The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

DMAP1  -  DNA methyltransferase 1 associated protein 1

Homo sapiens

Synonyms: DNA methyltransferase 1-associated protein 1, DNMAP1, DNMT1-associated protein 1, DNMTAP1, EAF2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of DMAP1


Psychiatry related information on DMAP1

  • When GPP was utilized as allylic substrate, adult prenyltransferase displayed cooperative behavior; while with DMAPP, biphasic kinetics were observed [3].
  • A total of 72 cyclization reactions were carried out to study the factors that influence head-to-tail cyclization: linear precursor sequence, coupling reagent, residue configuration, the proportion of DMAP additive, concentration, reaction temperature and reaction time [4].

High impact information on DMAP1

  • DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci [5].
  • DMAP1 has intrinsic transcription repressive activity, and binds to the transcriptional co-repressor TSG101 [5].
  • We have developed "planar-chiral" derivatives of 4-(dimethylamino)pyridine (DMAP), a highly versatile nucleophilic catalyst, that are effective in a diverse array of processes, including the Staudinger synthesis of beta-lactams, the acylation of silyl ketene acetals, and the kinetic resolution of amines [6].
  • This repeat is in the 5' untranslated region of the gene DIP2B, which encodes a protein with a DMAP1-binding domain, which suggests a role in DNA methylation machinery [7].
  • Using a yeast two-hybrid method, we isolated a putative corepressor, DNA methyltransferase 1-associating protein (DMAP1), which was found to bind to the CC domain of RMP [8].

Biological context of DMAP1


Anatomical context of DMAP1

  • RESULTS: Significantly high levels of GrA were found in the serum and supernatants of lymphocytes from patients with active Behçet's disease cultured in the presence of DMAPP [13].
  • Enzyme derived from corpora allata homogenates of both the larval and adult stage of M. sexta coupled each of the DMAPP analogs to produce homologous geranyl and farnesyl diphosphate products in the order (Z)-3-ethyl>(Z)-3-n-propyl>(Z)-3-methyl (DMAPP)>(Z)-3-i-propyl(Z)-3-n-butyl [14].
  • Isopentenyl diphosphate (IPP), dimethylallyl diphosphate (DMAPP) and some structural analogs of (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate also stimulated Vgamma9/Vdelta2 T-cell proliferation, albeit at much higher concentrations [15].

Associations of DMAP1 with chemical compounds

  • The Km for DMAPP was high at 8 mM, and the kcat of 1.7 s-1 was low, but similar to those of other allylic diphosphate-utilizing enzymes [16].
  • An enzyme extracted from aspen (Populus tremuloides) leaves was previously found to catalyze the Mg(2+)-dependent elimination of pyrophosphate from dimethylallyl diphosphate (DMAPP) to form isoprene (Silver, G. M., and Fall, R. (1991) Plant Physiol. 97, 1588-1591) [16].
  • The DMAP unit was shown to regioselectively relay 1,1'-carbonyldiimidazole (but not phosgene) to the proximal amino group, as designed, but rotation of the triptycene does not occur [17].
  • Carbon dioxide inserts reversibly into the Al-OR bond to give the compound (TPP)AlO(2)COR, and this reaction is promoted by the addition of DMAP [18].
  • Ureas 1 and 7 were prepared by reacting 2-aminopyridine and aminonaphthyridine 25, respectively, with triphosgene and 4-(dimethylamino)pyridine (DMAP) [19].

Physical interactions of DMAP1

  • We undertook a yeast two-hybrid screen for nuclear RGS6-binding proteins and here identify DMAP1 as an RGS6-interacting protein [20].
  • Both Daxx and DMAP1 formed a complex with DNMT1 and colocalized in the nucleus [21].

Enzymatic interactions of DMAP1

  • Molecular modeling shows that the modified IDI2 is still likely to catalyze the isomerization of IPP to DMAPP [22].

Regulatory relationships of DMAP1

  • RGS6 inhibited the transcriptional repressor activity of DMAP1 [20].

Other interactions of DMAP1

  • Gbeta5 and DMAP1 did not compete for each other's interaction with RGS6 [20].
  • Collectively, our findings suggest that Bmi1 incorporates Dmap1 in polycomb gene silencing [10].
  • This review covers the biosynthesis of the starter units of terpenoids, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) via the nonmevalonate pathway together with a new enzyme involved in the conversion of IPP and DMAPP, i.e type 2 IPP isomerase [23].

