubmed]
  7. New equipment for neuromuscular transmission monitoring: a comparison of the TOF-Guard with the Myograph 2000. Kirkegaard-Nielsen, H., Helbo-Hansen, H.S., Lindholm, P., Pedersen, H.S., Severinsen, I.K., Schmidt, M.B. Journal of clinical monitoring and computing. (1998) [Pubmed]
  8. Neuroproteomics: relevance to anxiety disorders. Uys, J.D., Stein, D.J., Daniels, W.M. Current psychiatry reports. (2006) [Pubmed]
  9. Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions. Hirata, T., Nakazawa, M., Muraoka, O., Nakayama, R., Suda, Y., Hibi, M. Development (2006) [Pubmed]
  10. 3,3'-Bis(trisarylsilyl)-substituted binaphtholate rare earth metal catalysts for asymmetric hydroamination. Gribkov, D.V., Hultzsch, K.C., Hampel, F. J. Am. Chem. Soc. (2006) [Pubmed]
  11. Reversal of enantioselectivity in the hydroformylation of styrene with [2S,4S-BDPP]Pt(SnCl3)Cl at high temperature arises from a change in the enantioselective-determining step. Casey, C.P., Martins, S.C., Fagan, M.A. J. Am. Chem. Soc. (2004) [Pubmed]
  12. Neostigmine-induced reversal of vecuronium in normal weight, overweight and obese female patients. Suzuki, T., Masaki, G., Ogawa, S. British journal of anaesthesia. (2006) [Pubmed]
  13. Response differences of paretic and healthy extremities to pancuronium and neostigmine in hemiplegic patients. Iwasaki, H., Namiki, A., Omote, K., Omote, T., Takahashi, T. Anesth. Analg. (1985) [Pubmed]
  14. Visual evaluation of residual curarization in anesthetized patients using one hundred-hertz, five-second tetanic stimulation at the adductor pollicis muscle. Baurain, M.J., Hennart, D.A., Godschalx, A., Huybrechts, I., Nasrallah, G., d'Hollander, A.A., Cantraine, F. Anesth. Analg. (1998) [Pubmed]
  15. Atracurium resistance in a critically Ill patient. Tschida, S.J., Hoey, L.L., Nahum, A., Vance-Bryan, K. Pharmacotherapy (1995) [Pubmed]
  16. Expression of the zinc finger gene fez-like in zebrafish forebrain. Hashimoto, H., Yabe, T., Hirata, T., Shimizu, T., Bae, Y., Yamanaka, Y., Hirano, T., Hibi, M. Mech. Dev. (2000) [Pubmed]
  17. Capillary array electrophoresis-MALDI mass spectrometry using a vacuum deposition interface. Preisler, J., Hu, P., Rejtar, T., Moskovets, E., Karger, B.L. Anal. Chem. (2002) [Pubmed]
  18. Proteomic analysis of the adaptive response of rat renal proximal tubules to metabolic acidosis. Curthoys, N.P., Taylor, L., Hoffert, J.D., Knepper, M.A. Am. J. Physiol. Renal Physiol. (2007) [Pubmed]
  19. MALDI-TOF/TOF de novo sequence analysis of 2-D PAGE-separated proteins from Halorhodospira halophila, a bacterium with unsequenced genome. Samyn, B., Sergeant, K., Memmi, S., Debyser, G., Devreese, B., Van Beeumen, J. Electrophoresis (2006) [Pubmed]
  20. Intramolecular isobaric fragmentation: a curiosity of accurate mass analysis of sulfadimethoxine in pond water. Thurman, E.M., Ferrer, I., Benotti, M., Heine, C.E. Anal. Chem. (2004) [Pubmed]
  21. Mild carotid artery atherosclerosis: assessment by 3-dimensional time-of-flight magnetic resonance angiography, with reference to intravascular ultrasound imaging and contrast angiography. Räsänen, H.T., Manninen, H.I., Vanninen, R.L., Vainio, P., Berg, M., Saari, T. Stroke (1999) [Pubmed]
  22. An integrated map of the murine hippocampal proteome based upon five mouse strains. Pollak, D.D., John, J., Hoeger, H., Lubec, G. Electrophoresis (2006) [Pubmed]
  23. Recovery from vecuronium neuromuscular blockade following neostigmine administration in infants, children, and adults during halothane anesthesia. Debaene, B., Meistelman, C., d'Hollander, A. Anesthesiology (1989) [Pubmed]
  24. Overestimation of carotid artery stenosis with magnetic resonance angiography compared with digital subtraction angiography. Nederkoorn, P.J., Elgersma, O.E., Mali, W.P., Eikelboom, B.C., Kappelle, L.J., van der Graaf, Y. J. Vasc. Surg. (2002) [Pubmed]
  25. Retention of configuration in the action of human plasma 3'-exonuclease on oligo(deoxynucleoside phosphorothioate). A new method for assignment of absolute configuration at phosphorus in isotopomeric deoxyadenosine 5'-O-[(18)O]phosphorothioate. Koziołkiewicz, M., Owczarek, A., Wójcik, M., Domański, K., Guga, P., Stec, W.J. J. Am. Chem. Soc. (2002) [Pubmed]
  26. Detection of tyrosine phosphorylated peptides by precursor ion scanning quadrupole TOF mass spectrometry in positive ion mode. Steen, H., Küster, B., Fernandez, M., Pandey, A., Mann, M. Anal. Chem. (2001) [Pubmed]
  27. Discrimination of neolacto-series gangliosides with alpha2-3- and alpha2-6-linked N-acetylneuraminic acid by nanoelectrospray ionization low-energy collision-induced dissociation tandem quadrupole TOF MS. Meisen, I., Peter-Katalinić, J., Müthing, J. Anal. Chem. (2003) [Pubmed]
  28. Enrichment and identification of cysteine-containing peptides from tryptic digests of performic oxidized proteins by strong cation exchange LC and MALDI-TOF/TOF MS. Dai, J., Wang, J., Zhang, Y., Lu, Z., Yang, B., Li, X., Cai, Y., Qian, X. Anal. Chem. (2005) [Pubmed]
  29. Rapid genotyping by MALDI-monitored nuclease selection from probe libraries. Stoerker, J., Mayo, J.D., Tetzlaff, C.N., Sarracino, D.A., Schwope, I., Richert, C. Nat. Biotechnol. (2000) [Pubmed]
  30. Building addressable libraries: the use of a mass spectrometry cleavable linker for monitoring reactions on a microelectrode array. Chen, C., Nagy, G., Walker, A.V., Maurer, K., McShea, A., Moeller, K.D. J. Am. Chem. Soc. (2006) [Pubmed]
WikiGenes - Universities