Disease relevance of CCAR1

• We utilized this system to assess the precise location of DIS/DLS in the 5' region of the HIV-1 genome with minimum effect on RNA packaging [1].
• Recently, we demonstrated that duplication of the DIS/DLS region in viral RNA caused the production of partially monomeric RNAs in virions, indicating that the region indeed mediated RNA-RNA interaction [1].
• The dimer initiation site/dimer linkage sequence (DIS/DLS) region in the human immunodeficiency virus type 1 (HIV-1) RNA genome is suggested to play important roles in various steps of the virus life cycle [1].
• In confirmation and extension of observations by Carp and his associates, brain tissue and sera from patients with multiple sclerosis (MS) were found to harbor an agent which induces a transitory depression in polymorphonuclear leukocytes (PMN) in mice as well as in rats, hamsters, and guinea pigs [2].
• Purpose: To evaluate the extent of distal intramural spread (DIS) after preoperative radiotherapy for rectal cancer [3].

Psychiatry related information on CCAR1

• 3. There were 1.4 million persons admitted to at least one inpatient mental health or addiction setting during a 1-year period; 80% of them had a current DIS/DSM-III disorder, and the remainder had a history of psychiatric disorder or significant psychiatric symptoms [4].
• Based on a morbidity cutoff index of 50 on the SDS and a positive DIS for depression, 112 patients (13%) were found to have a depressive disorder [5].
• We examined the symptom profiles and rates of comorbidity of panic attacks and DIS/DSM-III major depressive disorder in a population-based sample from four sites of the National Institute of Mental Health (NIMH) Epidemiologic Catchment Area Program (n = 12,668) [6].
• A majority of the DIS-negative schizophrenic subjects acknowledged significant psychopathology in the DIS and missed only one of the six DSM-III criteria items for schizophrenia [7].
• METHODS: We used a sample of 2914 community residents aged 18 or older who participated in the Duke University Epidemiologic Catchment Area Study to explore the relationship between both social and personal resources and the prevalence of DIS/DSM-III phobic disorder [8].

High impact information on CCAR1

• CARP-1 in the culture medium showed no cytotoxicity against HeLa and TMK-1 cells; however, introduction of this protein by electroporation induced apoptosis in these cells [9].
• Neither the nucleotide nor the deduced amino acid sequence of CARP-1 showed homology with pierisin-1 or -2 [9].
• However, a glutamic acid residue (E128) at the putative NAD-binding site, conserved in all ADP-ribosyltransferases, was found in CARP-1, and replacement of aspartic acid for this glutamic acid resulted in loss of almost all ADP-ribosylating activity [9].
• The protein synthesized in vitro from the cDNA in a reticulocyte lysate exhibited the same ADP-ribosylating activity as that of purified CARP-1 [9].
• Treatments with CD437 or chemotherapeutic agent adriamycin, as well as serum deprivation of HBC cells, stimulate CARP-1 expression [10].

Chemical compound and disease context of CCAR1

• In a sample of 55 consecutive methadone maintenance admissions to our clinic, 42% were diagnosed with antisocial personality disorder (ASPD) using the National Institute of Mental Health Diagnostic Interview Schedule NIMH DIS [11].
• After conventional hematoxylin and eosin (H&E) staining, the DIS margin of rectal cancer in large specimens was examined by immunohistochemistry [12].
• DIS was positively correlated with stage C2 (p less than 0.01), lymph node metastasis (p less than 0.03) and infiltrative growth of the tumor (p less than 0.05) [13].

Biological context of CCAR1

• Thus, apoptosis induction by CARP-1 involves sequestration of 14-3-3 and CARP-1-mediated altered expression of multiple cell cycle regulatory genes [10].
• Based on our quantitative structure-activity relationship study of MDRR agents, some compounds with desired substructural features and activity were identified from the MACCS-II and National Cancer Institute DIS databases and tested experimentally [14].
• Well-known examples include the TAR hairpin that forms the binding site for the viral Tat trans-activator protein and the DIS hairpin that is important for dimerization and subsequent packaging of the viral RNA into virion particles [15].
• CARP-1 overexpression inhibited FAK-397 phosphorylation [16].
• The algorithm reliably discriminated between pairs DIS, CON+ and CON- among the cohort of deltaF508 homozygotes [17].

Anatomical context of CCAR1

• Among the 11 clinically complete responders, DIS was found 1 to 5 mm from the microscopically detected ulceration of the mucosa in 5 patients [3].
• The DIS pacemakers closely resemble the pacemakers connected to the through-conducting nerve net [18].
• After dry immersion, percentage of muscle fibers containing type I MHC decreased by 6% (p<0.05) in group DI, but was not changed significantly in group DIS [19].

Associations of CCAR1 with chemical compounds

• The latent dimensionality of DIS/DSM-III-R nicotine dependence: exploratory analyses [20].
• The high wear rate emphasized that medical-grade zirconia (Y-TZP according to ISO/ DIS 13356) should not be used for acetabular cups [21].
• The GEE method identified C2 (MG2) as important for Q2 but only marginally important for Q1 and not important for DIS [22].
• AIM: To value whether omeprazole could induce the healing of DIS and regression of symptoms in patients with DGER [23].
• The GEE method identified C5 (MG1) as important for the quantitative trait Q1 and the corresponding affection status DIS, but the APM method was only suggestive [22].

Analytical, diagnostic and therapeutic context of CCAR1

• Purification and molecular cloning of a DNA ADP-ribosylating protein, CARP-1, from the edible clam Meretrix lamarckii [9].
• The NCI Drug Information System (DIS) is a collection of 24 interactively searchable databases which contain all the data associated with NCI's drug screening program [24].
• Protein sequence analysis revealed that Arpp is homologous (52.7% identity) to Carp which is shown to be involved in the regulation of the transcription of the cardiac ventricular myosin light chain 2 gene [25].
• (iii) To establish if MPS can remove mature cysts from contact lenses according to the ISO/DIS 14729 regimen test for microbe removal [26].
• All the samples were tested using a sensitive procedure based on ISO/DIS 16654:1999 (later ISO 16654:2001), which includes an immunomagnetic separation step [27].

References