Analytical, diagnostic and therapeutic context of DMAP1


  1. Molecular cloning, expression, and characterization of adenylate isopentenyltransferase from hop (Humulus lupulus L.). Sakano, Y., Okada, Y., Matsunaga, A., Suwama, T., Kaneko, T., Ito, K., Noguchi, H., Abe, I. Phytochemistry (2004) [Pubmed]
  2. Contrast of response to dacarbazine, mitomycin, doxorubicin, and cisplatin (DMAP) plus GM-CSF between patients with advanced malignant gastrointestinal stromal tumors and patients with other advanced leiomyosarcomas. Edmonson, J.H., Marks, R.S., Buckner, J.C., Mahoney, M.R. Cancer Invest. (2002) [Pubmed]
  3. Prenyltransferase of larval and adult M. sexta corpora allata. Sen, S.E., Clifford Brown, D., Sperry, A.E., Hitchcock, J.R. Insect Biochem. Mol. Biol. (2007) [Pubmed]
  4. Studies on the synthesis of cyclic pentapeptides as LHRH antagonists and the factors that influence cyclization yield. Gao, X.M., Ye, Y.H., Bernd, M., Kutscher, B. J. Pept. Sci. (2002) [Pubmed]
  5. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Rountree, M.R., Bachman, K.E., Baylin, S.B. Nat. Genet. (2000) [Pubmed]
  6. Asymmetric catalysis with "planar-chiral" derivatives of 4-(dimethylamino)pyridine. Fu, G.C. Acc. Chem. Res. (2004) [Pubmed]
  7. CGG-Repeat Expansion in the DIP2B Gene Is Associated with the Fragile Site FRA12A on Chromosome 12q13.1. Winnepenninckx, B., Debacker, K., Ramsay, J., Smeets, D., Smits, A., Fitzpatrick, D.R., Kooy, R.F. Am. J. Hum. Genet. (2007) [Pubmed]
  8. Subcellular localization of RPB5-mediating protein and its putative functional partner. Delgermaa, L., Hayashi, N., Dorjsuren, D., Nomura, T., Thuy, l.e. .T.T., Murakami, S. Mol. Cell. Biol. (2004) [Pubmed]
  9. Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells. Xin, H., Yoon, H.G., Singh, P.B., Wong, J., Qin, J. J. Biol. Chem. (2004) [Pubmed]
  10. Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing. Negishi, M., Saraya, A., Miyagi, S., Nagao, K., Inagaki, Y., Nishikawa, M., Tajima, S., Koseki, H., Tsuda, H., Takasaki, Y., Nakauchi, H., Iwama, A. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  11. Total synthesis of the ramoplanin A2 and ramoplanose aglycon. Jiang, W., Wanner, J., Lee, R.J., Bounaud, P.Y., Boger, D.L. J. Am. Chem. Soc. (2003) [Pubmed]
  12. The DMAP-catalyzed acetylation of alcohols--a mechanistic study (DMAP = 4-(dimethylamino)pyridine). Xu, S., Held, I., Kempf, B., Mayr, H., Steglich, W., Zipse, H. Chemistry (Weinheim an der Bergstrasse, Germany) (2005) [Pubmed]
  13. The level of soluble Granzyme A is elevated in the plasma and in the Vgamma9/Vdelta2 T cell culture supernatants of patients with active Behçet's disease. Accardo-Palumbo, A., Ferrante, A., Cadelo, M., Ciccia, F., Parrinello, G., Lipari, L., Giardina, A.R., Riili, M., Giardina, E., Dieli, F., Triolo, G. Clinical and experimental rheumatology. (2004) [Pubmed]
  14. Juvenile hormone biosynthesis in M. sexta: Substrate specificity of insect prenyltransferase utilizing homologous diphosphate analogs. Sen, S.E., Hitchcock, J.R., Jordan, J.L., Richard, T. Insect Biochem. Mol. Biol. (2006) [Pubmed]
  15. Stimulation of Vgamma9/Vdelta2 T-lymphocyte proliferation by the isoprenoid precursor, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate. Amslinger, S., Hecht, S., Rohdich, F., Eisenreich, W., Adam, P., Bacher, A., Bauer, S. Immunobiology (2007) [Pubmed]
  16. Characterization of aspen isoprene synthase, an enzyme responsible for leaf isoprene emission to the atmosphere. Silver, G.M., Fall, R. J. Biol. Chem. (1995) [Pubmed]
  17. Progress toward a Rationally Designed, Chemically Powered Rotary Molecular Motor. Kelly, T.R., Cai, X., Damkaci, F., Panicker, S.B., Tu, B., Bushell, S.M., Cornella, I., Piggott, M.J., Salives, R., Cavero, M., Zhao, Y., Jasmin, S. J. Am. Chem. Soc. (2007) [Pubmed]
  18. Concerning the mechanism of the ring opening of propylene oxide in the copolymerization of propylene oxide and carbon dioxide to give poly(propylene carbonate). Chisholm, M.H., Zhou, Z. J. Am. Chem. Soc. (2004) [Pubmed]
  19. Complexation-induced unfolding of heterocyclic ureas. Simple foldamers equilibrate with multiply hydrogen-bonded sheetlike structures. Corbin, P.S., Zimmerman, S.C., Thiessen, P.A., Hawryluk, N.A., Murray, T.J. J. Am. Chem. Soc. (2001) [Pubmed]
  20. RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity. Liu, Z., Fisher, R.A. J. Biol. Chem. (2004) [Pubmed]
  21. Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1. Muromoto, R., Sugiyama, K., Takachi, A., Imoto, S., Sato, N., Yamamoto, T., Oritani, K., Shimoda, K., Matsuda, T. J. Immunol. (2004) [Pubmed]
  22. Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication. Breitling, R., Laubner, D., Clizbe, D., Adamski, J., Krisans, S.K. J. Mol. Evol. (2003) [Pubmed]
  23. Diversity of the biosynthesis of the isoprene units. Kuzuyama, T., Seto, H. Natural product reports. (2003) [Pubmed]
  24. OsO(4) in ionic liquid [Bmim]PF(6): a recyclable and reusable catalyst system for olefin dihydroxylation. remarkable effect of DMAP. Yao, Q. Org. Lett. (2002) [Pubmed]
  25. Energy barriers to rotation in axially chiral analogues of 4-(dimethylamino)pyridine. Spivey, A.C., Charbonneau, P., Fekner, T., Hochmuth, D.H., Maddaford, A., Malardier-Jugroot, C., Redgrave, A.J., Whitehead, M.A. J. Org. Chem. (2001) [Pubmed]
  26. Assessment of 4-(dimethylamino)pyridine as a capping agent for gold nanoparticles. Gandubert, V.J., Lennox, R.B. Langmuir : the ACS journal of surfaces and colloids. (2005) [Pubmed]
WikiGenes - Universities